| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Lycopene | Acetaminophen Toxicity | 2 | PM | 28031152 | 📋 | Lycopene Pretreatment Improves Hepatotoxicity Induced by Acetaminophen in C57BL/6 Mice |
| Lycopene | Acetaminophen Toxicity | 1 | PM | 27989599 | 📋 | Lycopene Inhibits Reactive Oxygen Species Production in SK-Hep-1 Cells and Attenuates Acetaminophen-Induced Liver Injury in C57BL/6 Mice |
| Lycopene | Acrylamide Toxicity | 1 | PM | 33711552 | 📋 | Exploring the possible neuroprotective and antioxidant potency of lycopene against acrylamide-induced neurotoxicity in rats' brain |
| Lycopene | Air Pollution Toxicity | 1 | PM | 36456856 | 📋 | Polyunsaturated fatty acids, vitamin E and lycopene alleviate ambient particulate matter organic extracts-induced oxidative stress in canine lung cells via the Nrf2/HO-1 pathway |
| Lycopene | Alcohol Toxicity | 1 | PM | 35326169 | 📋 | Lycopene Inhibits IL-6 Expression by Upregulating NQO1 and HO-1 via Activation of Nrf2 in Ethanol/Lipopolysaccharide-Stimulated Pancreatic Acinar Cells |
| Lycopene | Aluminum Toxicity | 1 | PM | 30743053 | 📋 | Lycopene attenuates aluminum-induced hippocampal lesions by inhibiting oxidative stress-mediated inflammation and apoptosis in the rat |
| Lycopene | Anabolic Steroid Toxicity | 1 | PM | 31108192 | 📋 | Lycopene protects against renal cortical damage induced by nandrolone decanoate in adult male rats |
| Lycopene | Antibiotic Toxicity | 1 | PM | 34037090 | 📋 | The protective effect of lycopene against oxidative kidney damage associated with combined use of isoniazid and rifampicin in rats |
| Lycopene | Antibiotic Toxicity | 4 | PM | 31319718 | 📋 | Testicular toxicity of gentamicin in adult rats: Ameliorative effect of lycopene |
| Lycopene | Antibiotic Toxicity | 3 | PM | 27884046 | 📋 | Effect of Lycopene and Rosmarinic Acid on Gentamicin Induced Renal Cortical Oxidative Stress, Apoptosis, and Autophagy in Adult Male Albino Rat |
| Lycopene | Antibiotic Toxicity | 2 | PM | 16125832 | 📋 | Protective effect of lycopene on gentamicin-induced oxidative stress and nephrotoxicity in rats |
| Lycopene | Benzo(a)pyrene Toxicity | 1 | PM | 31568845 | 📋 | Protective effect of lycopene on testicular toxicity induced by Benzo[a]pyrene intake in rats |
| Lycopene | Bisphenol Toxicity | 6 | PM | 36194983 | 📋 | Lycopene protects against Bisphenol A induced toxicity on the submandibular salivary glands via the upregulation of PPAR-γ and modulation of Wnt/β-catenin signaling |
| Lycopene | Bisphenol Toxicity | 5 | PM | 33932206 | 📋 | Lycopene attenuates bisphenol A-induced lung injury in adult albino rats: a histological and biochemical study |
| Lycopene | Bisphenol Toxicity | 3 | PM | 32153214 | 📋 | Protective effects of lycopene on hippocampal neurotoxicity and memory impairment induced by bisphenol A in rats |
| Lycopene | Bisphenol Toxicity | 4 | PM | 31916151 | 📋 | Protective role of lycopene against metabolic disorders induced by chronic bisphenol A exposure in rats |
| Lycopene | Bisphenol Toxicity | 2 | PM | 30147835 | 📋 | Lycopene: Hepatoprotective and Antioxidant Effects toward Bisphenol A-Induced Toxicity in Female Wistar Rats |
| Lycopene | Bisphenol Toxicity | 1 | PM | 29948678 | 📋 | Lycopene Reduces in Utero Bisphenol A Exposure-Induced Mortality, Benefits Hormones, and Development of Reproductive Organs in Offspring Mice |
| Lycopene | Cadmium Toxicity | 1 | PM | 35814917 | 📋 | Comparative Potential of Zinc Sulfate, L-Carnitine, Lycopene, and Coenzyme Q10 on Cadmium-Induced Male Infertility |
