| Substance | Seq |
Src | Pic | PMID |
Dtl | Title ( Sorted by latest article per substance ) |
| Acai Berry | 1 | PM | | 25524621 | 📋 | Açai berry extract attenuates glycerol-induced acute renal failure in rats |
| Aged Garlic | 1 | PM | | 30714460 | 📋 | The aqueous extract of aged black garlic ameliorates colistin-induced acute kidney injury in rats |
| Aloin | 1 | PM | | 31254592 | 📋 | Renal protective effects of aloin in a mouse model of sepsis |
| Amygdalin | 1 | PM | | 31821727 | 📋 | Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice |
| Angelica | 1 | PM | | 38404557 | 📋 | The effect of Astragali Radix-Radix Angelica Sinensis on acute kidney injury: a network pharmacology and molecular docking study |
| Anthocyanins | 1 | PM | 📸 | 30825423 | 📋 | Protective Effects of Anthocyanins From Bilberry Extract in Rats Exposed to Nephrotoxic Effects of Carbon Tetrachloride |
| Asiatic Acid | 1 | PM | | 30257350 | 📋 | Asiatic acid protects against cisplatin-induced acute kidney injury via anti-apoptosis and anti-inflammation |
| Aspirin | 1 | PM | | 37179038 | 📋 | Aspirin alleviates cisplatin-induced acute kidney injury through the AMPK-PGC-1α signaling pathway |
| Astaxanthin | 6 | PM | | 34652584 | 📋 | Astaxanthin attenuates contrast-induced acute kidney injury in rats via ROS/NLRP3 inflammasome |
| Astaxanthin | 5 | PM | | 33758309 | 📋 | Astaxanthin protects against early acute kidney injury in severely burned rats by inactivating the TLR4/MyD88/NF-κB axis and upregulating heme oxygenase-1 |
| Astaxanthin | 4 | PM | | 33238688 | 📋 | [Effect and mechanism of astaxanthin on acute kidney injury in rats with full-thickness burns] |
| Astaxanthin | 3 | PM | | 31217873 | 📋 | Effect of Astaxanthin on Apoptosis of Rat Renal Tubular Epithelial Cells Induced by Iohexol |
| Astaxanthin | 1 | PM | | 30456546 | 📋 | Protective Effect of Astaxanthin Against Contrast-Induced Acute Kidney Injury via SIRT1-p53 Pathway in Rats |
| Astaxanthin | 2 | PM | | 29368247 | 📋 | Astaxanthin Attenuates Contrast Agent-Induced Acute Kidney Injury in Vitro and in Vivo via the Regulation of SIRT1/FOXO3a Expression |
| Astragalosides | 1 | PM | | 38494585 | 📋 | Research progress of astragaloside IV in treating acute kidney injury |
| Astragalosides | 2 | PM | | 33148504 | 📋 | Altered metabolic profiles and biomarkers associated with astragaloside IV-mediated protection against cisplatin-induced acute kidney injury in rats: An HPLC-TOF/MS-based untargeted metabolomics study |
| Astragalosides | 3 | PM | | 28871521 | 📋 | Astragaloside-IV Prevents Acute Kidney Injury and Inflammation by Normalizing Muscular Mitochondrial Function Associated With a Nitric Oxide Protective Mechanism in Crush Syndrome Rats |
| Astragalosides | 8 | PM | | 28750561 | 📋 | Renoprotective mechanisms of Astragaloside IV in cisplatin-induced acute kidney injury |
| Astragalosides | 7 | PM | | 23853656 | 📋 | Preventive Effects of a Natural Anti-Inflammatory Agent, Astragaloside IV, on Ischemic Acute Kidney Injury in Rats |
| Astragalosides | 6 | PM | | 23325448 | 📋 | Astragaloside IV prevents acute kidney injury in two rodent models by inhibiting oxidative stress and apoptosis pathways |
| Astragalus Root | 1 | PM | | 38404557 | 📋 | The effect of Astragali Radix-Radix Angelica Sinensis on acute kidney injury: a network pharmacology and molecular docking study |
| Baicalein | 2 | PM | | 37354967 | 📋 | Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation |
| Baicalein | 1 | PM | | 26550790 | 📋 | Baicalein, a Component of Scutellaria Baicalensis, Attenuates Kidney Injury Induced by Myocardial Ischemia and Reperfusion |
| Baicalin | 3 | PM | | 36196145 | 📋 | Baicalin Alleviates Contrast-Induced Acute Kidney Injury Through ROS/NLRP3/Caspase-1/GSDMD Pathway-Mediated Proptosis in vitro |
| Baicalin | 1 | PM | | 32392921 | 📋 | Baicalin attenuates lipopolysaccharide-induced renal tubular epithelial cell injury by inhibiting the TXNIP/NLRP3 signalling pathway via increasing miR-223-3p expression |
| Bee Pollen | 1 | PM | | 35589738 | 📋 | Protective effect of bee pollen in acute kidney injury, proteinuria, and crystalluria induced by ethylene glycol ingestion in rats |
| Bee Propolis | 1 | PM | | 30783919 | 📋 | Propolis and Its Combination With Boric Acid Protect Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Inhibiting Oxidative Stress, Inflammation, DNA Damage, and Apoptosis in Rats |
| Bee Venom | 4 | PM | | 32899913 | 📋 | Bee Venom Melittin Protects against Cisplatin-Induced Acute Kidney Injury in Mice via the Regulation of M2 Macrophage Activation |
| Berberine | 5 | PM | | 37922559 | 📋 | Berberine ameliorates contrast-induced acute kidney injury by regulating HDAC4-FoxO3a axis-induced autophagy: In vivo and in vitro |
| Berberine | 4 | PM | | 33329722 | 📋 | Integrated Analysis of m6A Methylome in Cisplatin-Induced Acute Kidney Injury and Berberine Alleviation in Mouse |
| Berberine | 3 | PM | | 32944532 | 📋 | Berberine alleviates cisplatin-induced acute kidney injury by regulating mitophagy via PINK 1/Parkin pathway |
| Berberine | 1 | PM | | 31603884 | 📋 | Reno-protective Effect of Berberine |
| Berberine | 2 | PM | | 31334048 | 📋 | Synergistic Effect of Berberine and Pentoxifylline in Attenuation of Acute Kidney Injury |
| Bilberry | 1 | PM | | 32864929 | 📋 | The Role of Vaccinium Myrtillus in the Prevention of Renal Injury in an Experimental Model of Ruptured Abdominal Aortic Aneurysm |
| Bilberry | 2 | PM | 📸 | 30825423 | 📋 | Protective Effects of Anthocyanins From Bilberry Extract in Rats Exposed to Nephrotoxic Effects of Carbon Tetrachloride |
| Boric Acid | 1 | PM | | 30783919 | 📋 | Propolis and Its Combination With Boric Acid Protect Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Inhibiting Oxidative Stress, Inflammation, DNA Damage, and Apoptosis in Rats |
| Boswellic Acid | 1 | PM | 📸 | 35863426 | 📋 | Repression of inflammatory pathways with Boswellia for alleviation of liver injury after renal ischemia reperfusion |
| Capsaicin | 2 | PM | | 37528882 | 📋 | Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro |
| Capsaicin | 1 | PM | | 35615576 | 📋 | Capsaicin Prevents Contrast-Associated Acute Kidney Injury through Activation of Nrf2 in Mice |
| Chokeberry | 1 | PM | | 33551679 | 📋 | The Protective Effect of Anthocyanins Extracted from Aronia Melanocarpa Berry in Renal Ischemia-Reperfusion Injury in Mice |
| Choline | 2 | PM | | 36519607 | 📋 | Choline and citicoline ameliorate oxidative stress in acute kidney injury in rats |
| Citicoline | 1 | PM | | 36519607 | 📋 | Choline and citicoline ameliorate oxidative stress in acute kidney injury in rats |
| Coffee | 1 | PM | 📸 | 35812301 | 📋 | Coffee Consumption May Mitigate the Risk for Acute Kidney Injury: Results From the Atherosclerosis Risk in Communities Study |
| CoQ10 | 2 | PM | 📸 | 35869439 | 📋 | Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury |
| CoQ10 | 1 | PM | | 34134745 | 📋 | Protection of coenzyme Q10 against contrast-induced acute kidney injury in male diabetic rats |
| Cordyceps | 3 | PM | | 38517396 | 📋 | Cordyceps sinensis extract protects against acute kidney injury by inhibiting perforin expression in NK cells via the STING/IRF3 pathway |
| Cordyceps | 2 | PM | | 36843056 | 📋 | Protective Mechanism of Cordyceps sinensis Treatment on Acute Kidney Injury-Induced Acute Lung Injury through AMPK/mTOR Signaling Pathway |
| Cordyceps | 1 | PM | 📸 | 32089779 | 📋 | Cordyceps cicadae Mycelia Ameliorate Cisplatin-Induced Acute Kidney Injury by Suppressing the TLR4/NF- κ B/MAPK and Activating the HO-1/Nrf2 and Sirt-1/AMPK Pathways in Mice |
| Costus | 1 | PM | | 34486350 | 📋 | Nephroprotective Effect of Costus ( Saussurea costus) Ethanolic Extract on Oxaliplatin ®-induced Nephrotoxicity in Adult Male Wistar Rats |
| Curcumin | 9 | PM | | 35809376 | 📋 | Role of curcumin in the treatment of acute kidney injury: research challenges and opportunities |
| Curcumin | 7 | PM | | 34802380 | 📋 | Mechanistic insights into the renoprotective role of curcumin in cisplatin-induced acute kidney injury: network pharmacology analysis and experimental validation |
| Curcumin | 6 | PM | 📸 | 34532973 | 📋 | Indispensable role of mitochondria in maintaining the therapeutic potential of curcumin in acute kidney injury |
| Curcumin | 5 | PM | | 34159091 | 📋 | Curcumin plays a protective role against septic acute kidney injury by regulating the TLR9 signaling pathway |
| Curcumin | 4 | PM | | 33548402 | 📋 | Systematic review and meta-analysis of preventative strategies for acute kidney injury in patients undergoing abdominal aortic aneurysm repair |
| Curcumin | 3 | PM | | 33376508 | 📋 | Curcumin prevents renal cell apoptosis in acute kidney injury in a rat model of dry-heat environment heatstroke via inhibition of the mitochondrial apoptotic pathway |
| Curcumin | 8 | PM | 📸 | 32980475 | 📋 | Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin |
| Curcumin | 2 | PM | | 32918794 | 📋 | Curcumin alleviates acute kidney injury in a dry-heat environment by reducing oxidative stress and inflammation in a rat model |
| Curcumin | 1 | PM | | 32615888 | 📋 | Curcumin Attenuates Inflammation and Cell Apoptosis Through Regulating NF-κB and JAK2/STAT3 Signaling Pathway Against Acute Kidney Injury |
| Cyanidin | 1 | PM | | 33551679 | 📋 | The Protective Effect of Anthocyanins Extracted from Aronia Melanocarpa Berry in Renal Ischemia-Reperfusion Injury in Mice |
| D-Limonene | 1 | PM | | 33510839 | 📋 | D-Limonene Alleviates Acute Kidney Injury Following Gentamicin Administration in Rats: Role of NF- κ B Pathway, Mitochondrial Apoptosis, Oxidative Stress, and PCNA |
| Dihydroartemisinin | 1 | PM | | 37777318 | 📋 | Dihydroartemisinin attenuates ischemia/reperfusion-induced renal tubular senescence by activating autophagy |
| Dihydromyricetin | 1 | PM | | 34490833 | 📋 | The role of miR-199b-3p in regulating Nrf2 pathway by dihydromyricetin to alleviate septic acute kidney injury |
| Dioscin | 1 | PM | 📸 | 36552651 | 📋 | Dioscin Protects against Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling |
| Echinacea | 1 | PM | | 33416087 | 📋 | Echinacea polysaccharide attenuates lipopolysaccharide‑induced acute kidney injury via inhibiting inflammation, oxidative stress and the MAPK signaling pathway |
| EGCG | 4 | PM | | 37847436 | 📋 | Alleviation effects of epigallocatechin-3-gallate against acute kidney injury following severe burns |
| EGCG | 3 | PM | | 37092712 | 📋 | Epigallocatechin-3-gallate in combination with corticosteroids mitigates heat stress-induced acute kidney injury through modulating heat shock protein 70 and toll-like receptor 4-dependent pathways |
| EGCG | 2 | PM | 📸 | 36028100 | 📋 | Rhabdomyolysis-induced acute kidney injury and concomitant apoptosis induction via ROS-mediated ER stress is efficaciously counteracted by epigallocatechin gallate |
| EGCG | 1 | PM | | 26675556 | 📋 | Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass |
| Ellagic Acid | 2 | PM | | 38465322 | 📋 | Renal protection by ellagic acid in a rat model of glycerol-induced acute kidney injury |
| Ellagic Acid | 1 | PM | | 35911650 | 📋 | Synaptic plasticity and cognitive impairment consequences to acute kidney injury: Protective role of ellagic acid |
| Emodin | 1 | PM | 📸 | 35356249 | 📋 | Emodin-Mediated Treatment of Acute Kidney Injury |
| Ferulic Acid | 1 | PM | 📸 | 37724953 | 📋 | Renoprotective effects of ferulic acid mediated by AMPKα1 against lipopolysaccharide-induced damage |
| Frankincense | 1 | PM | 📸 | 35863426 | 📋 | Repression of inflammatory pathways with Boswellia for alleviation of liver injury after renal ischemia reperfusion |
| Fucoidan | 1 | PM | | 33253922 | 📋 | Fucoidan-based micelles as P-selectin targeted carriers for synergistic treatment of acute kidney injury |
| Gallic Acid | 1 | PM | | 24433871 | 📋 | Explicit role of peroxisome proliferator-activated receptor gamma in gallic acid-mediated protection against ischemia-reperfusion-induced acute kidney injury in rats |
| Geniposide | 1 | PM | | 37634840 | 📋 | Geniposide ameliorates acute kidney injury via enhancing the phagocytic ability of macrophages towards neutrophil extracellular traps |
| Genistein | 1 | PM | | 32442578 | 📋 | Protective Effect of Genistein on the Ischemic Acute Kidney Injury in the Rat |
| Geraniol | 1 | PM | | 34889889 | 📋 | Geraniol Averts Methotrexate-Induced Acute Kidney Injury via Keap1/Nrf2/HO-1 and MAPK/NF-κB Pathways |
| Ginkgetin | 1 | PM | | 28852469 | 📋 | Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-κB signaling pathway |
| Ginkgolides | 1 | PM | | 37715308 | 📋 | Ginkgolide A downregulates transient receptor potential (melastatin) 2 to protect cisplatin-induced acute kidney injury in rats through the TWEAK/Fn14 pathway: Ginkgolide A improve acute renal injury |
| Ginseng | 1 | PM | 📸 | 34385105 | 📋 | Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway |
| Ginseng | 3 | PM | | 28703736 | 📋 | Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury |
| Ginsenosides | 7 | PM | 📸 | 36580761 | 📋 | Therapeutic propensity of ginsenosides Rg1 and Rg3 in rhabdomyolysis-induced acute kidney injury and renohepatic crosstalk in rats |
| Ginsenosides | 4 | PM | | 34461812 | 📋 | Protective Effect of 20(R)-Ginsenoside Rg3 Against Cisplatin-Induced Renal Toxicity via PI3K/AKT and NF-[Formula: see text]B Signaling Pathways Based on the Premise of Ensuring Anticancer Effect |
| Ginsenosides | 3 | PM | | 32932915 | 📋 | Minor Ginsenoside Rg2 and Rh1 Attenuates LPS-Induced Acute Liver and Kidney Damages via Downregulating Activation of TLR4-STAT1 and Inflammatory Cytokine Production in Macrophages |
| Ginsenosides | 5 | PM | | 31985021 | 📋 | Ginsenoside Protects Against AKI via Activation of HIF‑1α and VEGF‑A in the kidney‑brain Axis |
| Ginsenosides | 2 | PM | | 31527568 | 📋 | Ginsenoside Rg3 Reduces Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor-β1 by Inactivation of AKT in HMrSV5 Peritoneal Mesothelial Cells |
| Ginsenosides | 9 | PM | | 24324637 | 📋 | Protective effect of ginsenoside Rb1 against intestinal ischemia-reperfusion induced acute renal injury in mice |
| Ginsenosides | 1 | PM | | 10803758 | 📋 | The Role of ginsenoside-Rd in Cisplatin-Induced Acute Renal Failure |
| Gotu Kola | 1 | PM | | 30257350 | 📋 | Asiatic acid protects against cisplatin-induced acute kidney injury via anti-apoptosis and anti-inflammation |
| Grape Seed extract | 1 | PM | 📸 | 31685770 | 📋 | Preventive Effects of Grape Extract on Ischemia/Reperfusion-Induced Acute Kidney Injury in Mice |
| Grape Seed extract | 3 | PM | 📸 | 27690015 | 📋 | GSPE Inhibits HMGB1 Release, Attenuating Renal IR-Induced Acute Renal Injury and Chronic Renal Fibrosis |
| Grape Seed extract | 2 | PM | | 24158126 | 📋 | Perspective on rhabdomyolysis-induced acute kidney injury and new treatment options |
| Hesperidin | 2 | PM | | 32407847 | 📋 | Taurine and hesperidin rescues carbon tetrachloride-triggered testicular and kidney damage in rats via modulating oxidative stress and inflammation |
| Honokiol | 2 | PM | | 35297042 | 📋 | Honokiol ameliorates cisplatin-induced acute kidney injury via inhibition of mitochondrial fission |
| Honokiol | 1 | PM | 📸 | 32942603 | 📋 | Honokiol Protects the Kidney from Renal Ischemia and Reperfusion Injury by Upregulating the Glutathione Biosynthetic Enzymes |
| Hydroxytyrosol | 1 | PM | 📸 | 37699441 | 📋 | Modulation of mi-RNA25/Ox-LDL/NOX4 signaling pathway by polyphenolic compound Hydroxytyrosol as a new avenue to alleviate cisplatin-induced acute kidney injury, a mechanistic study in rats |
| Icariin | 1 | PM | | 35910780 | 📋 | Icariin and Competing Endogenous RNA Network: A Potential Protective Strategy Against Contrast-Induced Acute Kidney Injury |
| Isoliquiritigenin | 1 | PM | | 34924130 | 📋 | Renoprotective effect of isoliquiritigenin on cisplatin-induced acute kidney injury through inhibition of FPR2 in macrophage |
| Jujube | 1 | PM | | 34443393 | 📋 | The Nephroprotective Effect of Zizyphus lotus L. (Desf.) Fruits in a Gentamicin-Induced Acute Kidney Injury Model in Rats: A Biochemical and Histopathological Investigation |
| L-Carnitine | 3 | PM | | 38095023 | 📋 | L-carnitine pretreatment ameliorates heat stress-induced acute kidney injury by restoring mitochondrial function of tubular cells |
| L-Carnitine | 1 | PM | | 33613972 | 📋 | L-carnitine suppresses cisplatin-induced renal injury in rats: impact on cytoskeleton proteins expression |
| L-Carnitine | 2 | PM | | 22487906 | 📋 | Metabolomic changes and protective effect of (L)-carnitine in rat kidney ischemia/reperfusion injury |
| L-Glutamine | 3 | PM | | 36107633 | 📋 | Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells |
| L-Glutamine | 2 | PM | | 35035815 | 📋 | Analysis of microRNA Expression after Glutamine Intervention in Acute Renal Ischemia-Reperfusion Injury |
| Licochalcones | 1 | PM | | 26552405 | 📋 | Licochalcone A Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting NF-κB Activation |
| Limonin | 1 | PM | 📸 | 37324945 | 📋 | Limonin, a natural ERK2 agonist, protects against ischemic acute kidney injury |
| Lutein | 1 | PM | | 34187949 | 📋 | Protective effects of lutein against vancomycin-induced acute renal injury in mice via upregulation of peroxisome proliferator-activated receptor gamma/nuclear factor erythroid 2-related factor 2 and inhibition nuclear factor-kappaB/caspase 3 |
| Luteolin | 3 | PM | 📸 | 36358895 | 📋 | Renoprotective Effects of Luteolin: Therapeutic Potential for COVID-19-Associated Acute Kidney Injuries |
| Luteolin | 1 | PM | | 32938255 | 📋 | Luteolin Attenuates Glycerol-Induced Acute Renal Failure and Cardiac Complications Through Modulation of Kim-1/NF-κB/Nrf2 Signaling Pathways |
| Lycopene | 1 | PM | | 33376684 | 📋 | New insight into the effect of lycopene on the oxidative stress in acute kidney injury |
