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Some people who consume certain types of edible mushrooms, especially in large quantities, may experience stomach problems such as nausea, flatulence, diarrhea, or stomach rumbling. However, it is unclear if oyster mushrooms can cause those problems.
Also, some evidence suggests that mushrooms may interact with gabapentin, a medication traditionally prescribed to manage pain or epilepsy. But the limited research did not specifically include oyster mushrooms, and researchers concluded that the interaction might not be clinically significant.
Emerging scientific research touts the benefits of taking oyster mushrooms in dietary supplement form. Keep in mind that supplements haven't been tested for safety and dietary supplements are largely unregulated by the Food and Drug Administration (FDA). In some cases, the product may deliver doses that differ from the specified amount. In rare cases, the product may be contaminated with other substances such as metals.
However, there is little research regarding the safety of supplements in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications has not been established.
It is always advisable to check with your doctor before adding oyster mushrooms and/or supplements to your healthcare regimen. Oyster mushroom supplements should not be used as a substitute for standard medical care to treat serious health conditions such as high cholesterol.
Lastly, it is safest to consume mushrooms that have been purchased from a legitimate food vendor (such as a grocery store or local market). Eating mushrooms that are collected in the wild can lead to mushroom poisoning. Certain wild mushrooms are poisonous and may cause abdominal pain, dizziness, diarrhea, headache, and loss of consciousness. *
