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An oral toxicity test in humans found no adverse effects at a dosage of 4269-4330 mg/kg bodyweight Pomegranate Seed Oil; a dose of thrice that (13,710-14,214 mg/kg) was found to increase size of the liver, but may have been transiently due to punicic acid and was deemed not toxicologically relevant. Thus, Pomegranate seed oil up to 4.3 g/kg bodyweight is seen as free from harm.
Studies on the actual fruit extract, no adverse effects have been seen in rats with a gastric dose of 1.2 mg/kg bodyweight and oral intakes of up to 5 g/kg bodyweight Pomegranate Fruit Extract (standardized to 30% punicalagins) has been deemed non-toxic acutely, with 600mg/kg bodyweight showing no toxic effects over 90 days. *