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Dosages start at 100 mg per day and extend up to 600 mg per day as needed. Clinical studies of DMAE have used up to 1,600mg per day with no reports of side-effects and is believed to be relatively nontoxic.
Start slowly. DMAE can over-stimulate the nervous system and cause headaches, tense muscles, or insomnia, although these side-effects are uncommon. Drowsiness has also been reported. Begin with a low dose and see how you respond before gradually increasing the amount you take. If side-effects develop, stop taking the supplement for a day or two and begin at a lower dose.
For ADHD, memory problems or Alzheimer's: 100 to 300 mg, taken orally twice a day.
Overdosage can produce insomnia. Take in the morning to avoid this. Take DMAE with meals for best absorption. To help jump-start your day, open the capsules and pour the contents into a smoothie or fruit juice as part of your morning routine. *
How much DMAE should you take?
The sweet spot typically ranges between 300-500 mg daily for most people. This amount should provide most of the benefits without meaningful side effects.
The higher end of this range usually provides slightly more benefits in the short term. If you plan to take this nootropic for a longer time (multiple months or years), the lower end is probably a better way to go since it is safer and you would develop tolerance faster if you were to take higher doses. The upper safety limit for this nootropic is not well-established. To stay on the safe side, don’t take more than the recommended dose unless you have a great reason to do so. Higher amounts may cause problems if you take the supplement for a prolonged period.
Like most other nootropics, it is best to cycle DMAE and take about two days off weekly to reset your tolerance. That will allow you to keep getting the benefits in the long term.
Best time to take DMAE
The best time to take DMAE is about 90 minutes after you wake up.
In the early morning, a natural increase in cortisol is responsible for waking you up and getting you ready for the day. By taking any stimulant that has the potential to increase cortisol levels right after you wake up, you would interrupt this natural increase in cortisol, and your body would not be producing as much of it in the following days. That would lead to increased production of cortisol at the wrong times of the day, such as in the evening.
After the morning cortisol increase that typically lasts 90 minutes, you want to take DMAE as soon as possible so that most of it leaves your system before it’s time to go to bed. Do not take this nootropic later in the day unless you have a great reason to. It could worsen your sleep quality.
The best way to determine whether or not DMAE is damaging your sleep is to listen to your body and specifically look at how easily you fall asleep and how refreshed you wake up.
DMAE is water-soluble, so you don’t have to take it with food to absorb it well. Taking the supplement with food is better if it causes stomach upset when you take it on an empty stomach. If you take this nootropic on an empty stomach, the short-term effects will kick in faster and be more pronounced. *