| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Apple | Cadmium Toxicity | 2 | PM | 32820471 | 📋 | Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats |
| Apple | Cadmium Toxicity | 1 | PM | 29582325 | 📋 | Protective effect of grape or apple juices in bone tissue of rats exposed to cadmium: role of RUNX-2 and RANK/L expression |
| Apple | Cardiotoxicity | 1 | PM | 33977685 | 📋 | Comparative evaluation of cardioprotective activity of Gala and Fuji apple juice against isoprenaline-induced cardiotoxicity in rats |
| Apple | Genotoxicity | 1 | PM | 31515822 | 📋 | Protective effect of apple phlorizin on hydrogen peroxide-induced cell damage in HepG2 cells |
| Apple | Genotoxicity | 2 | PM | 26753515 | 📋 | Potential Prophylactic Properties of Apple and Characterization of Potent Bioactive from cv. "Granny Smith" Displaying Strong Antimutagenicity in Models Including Human Lymphoblast TK6(+/-) Cell Line |
| Apple | Hepatotoxicity | 2 | PM | 32326503 | 📋 | Hepatoprotective Effects of Standardized Extracts from an Ancient Italian Apple Variety (Mela Rosa dei Monti Sibillini) against Carbon Tetrachloride (CCl 4)-Induced Hepatotoxicity in Rats |
| Apple | Hepatotoxicity | 3 | PM | 31515822 | 📋 | Protective effect of apple phlorizin on hydrogen peroxide-induced cell damage in HepG2 cells |
| Apple | Hepatotoxicity | 4 | PM | 31445146 | 📋 | COX-2/iNOS regulation during experimental hepatic injury and its mitigation by cloudy apple juice |
| Apple | Hepatotoxicity | 5 | PM | 26811344 | 📋 | Antioxidant and hepatoprotective effect of polyphenols from apple pomace extract via apoptosis inhibition and Nrf2 activation in mice |
| Apple | Hydrogen Peroxide Toxicity | 1 | PM | 31515822 | 📋 | Protective effect of apple phlorizin on hydrogen peroxide-induced cell damage in HepG2 cells |
| Apple | Lead Toxicity | 2 | PM | 35167638 | 📋 | Apple phenolic extracts ameliorate lead-induced cognitive impairment and depression- and anxiety-like behavior in mice by abating oxidative stress, inflammation and apoptosis via the miR-22-3p/SIRT1 axis |
| Apple | Lead Toxicity | 1 | PM | 31760233 | 📋 | Malus micromalus Makino phenolic extract preserves hepatorenal function by regulating PKC-α signaling pathway and attenuating endoplasmic reticulum stress in lead (II) exposure mice |
| Apple | Nephrotoxicity | 1 | PM | 32820471 | 📋 | Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats |
