| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Crocin | Acetaminophen Toxicity | 1 | PM | 34804899 | 📋 | Saffron offers hepatoprotection via up-regulation of hepatic farnesoid-X-activated receptors in a rat model of acetaminophen-induced hepatotoxicity |
| Crocin | Acrolein Toxicity | 1 | PM | 35715565 | 📋 | Comparative study of oral versus parenteral crocin in mitigating acrolein-induced lung injury in albino rats |
| Crocin | Acrylamide Toxicity | 1 | PM | 34309867 | 📋 | Protective effects of crocin on acrylamide-induced testis damage |
| Crocin | Air Pollution Toxicity | 2 | PM | 35656072 | 📋 | Protective effect of crocin on hemodynamic parameters, electrocardiogram parameters, and oxidative stress in isolated hearts of rats exposed to PM 10 |
| Crocin | Air Pollution Toxicity | 1 | PM | 34604423 | 📋 | Effect of Total Suspended Particulate Matter in the Air on Inflammation Factors and Apoptotic Markers in Diabetic Rats: The Protective Effect of Insulin and Crocin |
| Crocin | Alcohol Toxicity | 3 | PM | 35040027 | 📋 | Neuroprotective Effects of Crocin Against Ethanol Neurotoxicity in the Animal Model of Fetal Alcohol Spectrum Disorders |
| Crocin | Alcohol Toxicity | 1 | PM | 32405348 | 📋 | Effect of Crocin, an Active Saffron Constituent, on Ethanol Toxicity in the Rat: Histopathological and Biochemical Studies |
| Crocin | Alcohol Toxicity | 2 | PM | 30798909 | 📋 | Crocin May Be Useful to Prevent or Treatment of Alcohol Induced Neurodegeneration and Neurobehavioral Sequels via Modulation of CREB/BDNF and Akt/GSK Signaling Pathway |
| Crocin | Antibiotic Toxicity | 1 | PM | 38234661 | 📋 | Renoprotective effects of crocin against colistin-induced nephrotoxicity in a rat model |
| Crocin | Arsenic Toxicity | 1 | PM | 32920515 | 📋 | Crocin ameliorates arsenic trioxide‑induced cardiotoxicity via Keap1-Nrf2/HO-1 pathway: Reducing oxidative stress, inflammation, and apoptosis |
| Crocin | Benzo(a)pyrene Toxicity | 1 | PM | 37649374 | 📋 | Saffron stigma extract and crocin play an important neuroprotective role in therapeutic measures against benzo[a]pyrene-induced behavioral alterations in zebrafish |
| Crocin | Bisphenol Toxicity | 3 | PM | 38458495 | 📋 | Rats' testicular toxicity induced by bisphenol A is lessened by crocin via an antiapoptotic mechanism and bumped P-glycoprotein expression |
| Crocin | Bisphenol Toxicity | 2 | PM | 32963736 | 📋 | Protective effect of crocin on bisphenol A - induced spatial learning and memory impairment in adult male rats: Role of oxidative stress and AMPA receptor |
| Crocin | Bisphenol Toxicity | 1 | PM | 28689058 | 📋 | Protective Effect of Crocin on BPA-induced Liver Toxicity in Rats Through Inhibition of Oxidative Stress and Downregulation of MAPK and MAPKAP Signaling Pathway and miRNA-122 Expression |
| Crocin | Cardiotoxicity | 3 | PM | 34981476 | 📋 | Evaluation of the Effect of Crocin on Doxorubicin-Induced Cardiotoxicity |
| Crocin | Cardiotoxicity | 2 | PM | 34567153 | 📋 | Protective Effect of Crocin on Malathion-induced Cardiotoxicity in Rats: A Biochemical, Histopathological and Proteomics Study |
| Crocin | Cardiotoxicity | 1 | PM | 34322808 | 📋 | Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats |
| Crocin | Cardiotoxicity | 4 | PM | 33793778 | 📋 | Study of the cardioprotective effects of crocin on Human Cardiac Myocyte cells and reduction of oxidative stress produced by aluminum phosphide poisoning |
| Crocin | Cardiotoxicity | 5 | PM | 32388215 | 📋 | Crocin protects against cardiotoxicity induced by doxorubicin through TLR-2/NF-κB signal pathway in vivo and vitro |
| Crocin | Cisplatin Toxicity | 4 | PM | 38010604 | 📋 | Nutritional Support of Crocin on Neurobehavioral Disabilities Induced by Cisplatin-Based Chemotherapy in Rats |
| Crocin | Cisplatin Toxicity | 3 | PM | 34584648 | 📋 | Evaluation of apoptotic effect of crocin, cisplatin, and their combination in human oral squamous cell carcinoma cell line HN5 |
| Crocin | Cisplatin Toxicity | 2 | PM | 34470647 | 📋 | The protective effect of crocin on cisplatin-induced testicular impairment in rats |
| Crocin | Cisplatin Toxicity | 1 | PM | 32259551 | 📋 | Crocin attenuates cisplatin-induced hepatotoxicity via TLR4/NF-κBp50 signaling and BAMBI modulation of TGF-β activity: Involvement of miRNA-9 and miRNA-29 |
| Crocin | Food and Additives Toxicity | 1 | PM | 32870427 | 📋 | Ameliorative effects of crocin on tartrazine dye-induced pancreatic adverse effects: a biochemical and histological study |
| Crocin | Genotoxicity | 2 | PM | 32395207 | 📋 | Protective Effect of Crocin on Electromagnetic Field-Induced Testicular Damage and Heat Shock Protein A2 Expression in Male BALB/c Mice |
| Crocin | Genotoxicity | 1 | PM | 28111973 | 📋 | Efficacy of Crocin and Safranal as Protective Agents Against Genotoxic Stress Induced by Gamma Radiation, Urethane and Procarbazine in Mice |
| Crocin | Hepatotoxicity | 6 | PM | 37523948 | 📋 | Antioxidant and anti-inflammatory potential of crocin on the doxorubicin mediated hepatotoxicity in Wistar rats |
| Crocin | Hepatotoxicity | 5 | PM | 37070111 | 📋 | Protective effects of crocin and gallic acid on the liver damage induced by methylglyoxal in male mice: role of inflammatory factors |
| Crocin | Hepatotoxicity | 4 | PM | 36874671 | 📋 | Protective Effects of Crocin Against Methotrexate-Induced Hepatotoxicity in Adult Male Albino Rats: Histological, Immunohistochemical, and Biochemical Study |
| Crocin | Hepatotoxicity | 3 | PM | 35814255 | 📋 | The Effect of Triptolide Combined With Crocin on Arthritis in Mice: From Side Effect Attenuation to Therapy |
| Crocin | Hepatotoxicity | 1 | PM | 34804899 | 📋 | Saffron offers hepatoprotection via up-regulation of hepatic farnesoid-X-activated receptors in a rat model of acetaminophen-induced hepatotoxicity |
| Crocin | Hepatotoxicity | 2 | PM | 27168751 | 📋 | Protective Effect of Crocin on Liver Toxicity Induced by Morphine |
| Crocin | Herbicide Toxicity | 3 | PM | 36185402 | 📋 | Neuroprotective effects of crocin and crocin-loaded niosomes against the paraquat-induced oxidative brain damage in rats |
| Crocin | Herbicide Toxicity | 2 | PM | 31911963 | 📋 | Ameliorative Effects of Crocin on Paraquat-Induced Oxidative Stress in Testis of Adult Mice: An Experimental Study |
| Crocin | Herbicide Toxicity | 1 | PM | 31710192 | 📋 | Ameliorative Effect of Crocin on Sperm Parameters and In Vitro Fertilization in Mice Under Oxidative Stress Induced by Paraquat |
| Crocin | Insecticide Toxicity | 1 | PM | 34567153 | 📋 | Protective Effect of Crocin on Malathion-induced Cardiotoxicity in Rats: A Biochemical, Histopathological and Proteomics Study |
| Crocin | Nephrotoxicity | 6 | PM | 38662441 | 📋 | Crocin, the compound of the dried stigma of Crocus sativus L (saffron), restores doxorubicin-induced disturbances in kidney functioning, oxidative stress, inflammation, renal tissue morphology and TGF-β signalling pathways |
| Crocin | Nephrotoxicity | 5 | PM | 38246228 | 📋 | Investigation of the effects of crocin on inflammation, oxidative stress, apoptosis, NF-κB, TLR-4 and Nrf-2/HO-1 pathways in gentamicin-induced nephrotoxicity in rats |
| Crocin | Nephrotoxicity | 4 | PM | 38234661 | 📋 | Renoprotective effects of crocin against colistin-induced nephrotoxicity in a rat model |
| Crocin | Nephrotoxicity | 3 | PM | 36190398 | 📋 | Chemotherapy-induced nephrotoxicity was improved by crocin in mouse model |
| Crocin | Nephrotoxicity | 2 | PM | 36060925 | 📋 | Evaluation of Crocin Effect on Contrast-Induced Nephropathy Following Coronary Angiography or Angioplasty: A Randomized Controlled Trial |
| Crocin | Nephrotoxicity | 1 | PM | 33628387 | 📋 | Antioxidant and Anti-Inflammatory Effects of Crocin Ameliorate Doxorubicin-Induced Nephrotoxicity in Rats |
| Crocin | Neurotoxicity | 3 | PM | 38010604 | 📋 | Nutritional Support of Crocin on Neurobehavioral Disabilities Induced by Cisplatin-Based Chemotherapy in Rats |
| Crocin | Neurotoxicity | 2 | PM | 37523128 | 📋 | Crocin alleviates neurotoxicity induced by bupivacaine in SH-SY5Y cells with inhibition of PI3K/AKT signaling |
| Crocin | Neurotoxicity | 1 | PM | 35274200 | 📋 | Crocin Protects Malathion-Induced Striatal Biochemical Deficits by Inhibiting Apoptosis and Increasing α-Synuclein in Rats' Striatum |
| Crocin | Pesticide Toxicity | 1 | PM | 35274200 | 📋 | Crocin Protects Malathion-Induced Striatal Biochemical Deficits by Inhibiting Apoptosis and Increasing α-Synuclein in Rats' Striatum |
| Crocin | Pesticide Toxicity | 2 | PM | 33793778 | 📋 | Study of the cardioprotective effects of crocin on Human Cardiac Myocyte cells and reduction of oxidative stress produced by aluminum phosphide poisoning |
| Crocin | Pesticide Toxicity | 4 | PM | 30975443 | 📋 | The Possible Alleviating Effect of Saffron on Chlorpyrifos Experimentally Induced Cardiotoxicity: Histological, Immunohistochemical and Biochemical Study |
| Crocin | Pesticide Toxicity | 5 | PM | 27470340 | 📋 | Crocin, the Main Active Saffron Constituent, Mitigates Dichlorvos-Induced Oxidative Stress and Apoptosis in HCT-116 Cells |
| Crocin | Pesticide Toxicity | 3 | PM | 27353299 | 📋 | Protective Effect of Crocin Against Apoptosis Induced by Subchronic Exposure of the Rat Vascular System to Diazinon |
| Crocin | Reproductive Toxicity Female | 1 | PM | 38014433 | 📋 | Investigation of crocin's protective effect on cyclophosphamide-induced hypothalamic-pituitary-gonadal axis defects in adult female rats |
| Crocin | Reproductive Toxicity Male | 7 | PM | 38458495 | 📋 | Rats' testicular toxicity induced by bisphenol A is lessened by crocin via an antiapoptotic mechanism and bumped P-glycoprotein expression |
| Crocin | Reproductive Toxicity Male | 6 | PM | 37615252 | 📋 | The protective effect of crocin against testicular toxicity induced by ionizing radiation via AKT/FOXO pathway |
| Crocin | Reproductive Toxicity Male | 5 | PM | 35450005 | 📋 | The effect of Crocin on sperm parameters disorders induced by peripheral administration of nitrosamines in male rats |
| Crocin | Reproductive Toxicity Male | 3 | PM | 34470647 | 📋 | The protective effect of crocin on cisplatin-induced testicular impairment in rats |
| Crocin | Reproductive Toxicity Male | 1 | PM | 34429734 | 📋 | Antioxidant Effects of Aerobic Training and Crocin Consumption on Doxorubicin-Induced Testicular Toxicity in Rats |
| Crocin | Reproductive Toxicity Male | 2 | PM | 34309867 | 📋 | Protective effects of crocin on acrylamide-induced testis damage |
| Crocin | Reproductive Toxicity Male | 4 | PM | 29486335 | 📋 | Crocin Attenuates Cyclophosphamide Induced Testicular Toxicity by Preserving Glutathione Redox System |
| Crocin | Tobacco Toxicity | 5 | PM | 38587323 | 📋 | Preventive effects of crocin, a natural compound from saffron, against nicotine‑induced oxidative stress and neurobehavioral disturbances |
| Crocin | Tobacco Toxicity | 4 | PM | 38294505 | 📋 | Oral supplementation with crocin (a constituent of saffron) in subjects with cigarette smoking: a clinical trial |
| Crocin | Tobacco Toxicity | 3 | PM | 35785730 | 📋 | GLP-1 mediates the neuroprotective action of crocin against cigarette smoking-induced cognitive disorders via suppressing HMGB1-RAGE/TLR4-NF-κB pathway |
| Crocin | Tobacco Toxicity | 2 | PM | 31659585 | 📋 | The Association of Cigarette Smoke Exposure With Lung Cellular Toxicity and Oxidative Stress: The Protective Role of Crocin |
| Crocin | Tobacco Toxicity | 1 | PM | 27123203 | 📋 | Crocin Improves Damage Induced by Nicotine on A Number of Reproductive Parameters in Male Mice |
