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The suggested dosages of L-arginine supplements depends a lot on the condition it’s being used to treat.
For example, with help treating heart conditions or erectile dysfunction, three to six grams daily (divided into two doses) might be taken, while for enhancing exercise performance, doses up to nine grams a day are not uncommon.
For generally healthy adults who are looking to prevent inflammation and benefit from better circulation, about one gram daily (1,000 milligrams) is usually the recommended dose.
Higher doses obviously come with more risk for side effects — plus some research shows that more is not always better when it comes to L-arginine’s functions within blood vessel walls. *
Doses of L-arginine vary widely depending on what it’s being used to treat.
For example, studies investigating the effects of L-arginine on blood pressure have used doses of 6–30 grams per day for 2–24 weeks.
In those with erectile dysfunction, research has suggested that supplementing daily with 1.5–5 grams of L-arginine may significantly improve symptoms.
When used to treat preeclampsia, the dose typically ranges from 3–4 grams daily for up to 12 weeks, or until delivery under a doctor’s supervision. L-arginine may also be given intravenously to pregnant women with high blood pressure in the clinical setting.
Although higher doses are often used in research and clinical settings, it’s recommended that daily dosing of L-arginine be kept under 9 grams per day to avoid potential gastrointestinal side effects, including nausea, diarrhea, and bloating.
Like other single amino acids, it’s recommended to take L-arginine between meals for maximum absorption. *
The standard preworkout dose for arginine is 3–6 grams.
Taking more than 10 grams of arginine at once can result in gastrointestinal distress and diarrhea, but it is possible to maintain elevated arginine levels throughout the day by taking three spaced doses (15–18 grams/day). However, *