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The amount of fisetin consumed in clinical trials vary greatly, with participants taking doses ranging from 100 milligrams per day to 1,400 milligrams daily. Recommendations on fisetin supplement labels vary as well, with doses ranging from 100–500 milligrams per day.
There isn’t enough research to make an educated recommendation on an appropriate fisetin dosage. Researchers do know that the antioxidant is fat-soluble, so consuming it with fats promotes better absorption. *
In a clinical study of colon cancer patients, 100 mg/day was effective for reducing inflammation.
In an ongoing clinical trial looking at the effects of fisetin on inflammation, bone health, and frailty in the elderly, fisetin will be used at a high dosage of 20 mg/kg for two consecutive days. This would be around 1,400 mg/day for a 155-lbs person.
We don’t recommend taking such a high dosage until the results of this study are published.
Some researchers are doubtful about the benefits of supplemental fisetin since it is poorly absorbed when taken orally.
But there is at least one simple way to, theoretically, increase its absorption: take it with fats. Fisetin is fat-soluble, similar to other flavonoids like quercetin. Fish oil and other oils enhance the bioavailability of quercetin, and they might do the same for fisetin.
Even so, new formulations combining fisetin into small fat-like molecules (liposomes) may be the only effective solution. These greatly improve its absorption and anticancer effects. However, they are not yet commercially available. *