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There is currently insufficient evidence to determine the safety of ursolic acid. While phase I safety studies suggest that side effects are tolerable, the long term safety of ursolic acid is unclear.
Three small safety studies have evaluated the safety of ursolic acid in patients with advanced solid tumors and healthy adults. According to the researchers, ursolic acid was tolerable and most side effects ranged from mild to moderate.
It’s important to note that these studies only evaluated the safety of ursolic acid. There’s no evidence that ursolic acid is effective for cancer treatment in humans.
Some of the common side effects found in these safety studies are listed below. However, this list does not cover all possible side effects. Contact your doctor or pharmacist if you notice any other side effects:
- • Nausea
- • Abdominal swelling
- • Trace amounts of blood in the urine
- • Elevated sodium levels
- • Skin rash
Researchers found that diarrhea and liver damage are the two most common dose-limiting toxicities.
On the other hand, animal and cell studies also suggest that ursolic acid may promote plaque formation in the arteries, which may be dangerous for those at risk for cardiovascular disease. *