Untitled Document
In mice, doses of pterostilbene up to 3,000 mg/kg daily (500-fold the estimated human intake) have failed to exert any significant clinical or biochemical toxicity.
Pterostilbene up to 250 mg daily (125 mg twice daily) in humans over the course of 6-8 weeks has failed to cause any biochemical or clinical signs of toxicity, with side effects not significantly different than placebo aside from one dropout due to worsening cholesterol which may be related to an increase in LDL-C seen with this dose when tested elsewhere in hypercholesterolemic adults. *