Untitled Document
Diosmin is commercially available in the United States and Europe as a nonprescription dietary supplement (ie, DiosVein). It is most often combined in a micronized form with hesperidin (diosmin 90% plus hesperidin 10%), referred to as micronized purified flavonoid fraction (MPFF), and marketed in the United States as Daflon 500 (diosmin 450 mg/hesperidin 50 mg). The usual diosmin dosage is 1,000 mg orally daily given in 2 divided doses for short durations (ie, 3 months or less).
Cardiac surgery (preoperative): Starting 7 days prior to CABG, MPFF 3,000 mg daily for 4 days, then 1,000 mg for 3 days.
Chronic venous insufficiency: Diosmin 1,000 mg/day for 60 days; MPFF 500 mg twice daily or 1,000 mg once daily for up to 6 months.
Hemorrhoidal crisis: Loading dose of MPFF 1,000 mg 3 times daily for 4 days, then 1,000 mg twice daily for 3 days.
Hemorrhoid management: MPFF 1,000 mg/day orally for 3 months.
Hemorrhoidectomy: Starting on the sixth day after surgery, MPFF 1,500 mg twice daily after meals for 3 days, followed by 1,000 mg twice daily on days 4 to 7.
Pelvic congestion/varicose veins: MPFF 1,000 mg once daily for up to 6 months; in women who do not respond, increase to 2,000 mg/day after 4 weeks.
Varicoceles/Male infertility: MPFF 1,000 mg/day for 6 months. *
Diosmin is sold in capsules and tablets, and is often included in combination with other supplements. There is no daily recommended allowance for diosmin. The following doses have been studied in specific conditions:
- Chronic Venous Disease: 900 mg of diosmin plus 100 mg of hesperidin daily for up to 2 months.
- Hemorrhoids: 1350 mg of diosmin plus 150 mg of hesperidin twice daily for 4 days followed by 900 mg of diosmin and 100 mg of hesperidin twice daily for 3 days. *