| Lycopene | 2 | PM | | 27884046 | 📋 | Effect of Lycopene and Rosmarinic Acid on Gentamicin Induced Renal Cortical Oxidative Stress, Apoptosis, and Autophagy in Adult Male Albino Rat |
| Madecassoside | 1 | PM | 📸 | 38056145 | 📋 | Madecassoside alleviates acute kidney injury by regulating JNK-mediated oxidative stress and programmed cell death |
| Magnesium | 4 | PM | | 34953401 | 📋 | Preloading magnesium attenuates cisplatin-associated nephrotoxicity: pilot randomized controlled trial (PRAGMATIC study) |
| Magnesium | 1 | PM | | 31429065 | 📋 | Prevention of Cisplatin-Induced Acute Kidney Injury: A Systematic Review and Meta-Analysis |
| Magnesium | 3 | PM | | 29394952 | 📋 | Renal protective effect of a hydration supplemented with magnesium in patients receiving cisplatin for head and neck cancer |
| Magnesium | 2 | PM | | 27966021 | 📋 | Short hydration regimen with magnesium supplementation prevents cisplatin-induced nephrotoxicity in lung cancer: a retrospective analysis |
| Mangiferin | 2 | PM | | 30083783 | 📋 | Mangiferin Attenuates Cisplatin-Induced Acute Kidney Injury in Rats Mediating Modulation of MAPK Pathway |
| Mangiferin | 3 | PM | 📸 | 29967581 | 📋 | Mangiferin Ameliorates Cisplatin Induced Acute Kidney Injury by Upregulating Nrf-2 via the Activation of PI3K and Exhibits Synergistic Anticancer Activity With Cisplatin |
| Matcha Tea | 1 | PM | | 38647648 | 📋 | Comparative study of the anti-inflammatory activity of etoricoxib and Matcha green tea against acute kidney injury induced by gamma radiation in rats |
| Melatonin | 10 | PM | | 38010077 | 📋 | Protective role of melatonin for acute kidney injury: A systematic review and meta-analysis |
| Melatonin | 8 | PM | | 36097885 | 📋 | Melatonin Attenuates Mitochondrial Damage in Aristolochic Acid-Induced Acute Kidney Injury |
| Melatonin | 6 | PM | | 35979396 | 📋 | Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis |
| Melatonin | 5 | PM | | 35367536 | 📋 | Melatonin attenuates cisplatin-induced acute kidney injury in mice: Involvement of PPARα and fatty acid oxidation |
| Melatonin | 3 | PM | | 34152824 | 📋 | Reno-protective effects of melatonin against vancomycin-related acute kidney injury in hospitalized patients: a retrospective cohort study |
| Melatonin | 2 | PM | | 34122726 | 📋 | Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3 |
| Melatonin | 1 | PM | | 31452866 | 📋 | Combined melatonin and poricoic acid A inhibits renal fibrosis through modulating the interaction of Smad3 and β-catenin pathway in AKI-to-CKD continuum |
| Metformin | 2 | PM | | 38345758 | 📋 | Metformin Protects Against Acute Kidney Injury Induced by Lipopolysaccharide via Up-Regulating the MCPIP1/SIRT1 Pathway |
| Metformin | 1 | PM | | 36980186 | 📋 | Sestrin2 Mediates Metformin Rescued the Age-Related Cardiac Dysfunctions of Cardiorenal Syndrome Type 3 |
| Modified Citrus Pectin | 1 | PM | 📸 | 31709320 | 📋 | Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway |
| Modified Citrus Pectin | 2 | PM | | 21494626 | 📋 | Modified citrus pectin reduces galectin-3 expression and disease severity in experimental acute kidney injury |
| Moringa Oleifera | 3 | PM | 📸 | 35560259 | 📋 | Moringa oleifera extract protects against rhabdomyolysis-induced acute kidney injury |
| Moringa Oleifera | 2 | PM | | 33402987 | 📋 | Nephroprotective effect of methanol extract of Moringa oleifera leaves on acute kidney injury induced by ischemia-reperfusion in rats |
| Moringa Oleifera | 1 | PM | 📸 | 27441110 | 📋 | The modulatory effect of Moringa oleifera leaf extract on endogenous antioxidant systems and inflammatory markers in an acetaminophen-induced nephrotoxic mice model |
| Motherwort | 1 | PM | | 34980736 | 📋 | Leonurine Preconditioning Attenuates Ischemic Acute Kidney Injury in Rats by Promoting Nrf2 Nuclear Translocation and Suppressing TLR4/NF-κB Pathway |
| N-Acetyl Cysteine | 5 | PM | | 35655853 | 📋 | Protection Against Post-resuscitation Acute Kidney Injury by N-Acetylcysteine via Activation of the Nrf2/HO-1 Pathway |
| N-Acetyl Cysteine | 1 | PM | | 32438104 | 📋 | Protective Effect of N-Acetylcysteine Pretreatment on Acute Kidney Injury in Septic Rats |
| N-Acetyl Cysteine | 2 | PM | | 31640182 | 📋 | N-Acetylcysteine Attenuates the Increasing Severity of Distant Organ Liver Dysfunction After Acute Kidney Injury in Rats Exposed to Bisphenol A |
| N-Acetyl Cysteine | 4 | PM | | 27845599 | 📋 | N-acetylcysteine protects against star fruit-induced acute kidney injury |
