| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Ginsenosides | Arthritis | 3 | PM | 34943075 | 📋 | Ginsenoside Rg3 Attenuates TNF-α-Induced Damage in Chondrocytes through Regulating SIRT1-Mediated Anti-Apoptotic and Anti-Inflammatory Mechanisms |
| Ginsenosides | Arthritis | 2 | PM | 33265080 | 📋 | Ginsenoside Rg1 promotes lymphatic drainage and improves chronic inflammatory arthritis |
| Ginsenosides | Arthritis | 1 | PM | 31165333 | 📋 | Ginsenoside compound-K Inhibits the Activity of B Cells Through Inducing IgD-B Cell Receptor Endocytosis in Mice With Collagen-Induced Arthritis |
| Ginsenosides | Bone Cancer | 11 | PM | 38086608 | 📋 | Exploration in the Mechanism of Ginsenoside Rg5 for the Treatment of Osteosarcoma by Network Pharmacology and Molecular Docking |
| Ginsenosides | Bone Cancer | 10 | PM | 37498992 | 📋 | Synergistic anti-tumour activity of ginsenoside Rg3 and doxorubicin on proliferation, metastasis and angiogenesis in osteosarcoma by modulating mTOR/HIF-1α/VEGF and EMT signalling pathways |
| Ginsenosides | Bone Cancer | 8 | PM | 34930332 | 📋 | Ginsenoside Rg3 inhibits osteosarcoma progression by reducing circ_0003074 expression in a miR-516b-5p/KPNA4-dependent manner |
| Ginsenosides | Bone Cancer | 7 | PM | 34257801 | 📋 | Ginsenoside Rg5 Inhibits Human Osteosarcoma Cell Proliferation and Induces Cell Apoptosis through PI3K/Akt/mTORC1-Related LC3 Autophagy Pathway |
| Ginsenosides | Bone Cancer | 6 | PM | 33957363 | 📋 | Integrated bioinformatic analysis and experiment confirmation of the antagonistic effect and molecular mechanism of ginsenoside Rh2 in metastatic osteosarcoma |
| Ginsenosides | Bone Cancer | 9 | PM | 33128383 | 📋 | Notoginsenoside R1 counteracts mesenchymal stem cell-evoked oncogenesis and doxorubicin resistance in osteosarcoma cells by blocking IL-6 secretion-induced JAK2/STAT3 signaling |
| Ginsenosides | Bone Cancer | 5 | PM | 32774433 | 📋 | Ginsenoside Rg1 Drives Stimulations of Timosaponin AIII-Induced Anticancer Effects in Human Osteosarcoma Cells |
| Ginsenosides | Bone Cancer | 4 | PM | 32733585 | 📋 | Ginsenoside Rg3 Inhibits the Growth of Osteosarcoma and Attenuates Metastasis through the Wnt/ β-Catenin and EMT Signaling Pathway |
| Ginsenosides | Bone Cancer | 3 | PM | 29750154 | 📋 | Ginsenoside Rg3 Suppresses Proliferation and Induces Apoptosis in Human Osteosarcoma |
| Ginsenosides | Bone Cancer | 2 | PM | 24337872 | 📋 | Ginsenoside Rg3 induces DNA damage in human osteosarcoma cells and reduces MNNG-induced DNA damage and apoptosis in normal human cells |
| Ginsenosides | Bone Cancer | 1 | PM | 24173574 | 📋 | Induction of G2/M phase cell cycle arrest and apoptosis by ginsenoside Rf in human osteosarcoma MG‑63 cells through the mitochondrial pathway |
| Ginsenosides | Bone Disease | 2 | PM | 34694773 | 📋 | Ginsenoside Rg3 Alleviates Aluminum Chloride-Induced Bone Impairment in Rats by Activating the TGF-β1/Smad Signaling Pathway |
| Ginsenosides | Bone Disease | 1 | PM | 19428246 | 📋 | 20(R)-ginsenoside Rh2, Not 20(S), Is a Selective Osteoclastgenesis Inhibitor Without Any Cytotoxicity |
| Ginsenosides | Bone Formation | 4 | PM | 38614042 | 📋 | Research progress of the mechanisms and applications of ginsenosides in promoting bone formation |
| Ginsenosides | Bone Formation | 3 | PM | 35682866 | 📋 | Ginsenoside Rc Promotes Bone Formation in Ovariectomy-Induced Osteoporosis In Vivo and Osteogenic Differentiation In Vitro |
| Ginsenosides | Bone Formation | 2 | PM | 32391072 | 📋 | Effects of Ginsenosides on Bone Remodelling for Novel Drug Applications: A Review |
| Ginsenosides | Bone Formation | 1 | PM | 32173789 | 📋 | Ginsenoside Rg3 Attenuates Aluminum-Induced Osteoporosis Through Regulation of Oxidative Stress and Bone Metabolism in Rats |
| Ginsenosides | Bone Fractures | 1 | PM | 35462912 | 📋 | Ginsenoside Compound K Enhances Fracture Healing via Promoting Osteogenesis and Angiogenesis |
| Ginsenosides | Cartilage Injury | 1 | PM | 37750082 | 📋 | Adhesive ginsenoside compound K patches for cartilage tissue regeneration |
| Ginsenosides | Degenerative Disk Disease | 4 | PM | 38485818 | 📋 | Ginsenoside Rg1 relieves rat intervertebral disc degeneration and inhibits IL-1β-induced nucleus pulposus cell apoptosis and inflammation via NF-κB signaling pathway |
| Ginsenosides | Degenerative Disk Disease | 3 | PM | 38372089 | 📋 | Ginsenoside Rg3 exhibits anti-catabolic and anti-apoptotic effects in IL-1β treated human disc nucleus pulposus cells and in a rat model of disc degeneration by inactivating the MAPK pathway |
| Ginsenosides | Degenerative Disk Disease | 2 | PM | 36539815 | 📋 | Ginsenoside Rg1 inhibits nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via the YAP1/TAZ pathway in rats with intervertebral disc degeneration |
| Ginsenosides | Degenerative Disk Disease | 1 | PM | 30428306 | 📋 | Protective effects of ginsenoside Rg3 on TNF-α-induced human nucleus pulposus cells through inhibiting NF-κB signaling pathway |
| Ginsenosides | Diabetic Osteoporosis | 1 | PM | 36467080 | 📋 | Ginsenoside Rg1 interferes with the progression of diabetic osteoporosis by promoting type H angiogenesis modulating vasculogenic and osteogenic coupling |
| Ginsenosides | Osteoarthritis | 14 | PM | 37750082 | 📋 | Adhesive ginsenoside compound K patches for cartilage tissue regeneration |
| Ginsenosides | Osteoarthritis | 13 | PM | 37664679 | 📋 | Protective effects of ginseng and ginsenosides in the development of osteoarthritis (Review) |
| Ginsenosides | Osteoarthritis | 12 | PM | 37522058 | 📋 | Ginsenoside compound K alleviates osteoarthritis by inhibiting NLRP3‑mediated pyroptosis |
| Ginsenosides | Osteoarthritis | 9 | PM | 36630614 | 📋 | Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis |
| Ginsenosides | Osteoarthritis | 8 | PM | 35866931 | 📋 | Ginsenoside Rb1 from Panax ginseng attenuates monoiodoacetate-induced osteoarthritis by inhibiting miR-21-5p/FGF18-mediated inflammation |
| Ginsenosides | Osteoarthritis | 7 | PM | 35344713 | 📋 | Ginsenoside-Rb1 prevents bone cartilage destruction through down-regulation of p-Akt, p-P38, and p-P65 signaling in rabbit |
| Ginsenosides | Osteoarthritis | 6 | PM | 33841009 | 📋 | Ginsenoside Rb 1 inhibits monoiodoacetate-induced osteoarthritis in postmenopausal rats through prevention of cartilage degradation |
| Ginsenosides | Osteoarthritis | 1 | PM | 28287423 | 📋 | Chondroprotective Effects of Ginsenoside Rg1 in Human Osteoarthritis Chondrocytes and a Rat Model of Anterior Cruciate Ligament Transection |
| Ginsenosides | Osteoarthritis | 3 | PM | 28112382 | 📋 | Ginsenoside‑Rg5 Treatment Inhibits Apoptosis of Chondrocytes and Degradation of Cartilage Matrix in a Rat Model of Osteoarthritis |
| Ginsenosides | Osteoarthritis | 5 | PM | 27368432 | 📋 | Therapeutic potential of compound K as an IKK inhibitor with implications for osteoarthritis prevention: an in silico and in vitro study |
| Ginsenosides | Osteoarthritis | 10 | PM | 24384406 | 📋 | Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation |
| Ginsenosides | Osteoarthritis | 11 | PM | 23835558 | 📋 | Ginsenoside Rb1 prevents interleukin-1 beta induced inflammation and apoptosis in human articular chondrocytes |
| Ginsenosides | Osteoarthritis | 2 | PM | 23717116 | 📋 | Protective Effect of Ginsenoside Rb1 on Hydrogen Peroxide-induced Oxidative Stress in Rat Articular Chondrocytes |
| Ginsenosides | Osteoarthritis | 4 | PM | 22454193 | 📋 | Protective effects of ginsenoside Rg3 on human osteoarthritic chondrocytes |
| Ginsenosides | Osteoporosis | 20 | PM | 38650149 | 📋 | Ginsenoside Rc alleviates osteoporosis by the TGF-β/Smad signaling pathway |
| Ginsenosides | Osteoporosis | 19 | PM | 38649090 | 📋 | Therapeutic effects of ginsenosides on osteoporosis for novel drug applications |
| Ginsenosides | Osteoporosis | 18 | PM | 38240189 | 📋 | Ginsenoside Rb2 exhibits therapeutic value for male osteoporosis in orchiectomy mice by suppressing osteoclastogenesis and modulating NF-κB/MAPK signaling pathways |
| Ginsenosides | Osteoporosis | 17 | PM | 38176267 | 📋 | Ginsenoside Rg1 modulates PI3K/AKT pathway for enhanced osteogenesis via GPER |
| Ginsenosides | Osteoporosis | 16 | PM | 37940733 | 📋 | Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress |
| Ginsenosides | Osteoporosis | 15 | PM | 37605614 | 📋 | Ginsenoside Rg2 inhibits osteoclastogenesis by downregulating the NFATc1, c-Fos, and MAPK pathways |
| Ginsenosides | Osteoporosis | 14 | PM | 36430397 | 📋 | Biochemical Targets and Molecular Mechanism of Ginsenoside Compound K in Treating Osteoporosis Based on Network Pharmacology |
| Ginsenosides | Osteoporosis | 13 | PM | 36267094 | 📋 | Ginsenoside Rg1 Reduces Oxidative Stress Via Nrf2 Activation to Regulate Age-Related Mesenchymal Stem Cells Fate Switch Between Osteoblasts and Adipocytes |
| Ginsenosides | Osteoporosis | 12 | PM | 35791093 | 📋 | A network pharmacology approach to explore and validate the potential targets of ginsenoside on osteoporosis |
| Ginsenosides | Osteoporosis | 11 | PM | 35716470 | 📋 | Ginsenoside Rb1 prevents osteoporosis via the AHR/PRELP/NF-κB signaling axis |
| Ginsenosides | Osteoporosis | 10 | PM | 35682866 | 📋 | Ginsenoside Rc Promotes Bone Formation in Ovariectomy-Induced Osteoporosis In Vivo and Osteogenic Differentiation In Vitro |
| Ginsenosides | Osteoporosis | 9 | PM | 34786818 | 📋 | Notoginsenoside R1 attenuates oxidative stress-induced osteoblast dysfunction through JNK signalling pathway |
| Ginsenosides | Osteoporosis | 8 | PM | 34632364 | 📋 | Bioactive strontium ions/ginsenoside Rg1-incorporated biodegradable silk fibroin-gelatin scaffold promoted challenging osteoporotic bone regeneration |
| Ginsenosides | Osteoporosis | 7 | PM | 33519454 | 📋 | The Ginsenoside Exhibits Antiosteoporosis Effects in Ketogenic-Diet-Induced Osteoporosis via Rebalancing Bone Turnover |
| Ginsenosides | Osteoporosis | 6 | PM | 32898934 | 📋 | Ginsenoside Rg3 attenuates ovariectomy-induced osteoporosis via AMPK/mTOR signaling pathway |
| Ginsenosides | Osteoporosis | 1 | PM | 32391072 | 📋 | Effects of Ginsenosides on Bone Remodelling for Novel Drug Applications: A Review |
| Ginsenosides | Osteoporosis | 2 | PM | 32173789 | 📋 | Ginsenoside Rg3 Attenuates Aluminum-Induced Osteoporosis Through Regulation of Oxidative Stress and Bone Metabolism in Rats |
| Ginsenosides | Osteoporosis | 4 | PM | 27470910 | 📋 | Ginsenoside Rb1 alleviates aluminum chloride-induced rat osteoblasts dysfunction |
| Ginsenosides | Osteoporosis | 3 | PM | 27387537 | 📋 | Ginsenosides Rg3 Attenuates Glucocorticoid-Induced Osteoporosis Through Regulating BMP-2/BMPR1A/Runx2 Signaling Pathway |
| Ginsenosides | Osteoporosis | 5 | PM | 22484180 | 📋 | Ginsenoside Rh2 inhibits osteoclastogenesis through down-regulation of NF-κB, NFATc1 and c-Fos |
| Ginsenosides | Postmenopausal Osteoporosis | 1 | PM | 32898934 | 📋 | Ginsenoside Rg3 attenuates ovariectomy-induced osteoporosis via AMPK/mTOR signaling pathway |
| Ginsenosides | Rheumatoid Arthritis | 10 | PM | 37883815 | 📋 | Ginsenoside compound K exerts anti-inflammatory effects through transcriptional activation and transcriptional inhibition of glucocorticoid receptor in rheumatoid arthritis fibroblast-like synoviocytes |
| Ginsenosides | Rheumatoid Arthritis | 9 | PM | 37559380 | 📋 | Glucocorticoid receptors involved in ginsenoside compound K ameliorate adjuvant arthritis by inhibiting the glycolysis of fibroblast-like synoviocytes via the NF-κB/HIF-1α pathway |
| Ginsenosides | Rheumatoid Arthritis | 7 | PM | 35707715 | 📋 | Computation-Based Discovery of Potential Targets for Rheumatoid Arthritis and Related Molecular Screening and Mechanism Analysis of Traditional Chinese Medicine |
| Ginsenosides | Rheumatoid Arthritis | 6 | PM | 34034706 | 📋 | Therapeutic effect of various ginsenosides on rheumatoid arthritis |
| Ginsenosides | Rheumatoid Arthritis | 5 | PM | 33609698 | 📋 | Ginsenoside compound K- a potential drug for rheumatoid arthritis |
| Ginsenosides | Rheumatoid Arthritis | 4 | PM | 33198544 | 📋 | Combination therapy of ginsenoside compound K and methotrexate was efficient in elimination of anaemia and reduction of disease activity in adjuvant-induced arthritis rats |
| Ginsenosides | Rheumatoid Arthritis | 1 | PM | 32275817 | 📋 | Ginsenoside Rg3 Alleviates Complete Freund's Adjuvant - Induced Rheumatoid Arthritis in Mice by Regulating CD4+CD25+Foxp3+ Treg Cell |
