| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Luteolin | Acetaminophen Toxicity | 2 | PM | 31956559 | 📋 | Protective effects of luteolin on injury induced inflammation through reduction of tissue uric acid and pro-inflammatory cytokines in rats |
| Luteolin | Acetaminophen Toxicity | 1 | PM | 26002582 | 📋 | Protective Effects of Luteolin Against Acetaminophen-Induced Acute Liver Failure in Mouse |
| Luteolin | Acrolein Toxicity | 1 | PM | 34958803 | 📋 | Exploring the molecular mechanism of the inhibition of acrolein-induced BEAS-2B cytotoxicity by luteolin using network pharmacology and cell biology technology |
| Luteolin | Alcohol Toxicity | 1 | PM | 33749262 | 📋 | Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways |
| Luteolin | Arsenic Toxicity | 1 | PM | 29914629 | 📋 | Dietary Flavonoids Improve Urinary Arsenic Elimination Among Mexican Women |
| Luteolin | Arsenic Toxicity | 2 | PM | 28583009 | 📋 | Inhibition of α-Synuclein contributes to the ameliorative effects of dietary flavonoids luteolin on arsenite-induced apoptotic cell death in the dopaminergic PC12 cells |
| Luteolin | Bisphenol Toxicity | 1 | PM | 32504732 | 📋 | Luteolin-Supplemented Diets Ameliorates Bisphenol A-Induced Toxicity in Drosophila Melanogaster |
| Luteolin | Bisphenol Toxicity | 2 | PM | 31091348 | 📋 | Protective role of luteolin against bisphenol A-induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/ HO-1 pathway |
| Luteolin | Cadmium Toxicity | 2 | PM | 36936530 | 📋 | Potential effect of luteolin, epiafzelechin, and albigenin on rats under cadmium-induced inflammatory insult: In silico and in vivo approach |
| Luteolin | Cadmium Toxicity | 1 | PM | 34134961 | 📋 | [Luteolin has a significant protective effect against cadmium-induced injury in lung epithelial Beas-2B cells] |
| Luteolin | Cardiotoxicity | 2 | PM | 35468014 | 📋 | Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway |
| Luteolin | Cardiotoxicity | 1 | PM | 34722681 | 📋 | Luteolin Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer |
| Luteolin | Cardiotoxicity | 3 | PM | 34272807 | 📋 | Luteolin mitigates potassium dichromate-induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim-1/Nrf2 signaling pathways |
| Luteolin | Chromium Toxicity | 1 | PM | 34272807 | 📋 | Luteolin mitigates potassium dichromate-induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim-1/Nrf2 signaling pathways |
| Luteolin | Cisplatin Toxicity | 3 | PM | 38414247 | 📋 | Inhibition of Gpx4-mediated Ferroptosis Alleviates Cisplatin-Induced Hearing Loss in C57BL/6 mice |
| Luteolin | Cisplatin Toxicity | 1 | PM | 35468014 | 📋 | Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway |
| Luteolin | Cisplatin Toxicity | 2 | PM | 23770416 | 📋 | Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney |
| Luteolin | Cytotoxicity | 4 | PM | 36065273 | 📋 | β-Cyfluthrin-Mediated Cytotoxicity of Cultured Rat Primary Hepatocytes Ameliorated by Cotreatment with Luteolin |
| Luteolin | Cytotoxicity | 1 | PM | 34958803 | 📋 | Exploring the molecular mechanism of the inhibition of acrolein-induced BEAS-2B cytotoxicity by luteolin using network pharmacology and cell biology technology |
| Luteolin | Cytotoxicity | 2 | PM | 25947916 | 📋 | Luteolin attenuates doxorubicin-induced cytotoxicity to MCF-7 human breast cancer cells |
| Luteolin | Cytotoxicity | 3 | PM | 25051393 | 📋 | Luteolin decreases the attachment, invasion and cytotoxicity of UPEC in bladder epithelial cells and inhibits UPEC biofilm formation |
| Luteolin | Environmental Pollutants Toxicity | 1 | PM | 35861671 | 📋 | Protective effect of luteolin against chemical and natural toxicants by targeting NF-κB pathway |
| Luteolin | Fluoride Toxicity | 1 | PM | 32757682 | 📋 | Exacerbation of diclofenac-induced gastroenterohepatic damage by concomitant exposure to sodium fluoride in rats: protective role of luteolin |
