| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Lipoic Acid | Acetaminophen Toxicity | 2 | PM | 31117289 | 📋 | Hepatoprotective Actions of Ascorbic Acid, Alpha Lipoic Acid and Silymarin or Their Combination Against Acetaminophen-Induced Hepatotoxicity in Rats |
| Lipoic Acid | Acetaminophen Toxicity | 1 | PM | 18068886 | 📋 | The Potential Protective Role of Alpha-Lipoic Acid Against Acetaminophen-Induced Hepatic and Renal Damage |
| Lipoic Acid | Acrylamide Toxicity | 1 | PM | 38465655 | 📋 | Dietary lipoic acid alleviates autism-like behavior induced by acrylamide in adolescent mice: the potential involvement of the gut-brain axis |
| Lipoic Acid | Alcohol Toxicity | 4 | PM | 37657070 | 📋 | Alpha-lipoic Acid Protects Against Chronic Alcohol Consumption-induced Cardiac Damage via the ALDH2-associated PINK/Parkin Pathway |
| Lipoic Acid | Alcohol Toxicity | 3 | PM | 34096217 | 📋 | Alpha-Lipoic Acid Can Overcome The Reduced Developmental Competency Induced by Alcohol Toxicity during Ovine Oocyte Maturation |
| Lipoic Acid | Alcohol Toxicity | 1 | PM | 31602508 | 📋 | Administration of Alpha-Lipoic Acid Could Maintain Bone Mass and Bone Strength in Senile Female Rats With Alcohol Consumption |
| Lipoic Acid | Alcohol Toxicity | 2 | PM | 18025842 | 📋 | Antioxidant Effect of Alpha-Lipoic Acid Against Ethanol-Induced Gastric Mucosal Erosion in Rats |
| Lipoic Acid | Aluminum Toxicity | 1 | PM | 29861723 | 📋 | Synergistic Effect of Quercetin and α-Lipoic Acid on Aluminium Chloride Induced Neurotoxicity in Rats |
| Lipoic Acid | Arsenic Toxicity | 4 | PM | 36595328 | 📋 | Alpha-lipoic acid inhibits sodium arsenite-mediated autophagic death of rat insulinoma cells |
| Lipoic Acid | Arsenic Toxicity | 3 | PM | 33866498 | 📋 | Protective Effects of Alpha Lipoic Acid Against Arsenic Induced Oxidative Stress in Isolated Rat Liver Mitochondria |
| Lipoic Acid | Arsenic Toxicity | 2 | PM | 32272544 | 📋 | Protective Effect of α-Lipoic Acid Against Arsenic Trioxide-Induced Acute Cardiac Toxicity in Rats |
| Lipoic Acid | Arsenic Toxicity | 1 | PM | 20129497 | 📋 | Antioxidant Therapies for Traumatic Brain Injury |
| Lipoic Acid | Bisphenol Toxicity | 1 | PM | 34058234 | 📋 | Protective effect of alpha-lipoic acid on bisphenol A-induced learning and memory impairment in developing mice: nNOS and keap1/Nrf2 pathway |
| Lipoic Acid | Cadmium Toxicity | 1 | PM | 33689146 | 📋 | Alpha-Lipoic Acid Attenuates Cadmium- and Lead-Induced Neurotoxicity by Inhibiting Both Endoplasmic-Reticulum Stress and Activation of Fas/FasL and Mitochondrial Apoptotic Pathways in Rat Cerebral Cortex |
| Lipoic Acid | Cardiotoxicity | 2 | PM | 35930219 | 📋 | Alpha-Lipoic Acid Protects Against Doxorubicin-Induced Cardiotoxicity by Regulating Pyruvate Dehydrogenase Kinase 4 |
| Lipoic Acid | Cardiotoxicity | 1 | PM | 35596774 | 📋 | Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients |
| Lipoic Acid | Cardiotoxicity | 3 | PM | 21034734 | 📋 | Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies |
| Lipoic Acid | Cisplatin Toxicity | 3 | PM | 37165582 | 📋 | The chemoprotective potentials of alpha-lipoic acid against cisplatin-induced ototoxicity: A systematic review |
| Lipoic Acid | Cisplatin Toxicity | 2 | PM | 36142894 | 📋 | Alpha-Lipoic Acid Attenuates Apoptosis and Ferroptosis in Cisplatin-Induced Ototoxicity via the Reduction of Intracellular Lipid Droplets |
| Lipoic Acid | Cisplatin Toxicity | 1 | PM | 32328233 | 📋 | Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity |
| Lipoic Acid | Copper Toxicity | 3 | PM | 37751556 | 📋 | α-lipoic acid ameliorates consequences of copper overload by up-regulating selenoproteins and decreasing redox misbalance |
| Lipoic Acid | Copper Toxicity | 2 | PM | 36548551 | 📋 | Alpha Lipoic Acid and Monoisoamyl-DMSA Combined Treatment Ameliorates Copper-Induced Neurobehavioral Deficits, Oxidative Stress, and Inflammation |
| Lipoic Acid | Copper Toxicity | 1 | PM | 7605337 | 📋 | Thioctic (Lipoic) Acid: A Therapeutic Metal-Chelating Antioxidant? |
| Lipoic Acid | Environmental Pollutants Toxicity | 2 | PM | 36815965 | 📋 | Efficacy and mechanism of lipoic acid in the treatment of reproductive injury caused by perfluorooctanoic acid |
| Lipoic Acid | Environmental Pollutants Toxicity | 1 | PM | 32766117 | 📋 | Evaluation of the Possible Protective Effect of Alpha Lipoic Acid on Testicular Toxicity Induced by Polychlorinated Biphenyl in Adult Albino Rats: A Histological Study |
| Lipoic Acid | Fluoride Toxicity | 3 | PM | 37739047 | 📋 | α-Lipoic acid improves mitochondrial biogenesis and dynamics by enhancing antioxidant and inhibiting Wnt/Ca2+ pathway to relieve fluoride-induced hepatotoxic injury |
| Lipoic Acid | Fluoride Toxicity | 2 | PM | 36459405 | 📋 | α-Lipoic Acid Alleviated Fluoride-Induced Hepatocyte Injury via Inhibiting Ferroptosis |
| Lipoic Acid | Fluoride Toxicity | 1 | PM | 33342149 | 📋 | [The protective effects of α-lipoic acid on fluoride-induced reproductive lesion in rats via oxidative stress-mediated endoplasmic reticulum stress] |
| Lipoic Acid | Formaldehyde Toxicity | 1 | PM | 29249928 | 📋 | The Antioxidant Cofactor Alpha-Lipoic Acid May Control Endogenous Formaldehyde Metabolism in Mammals |
| Lipoic Acid | Genotoxicity | 3 | PM | 36617206 | 📋 | Alpha-Lipoic Acid Supplementation for Male Partner of Couples with Recurrent Pregnancy Loss: A Post hoc analysis in Clinical Trial |
| Lipoic Acid | Genotoxicity | 2 | PM | 36259478 | 📋 | Alpha-Lipoic Acid Ameliorates Sperm DNA Damage and Chromatin Integrity in Men with High DNA Damage: A Triple Blind Randomized Clinical Trial |
| Lipoic Acid | Genotoxicity | 1 | PM | 11854529 | 📋 | Memory Loss in Old Rats Is Associated With Brain Mitochondrial Decay and RNA/DNA Oxidation: Partial Reversal by Feeding acetyl-L-carnitine and/or R-alpha -Lipoic Acid |
| Lipoic Acid | Glyphosate Toxicity | 3 | PM | 36252731 | 📋 | Investigation of the toxicity of a glyphosate-based herbicide in a human liver cell line: Assessing the involvement of Nrf2 pathway and protective effects of vitamin E and α-lipoic acid |
| Lipoic Acid | Glyphosate Toxicity | 2 | PM | 23465731 | 📋 | Pesticide-induced Decrease in Rat Testicular Steroidogenesis Is Differentially Prevented by Lipoate and Tocopherol |
| Lipoic Acid | Glyphosate Toxicity | 1 | PM | 22995786 | 📋 | The Oxidative Damage and Inflammation Caused by Pesticides Are Reverted by Lipoic Acid in Rat Brain |
| Lipoic Acid | Hepatotoxicity | 11 | PM | 37739047 | 📋 | α-Lipoic acid improves mitochondrial biogenesis and dynamics by enhancing antioxidant and inhibiting Wnt/Ca2+ pathway to relieve fluoride-induced hepatotoxic injury |
| Lipoic Acid | Hepatotoxicity | 10 | PM | 37403907 | 📋 | Protective Effects of Alpha Lipoic Acid Against Ionizing Radiation- Induced Hepatotoxicity in Rats |
| Lipoic Acid | Hepatotoxicity | 9 | PM | 37013745 | 📋 | Elucidation of the role of α-lipoic acid and vitamin C in methotrexate-induced hepatoxicity in mice |
| Lipoic Acid | Hepatotoxicity | 8 | PM | 36459405 | 📋 | α-Lipoic Acid Alleviated Fluoride-Induced Hepatocyte Injury via Inhibiting Ferroptosis |
| Lipoic Acid | Hepatotoxicity | 7 | PM | 36006121 | 📋 | α-Lipoic Acid Protects against Cyclosporine A-Induced Hepatic Toxicity in Rats: Effect on Oxidative Stress, Inflammation, and Apoptosis |
| Lipoic Acid | Hepatotoxicity | 6 | PM | 35250410 | 📋 | The Potential Protective Effect of Curcumin and α-Lipoic Acid on N-(4-Hydroxyphenyl) Acetamide-induced Hepatotoxicity Through Downregulation of α-SMA and Collagen III Expression |
| Lipoic Acid | Hepatotoxicity | 1 | PM | 34903999 | 📋 | The Effect of acetyl-L-carnitine, Alpha-lipoic Acid, and Coenzyme Q10 Combination in Preventing Anti-tuberculosis Drug-induced Hepatotoxicity: A Randomized, Double-blind, Placebo-controlled Clinical Trial |
| Lipoic Acid | Hepatotoxicity | 5 | PM | 33973131 | 📋 | The protective potential of alpha lipoic acid on amiodarone-induced pulmonary fibrosis and hepatic injury in rats |
| Lipoic Acid | Hepatotoxicity | 3 | PM | 32636594 | 📋 | Alpha-lipoic Acid Ameliorates Sodium Valproate-Induced Liver Injury in Mice |
| Lipoic Acid | Hepatotoxicity | 2 | PM | 31117289 | 📋 | Hepatoprotective Actions of Ascorbic Acid, Alpha Lipoic Acid and Silymarin or Their Combination Against Acetaminophen-Induced Hepatotoxicity in Rats |
| Lipoic Acid | Hepatotoxicity | 4 | PM | 29500983 | 📋 | Alpha Lipoic Acid Protects Against Chlorpyrifos-Induced Toxicity in Wistar Rats via Modulating the Apoptotic Pathway |
| Lipoic Acid | Herbicide Toxicity | 1 | PM | 32774841 | 📋 | Lipoic acid antagonizes paraquat-induced vascular endothelial dysfunction by suppressing mitochondrial reactive oxidative stress |
| Lipoic Acid | Hydrogen Peroxide Toxicity | 1 | PM | 32787513 | 📋 | Alpha-lipoic acid ameliorates H 2 O 2-induced human vein endothelial cells injury via suppression of inflammation and oxidative stress |
| Lipoic Acid | Insecticide Toxicity | 1 | PM | 32911022 | 📋 | The protective role of alpha-lipoic acid on the appearance of fibronectin and laminin in renal tubules following diazinon exposure: an experimental immunohistochemical study |
| Lipoic Acid | Lead Toxicity | 2 | PM | 34305580 | 📋 | Alpha-Lipoic Acid Protects Co-Exposure to Lead and Zinc Oxide Nanoparticles Induced Neuro, Immuno and Male Reproductive Toxicity in Rats |
| Lipoic Acid | Lead Toxicity | 1 | PM | 33689146 | 📋 | Alpha-Lipoic Acid Attenuates Cadmium- and Lead-Induced Neurotoxicity by Inhibiting Both Endoplasmic-Reticulum Stress and Activation of Fas/FasL and Mitochondrial Apoptotic Pathways in Rat Cerebral Cortex |
| Lipoic Acid | Manganese Toxicity | 1 | PM | 32441205 | 📋 | Manganese-induced Neurotoxicity and the Potential Protective Effects of Lipoic Acid and Spirulina platensis |
| Lipoic Acid | Mercury Toxicity | 1 | PM | 29481853 | 📋 | Protective Role of Alpha-Lipoic Acid in Impairments of Social and Stereotyped Behaviors Induced by Early Postnatal Administration of Thimerosal in Male Rat |
| Lipoic Acid | Mercury Toxicity | 3 | PM | 26986620 | 📋 | Protective Effects of Alpha-lipoic Acid on MeHg-induced Oxidative Damage and Intracellular Ca(2+) Dyshomeostasis in Primary Cultured Neurons |
| Lipoic Acid | Nephrotoxicity | 2 | PM | 33565443 | 📋 | The protective effect of alpha-lipoic acid on the expression of collagen IV, renal function, and oxidative stress induced by diazinon in the renal parenchyma of rat |
| Lipoic Acid | Nephrotoxicity | 3 | PM | 32921159 | 📋 | Alpha lipoic acid attenuates iron induced oxidative acute kidney injury in rats |
| Lipoic Acid | Nephrotoxicity | 1 | PM | 32328233 | 📋 | Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity |
| Lipoic Acid | Nephrotoxicity | 4 | PM | 32099361 | 📋 | The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles |
| Lipoic Acid | Neurotoxicity | 7 | PM | 37904548 | 📋 | Alpha-Lipoic acid alleviates imidacloprid-induced neuro-behavioral deficits in rats via Nrf2/HO-1 pathway |
| Lipoic Acid | Neurotoxicity | 6 | PM | 37017891 | 📋 | Alpha-Lipoic Acid Ameliorates Doxorubicin-Induced Cognitive Impairments by Modulating Neuroinflammation and Oxidative Stress via NRF-2/HO-1 Signaling Pathway in the Rat Hippocampus |
| Lipoic Acid | Neurotoxicity | 5 | PM | 36548551 | 📋 | Alpha Lipoic Acid and Monoisoamyl-DMSA Combined Treatment Ameliorates Copper-Induced Neurobehavioral Deficits, Oxidative Stress, and Inflammation |
| Lipoic Acid | Neurotoxicity | 4 | PM | 35596774 | 📋 | Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients |
| Lipoic Acid | Neurotoxicity | 2 | PM | 35146598 | 📋 | Alpha-Lipoic Acid Attenuates MPTP/MPP +-Induced Neurotoxicity: Roles of SIRT1-Dependent PGC-1α Signaling Pathways |
| Lipoic Acid | Neurotoxicity | 3 | PM | 33689146 | 📋 | Alpha-Lipoic Acid Attenuates Cadmium- and Lead-Induced Neurotoxicity by Inhibiting Both Endoplasmic-Reticulum Stress and Activation of Fas/FasL and Mitochondrial Apoptotic Pathways in Rat Cerebral Cortex |
| Lipoic Acid | Neurotoxicity | 1 | PM | 32662911 | 📋 | Alpha-lipoic acid prevents brain injury in rats administered with valproic acid |
| Lipoic Acid | Ototoxicity | 2 | PM | 37165582 | 📋 | The chemoprotective potentials of alpha-lipoic acid against cisplatin-induced ototoxicity: A systematic review |
| Lipoic Acid | Ototoxicity | 1 | PM | 36142894 | 📋 | Alpha-Lipoic Acid Attenuates Apoptosis and Ferroptosis in Cisplatin-Induced Ototoxicity via the Reduction of Intracellular Lipid Droplets |
| Lipoic Acid | Pesticide Toxicity | 11 | PM | 37904548 | 📋 | Alpha-Lipoic acid alleviates imidacloprid-induced neuro-behavioral deficits in rats via Nrf2/HO-1 pathway |
| Lipoic Acid | Pesticide Toxicity | 10 | PM | 33565443 | 📋 | The protective effect of alpha-lipoic acid on the expression of collagen IV, renal function, and oxidative stress induced by diazinon in the renal parenchyma of rat |
| Lipoic Acid | Pesticide Toxicity | 9 | PM | 33005594 | 📋 | α-lipoic acid protects testis and epididymis against linuron-induced oxidative toxicity in adult rats |
| Lipoic Acid | Pesticide Toxicity | 6 | PM | 29736639 | 📋 | Chronic Co-Exposure to Chlorpyrifos and Deltamethrin Pesticides Induces Alterations in Serum Lipids and Oxidative Stress in Wistar Rats: Mitigating Role of Alpha-Lipoic Acid |
| Lipoic Acid | Pesticide Toxicity | 3 | PM | 29500983 | 📋 | Alpha Lipoic Acid Protects Against Chlorpyrifos-Induced Toxicity in Wistar Rats via Modulating the Apoptotic Pathway |
| Lipoic Acid | Pesticide Toxicity | 7 | PM | 28847703 | 📋 | Protective Effect of α-Lipoic Acid Against α-Cypermethrin-Induced Changes in Rat Cerebellum |
| Lipoic Acid | Pesticide Toxicity | 5 | PM | 26697883 | 📋 | The Protective Role of Alpha-Lipoic Acid on Long-Term Exposure of Rats to the Combination of Chlorpyrifos and Deltamethrin Pesticides |
| Lipoic Acid | Pesticide Toxicity | 8 | PM | 26221319 | 📋 | Garlic and Alpha Lipoic Supplementation Enhance the Immune System of Albino Rats and Alleviate Implications of Pesticides Mixtures |
| Lipoic Acid | Pesticide Toxicity | 1 | PM | 20663516 | 📋 | Augmentation of Cholinesterases and ATPase Activities in the Cerebellum and Pons-Medulla Oblongata, by a Combination of Antioxidants (Resveratrol, Ascorbic Acid, Alpha-Lipoic Acid and Vitamin E), in Acutely Lindane Intoxicated Mice |
| Lipoic Acid | Pesticide Toxicity | 4 | PM | 20490610 | 📋 | Inhibition of Lindane-Induced Toxicity Using Alpha-Lipoic Acid and Vitamin E in the Brain of Mus Musculus |
| Lipoic Acid | Pesticide Toxicity | 2 | PM | 20455324 | 📋 | Ameliorative Effect of a Combination of Vitamin E, Vitamin C, Alpha-Lipoic Acid and Stilbene Resveratrol on Lindane Induced Toxicity in Mice Olfactory Lobe and Cerebrum |
| Lipoic Acid | Phthalate Toxicity | 1 | PM | 32030592 | 📋 | Protective Effect of Alpha-Lipoic Acid on di-(2-ethylhexyl) Phthalate-Induced Testicular Toxicity in Mice |
| Lipoic Acid | Reproductive Toxicity Female | 1 | PM | 37838213 | 📋 | Alpha-lipoic acid supplementation reverses the declining quality of oocytes exposed to cyclophosphamide |
| Lipoic Acid | Reproductive Toxicity Male | 4 | PM | 36815965 | 📋 | Efficacy and mechanism of lipoic acid in the treatment of reproductive injury caused by perfluorooctanoic acid |
| Lipoic Acid | Reproductive Toxicity Male | 1 | PM | 35067888 | 📋 | Biochemical, molecular and cytological impacts of alpha-lipoic acid and Ginkgo biloba in ameliorating testicular dysfunctions induced by silver nanoparticles in rats |
| Lipoic Acid | Reproductive Toxicity Male | 2 | PM | 33529370 | 📋 | Alpha-lipoic acid may ameliorate testicular damage by targeting dox-induced altered antioxidant parameters, mitofusin-2 and apoptotic gene expression |
| Lipoic Acid | Reproductive Toxicity Male | 3 | PM | 32766117 | 📋 | Evaluation of the Possible Protective Effect of Alpha Lipoic Acid on Testicular Toxicity Induced by Polychlorinated Biphenyl in Adult Albino Rats: A Histological Study |
| Lipoic Acid | Statin-Induced Pathologies | 1 | PM | 32119925 | 📋 | Alpha lipoic acid and vitamin E improve atorvastatin-induced mitochondrial dysfunctions in rats |
| Lipoic Acid | Tobacco Toxicity | 1 | PM | 36650104 | 📋 | Alpha-lipoic acid modulates the oxidative and inflammatory responses induced by traditional and novel tobacco products in human liver epithelial cells |
