| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Rutin | Acrolein Toxicity | 1 | PM | 36051900 | 📋 | Rutin alleviated acrolein-induced cytotoxicity in Caco-2 and GES-1 cells by forming a cyclic hemiacetal product |
| Rutin | Acrylamide Toxicity | 2 | PM | 36657526 | 📋 | Protective Effect of Rutin on Spinal Motor Neuron in Rats Exposed to Acrylamide and the Underlying Mechanism |
| Rutin | Acrylamide Toxicity | 1 | PM | 35237426 | 📋 | Protective efficacy of rutin against acrylamide-induced oxidative stress, biochemical alterations and histopathological lesions in rats |
| Rutin | Air Pollution Toxicity | 1 | PM | 35279519 | 📋 | Rutin ameliorates the promotion effect of fine particulate matter on vascular calcification in calcifying vascular cells and ApoE -/- mice |
| Rutin | Alcohol Toxicity | 4 | PM | 35807511 | 📋 | Mulberry Ethanol Extract and Rutin Protect Alcohol-Damaged GES-1 Cells by Inhibiting the MAPK Pathway |
| Rutin | Alcohol Toxicity | 3 | PM | 33717419 | 📋 | Rutin inhibits DRP1-mediated mitochondrial fission and prevents ethanol-induced hepatotoxicity in HepG2 cells and zebrafish |
| Rutin | Alcohol Toxicity | 2 | PM | 29025321 | 📋 | Rutin Ameliorates Oxidative Stress and Preserves Hepatic and Renal Functions Following Exposure to Cadmium and Ethanol |
| Rutin | Alcohol Toxicity | 1 | PM | 24516008 | 📋 | Rutin Rich Emblica Officinalis Geart. Fruit Extract Ameliorates Inflammation in the Pancreas of Rats Subjected to Alcohol and Cerulein Administration |
| Rutin | Aluminum Toxicity | 3 | PM | 38408719 | 📋 | Benefits of rutin on mitochondrial function and inflammation in an aluminum-induced neurotoxicity rat model: Potential interest for the prevention of neurodegeneration |
| Rutin | Aluminum Toxicity | 2 | PM | 37289414 | 📋 | Rutin, Puerarin and Silymarin Regulated Aluminum-Induced Imbalance of Neurotransmitters and Metal Elements in Brain of Rats |
| Rutin | Aluminum Toxicity | 1 | PM | 32950828 | 📋 | Flavonoids ameliorate aluminum chloride-induced learning and memory impairments via suppression of apoptosis and oxidative stress in rats |
| Rutin | Antibiotic Toxicity | 3 | PM | 36284937 | 📋 | An Examination of the Effect of Rutin against Neurotoxicity Induced by Ciprofloxacin Antibiotic in Wistar Rats |
| Rutin | Antibiotic Toxicity | 1 | PM | 32030599 | 📋 | Neuroprotective Effect of Rutin Against Colistin-Induced Oxidative Stress, Inflammation and Apoptosis in Rat Brain Associated With the CREB/BDNF Expressions |
| Rutin | Antibiotic Toxicity | 2 | PM | 31209949 | 📋 | Rutin Attenuates Vancomycin-Induced Renal Tubular Cell Apoptosis via Suppression of Apoptosis, Mitochondrial Dysfunction, and Oxidative Stress |
| Rutin | Arsenic Toxicity | 1 | PM | 25740435 | 📋 | Rutin, a Flavonoid Phytochemical, Ameliorates Certain Behavioral and Electrophysiological Alterations and General Toxicity of Oral Arsenic in Rats |
| Rutin | Asbestos Toxicity | 1 | PM | 8886799 | 📋 | Protective Effect of Natural Flavonoids on Rat Peritoneal Macrophages Injury Caused by Asbestos Fibers |
| Rutin | Bisphenol Toxicity | 3 | PM | 36573050 | 📋 | To investigate the role of rutin on bisphenol-A induced female infertility in rats |
| Rutin | Bisphenol Toxicity | 2 | PM | 36413001 | 📋 | Rutin alleviates bisphenol A-glycidyl methacrylate-induced generation of proinflammatory mediators through the MAPK and NF-κB pathways in macrophages |
| Rutin | Bisphenol Toxicity | 1 | PM | 34384828 | 📋 | Rutin prevents cardiac oxidative stress and inflammation induced by bisphenol A and dibutyl phthalate exposure via NRF-2/NF-κB pathway |
| Rutin | Cadmium Toxicity | 5 | PM | 34091842 | 📋 | Rutin Ameliorates Cadmium-Induced Necroptosis in the Chicken Liver via Inhibiting Oxidative Stress and MAPK/NF-κB Pathway |
| Rutin | Cadmium Toxicity | 4 | PM | 33844168 | 📋 | Rutin Improves Cardiac and Erythrocyte Membrane-Bound ATPase Activities in Male Rats Exposed to Cadmium Chloride and Lead Acetate |
| Rutin | Cadmium Toxicity | 3 | PM | 31836556 | 📋 | Rutin Restores Neurobehavioral Deficits via Alterations in Cadmium Bioavailability in the Brain of Rats Exposed to Cadmium |
| Rutin | Cadmium Toxicity | 1 | PM | 30972687 | 📋 | Rutin Alleviates Cadmium-Induced Neurotoxicity in Wistar Rats: Involvement of Modulation of Nucleotide-Degrading Enzymes and Monoamine Oxidase |
| Rutin | Cadmium Toxicity | 2 | PM | 29025321 | 📋 | Rutin Ameliorates Oxidative Stress and Preserves Hepatic and Renal Functions Following Exposure to Cadmium and Ethanol |
| Rutin | Cadmium Toxicity | 6 | PM | 26455473 | 📋 | Selenium and Rutin Alone or in Combination Do Not Have Stronger Protective Effects Than Their Separate Effects Against Cadmium-Induced Renal Damage |
| Rutin | Cardiotoxicity | 5 | PM | 36874615 | 📋 | Rutin and Hesperidin Alleviate Paclitaxel-Induced Nephrocardiotoxicity in Wistar Rats via Suppressing the Oxidative Stress and Enhancing the Antioxidant Defense Mechanisms |
| Rutin | Cardiotoxicity | 4 | PM | 36655104 | 📋 | The protective effects of rutin on the liver, kidneys, and heart by counteracting organ toxicity caused by synthetic and natural compounds |
| Rutin | Cardiotoxicity | 3 | PM | 35509154 | 📋 | Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP |
| Rutin | Cardiotoxicity | 1 | PM | 34384828 | 📋 | Rutin prevents cardiac oxidative stress and inflammation induced by bisphenol A and dibutyl phthalate exposure via NRF-2/NF-κB pathway |
| Rutin | Cardiotoxicity | 2 | PM | 32864822 | 📋 | Rutin treats myocardial damage caused by pirarubicin via regulating miR-22-5p-regulated RAP1/ERK signaling pathway |
| Rutin | Cardiotoxicity | 6 | PM | 29078725 | 📋 | Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity |
| Rutin | Cisplatin Toxicity | 6 | PM | 35304134 | 📋 | The Protective Effect of Rutin against the Cisplatin-induced Cochlear Damage in vitro |
| Rutin | Cisplatin Toxicity | 5 | PM | 34888222 | 📋 | Modulatory Effect of Rutin on the Antitumor Activity and Genotoxicity of Cisplatin in Tumor-Bearing Mice |
| Rutin | Cisplatin Toxicity | 4 | PM | 33031932 | 📋 | Rutin prevents cisplatin-induced ovarian damage via antioxidant activity and regulation of PTEN and FOXO3a phosphorylation in mouse model |
| Rutin | Cisplatin Toxicity | 7 | PM | 32787450 | 📋 | Histoprotective effect of rutin against cisplatin-induced toxicities in tumor-bearing mice: Rutin lessens cisplatin-induced toxicities |
| Rutin | Cisplatin Toxicity | 1 | PM | 30152807 | 📋 | The Effect of Rutin on Cisplatin-Induced Oxidative Cardiac Damage in Rats |
| Rutin | Cisplatin Toxicity | 3 | PM | 29962303 | 📋 | Effect of Rutin on Cisplatin-Induced Damage in Human Mesangial Cells via Apoptotic Pathway |
| Rutin | Cisplatin Toxicity | 2 | PM | 28619064 | 📋 | Protective Effect of Rutin Supplementation Against Cisplatin-Induced Nephrotoxicity in Rats |
| Rutin | Copper Toxicity | 1 | PM | 32881150 | 📋 | Rutin ameliorates copper sulfate-induced brain damage via antioxidative and anti-inflammatory activities in rats |
| Rutin | Cytotoxicity | 1 | PM | 36051900 | 📋 | Rutin alleviated acrolein-induced cytotoxicity in Caco-2 and GES-1 cells by forming a cyclic hemiacetal product |
| Rutin | Environmental Pollutants Toxicity | 4 | PM | 37890710 | 📋 | Rutin ameliorate PFOA induced renal damage by reducing oxidative stress and improving lipid metabolism |
| Rutin | Environmental Pollutants Toxicity | 2 | PM | 36346126 | 📋 | Molecular and biochemical investigation of the protective effects of rutin against liver and kidney toxicity caused by malathion administration in a rat model |
| Rutin | Environmental Pollutants Toxicity | 1 | PM | 34311832 | 📋 | [Rutin activates AMPKα to ameliorate liver damage caused by perfluorooctanoic acid in mice] |
| Rutin | Environmental Pollutants Toxicity | 3 | PM | 23876083 | 📋 | Protective effect of rutin on hexachlorobutadiene-induced nephrotoxicity |
| Rutin | Fluoride Toxicity | 1 | PM | 38479315 | 📋 | Rutin mitigates fluoride-induced nephrotoxicity by inhibiting ROS-mediated lysosomal membrane permeabilization and the GSDME-HMGB1 axis involved in pyroptosis and inflammation |
| Rutin | Genotoxicity | 3 | PM | 35237426 | 📋 | Protective efficacy of rutin against acrylamide-induced oxidative stress, biochemical alterations and histopathological lesions in rats |
| Rutin | Genotoxicity | 4 | PM | 34888222 | 📋 | Modulatory Effect of Rutin on the Antitumor Activity and Genotoxicity of Cisplatin in Tumor-Bearing Mice |
| Rutin | Genotoxicity | 1 | PM | 30020319 | 📋 | Analysis of Radioprotection and Antimutagenic Effects of Ilex Paraguariensis Infusion and Its Component Rutin |
| Rutin | Genotoxicity | 2 | PM | 20399630 | 📋 | Investigation of Cytotoxic, Apoptosis-Inducing, Genotoxic and Protective Effects of the Flavonoid Rutin in HTC Hepatic Cells |
| Rutin | Heavy Metal Toxicity | 2 | PM | 37541166 | 📋 | Mitigation potential of zingerone and rutin on toxicity mechanisms of nickel to zebrafish based on morphological, DNA damage and apoptosis outcome analysis |
| Rutin | Heavy Metal Toxicity | 1 | PM | 37302585 | 📋 | Toxicity of Copper and Zinc alone and in combination in Caenorhabditis elegans model of Huntington's disease and protective effects of rutin |
| Rutin | Hepatotoxicity | 12 | PM | 38789868 | 📋 | Rutin attenuates ensartinib-induced hepatotoxicity by non-transcriptional regulation of TXNIP |
| Rutin | Hepatotoxicity | 11 | PM | 38581023 | 📋 | The ameliorating effect of Rutin on hepatotoxicity and inflammation induced by the daily administration of vortioxetine in rats |
| Rutin | Hepatotoxicity | 10 | PM | 37886008 | 📋 | Rutin mitigates perfluorooctanoic acid-induced liver injury via modulation of oxidative stress, apoptosis, and inflammation |
| Rutin | Hepatotoxicity | 9 | PM | 37275575 | 📋 | Rutin and Hesperidin Revoke the Hepatotoxicity Induced by Paclitaxel in Male Wistar Rats via Their Antioxidant, Anti-Inflammatory, and Antiapoptotic Activities |
| Rutin | Hepatotoxicity | 8 | PM | 36655104 | 📋 | The protective effects of rutin on the liver, kidneys, and heart by counteracting organ toxicity caused by synthetic and natural compounds |
| Rutin | Hepatotoxicity | 7 | PM | 36346126 | 📋 | Molecular and biochemical investigation of the protective effects of rutin against liver and kidney toxicity caused by malathion administration in a rat model |
| Rutin | Hepatotoxicity | 6 | PM | 35936216 | 📋 | Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2 |
| Rutin | Hepatotoxicity | 5 | PM | 35658761 | 📋 | Protective effect of rutin and β-cyclodextrin against hepatotoxicity and nephrotoxicity induced by lambda-cyhalothrin in Wistar rats: Biochemical, pathological indices and molecular analysis |
| Rutin | Hepatotoxicity | 4 | PM | 35352204 | 📋 | Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy |
| Rutin | Hepatotoxicity | 3 | PM | 34311832 | 📋 | [Rutin activates AMPKα to ameliorate liver damage caused by perfluorooctanoic acid in mice] |
| Rutin | Hepatotoxicity | 2 | PM | 34218375 | 📋 | Protective effects of rutin against deltamethrin-induced hepatotoxicity and nephrotoxicity in rats via regulation of oxidative stress, inflammation, and apoptosis |
| Rutin | Hepatotoxicity | 1 | PM | 34091842 | 📋 | Rutin Ameliorates Cadmium-Induced Necroptosis in the Chicken Liver via Inhibiting Oxidative Stress and MAPK/NF-κB Pathway |
| Rutin | Insecticide Toxicity | 1 | PM | 34218375 | 📋 | Protective effects of rutin against deltamethrin-induced hepatotoxicity and nephrotoxicity in rats via regulation of oxidative stress, inflammation, and apoptosis |
| Rutin | Lead Toxicity | 1 | PM | 33844168 | 📋 | Rutin Improves Cardiac and Erythrocyte Membrane-Bound ATPase Activities in Male Rats Exposed to Cadmium Chloride and Lead Acetate |
| Rutin | Mercury Toxicity | 3 | PM | 34182094 | 📋 | Evaluation of the neuroprotective effect of rutin on Drosophila melanogaster about behavioral and biochemical aspects induced by mercury chloride (HgCl2) |
| Rutin | Mercury Toxicity | 1 | PM | 32022330 | 📋 | Protective Effect of Rutin on Mercuric Chloride-Induced Reproductive Damage in Male Rats |
| Rutin | Mercury Toxicity | 2 | PM | 31109623 | 📋 | Rutin Protects Mercuric Chloride-Induced Nephrotoxicity via Targeting of Aquaporin 1 Level, Oxidative Stress, Apoptosis and Inflammation in Rats |
| Rutin | Mycotoxins Toxicity | 1 | PM | 38535787 | 📋 | Alleviative Effect of Rutin on Zearalenone-Induced Reproductive Toxicity in Male Mice by Preventing Spermatogenic Cell Apoptosis and Modulating Gene Expression in the Hypothalamic-Pituitary-Gonadal Axis |
| Rutin | Nephrotoxicity | 14 | PM | 38479315 | 📋 | Rutin mitigates fluoride-induced nephrotoxicity by inhibiting ROS-mediated lysosomal membrane permeabilization and the GSDME-HMGB1 axis involved in pyroptosis and inflammation |
| Rutin | Nephrotoxicity | 13 | PM | 37890710 | 📋 | Rutin ameliorate PFOA induced renal damage by reducing oxidative stress and improving lipid metabolism |
| Rutin | Nephrotoxicity | 11 | PM | 36874615 | 📋 | Rutin and Hesperidin Alleviate Paclitaxel-Induced Nephrocardiotoxicity in Wistar Rats via Suppressing the Oxidative Stress and Enhancing the Antioxidant Defense Mechanisms |
| Rutin | Nephrotoxicity | 10 | PM | 36655104 | 📋 | The protective effects of rutin on the liver, kidneys, and heart by counteracting organ toxicity caused by synthetic and natural compounds |
| Rutin | Nephrotoxicity | 9 | PM | 36346126 | 📋 | Molecular and biochemical investigation of the protective effects of rutin against liver and kidney toxicity caused by malathion administration in a rat model |
| Rutin | Nephrotoxicity | 8 | PM | 35658761 | 📋 | Protective effect of rutin and β-cyclodextrin against hepatotoxicity and nephrotoxicity induced by lambda-cyhalothrin in Wistar rats: Biochemical, pathological indices and molecular analysis |
| Rutin | Nephrotoxicity | 7 | PM | 35352204 | 📋 | Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy |
| Rutin | Nephrotoxicity | 1 | PM | 34218375 | 📋 | Protective effects of rutin against deltamethrin-induced hepatotoxicity and nephrotoxicity in rats via regulation of oxidative stress, inflammation, and apoptosis |
| Rutin | Nephrotoxicity | 2 | PM | 31209949 | 📋 | Rutin Attenuates Vancomycin-Induced Renal Tubular Cell Apoptosis via Suppression of Apoptosis, Mitochondrial Dysfunction, and Oxidative Stress |
| Rutin | Nephrotoxicity | 3 | PM | 31109623 | 📋 | Rutin Protects Mercuric Chloride-Induced Nephrotoxicity via Targeting of Aquaporin 1 Level, Oxidative Stress, Apoptosis and Inflammation in Rats |
| Rutin | Nephrotoxicity | 4 | PM | 29962303 | 📋 | Effect of Rutin on Cisplatin-Induced Damage in Human Mesangial Cells via Apoptotic Pathway |
| Rutin | Nephrotoxicity | 5 | PM | 28619064 | 📋 | Protective Effect of Rutin Supplementation Against Cisplatin-Induced Nephrotoxicity in Rats |
| Rutin | Nephrotoxicity | 6 | PM | 26455473 | 📋 | Selenium and Rutin Alone or in Combination Do Not Have Stronger Protective Effects Than Their Separate Effects Against Cadmium-Induced Renal Damage |
| Rutin | Nephrotoxicity | 12 | PM | 23876083 | 📋 | Protective effect of rutin on hexachlorobutadiene-induced nephrotoxicity |
| Rutin | Neurotoxicity | 7 | PM | 38408719 | 📋 | Benefits of rutin on mitochondrial function and inflammation in an aluminum-induced neurotoxicity rat model: Potential interest for the prevention of neurodegeneration |
| Rutin | Neurotoxicity | 3 | PM | 36723781 | 📋 | Protective Effects of Flavonoid Rutin Against Aminochrome Neurotoxicity |
| Rutin | Neurotoxicity | 2 | PM | 36657526 | 📋 | Protective Effect of Rutin on Spinal Motor Neuron in Rats Exposed to Acrylamide and the Underlying Mechanism |
| Rutin | Neurotoxicity | 1 | PM | 36284937 | 📋 | An Examination of the Effect of Rutin against Neurotoxicity Induced by Ciprofloxacin Antibiotic in Wistar Rats |
| Rutin | Neurotoxicity | 6 | PM | 24152430 | 📋 | The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful peripheral neuropathy |
| Rutin | Neurotoxicity | 5 | PM | 24148604 | 📋 | Rutin activates the MAPK pathway and BDNF gene expression on beta-amyloid induced neurotoxicity in rats |
| Rutin | Neurotoxicity | 4 | PM | 23670213 | 📋 | Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity |
| Rutin | Ototoxicity | 2 | PM | 38653908 | 📋 | Rutin Attenuates Gentamycin-induced Hair Cell Injury in the Zebrafish Lateral Line via Suppressing STAT1 |
| Rutin | Ototoxicity | 1 | PM | 35304134 | 📋 | The Protective Effect of Rutin against the Cisplatin-induced Cochlear Damage in vitro |
| Rutin | Persistent Organic Pollutants Toxicity | 1 | PM | 37886008 | 📋 | Rutin mitigates perfluorooctanoic acid-induced liver injury via modulation of oxidative stress, apoptosis, and inflammation |
| Rutin | Pesticide Toxicity | 2 | PM | 37184799 | 📋 | Rutin protects against gamma-irradiation and malathion-induced oxidative stress and inflammation through regulation of mir-129-3p, mir-200C-3p, and mir-210 gene expressions in rats' kidney |
| Rutin | Pesticide Toxicity | 1 | PM | 19833193 | 📋 | Bifenthrin-induced Oxidative Stress in Human Erythrocytes in Vitro and Protective Effect of Selected Flavonols |
| Rutin | Reproductive Toxicity Female | 2 | PM | 36573050 | 📋 | To investigate the role of rutin on bisphenol-A induced female infertility in rats |
| Rutin | Reproductive Toxicity Female | 1 | PM | 33031932 | 📋 | Rutin prevents cisplatin-induced ovarian damage via antioxidant activity and regulation of PTEN and FOXO3a phosphorylation in mouse model |
| Rutin | Reproductive Toxicity Male | 3 | PM | 38535787 | 📋 | Alleviative Effect of Rutin on Zearalenone-Induced Reproductive Toxicity in Male Mice by Preventing Spermatogenic Cell Apoptosis and Modulating Gene Expression in the Hypothalamic-Pituitary-Gonadal Axis |
| Rutin | Reproductive Toxicity Male | 2 | PM | 36373176 | 📋 | Rutin ameliorates perfluorooctanoic acid-induced testicular injury in mice by reducing oxidative stress and improving lipid metabolism |
| Rutin | Reproductive Toxicity Male | 1 | PM | 32757678 | 📋 | The protective effect of rutin against busulfan-induced testicular damage in adult rats |
| Rutin | Snake Venom Toxicity | 1 | PM | 35264963 | 📋 | The Bioflavonoids Rutin and Rutin Succinate Neutralize the Toxins of B. jararaca Venom and Inhibit its Lethality |