| Lycopene | Cadmium Toxicity | 2 | PM | 28615536 | 📋 | Antagonistic effects of lycopene on cadmium-induced hippocampal dysfunctions in autophagy, calcium homeostatis and redox |
| Lycopene | Cardiotoxicity | 4 | PM | 37440131 | 📋 | Antioxidant and anti-apoptotic potency of allicin and lycopene against methotrexate-induced cardiac injury in rats |
| Lycopene | Cardiotoxicity | 3 | PM | 36646601 | 📋 | Lycopene abolishes palmitate-mediated myocardial inflammation in female Wistar rats via modulation of lipid metabolism, NF-κB signalling pathway, and augmenting the antioxidant systems |
| Lycopene | Cardiotoxicity | 2 | PM | 35348563 | 📋 | Lycopene regulates the mitochondrial unfolded protein response to prevent DEHP-induced cardiac mitochondrial damage in mice |
| Lycopene | Cardiotoxicity | 1 | PM | 27112537 | 📋 | The chemopreventive potential of lycopene against atrazine-induced cardiotoxicity: modulation of ionic homeostasis |
| Lycopene | Cisplatin Toxicity | 4 | PM | 34825328 | 📋 | Testicular toxicity of cisplatin in rats: ameliorative effect of lycopene and N-acetylcysteine |
| Lycopene | Cisplatin Toxicity | 3 | PM | 34234176 | 📋 | Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats |
| Lycopene | Cisplatin Toxicity | 1 | PM | 30806633 | 📋 | Effect of lycopene on oxidative ovary-damage induced by cisplatin in rats |
| Lycopene | Cisplatin Toxicity | 7 | PM | 28975094 | 📋 | Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patient |
| Lycopene | Cisplatin Toxicity | 5 | PM | 28639555 | 📋 | Ginkgo biloba and Lycopene are Effective on Cisplatin Induced Ototoxicity? |
| Lycopene | Cisplatin Toxicity | 6 | PM | 23358585 | 📋 | The effects of lycopene on cisplatin-induced ototoxicity |
| Lycopene | Cisplatin Toxicity | 2 | PM | 15946783 | 📋 | Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats |
| Lycopene | Cytotoxicity | 1 | PM | 36465840 | 📋 | Antioxidant and anti-inflammatory activities of lycopene against 5-fluorouracil-induced cytotoxicity in Caco2 cells |
| Lycopene | Environmental Pollutants Toxicity | 8 | PM | 37125846 | 📋 | The possible ameliorative role of Lycopene on Tributyltin induced thyroid damage in adult male albino rats (histological, immunohistochemical and biochemical study) |
| Lycopene | Environmental Pollutants Toxicity | 7 | PM | 36610486 | 📋 | Lycopene ameliorates DEHP exposure-induced renal pyroptosis through the Nrf2/Keap-1/NLRP3/Caspase-1 axis |
| Lycopene | Environmental Pollutants Toxicity | 2 | PM | 36134885 | 📋 | Lycopene Ameliorate Atrazine-Induced Oxidative Damage in the B Cell Zone via Targeting the miR-27a-3p/Foxo1 Axis |
| Lycopene | Environmental Pollutants Toxicity | 6 | PM | 33965855 | 📋 | Lycopene prevents DEHP-induced hepatic oxidative stress damage by crosstalk between AHR-Nrf2 pathway |
| Lycopene | Environmental Pollutants Toxicity | 5 | PM | 33908429 | 📋 | Lycopene attenuates di(2-ethylhexyl) phthalate-induced mitophagy in spleen by regulating the sirtuin3-mediated pathway |
| Lycopene | Environmental Pollutants Toxicity | 1 | PM | 33615188 | 📋 | Potential Role of Lycopene in the Inhibition of Di(2-ethylhexyl) Phthalate-Induced Ferroptosis in Spleen Via Modulation of Iron Ion Homeostasis |
| Lycopene | Environmental Pollutants Toxicity | 3 | PM | 30907024 | 📋 | Evaluation of ameliorating effect of lycopene against testicular toxicity due to diethylnitrosamine using biochemical, spermatological and histopathological data |
| Lycopene | Environmental Pollutants Toxicity | 4 | PM | 30339717 | 📋 | Protective effect of lycopene against chemical and natural toxins: A review |
| Lycopene | Fluoride Toxicity | 1 | PM | 32770329 | 📋 | The Effect of Lycopene on DNA Damage and Repair in Fluoride-Treated NRK-52E Cell Line |
| Lycopene | Fluoride Toxicity | 2 | PM | 29273675 | 📋 | Vitamin E and lycopene reduce coal burning fluorosis-induced spermatogenic cell apoptosis via oxidative stress-mediated JNK and ERK signaling pathways |
| Lycopene | Fluoride Toxicity | 3 | PM | 27871895 | 📋 | Protective effect of lycopene on fluoride-induced ameloblasts apoptosis and dental fluorosis through oxidative stress-mediated Caspase pathways |
| Lycopene | Furan Toxicity | 1 | PM | 28918453 | 📋 | Furan induced ovarian damage in non-diabetic and diabetic rats and cellular protective role of lycopene |
| Lycopene | Genotoxicity | 1 | PM | 32770329 | 📋 | The Effect of Lycopene on DNA Damage and Repair in Fluoride-Treated NRK-52E Cell Line |
| Lycopene | Genotoxicity | 4 | PM | 28913689 | 📋 | The evaluation of protective effect of lycopene against genotoxic influence of X-irradiation in human blood lymphocytes |
| Lycopene | Genotoxicity | 3 | PM | 23867521 | 📋 | The carotenoid lycopene protects rats against DNA damage induced by Ochratoxin A |
| Lycopene | Genotoxicity | 2 | PM | 17189673 | 📋 | Lycopene as a natural protector against gamma-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes in vitro |
| Lycopene | Hepatotoxicity | 10 | PM | 37485620 | 📋 | Co-occurrence of Mycotoxin-Induced Hepatotoxicity in Mice Inhibited by Lycopene: Mitochondrial Impairment and Early Hepatic Fibrosis |
| Lycopene | Hepatotoxicity | 9 | PM | 37329850 | 📋 | Lycopene attenuates chlorpyrifos-induced hepatotoxicity in rats via activation of Nrf2/HO-1 axis |
| Lycopene | Hepatotoxicity | 6 | PM | 34869769 | 📋 | Lycopene Ameliorates Liver Inflammation and Redox Status in Mice Exposed to Long-Term Cigarette Smoke |
| Lycopene | Hepatotoxicity | 7 | PM | 33965855 | 📋 | Lycopene prevents DEHP-induced hepatic oxidative stress damage by crosstalk between AHR-Nrf2 pathway |
| Lycopene | Hepatotoxicity | 2 | PM | 31378089 | 📋 | The effect of lycopene on hepatotoxicity of aflatoxin B1 in rats |
| Lycopene | Hepatotoxicity | 3 | PM | 30251044 | 📋 | The molecular and biochemical insight view of lycopene in ameliorating tramadol-induced liver toxicity in a rat model: implication of oxidative stress, apoptosis, and MAPK signaling pathways |
| Lycopene | Hepatotoxicity | 1 | PM | 30147835 | 📋 | Lycopene: Hepatoprotective and Antioxidant Effects toward Bisphenol A-Induced Toxicity in Female Wistar Rats |
| Lycopene | Hepatotoxicity | 5 | PM | 30001773 | 📋 | The hepatoprotective effect of lycopene on Con A-induced liver injury in mice |
| Lycopene | Hepatotoxicity | 8 | PM | 28471231 | 📋 | The effects of lycopene on methotrexate-induced liver injury in rats |
| Lycopene | Hepatotoxicity | 4 | PM | 28031152 | 📋 | Lycopene Pretreatment Improves Hepatotoxicity Induced by Acetaminophen in C57BL/6 Mice |
| Lycopene | Hepatotoxicity | 11 | PM | 23572394 | 📋 | Ameliorative effect of lycopene against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced rat liver microsomal toxicity: an in vitro study |
| Lycopene | Herbicide Toxicity | 4 | PM | 38820047 | 📋 | Lycopene Protects against Atrazine-Induced Kidney STING-Dependent PANoptosis through Stabilizing mtDNA via Interaction with Sam50/PHB1 |
| Lycopene | Herbicide Toxicity | 3 | PM | 38052101 | 📋 | Holistic Assessment Based On Hepatocyte Mitochondria: Lycopene Repairs Oxidized mtDNA to Alleviate Mitochondrial Stress Induced by Atrazine |
| Lycopene | Herbicide Toxicity | 2 | PM | 36791905 | 📋 | Lycopene ameliorates atrazine-induced spatial learning and memory impairments by inhibiting ferroptosis in the hippocampus of mice |
| Lycopene | Herbicide Toxicity | 1 | PM | 34617222 | 📋 | The protective role of lycopene against toxic effects induced by the herbicide Harness® and its active ingredient acetochlor on the African catfish Clarias gariepinus (Burchell, 1822) |
| Lycopene | Hydrogen Peroxide Toxicity | 1 | PM | 31576860 | 📋 | Lycopene alleviates H 2 O 2-induced oxidative stress, inflammation and apoptosis in bovine mammary epithelial cells via the NFE2L2 signaling pathway |
| Lycopene | Hydrogen Peroxide Toxicity | 2 | PM | 29903284 | 📋 | [Lycopene's protective effect on oxidative damage of L02 cells and its mechanism] |
| Lycopene | Hydrogen Peroxide Toxicity | 3 | PM | 27035331 | 📋 | Lycopene protects human SH‑SY5Y neuroblastoma cells against hydrogen peroxide‑induced death via inhibition of oxidative stress and mitochondria‑associated apoptotic pathways |
| Lycopene | Insecticide Toxicity | 1 | PM | 22865284 | 📋 | Protective effect of lycopene on deltamethrin-induced histological and ultrastructural changes in kidney tissue of rats |
| Lycopene | Lead Toxicity | 1 | PM | 34766121 | 📋 | Lycopene antagonizes lead toxicity by reducing mitochondrial oxidative damage and mitochondria-mediated apoptosis in cultured hippocampal neurons |
| Lycopene | Mercury Toxicity | 1 | PM | 24120987 | 📋 | Protective effects of lycopene against methylmercury-induced neurotoxicity in cultured rat cerebellar granule neurons |
| Lycopene | MSG Toxicity | 1 | PM | 26900785 | 📋 | Lycopene modulates cholinergic dysfunction, Bcl-2/Bax balance, and antioxidant enzymes gene transcripts in monosodium glutamate (E621) induced neurotoxicity in a rat model |
| Lycopene | Mycotoxins Toxicity | 11 | PM | 38671900 | 📋 | Lycopene as a Therapeutic Agent against Aflatoxin B1-Related Toxicity: Mechanistic Insights and Future Directions |
| Lycopene | Mycotoxins Toxicity | 9 | PM | 37485620 | 📋 | Co-occurrence of Mycotoxin-Induced Hepatotoxicity in Mice Inhibited by Lycopene: Mitochondrial Impairment and Early Hepatic Fibrosis |
| Lycopene | Mycotoxins Toxicity | 8 | PM | 37429407 | 📋 | Protective effects of lycopene against zearalenone-induced reproductive toxicity in early pregnancy through anti-inflammatory, antioxidant and anti-apoptotic effects |
| Lycopene | Mycotoxins Toxicity | 7 | PM | 37018856 | 📋 | Lycopene ameliorates aflatoxin B1-induced testicular lesion by attenuating oxidative stress and mitochondrial damage with Nrf2 activation in mice |
| Lycopene | Mycotoxins Toxicity | 6 | PM | 36318035 | 📋 | Lycopene alleviates multiple-mycotoxin-induced toxicity by inhibiting mitochondrial damage and ferroptosis in the mouse jejunum |
| Lycopene | Mycotoxins Toxicity | 5 | PM | 34573125 | 📋 | Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling |
| Lycopene | Mycotoxins Toxicity | 3 | PM | 31954314 | 📋 | Protective effects of lycopene against AFB 1-induced erythrocyte dysfunction and oxidative stress in mice |
| Lycopene | Mycotoxins Toxicity | 4 | PM | 31378089 | 📋 | The effect of lycopene on hepatotoxicity of aflatoxin B1 in rats |
| Lycopene | Mycotoxins Toxicity | 1 | PM | 30462120 | 📋 | Lycopene attenuates AFB 1-induced renal injury with the activation of the Nrf2 antioxidant signaling pathway in mice |
| Lycopene | Mycotoxins Toxicity | 2 | PM | 30059796 | 📋 | Aflatoxin B 1 induced renal and cardiac damage in rats: Protective effect of lycopene |
| Lycopene | Mycotoxins Toxicity | 10 | PM | 23867521 | 📋 | The carotenoid lycopene protects rats against DNA damage induced by Ochratoxin A |
| Lycopene | N-nitrosodiethylamine Toxicity | 1 | PM | 27803767 | 📋 | Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma |
| Lycopene | N-nitrosodiethylamine Toxicity | 2 | PM | 26474105 | 📋 | Lycopene Enriched Tomato Extract Inhibits Hypoxia, Angiogenesis, and Metastatic Markers in early Stage N-Nitrosodiethylamine Induced Hepatocellular Carcinoma |
| Lycopene | Nephrotoxicity | 13 | PM | 38820047 | 📋 | Lycopene Protects against Atrazine-Induced Kidney STING-Dependent PANoptosis through Stabilizing mtDNA via Interaction with Sam50/PHB1 |
| Lycopene | Nephrotoxicity | 9 | PM | 36610486 | 📋 | Lycopene ameliorates DEHP exposure-induced renal pyroptosis through the Nrf2/Keap-1/NLRP3/Caspase-1 axis |
| Lycopene | Nephrotoxicity | 8 | PM | 36565226 | 📋 | Resveratrol and lycopene ameliorate contrast-induced nephropathy in a rabbit model |
| Lycopene | Nephrotoxicity | 7 | PM | 34670089 | 📋 | Lycopene Preventing DEHP-Induced Renal Cell Damage Is Targeted by Aryl Hydrocarbon Receptor |
| Lycopene | Nephrotoxicity | 2 | PM | 34037090 | 📋 | The protective effect of lycopene against oxidative kidney damage associated with combined use of isoniazid and rifampicin in rats |
| Lycopene | Nephrotoxicity | 3 | PM | 31108192 | 📋 | Lycopene protects against renal cortical damage induced by nandrolone decanoate in adult male rats |
| Lycopene | Nephrotoxicity | 4 | PM | 30462120 | 📋 | Lycopene attenuates AFB 1-induced renal injury with the activation of the Nrf2 antioxidant signaling pathway in mice |
| Lycopene | Nephrotoxicity | 12 | PM | 28975094 | 📋 | Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patient |
| Lycopene | Nephrotoxicity | 5 | PM | 26320496 | 📋 | Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats |
| Lycopene | Nephrotoxicity | 10 | PM | 23332503 | 📋 | Protective effect of lycopene against ochratoxin A induced renal oxidative stress and apoptosis in rats |
| Lycopene | Nephrotoxicity | 11 | PM | 22865284 | 📋 | Protective effect of lycopene on deltamethrin-induced histological and ultrastructural changes in kidney tissue of rats |
| Lycopene | Nephrotoxicity | 1 | PM | 16125832 | 📋 | Protective effect of lycopene on gentamicin-induced oxidative stress and nephrotoxicity in rats |
| Lycopene | Nephrotoxicity | 6 | PM | 15946783 | 📋 | Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats |
| Lycopene | Neurotoxicity | 3 | PM | 36791905 | 📋 | Lycopene ameliorates atrazine-induced spatial learning and memory impairments by inhibiting ferroptosis in the hippocampus of mice |
| Lycopene | Neurotoxicity | 6 | PM | 34766121 | 📋 | Lycopene antagonizes lead toxicity by reducing mitochondrial oxidative damage and mitochondria-mediated apoptosis in cultured hippocampal neurons |
| Lycopene | Neurotoxicity | 2 | PM | 34577640 | 📋 | Antioxidant and Anti-Inflammatory Potential of Thymoquinone and Lycopene Mitigate the Chlorpyrifos-Induced Toxic Neuropathy |
| Lycopene | Neurotoxicity | 1 | PM | 33711552 | 📋 | Exploring the possible neuroprotective and antioxidant potency of lycopene against acrylamide-induced neurotoxicity in rats' brain |
| Lycopene | Neurotoxicity | 5 | PM | 24120987 | 📋 | Protective effects of lycopene against methylmercury-induced neurotoxicity in cultured rat cerebellar granule neurons |
| Lycopene | Neurotoxicity | 4 | PM | 24075937 | 📋 | Lycopene protects against memory impairment and mito-oxidative damage induced by colchicine in rats: an evidence of nitric oxide signaling |
| Lycopene | Ototoxicity | 1 | PM | 28639555 | 📋 | Ginkgo biloba and Lycopene are Effective on Cisplatin Induced Ototoxicity? |
| Lycopene | Ototoxicity | 2 | PM | 23358585 | 📋 | The effects of lycopene on cisplatin-induced ototoxicity |
| Lycopene | Persistent Organic Pollutants Toxicity | 1 | PM | 34670089 | 📋 | Lycopene Preventing DEHP-Induced Renal Cell Damage Is Targeted by Aryl Hydrocarbon Receptor |
| Lycopene | Persistent Organic Pollutants Toxicity | 2 | PM | 23749762 | 📋 | Impact of lycopene on epididymal androgen and estrogen receptors' expression in polychlorinated biphenyls-exposed rat |
| Lycopene | Pesticide Toxicity | 3 | PM | 37329850 | 📋 | Lycopene attenuates chlorpyrifos-induced hepatotoxicity in rats via activation of Nrf2/HO-1 axis |
| Lycopene | Pesticide Toxicity | 2 | PM | 34577640 | 📋 | Antioxidant and Anti-Inflammatory Potential of Thymoquinone and Lycopene Mitigate the Chlorpyrifos-Induced Toxic Neuropathy |
| Lycopene | Pesticide Toxicity | 1 | PM | 27112537 | 📋 | The chemopreventive potential of lycopene against atrazine-induced cardiotoxicity: modulation of ionic homeostasis |
| Lycopene | Phthalate Toxicity | 13 | PM | 37871231 | 📋 | Lycopene Prevents Phthalate-Induced Cognitive Impairment via Modulating Ferroptosis |
| Lycopene | Phthalate Toxicity | 12 | PM | 36958386 | 📋 | Role of ROS/JAK2/STAT3 signaling pathway in di-n-butyl phthalate-induced testosterone synthesis inhibition and antagonism of lycopene |
| Lycopene | Phthalate Toxicity | 11 | PM | 36796548 | 📋 | Lycopene prevents Di-(2-ethylhexyl) phthalate-induced mitophagy and oxidative stress in mice heart via modulating mitochondrial homeostasis |
| Lycopene | Phthalate Toxicity | 10 | PM | 36403809 | 📋 | Xenobiotic-sensing nuclear receptors as targets for phthalates-induced lung injury and antagonism of lycopene |
| Lycopene | Phthalate Toxicity | 9 | PM | 36104915 | 📋 | Phthalate-induced testosterone/androgen receptor pathway disorder on spermatogenesis and antagonism of lycopene |
| Lycopene | Phthalate Toxicity | 8 | PM | 35917956 | 📋 | Lycopene alleviates di(2-ethylhexyl) phthalate-induced splenic injury by activating P62-Keap1-NRF2 signaling |
| Lycopene | Phthalate Toxicity | 7 | PM | 35348563 | 📋 | Lycopene regulates the mitochondrial unfolded protein response to prevent DEHP-induced cardiac mitochondrial damage in mice |
| Lycopene | Phthalate Toxicity | 5 | PM | 34699919 | 📋 | Lycopene mitigates DEHP-induced hepatic mitochondrial quality control disorder via regulating SIRT1/PINK1/mitophagy axis and mitochondrial unfolded protein response |
| Lycopene | Phthalate Toxicity | 4 | PM | 34673871 | 📋 | Lycopene prevents DEHP-induced testicular endoplasmic reticulum stress via regulating nuclear xenobiotic receptors and unfolded protein response in mice |
| Lycopene | Phthalate Toxicity | 3 | PM | 33965855 | 📋 | Lycopene prevents DEHP-induced hepatic oxidative stress damage by crosstalk between AHR-Nrf2 pathway |
| Lycopene | Phthalate Toxicity | 2 | PM | 32962341 | 📋 | Lycopene prevents DEHP-induced liver lipid metabolism disorder by inhibiting HIF-1α-induced PPARα/PPARγ/FXR/LXR system |
| Lycopene | Phthalate Toxicity | 1 | PM | 31814398 | 📋 | Lycopene Prevents DEHP-Induced Leydig Cell Damage with the Nrf2 Antioxidant Signaling Pathway in Mice |
| Lycopene | Phthalate Toxicity | 6 | PM | 29886059 | 📋 | Lycopene abrogates di-(2-ethylhexyl) phthalate induced testicular injury by modulating oxidative, endocrine and inflammatory changes in mice |
| Lycopene | Reproductive Toxicity Female | 3 | PM | 37429407 | 📋 | Protective effects of lycopene against zearalenone-induced reproductive toxicity in early pregnancy through anti-inflammatory, antioxidant and anti-apoptotic effects |
| Lycopene | Reproductive Toxicity Female | 2 | PM | 30806633 | 📋 | Effect of lycopene on oxidative ovary-damage induced by cisplatin in rats |
| Lycopene | Reproductive Toxicity Female | 1 | PM | 29948678 | 📋 | Lycopene Reduces in Utero Bisphenol A Exposure-Induced Mortality, Benefits Hormones, and Development of Reproductive Organs in Offspring Mice |
| Lycopene | Reproductive Toxicity Female | 4 | PM | 28918453 | 📋 | Furan induced ovarian damage in non-diabetic and diabetic rats and cellular protective role of lycopene |
| Lycopene | Reproductive Toxicity Male | 11 | PM | 38268887 | 📋 | Lycopene protects against ionizing radiation-induced testicular damage by inhibition of apoptosis and mitochondrial dysfunction |
| Lycopene | Reproductive Toxicity Male | 10 | PM | 36958386 | 📋 | Role of ROS/JAK2/STAT3 signaling pathway in di-n-butyl phthalate-induced testosterone synthesis inhibition and antagonism of lycopene |
| Lycopene | Reproductive Toxicity Male | 9 | PM | 36104915 | 📋 | Phthalate-induced testosterone/androgen receptor pathway disorder on spermatogenesis and antagonism of lycopene |
| Lycopene | Reproductive Toxicity Male | 8 | PM | 35940575 | 📋 | Lycopene modulates hepatic toxicity and testis injury induced by etoposide in male rats |
| Lycopene | Reproductive Toxicity Male | 7 | PM | 35814917 | 📋 | Comparative Potential of Zinc Sulfate, L-Carnitine, Lycopene, and Coenzyme Q10 on Cadmium-Induced Male Infertility |
| Lycopene | Reproductive Toxicity Male | 2 | PM | 34825328 | 📋 | Testicular toxicity of cisplatin in rats: ameliorative effect of lycopene and N-acetylcysteine |
| Lycopene | Reproductive Toxicity Male | 3 | PM | 34396458 | 📋 | Lycopene Alleviates Titanium Dioxide Nanoparticle-Induced Testicular Toxicity by Inhibiting Oxidative Stress and Apoptosis in Mice |
| Lycopene | Reproductive Toxicity Male | 4 | PM | 31568845 | 📋 | Protective effect of lycopene on testicular toxicity induced by Benzo[a]pyrene intake in rats |
| Lycopene | Reproductive Toxicity Male | 1 | PM | 31319718 | 📋 | Testicular toxicity of gentamicin in adult rats: Ameliorative effect of lycopene |
| Lycopene | Reproductive Toxicity Male | 5 | PM | 30907024 | 📋 | Evaluation of ameliorating effect of lycopene against testicular toxicity due to diethylnitrosamine using biochemical, spermatological and histopathological data |
| Lycopene | Reproductive Toxicity Male | 6 | PM | 29886059 | 📋 | Lycopene abrogates di-(2-ethylhexyl) phthalate induced testicular injury by modulating oxidative, endocrine and inflammatory changes in mice |
| Lycopene | Tobacco Toxicity | 5 | PM | 34869769 | 📋 | Lycopene Ameliorates Liver Inflammation and Redox Status in Mice Exposed to Long-Term Cigarette Smoke |
| Lycopene | Tobacco Toxicity | 1 | PM | 33548472 | 📋 | Dietary lycopene attenuates cigarette smoke-promoted nonalcoholic steatohepatitis by preventing suppression of antioxidant enzymes in ferrets |
| Lycopene | Tobacco Toxicity | 3 | PM | 31177203 | 📋 | Lycopene Inhibits Smoke-Induced Chronic Obstructive Pulmonary Disease and Lung Carcinogenesis by Modulating Reverse Cholesterol Transport in Ferrets |
| Lycopene | Tobacco Toxicity | 4 | PM | 30660958 | 📋 | Lycopene mitigates pulmonary emphysema induced by cigarette smoke in a murine model |
| Lycopene | Tobacco Toxicity | 6 | PM | 28651168 | 📋 | The antioxidant and anti-inflammatory properties of lycopene in mice lungs exposed to cigarette smoke |
| Lycopene | Tobacco Toxicity | 2 | PM | 27116542 | 📋 | Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation |
