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List of Ginsenosides and group Toxicity intersectionsRows: 113■ Human ■ Animal ■ Risk ■ Review

SubstanceConditionSeqSrc
PMID
Dtl
Title
Ginsenosides Acetaminophen Toxicity
11
PM
36278209📋Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity via relieving inflammation and oxidative stress
Ginsenosides Acetaminophen Toxicity
10
PM
34397062📋Hepatoprotective effects of ginsenoside Rk3 in acetaminophen-induced liver injury in mice by activation of autophagy
Ginsenosides Acetaminophen Toxicity
9
PM
34155666📋Ginsenoside Rg1 and ginsenoside Rh1 prevent liver injury induced by acetaminophen in mice
Ginsenosides Acetaminophen Toxicity
8
PM
33793882📋Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity by suppressing inflammation and oxidative stress
Ginsenosides Acetaminophen Toxicity
1
PM
31786947📋Ginsenoside Rb1, A Major Saponin From Panax ginseng, Exerts Protective Effects Against Acetaminophen-Induced Hepatotoxicity in Mice
Ginsenosides Acetaminophen Toxicity
2
PM
30662289📋Ginsenoside Rk1 Ameliorates Paracetamol-Induced Hepatotoxicity in Mice Through Inhibition of Inflammation, Oxidative Stress, Nitrative Stress and Apoptosis
Ginsenosides Acetaminophen Toxicity
3
PM
30608002📋Ginsenoside Rg1 Prevents Acetaminophen-Induced Oxidative Stress and Apoptosis via Nrf2/ARE Signaling Pathway
Ginsenosides Acetaminophen Toxicity
4
PM
30030101📋Ginsenoside Rg1 Protects Against Acetaminophen-Induced Liver Injury via Activating Nrf2 Signaling Pathway in Vivo and in Vitro
Ginsenosides Acetaminophen Toxicity
5
PM
28965396📋Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice
Ginsenosides Acetaminophen Toxicity
6
PM
28429935📋Saponins (Ginsenosides) From the Leaves of Panax Quinquefolius Ameliorated Acetaminophen-Induced Hepatotoxicity in Mice
Ginsenosides Acetaminophen Toxicity
7
PM
23750847📋Korean Red Ginseng Extract Prevents APAP-induced Hepatotoxicity Through Metabolic Enzyme Regulation: The Role of Ginsenoside Rg3, a Protopanaxadiol
Ginsenosides Air Pollution Toxicity
1
PM
31505827📋Particulate Matter 2.5 Mediates Cutaneous Cellular Injury by Inducing Mitochondria-Associated Endoplasmic Reticulum Stress: Protective Effects of Ginsenoside Rb1
Ginsenosides Air Pollution Toxicity
2
PM
30917762📋Inhibitory Effects of Protopanaxatriol Type Ginsenoside Fraction (Rgx365) on Particulate Matter-Induced Pulmonary Injury
Ginsenosides Air Pollution Toxicity
3
PM
24346058📋Ginsenoside Rg1 reduces toxicity of fine particulate matter on human alveolar epithelial cells: a preliminary observation
Ginsenosides Alcohol Toxicity
5
PM
37572500📋Reduction of alcohol-induced mitochondrial damage with ginsenoside Rg1 studied by atomic force microscopy
Ginsenosides Alcohol Toxicity
4
PM
37232350📋Ginsenoside Rg1 regulates autophagy and endoplasmic reticulum stress via the AMPK/mTOR and PERK/ATF4/CHOP pathways to alleviate alcohol‑induced myocardial injury
Ginsenosides Alcohol Toxicity
3
PM
37184519📋Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-κB signaling pathway
Ginsenosides Alcohol Toxicity
2
PM
36573411📋[Ginsenosides affect the system of Toll-like receptors in the brain of rats under conditions of long-term alcohol withdrawal]
Ginsenosides Alcohol Toxicity
1
PM
27614967📋Ginsenosides from stems and leaves of ginseng prevent ethanol-induced lipid accumulation in human L02 hepatocytes
Ginsenosides Aluminum Toxicity
3
PM
34694773📋Ginsenoside Rg3 Alleviates Aluminum Chloride-Induced Bone Impairment in Rats by Activating the TGF-β1/Smad Signaling Pathway
Ginsenosides Aluminum Toxicity
1
PM
32173789📋Ginsenoside Rg3 Attenuates Aluminum-Induced Osteoporosis Through Regulation of Oxidative Stress and Bone Metabolism in Rats
Ginsenosides Aluminum Toxicity
2
PM
27470910📋Ginsenoside Rb1 alleviates aluminum chloride-induced rat osteoblasts dysfunction
Ginsenosides Benzo(a)pyrene Toxicity
1
PM
36941308📋The preventive role of the red gingeng ginsenoside Rg3 in the treatment of lung tumorigenesis induced by benzo(a)pyrene
Ginsenosides Cadmium Toxicity
1
PM
34661679📋Gisenoside Rg1 attenuates cadmium-induced neurotoxicity in vitro and in vivo by attenuating oxidative stress and inflammation
Ginsenosides Cardiotoxicity
11
PM
38593619📋Ginsenoside Rb1 attenuates doxorubicin induced cardiotoxicity by suppressing autophagy and ferroptosis
Ginsenosides Cardiotoxicity
10
PM
38519012📋Protective effect of ginsenoside Rb1 against aconitine cardiotoxicity studied by myocardial injury, action potential, and calcium signaling
Ginsenosides Cardiotoxicity
9
PM
37990515📋Ginsenoside Rg3 improves microcystin-induced cardiotoxicity through the miR-128-3p/MDM4 axis
Ginsenosides Cardiotoxicity
7
PM
36644383📋Ginsenoside F1 attenuates pirarubicin-induced cardiotoxicity by modulating Nrf2 and AKT/Bcl-2 signaling pathways
Ginsenosides Cardiotoxicity
6
PM
35723815📋Ginsenoside Rg 1 Reduces Cardiotoxicity While Increases Cardiotonic Effect of Aconitine in vitro
Ginsenosides Cardiotoxicity
5
PM
35534947📋Ginsenoside Rh2 mitigates doxorubicin-induced cardiotoxicity by inhibiting apoptotic and inflammatory damage and weakening pathological remodelling in breast cancer-bearing mice
Ginsenosides Cardiotoxicity
4
PM
35370720📋Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway
Ginsenosides Cardiotoxicity
1
PM
35071601📋Ginsenoside Rg2 Attenuated Trastuzumab-Induced Cardiotoxicity in Rats
Ginsenosides Cardiotoxicity
2
PM
33767768📋Ginsenoside Rg2 protects cardiomyocytes against trastuzumab-induced toxicity by inducing autophagy
Ginsenosides Cardiotoxicity
3
PM
33513559📋Ginsenoside Rb1 ameliorates cardiotoxicity triggered by aconitine via inhibiting calcium overload and pyroptosis
Ginsenosides Cardiotoxicity
8
PM
29137383📋Oral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis
Ginsenosides Cisplatin Toxicity
9
PM
38141010📋20(S)-Ginsenoside Rh1 alleviates sevoflurane-induced ototoxicity by reducing oxidative stress levels
Ginsenosides Cisplatin Toxicity
8
PM
36931607📋20(S)-Ginsenoside Rh1 inhibits cisplatin-induced hearing loss by inhibiting the MAPK signaling pathway and suppressing apoptosis in vitro
Ginsenosides Cisplatin Toxicity
7
PM
36575152📋Ginsenoside Re Attenuates Cisplatin-Induced Intestinal Toxicity via Suppressing GSK-3β-Dependent Wnt/β-Catenin Signaling Pathway In Vivo and in Vitro
Ginsenosides Cisplatin Toxicity
6
PM
34461812📋Protective Effect of 20(R)-Ginsenoside Rg3 Against Cisplatin-Induced Renal Toxicity via PI3K/AKT and NF-[Formula: see text]B Signaling Pathways Based on the Premise of Ensuring Anticancer Effect
Ginsenosides Cisplatin Toxicity
5
PM
34423507📋Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3
Ginsenosides Cisplatin Toxicity
4
PM
33510805📋Ginsenoside Rb3 Alleviates the Toxic Effect of Cisplatin on the Kidney during Its Treatment to Oral Cancer via TGF- β-Mediated Mitochondrial Apoptosis
Ginsenosides Cisplatin Toxicity
2
PM
31695559📋Ginsenoside Rb1 Ameliorates Cisplatin-Induced Learning and Memory Impairments
Ginsenosides Cisplatin Toxicity
3
PM
22266358📋Ginsenoside Rg3 enhances the chemosensitivity of tumors to cisplatin by reducing the basal level of nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1/NAD(P)H quinone oxidoreductase-1 and prevents normal tissue damage by scavenging cisplatin-induced intracellular reactive oxygen species
Ginsenosides Cisplatin Toxicity
1
PM
10803758📋The Role of ginsenoside-Rd in Cisplatin-Induced Acute Renal Failure
Ginsenosides Cytotoxicity
2
PM
35046796📋Ginsenoside Rb1 Attenuates Triptolide-Induced Cytotoxicity in HL-7702 Cells via the Activation of Keap1/Nrf2/ARE Pathway
Ginsenosides Cytotoxicity
3
PM
34956378📋Protective Effect of NGR1 against Glutamate-Induced Cytotoxicity in HT22 Hippocampal Neuronal Cells by Upregulating the SIRT1/Wnt/ β-Catenin Pathway
Ginsenosides Cytotoxicity
1
PM
33359145📋Ginsenoside Rb1 protected PC12 cells from Aβ 25-35-induced cytotoxicity via PPARγ activation and cholesterol reduction
Ginsenosides Food and Additives Toxicity
1
PM
34812491📋Ginsenoside Rb1 alleviates liver injury induced by 3-chloro-1,2-propanediol by stimulating autophagic flux
Ginsenosides Genotoxicity
3
PM
31590397📋Ginsenoside Rb1 Attenuates High Glucose-Induced Oxidative Injury via the NAD-PARP-SIRT Axis in Rat Retinal Capillary Endothelial Cells
Ginsenosides Genotoxicity
4
PM
25226533📋Antioxidative Dietary Compounds Modulate Gene Expression Associated With Apoptosis, DNA Repair, Inhibition of Cell Proliferation and Migration
Ginsenosides Genotoxicity
7
PM
24335839📋Ginsenoside Rg1 enhances the resistance of hematopoietic stem/progenitor cells to radiation-induced aging in mice
Ginsenosides Genotoxicity
5
PM
21956953📋Cytoprotective Effect of 20S-Rg3 on Benzo[a]pyrene-Induced DNA Damage
Ginsenosides Genotoxicity
1
PM
20491513📋Radioprotective Effect of American Ginseng on Human Lymphocytes at 90 Minutes Postirradiation: A Study of 40 Cases
Ginsenosides Genotoxicity
6
PM
19420751📋Ginsenoside Rb1 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair
Ginsenosides Genotoxicity
2
PM
17598087📋Protective Effects of Ginsenoside Rg(3) Against Cyclophosphamide-Induced DNA Damage and Cell Apoptosis in Mice
Ginsenosides Hepatotoxicity
16
PM
38708102📋Ameliorative effect of total ginsenosides from heat-treated fresh ginseng against cyclophosphamide-induced liver injury in mice
Ginsenosides Hepatotoxicity
15
PM
38244950📋Ginsenoside Rg1 attenuates lipopolysaccharide-induced chronic liver damage by activating Nrf2 signaling and inhibiting inflammasomes in hepatic cells
Ginsenosides Hepatotoxicity
14
PM
36278209📋Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity via relieving inflammation and oxidative stress
Ginsenosides Hepatotoxicity
13
PM
36152060📋Ros-mediated mitochondrial oxidative stress is involved in the ameliorating effect of ginsenoside GSLS on chlorpyrifos induced hepatotoxicity in mice
Ginsenosides Hepatotoxicity
12
PM
35875589📋Gut Microbiota Modulates the Protective Role of Ginsenoside Compound K Against Sodium Valproate-Induced Hepatotoxicity in Rat
Ginsenosides Hepatotoxicity
11
PM
35595219📋Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury by inhibiting CYP1A1 through the aryl hydrocarbon receptor
Ginsenosides Hepatotoxicity
7
PM
35046796📋Ginsenoside Rb1 Attenuates Triptolide-Induced Cytotoxicity in HL-7702 Cells via the Activation of Keap1/Nrf2/ARE Pathway
Ginsenosides Hepatotoxicity
1
PM
34812491📋Ginsenoside Rb1 alleviates liver injury induced by 3-chloro-1,2-propanediol by stimulating autophagic flux
Ginsenosides Hepatotoxicity
10
PM
34397062📋Hepatoprotective effects of ginsenoside Rk3 in acetaminophen-induced liver injury in mice by activation of autophagy
Ginsenosides Hepatotoxicity
8
PM
34155666📋Ginsenoside Rg1 and ginsenoside Rh1 prevent liver injury induced by acetaminophen in mice
Ginsenosides Hepatotoxicity
2
PM
33793882📋Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity by suppressing inflammation and oxidative stress
Ginsenosides Hepatotoxicity
6
PM
33096694📋Hepatoprotection by Traditional Essence of Ginseng against Carbon Tetrachloride-Induced Liver Damage
Ginsenosides Hepatotoxicity
3
PM
30608002📋Ginsenoside Rg1 Prevents Acetaminophen-Induced Oxidative Stress and Apoptosis via Nrf2/ARE Signaling Pathway
Ginsenosides Hepatotoxicity
9
PM
28965396📋Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice
Ginsenosides Hepatotoxicity
5
PM
28429935📋Saponins (Ginsenosides) From the Leaves of Panax Quinquefolius Ameliorated Acetaminophen-Induced Hepatotoxicity in Mice
Ginsenosides Hepatotoxicity
4
PM
16162168📋Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury
Ginsenosides Herbicide Toxicity
1
PM
35657166📋Ginsenoside Rg1 suppresses paraquat-induced epithelial cell senescence by enhancing autophagy in an ATG12-dependent manner
Ginsenosides Hydrogen Peroxide Toxicity
6
PM
33624427📋Protective effects of ginsenosides 20(R)-Rg3 on H2O2-induced myocardial cell injury by activating Keap-1/Nrf2/HO-1 signaling pathway
Ginsenosides Hydrogen Peroxide Toxicity
4
PM
31178974📋Protective Effect of Ginsenoside Rg1 on Oxidative Damage Induced by Hydrogen Peroxide in Chicken Splenic Lymphocytes
Ginsenosides Hydrogen Peroxide Toxicity
5
PM
31133133📋[Protective effects of ginsenoside F2 on hydrogen peroxide induced cell injury]
Ginsenosides Hydrogen Peroxide Toxicity
1
PM
27630703📋Protective effects of ginsenoside Rg1 against hydrogen peroxide-induced injury in human neuroblastoma cells
Ginsenosides Hydrogen Peroxide Toxicity
3
PM
23717116📋Protective Effect of Ginsenoside Rb1 on Hydrogen Peroxide-induced Oxidative Stress in Rat Articular Chondrocytes
Ginsenosides Hydrogen Peroxide Toxicity
2
PM
18827356📋Protective effects of ginsenoside Rd on PC12 cells against hydrogen peroxide
Ginsenosides Immunotoxicity
1
PM
34058674📋Ginsenoside Rb1 prevents deoxynivalenol-induced immune injury via alleviating oxidative stress and apoptosis in mice
Ginsenosides Lead Toxicity
1
PM
29145145📋Alleviation of ginsenoside Rg1 on hematopoietic homeostasis defects caused by lead-acetate
Ginsenosides Mycotoxins Toxicity
1
PM
34058674📋Ginsenoside Rb1 prevents deoxynivalenol-induced immune injury via alleviating oxidative stress and apoptosis in mice
Ginsenosides Nephrotoxicity
1
PM
35873571📋Ginsenoside Rb1 Ameliorated Bavachin-Induced Renal Fibrosis via Suppressing Bip/eIF2α/CHOP Signaling-Mediated EMT
Ginsenosides Nephrotoxicity
2
PM
29348725📋Protective effect of ginsenoside Rb1 against tacrolimus-induced apoptosis in renal proximal tubular LLC-PK1 cells
Ginsenosides Neurotoxicity
14
PM
38613520📋Ginsenoside Re protects against kainate-induced neurotoxicity in mice by attenuating mitochondrial dysfunction through activation of the signal transducers and activators of transcription 3 signaling
Ginsenosides Neurotoxicity
8
PM
37308051📋Ginsenoside Re blocks Bay k-8644-induced neurotoxicity via attenuating mitochondrial dysfunction and PKCδ activation in the hippocampus of mice: Involvement of antioxidant potential
Ginsenosides Neurotoxicity
7
PM
36811218📋Evaluating the effect of ginsenoside Rg1 on CPF-induced brain injury in mice via PI3k/AKT pathway
Ginsenosides Neurotoxicity
6
PM
36587558📋Ginsenoside Rk3 ameliorates Aβ-induced neurotoxicity in APP/PS1 model mice via AMPK signaling pathway
Ginsenosides Neurotoxicity
5
PM
36573411📋[Ginsenosides affect the system of Toll-like receptors in the brain of rats under conditions of long-term alcohol withdrawal]
Ginsenosides Neurotoxicity
4
PM
35600772📋Ginsenoside Rb1 attenuates methamphetamine (METH)-induced neurotoxicity through the NR2B/ERK/CREB/BDNF signalings in vitro and in vivo models
Ginsenosides Neurotoxicity
3
PM
35543148📋Neuroprotective effect of Ginsenoside Re against neurotoxin‑induced Parkinson's disease models via induction of Nrf2
Ginsenosides Neurotoxicity
2
PM
33335762📋Notoginsenoside R1 attenuates sevoflurane-induced neurotoxicity
Ginsenosides Neurotoxicity
10
PM
33290066📋Vina-Ginsenoside R4 from Panax ginseng Leaves Alleviates 6-OHDA-Induced Neurotoxicity in PC12 Cells Via the PI3K/Akt/GSK-3β Signaling Pathway
Ginsenosides Neurotoxicity
12
PM
29037473📋Ginsenoside Re protects against phencyclidine-induced behavioral changes and mitochondrial dysfunction via interactive modulation of glutathione peroxidase-1 and NADPH oxidase in the dorsolateral cortex of mice
Ginsenosides Neurotoxicity
13
PM
28884396📋Ginsenoside Re Protects Trimethyltin-Induced Neurotoxicity via Activation of IL-6-Mediated Phosphoinositol 3-Kinase/Akt Signaling in Mice
Ginsenosides Neurotoxicity
1
PM
28849171📋Ginsenoside Rg1 Protects Against Neuronal Degeneration Induced by Chronic Dexamethasone Treatment by Inhibiting NLRP-1 Inflammasomes in Mice
Ginsenosides Neurotoxicity
9
PM
24223941📋Neuroprotective effects of ginsenoside Rb1 on high glucose-induced neurotoxicity in primary cultured rat hippocampal neurons
Ginsenosides Neurotoxicity
11
PM
24170279📋Protective effects of ginsenoside Rg1 against colistin sulfate-induced neurotoxicity in PC12 cells
Ginsenosides Ototoxicity
2
PM
38141010📋20(S)-Ginsenoside Rh1 alleviates sevoflurane-induced ototoxicity by reducing oxidative stress levels
Ginsenosides Ototoxicity
1
PM
36931607📋20(S)-Ginsenoside Rh1 inhibits cisplatin-induced hearing loss by inhibiting the MAPK signaling pathway and suppressing apoptosis in vitro
Ginsenosides Pesticide Toxicity
3
PM
36811218📋Evaluating the effect of ginsenoside Rg1 on CPF-induced brain injury in mice via PI3k/AKT pathway
Ginsenosides Pesticide Toxicity
2
PM
36152060📋Ros-mediated mitochondrial oxidative stress is involved in the ameliorating effect of ginsenoside GSLS on chlorpyrifos induced hepatotoxicity in mice
Ginsenosides Pesticide Toxicity
1
PM
17123556📋Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity
Ginsenosides Reproductive Toxicity Female
1
PM
33331133📋Ginsenoside Rg1 ameliorates reproductive function injury in C57BL/6J mice induced by di-N-butyl-phthalate
Ginsenosides Reproductive Toxicity Male
1
PM
37102430📋Rg1 alleviates oxidative stress and spermatogonium apoptosis in D-gal-induced testicular toxicity by activating Akt
Ginsenosides Tobacco Toxicity
9
PM
37662486📋Ginseng Saponin Rb1 Attenuates Cigarette Smoke Exposure-Induced Inflammation, Apoptosis and Oxidative Stress via Activating Nrf2 and Inhibiting NF-κB Signaling Pathways
Ginsenosides Tobacco Toxicity
8
PM
35600779📋Compound K ameliorates airway inflammation and mucus secretion through the regulation of PKC signaling in vitro and in vivo
Ginsenosides Tobacco Toxicity
7
PM
33705682📋Ginsenoside Rb3 Alleviates CSE-induced TROP2 Upregulation Through p38 MAPK and NF-κB Pathways in BCs
Ginsenosides Tobacco Toxicity
6
PM
33523607📋Ginsenoside Rb3 alleviates smoke-induced lung injury via the H19/miR-29b-3p/HGMB1/TLR4 signalling pathway
Ginsenosides Tobacco Toxicity
5
PM
32920289📋Effects of a dammarane-type saponin, ginsenoside Rd, in nicotine-induced vascular endothelial injury
Ginsenosides Tobacco Toxicity
3
PM
32194898📋Ginsenoside Rg1 Protects Against Cigarette Smoke-Induced Airway Remodeling by Suppressing the TGF-β1/Smad3 Signaling Pathway
Ginsenosides Tobacco Toxicity
4
PM
30372878📋Ginsenoside Rb3 exerts protective properties against cigarette smoke extract-induced cell injury by inhibiting the p38 MAPK/NF-κB and TGF-β1/VEGF pathways in fibroblasts and epithelial cells
Ginsenosides Tobacco Toxicity
1
PM
29104873📋Ginsenoside Rg1 Attenuates Cigarette Smoke-Induced Pulmonary Epithelial-Mesenchymal Transition via Inhibition of the TGF- β 1/Smad Pathway
Ginsenosides Tobacco Toxicity
2
PM
28421197📋Ginsenoside Rg1 Ameliorates Cigarette Smoke-Induced Airway Fibrosis by Suppressing the TGF- β 1/Smad Pathway In Vivo and In Vitro