| Luteolin | Genotoxicity | 2 | PM | 34717250 | 📋 | The effect of Luteolin on DNA damage mediated by a copper catalyzed Fenton reaction |
| Luteolin | Genotoxicity | 3 | PM | 34272807 | 📋 | Luteolin mitigates potassium dichromate-induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim-1/Nrf2 signaling pathways |
| Luteolin | Genotoxicity | 1 | PM | 28113103 | 📋 | Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells |
| Luteolin | Heavy Metal Toxicity | 1 | PM | 29115570 | 📋 | Luteolin inhibits multi-heavy metal mixture-induced HL7702 cell apoptosis through downregulation of ROS-activated mitochondrial pathway |
| Luteolin | Hepatotoxicity | 8 | PM | 36509263 | 📋 | Luteolin ameliorates palmitate-induced lipotoxicity in hepatocytes by mediating endoplasmic reticulum stress and autophagy |
| Luteolin | Hepatotoxicity | 7 | PM | 36065273 | 📋 | β-Cyfluthrin-Mediated Cytotoxicity of Cultured Rat Primary Hepatocytes Ameliorated by Cotreatment with Luteolin |
| Luteolin | Hepatotoxicity | 2 | PM | 33827303 | 📋 | Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis |
| Luteolin | Hepatotoxicity | 4 | PM | 33679421 | 📋 | Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats |
| Luteolin | Hepatotoxicity | 3 | PM | 33530773 | 📋 | The protective role of luteolin against the methotrexate-induced hepato-renal toxicity via its antioxidative, anti-inflammatory, and anti-apoptotic effects in rats |
| Luteolin | Hepatotoxicity | 1 | PM | 32407927 | 📋 | Luteolin Prevents Liver From Tunicamycin-Induced Endoplasmic Reticulum Stress via Nuclear Factor Erythroid 2-related Factor 2-dependent Sestrin 2 Induction |
| Luteolin | Hepatotoxicity | 6 | PM | 31956559 | 📋 | Protective effects of luteolin on injury induced inflammation through reduction of tissue uric acid and pro-inflammatory cytokines in rats |
| Luteolin | Hepatotoxicity | 5 | PM | 19186041 | 📋 | Dose- and time-dependent effects of luteolin on carbon tetrachloride-induced hepatotoxicity in mice |
| Luteolin | Hydrogen Peroxide Toxicity | 3 | PM | 34187948 | 📋 | Luteolin inhibits H 2 O 2-induced cellular senescence via modulation of SIRT1 and p53 |
| Luteolin | Hydrogen Peroxide Toxicity | 1 | PM | 30802826 | 📋 | Luteolin protects PC-12 cells from H 2 O 2-induced injury by up-regulation of microRNA-21 |
| Luteolin | Hydrogen Peroxide Toxicity | 2 | PM | 27525270 | 📋 | Luteolin Prevents H2O2-Induced Apoptosis in H9C2 Cells through Modulating Akt-P53/Mdm2 Signaling Pathway |
| Luteolin | Insecticide Toxicity | 1 | PM | 38818490 | 📋 | The potential neuroprotective of luteolin against acetamiprid-induced neurotoxicity in the rat cerebral cortex |
| Luteolin | Lead Toxicity | 1 | PM | 32478470 | 📋 | Luteolin Protects Against Testicular Injury Induced by Lead Acetate by Activating the Nrf2/HO-1 Pathway |
| Luteolin | Lead Toxicity | 3 | PM | 32208856 | 📋 | Neuroprotective role of luteolin against lead acetate-induced cortical damage in rats |
| Luteolin | Lead Toxicity | 2 | PM | 31877779 | 📋 | Antagonistic Efficacy of Luteolin against Lead Acetate Exposure-Associated with Hepatotoxicity is Mediated via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Activities |
| Luteolin | Mercury Toxicity | 4 | PM | 36336778 | 📋 | Luteolin alleviates inorganic mercury-induced liver injury in quails by resisting oxidative stress and promoting mercury ion excretion |
| Luteolin | Mercury Toxicity | 3 | PM | 34428638 | 📋 | Luteolin alleviates inorganic mercury-induced kidney injury via activation of the AMPK/mTOR autophagy pathway |
| Luteolin | Mercury Toxicity | 1 | PM | 29156292 | 📋 | Dietary luteolin protects against HgCl 2-induced renal injury via activation of Nrf2-mediated signaling in rat |
| Luteolin | Mercury Toxicity | 2 | PM | 21244751 | 📋 | Luteolin and thiosalicylate inhibit HgCl(2) and thimerosal-induced VEGF release from human mast cells |
| Luteolin | Mycotoxins Toxicity | 3 | PM | 38013056 | 📋 | Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1-induced intestinal inflammatory injury |
| Luteolin | Mycotoxins Toxicity | 2 | PM | 36840879 | 📋 | Protective efficacy of luteolin against aflatoxinB1-induced toxicity, oxidative damage, and apoptosis in the rat liver |
| Luteolin | Mycotoxins Toxicity | 1 | PM | 34439516 | 📋 | Luteolin Alleviates AflatoxinB 1-Induced Apoptosis and Oxidative Stress in the Liver of Mice through Activation of Nrf2 Signaling Pathway |
| Luteolin | Nephrotoxicity | 5 | PM | 35947836 | 📋 | Luteolin normalizes blood pressure via its antioxidant activity and down-regulation of renal Angiotensin II receptor and Mineralocorticoid receptor expressions in rats co-exposed to Diclofenac and sodium fluoride |
| Luteolin | Nephrotoxicity | 4 | PM | 35368760 | 📋 | Luteolin Ameliorates Methamphetamine-Induced Podocyte Pathology by Inhibiting Tau Phosphorylation in Mice |
| Luteolin | Nephrotoxicity | 3 | PM | 34428638 | 📋 | Luteolin alleviates inorganic mercury-induced kidney injury via activation of the AMPK/mTOR autophagy pathway |
| Luteolin | Nephrotoxicity | 6 | PM | 34272807 | 📋 | Luteolin mitigates potassium dichromate-induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim-1/Nrf2 signaling pathways |
| Luteolin | Nephrotoxicity | 1 | PM | 33827303 | 📋 | Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis |
| Luteolin | Nephrotoxicity | 2 | PM | 33530773 | 📋 | The protective role of luteolin against the methotrexate-induced hepato-renal toxicity via its antioxidative, anti-inflammatory, and anti-apoptotic effects in rats |
| Luteolin | Nephrotoxicity | 7 | PM | 23770416 | 📋 | Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney |
| Luteolin | Neurotoxicity | 5 | PM | 38818490 | 📋 | The potential neuroprotective of luteolin against acetamiprid-induced neurotoxicity in the rat cerebral cortex |
| Luteolin | Neurotoxicity | 4 | PM | 38565590 | 📋 | Neuroprotective mechanisms of luteolin in glutamate-induced oxidative stress and autophagy-mediated neuronal cell death |
| Luteolin | Neurotoxicity | 3 | PM | 38266975 | 📋 | Luteolin amends neural neurotransmitters, antioxidants, and inflammatory markers in the cerebral cortex of Adderall exposed rats |
| Luteolin | Neurotoxicity | 2 | PM | 34766659 | 📋 | Biochemical and histological alterations of doxorubicin-induced neurotoxicity in rats: Protective role of luteolin |
| Luteolin | Neurotoxicity | 1 | PM | 33771263 | 📋 | Luteolin attenuates Fipronil-induced neurotoxicity through reduction of the ROS-mediated oxidative stress in rat brain mitochondria |
| Luteolin | Ototoxicity | 1 | PM | 38414247 | 📋 | Inhibition of Gpx4-mediated Ferroptosis Alleviates Cisplatin-Induced Hearing Loss in C57BL/6 mice |
| Luteolin | Persistent Organic Pollutants Toxicity | 1 | PM | 36639049 | 📋 | Luteolin protects against adipogenic and lipogenic potency induced by human relevant mixtures of persistent organic pollutants (POPs) in the 3T3-L1 model |
| Luteolin | Pesticide Toxicity | 1 | PM | 33771263 | 📋 | Luteolin attenuates Fipronil-induced neurotoxicity through reduction of the ROS-mediated oxidative stress in rat brain mitochondria |
| Luteolin | Tobacco Toxicity | 2 | PM | 38203542 | 📋 | Luteolin Alleviates Oxidative Stress in Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke via Modulation of the TRPV1 and CYP2A13/NRF2 Signaling Pathways |
| Luteolin | Tobacco Toxicity | 1 | PM | 37922675 | 📋 | Skeletal and neurological risks demonstrated in zebrafish due to second-hand cigarette smoke and the neutralization of luteolin |