| Neferine | 2 | PM | | 38658442 | 📋 | Neferine alleviates acute kidney injury by regulating the PPAR-α/NF-κB pathway |
| Neferine | 1 | PM | | 36326941 | 📋 | Neferine mitigates cisplatin-induced acute kidney injury in mice by regulating autophagy and apoptosis |
| Neohesperidin | 1 | PM | | 36608504 | 📋 | Neohesperidin dihydrochalbazone protects against septic acute kidney injury in mice |
| Nicotinamide | 3 | PM | 📸 | 34950458 | 📋 | Nicotinamide and acute kidney injury |
| Nicotinamide | 2 | PM | | 34274652 | 📋 | NAicotinamide retains Klotho expression and ameliorates rhabdomyolysis-induced acute kidney injury |
| Nicotinamide | 1 | PM | | 33722665 | 📋 | NAM protects against cisplatin-induced acute kidney injury by suppressing the PARP1/p53 pathway |
| Nicotinamide Riboside | 2 | PM | 📸 | 34950458 | 📋 | Nicotinamide and acute kidney injury |
| Nicotinamide Riboside | 1 | PM | | 32791973 | 📋 | Nicotinamide riboside with pterostilbene (NRPT) increases NAD + in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI |
| Nigella Sativa | 1 | PM | | 36583174 | 📋 | Nigella sativa and its main constituent, thymoquinone protect against glycerol-induced acute kidney injury in rats |
| Nigella Sativa | 3 | PM | | 27930989 | 📋 | Protective effect of Nigella sativa oil on cisplatin induced nephrotoxicity and oxidative damage in rat kidney |
| NMN | 3 | PM | | 35137552 | 📋 | NAD + ameliorates endotoxin-induced acute kidney injury in a sirtuin1-dependent manner via GSK-3β/Nrf2 signalling pathway |
| NMN | 2 | PM | 📸 | 34950458 | 📋 | Nicotinamide and acute kidney injury |
| NMN | 1 | PM | | 33833691 | 📋 | Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence |
| NMN | 4 | PM | | 28246130 | 📋 | Nicotinamide Mononucleotide, an NAD+ Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1-Dependent Manner |
| Nobiletin | 1 | PM | | 26002685 | 📋 | Nobiletin ameliorates cisplatin-induced acute kidney injury due to its anti-oxidant, anti-inflammatory and anti-apoptotic effects |
| Nuciferine | 1 | PM | | 33450067 | 📋 | Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis |
| Oleic Acid | 1 | PM | | 34798521 | 📋 | Oleic acid alleviates LPS-induced acute kidney injury by restraining inflammation and oxidative stress via the Ras/MAPKs/PPAR-γ signaling pathway |
| Ollive Leaf extract | 1 | PM | | 32291641 | 📋 | Olive leaf extract modulates glycerol-induced kidney and liver damage in rats |
| Paeoniflorin | 1 | PM | | 36753983 | 📋 | Paeoniflorin alleviates ischemia/reperfusion induced acute kidney injury by inhibiting Slc7a11-mediated ferroptosis |
| Phloretin | 1 | PM | | 37218423 | 📋 | Concomitant inhibition of TLR-4 and SGLT2 by phloretin and empagliflozin prevents diabetes-associated ischemic acute kidney injury |
| Pine Bark | 1 | PM | | 28178874 | 📋 | Ameliorative effects of pine bark extract on cisplatin-induced acute kidney injury in rats |
| Piperine | 1 | PM | | 31463384 | 📋 | Piperine Pretreatment Attenuates Renal Ischemia-Reperfusion Induced Liver Injury |
| Polydatin | 1 | PM | | 31445125 | 📋 | Polydatin prevents LPS-induced acute kidney injury through inhibiting inflammatory and oxidative responses |
| Pomegranate | 1 | PM | | 27956780 | 📋 | Benefits of pomegranate ( Punica granatum Linn) fruit extracts to weight changes, total protein, and uric acid in white rats ( Rattus norvegicus) as an animal model of acute renal failure |
| Poria Mushrooms | 1 | PM | | 31452866 | 📋 | Combined melatonin and poricoic acid A inhibits renal fibrosis through modulating the interaction of Smad3 and β-catenin pathway in AKI-to-CKD continuum |
| Pterostilbene | 1 | PM | | 32791973 | 📋 | Nicotinamide riboside with pterostilbene (NRPT) increases NAD + in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI |
| Puerarin | 1 | PM | | 37488808 | 📋 | [Puerarin alleviates lipopolysaccharide-induced acute kidney injury in mice by modulating the SIRT1/NF-κB pathway] |
| Punicalagin | 1 | PM | | 27464552 | 📋 | Nephroprotection of punicalagin in rat model of endotoxemic acute kidney injury |
| Quercetin | 6 | PM | | 38186644 | 📋 | Preclinical evidence of reno-protective effect of quercetin on acute kidney injury: a meta-analysis of animal studies |
| Quercetin | 5 | PM | 📸 | 33364059 | 📋 | Quercetin alleviates acute kidney injury by inhibiting ferroptosis |
| Quercetin | 4 | PM | | 33297540 | 📋 | Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury |
| Quercetin | 2 | PM | | 32013615 | 📋 | Suppression of Glomerular Damage and Apoptosis and Biomarkers of Acute Kidney Injury Induced by Acetaminophen Toxicity Using a Combination of Resveratrol and Quercetin |
| Quercetin | 3 | PM | | 31497913 | 📋 | Quercetin Protects Against Cisplatin-Induced Acute Kidney Injury by Inhibiting Mincle/Syk/NF-κB Signaling Maintained Macrophage Inflammation |
| Quercetin | 1 | PM | | 12739822 | 📋 | Role of Quercetin on Hepatic Urea Production in Acute Renal Failure |
| Red Sage | 1 | PM | | 35401224 | 📋 | Salvia miltiorrhiza Bunge (Danshen) and Bioactive Compound Tanshinone IIA Alleviates Cisplatin-Induced Acute Kidney Injury Through Regulating PXR/NF-κB Signaling |
| Red Sage | 2 | PM | | 29855534 | 📋 | Simultaneous purification of dihydrotanshinone, tanshinone I, cryptotanshinone, and tanshinone IIA from Salvia miltiorrhiza and their anti-inflammatory activities investigation |
| Resveratrol | 3 | PM | | 38203174 | 📋 | Molecular Mechanisms of Oxidative Stress in Acute Kidney Injury: Targeting the Loci by Resveratrol |
| Resveratrol | 6 | PM | | 37843077 | 📋 | Arsenic Exposure-Induced Acute Kidney Injury by Regulating SIRT1/PINK1/Mitophagy Axis in Mice and in HK-2 Cells |
| Resveratrol | 4 | PM | | 36269038 | 📋 | The anti-inflammatory activity of resveratrol in acute kidney injury: a systematic review and meta-analysis of animal studies |
| Resveratrol | 2 | PM | | 32938235 | 📋 | Resveratrol prevents acute renal injury in a model of ruptured abdominal aortic aneurysm |
| Resveratrol | 1 | PM | | 32013615 | 📋 | Suppression of Glomerular Damage and Apoptosis and Biomarkers of Acute Kidney Injury Induced by Acetaminophen Toxicity Using a Combination of Resveratrol and Quercetin |
| Retinoic Acid | 1 | PM | | 32719599 | 📋 | Retinoic Acid Alleviates Cisplatin-Induced Acute Kidney Injury Through Activation of Autophagy |
| Rosmarinic Acid | 2 | PM | 📸 | 35079027 | 📋 | NLRP3 inflammasome in rosmarinic acid-afforded attenuation of acute kidney injury in mice |
| Rosmarinic Acid | 1 | PM | | 27884046 | 📋 | Effect of Lycopene and Rosmarinic Acid on Gentamicin Induced Renal Cortical Oxidative Stress, Apoptosis, and Autophagy in Adult Male Albino Rat |
| Salidroside | 1 | PM | | 35386851 | 📋 | Salidroside Protects Acute Kidney Injury in Septic Rats by Inhibiting Inflammation and Apoptosis |
| Salvianolic Acid | 4 | PM | 📸 | 35795279 | 📋 | Salvianolic Acid B Attenuates Iopromide-Induced Renal Tubular Epithelial Cell Injury by Inhibiting the TLR4/NF- κ B/NLRP3 Signaling Pathway |
| Salvianolic Acid | 1 | PM | 📸 | 34679755 | 📋 | Salvianolic Acid C Protects against Cisplatin-Induced Acute Kidney Injury through Attenuation of Inflammation, Oxidative Stress and Apoptotic Effects and Activation of the CaMKK-AMPK-Sirt1-Associated Signaling Pathway in Mouse Models |
| Salvianolic Acid | 2 | PM | | 31654708 | 📋 | Preventive effects of a natural anti-inflammatory agent Salvianolic acid A on acute kidney injury in mice |
| Scutellarein | 1 | PM | | 34619498 | 📋 | Scutellarein relieves the death and inflammation of tubular epithelial cells in ischemic kidney injury by degradation of COX-2 protein |
| Scutellarin | 2 | PM | | 36177678 | 📋 | Protective activities of scutellarin against alcohol-induced acute kidney injury |
| Shogaol | 1 | PM | | 34641472 | 📋 | Protective Effects of 6-Shogaol, an Active Compound of Ginger, in a Murine Model of Cisplatin-Induced Acute Kidney Injury |
| Silymarin | 1 | PM | | 35128959 | 📋 | Silymarin protects the rats against paraquat-induced acute kidney injury via Nrf2 |
| Skullcap | 1 | PM | | 31291609 | 📋 | The concurrent treatment of Scutellaria baicalensis Georgi enhances the therapeutic efficacy of cisplatin but also attenuates chemotherapy-induced cachexia and acute kidney injury |
| Stinging Nettle | 1 | PM | | 32523882 | 📋 | Ameliorative Effect of Cotreatment With the Methanolic Leaf Extract of Urtica dioica on Acute Kidney Injury Induced by Gentamicin in Rats |
| Strawberry | 1 | PM | | 28567583 | 📋 | Protective Effects of Fragaria ananassa Extract Against Cadmium Chloride-Induced Acute Renal Toxicity in Rats |
| Sulforaphane | 2 | PM | | 37567014 | 📋 | Restoring glomerular filtration rate by sulforaphane modulates ERK1/2/JNK/p38MAPK, IRF3/iNOS, Nrf2/HO-1 signaling pathways against folic acid-induced acute renal injury in rats |
| Sulforaphane | 1 | PM | 📸 | 32315768 | 📋 | Altered Proximal Tubule Fatty Acid Utilization, Mitophagy, Fission and Supercomplexes Arrangement in Experimental Fanconi Syndrome Are Ameliorated by Sulforaphane-Induced Mitochondrial Biogenesis |
| Tanshinone | 4 | PM | | 36651254 | 📋 | [Tanshinone IIA alleviates lipopolysaccharide-induced renal tubular epithelial cell apoptosis by inhibiting RIP3/FUNDC1 signaling pathway] |
| Tanshinone | 1 | PM | | 36279396 | 📋 | Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats |
| Tanshinone | 3 | PM | | 35401224 | 📋 | Salvia miltiorrhiza Bunge (Danshen) and Bioactive Compound Tanshinone IIA Alleviates Cisplatin-Induced Acute Kidney Injury Through Regulating PXR/NF-κB Signaling |
| Taurine | 1 | PM | | 32407847 | 📋 | Taurine and hesperidin rescues carbon tetrachloride-triggered testicular and kidney damage in rats via modulating oxidative stress and inflammation |
| Tea | 1 | PM | | 37432322 | 📋 | Tea Consumption and New-Onset Acute Kidney Injury: The Effects of Milk or Sweeteners Addition and Caffeine/Coffee |
| Thymol | 1 | PM | | 37417222 | 📋 | Protective effect of thymol on glycerol-induced acute kidney injury |
| Thymoquinone | 2 | PM | | 38629092 | 📋 | Renoprotective effect of thymoquinone against rhabdomyolysis-induced acute kidney injury in the rat model |
| Thymoquinone | 5 | PM | | 36583174 | 📋 | Nigella sativa and its main constituent, thymoquinone protect against glycerol-induced acute kidney injury in rats |
| Thymoquinone | 4 | PM | | 35989671 | 📋 | Thymoquinone alleviates doxorubicin induced acute kidney injury by decreasing endoplasmic reticulum stress, inflammation and apoptosis |
| Thymoquinone | 1 | PM | | 33165700 | 📋 | Thymoquinone alleviates mitochondrial viability and apoptosis in diclofenac-induced acute kidney injury (AKI) via regulating Mfn2 and miR-34a mRNA expressions |
| Thymoquinone | 3 | PM | | 17439407 | 📋 | Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats |
| Tribulus Terrestris | 1 | PM | | 25001135 | 📋 | Protective effects of Tribulus terrestris L extract against acute kidney injury induced by reperfusion injury in rats |
| TUDCA | 3 | PM | | 30314894 | 📋 | Endoplasmic reticulum stress is activated in post-ischemic kidneys to promote chronic kidney disease |
| TUDCA | 2 | PM | | 23152827 | 📋 | Prevention of acute kidney injury by tauroursodeoxycholic acid in rat and cell culture models |
| TUDCA | 1 | PM | | 22212133 | 📋 | The nephroprotective effect of tauroursodeoxycholic acid on ischaemia/reperfusion-induced acute kidney injury by inhibiting endoplasmic reticulum stress |
| Vitamin B8 | 1 | PM | | 36611810 | 📋 | Myo-Inositol Supplementation Alleviates Cisplatin-Induced Acute Kidney Injury via Inhibition of Ferroptosis |
| Vitamin C | 4 | PM | | 36567585 | 📋 | [Study of protective effect and mechanism of vitamin C in lipopolysaccharide-induced septic renal injury] |
| Vitamin C | 1 | PM | | 29160372 | 📋 | An experimental study of ascorbic acid effects in acute renal failure under general anesthesia |
| Vitamin C | 2 | PM | | 26142728 | 📋 | Investigation of the role of nitric oxide/soluble guanylyl cyclase pathway in ascorbic acid-mediated protection against acute kidney injury in rats |
| Vitamin D3 | 5 | PM | | 37667858 | 📋 | Vitamin D/Vitamin D receptor mitigates cisplatin-induced acute kidney injury by down-regulating C5aR |
| Vitamin D3 | 4 | PM | | 36555517 | 📋 | Calcitriol Reduces the Inflammation, Endothelial Damage and Oxidative Stress in AKI Caused by Cisplatin |
| Vitamin D3 | 3 | PM | | 35334282 | 📋 | Cholecalciferol pretreatment ameliorates ischemia/reperfusion-induced acute kidney injury through inhibiting ROS production, NF-κB pathway and pyroptosis |
| Vitamin D3 | 2 | PM | | 33953855 | 📋 | The combination of vitamin D3 and erythropoietin alleviates acute kidney injury induced by ischemia-reperfusion via inhibiting inflammation and apoptosis |
| Vitamin D3 | 1 | PM | | 32741217 | 📋 | Ferrotoxicity and its amelioration by endogenous vitamin D in experimental acute kidney injury |
| Vitamin E | 2 | PM | | 34884479 | 📋 | γ-Tocotrienol Protects against Mitochondrial Dysfunction, Energy Deficits, Morphological Damage, and Decreases in Renal Functions after Renal Ischemia |
| Vitamin E | 1 | PM | | 32767013 | 📋 | The protective efficacy of vitamin E and cod liver oil against cisplatin-induced acute kidney injury in rats |
| Vitamin E | 3 | PM | | 29500805 | 📋 | α-Tocopherol Reduces Morphological Changes and Oxidative Stress during Gentamicin-Induced Acute Renal Failure |
| Zinc | 1 | PM | | 35769374 | 📋 | The Impact of Zinc Supplementation on Critically Ill Patients With Acute Kidney Injury: A Propensity Score Matching Analysis |