| Ginsenosides | Rheumatoid Arthritis | 3 | PM | 31308803 | 📋 | Ameliorative Effects of Ginseng and Ginsenosides on Rheumatic Diseases |
| Ginsenosides | Rheumatoid Arthritis | 2 | PM | 28903427 | 📋 | Ginsenoside Rg1 Attenuates Adjuvant-Induced Arthritis in Rats via Modulation of PPAR-γ/NF-κB Signal Pathway |
| Ginsenosides | Rheumatoid Arthritis | 8 | PM | 23370854 | 📋 | Joint-protective effects of compound K, a major ginsenoside metabolite, in rheumatoid arthritis: in vitro evidence |
| Ginsenosides | Spinal Cord Injury | 18 | PM | 36881751 | 📋 | Ginsenoside Rg1 attenuation of neurogenesis disorder and neuronal apoptosis in the rat hippocampus after spinal cord injury may involve brain-derived neurotrophic factor/extracellular signal-regulated kinase signaling |
| Ginsenosides | Spinal Cord Injury | 17 | PM | 36453420 | 📋 | Ginsenoside Rb1 improves energy metabolism after spinal cord injury |
| Ginsenosides | Spinal Cord Injury | 16 | PM | 36352836 | 📋 | Ginsenoside Rg1 promotes astrocyte-to-neuron transdifferentiation in rat and its possible mechanism |
| Ginsenosides | Spinal Cord Injury | 15 | PM | 36112741 | 📋 | The Neuroprotective Effects of Ginsenoside Rd Pretreatment in a Rat Model of Spinal Cord Ischemia-Reperfusion Injury |
| Ginsenosides | Spinal Cord Injury | 14 | PM | 36081662 | 📋 | Mechanisms of ginsenosides exert neuroprotective effects on spinal cord injury: A promising traditional Chinese medicine |
| Ginsenosides | Spinal Cord Injury | 13 | PM | 35776939 | 📋 | Notoginsenoside R1 alleviates spinal cord injury by inhibiting oxidative stress, neuronal apoptosis, and inflammation via activating the nuclear factor erythroid 2 related factor 2/heme oxygenase-1 signaling pathway |
| Ginsenosides | Spinal Cord Injury | 12 | PM | 35775321 | 📋 | Notoginsenoside R1 alleviates spinal cord injury by inhibiting oxidative stress, neuronal apoptosis, and inflammation via activating the nuclear factor erythroid 2 related factor 2/heme oxygenase-1 signaling pathway |
| Ginsenosides | Spinal Cord Injury | 11 | PM | 35058723 | 📋 | Ginseng extract and ginsenosides improve neurological function and promote antioxidant effects in rats with spinal cord injury: A meta-analysis and systematic review |
| Ginsenosides | Spinal Cord Injury | 10 | PM | 34954769 | 📋 | Ginsenoside Rg1 inhibits oxidative stress and inflammation in rats with spinal cord injury via Nrf2/HO-1 signaling pathway |
| Ginsenosides | Spinal Cord Injury | 9 | PM | 32761843 | 📋 | Ginsenoside Rb1 attenuates microglia activation to improve spinal cord injury via microRNA-130b-5p/TLR4/NF-κB axis |
| Ginsenosides | Spinal Cord Injury | 1 | PM | 31412899 | 📋 | Effects of Ginsenoside Rb1 on Spinal Cord Ischemia-Reperfusion Injury in Rats |
| Ginsenosides | Spinal Cord Injury | 3 | PM | 30184471 | 📋 | Ginsenoside Rb1 Protects Against Spinal Cord Ischemia-Reperfusion Injury in Rats by Downregulating the Bax/Bcl-2 Ratio and caspase-3 and p-Ask-1 Levels |
| Ginsenosides | Spinal Cord Injury | 2 | PM | 30116359 | 📋 | Effects of Ginsenoside Rb1 on Oxidative Stress Injury in Rat Spinal Cords by Regulating the eNOS/Nrf2/HO-1 Signaling Pathway |
| Ginsenosides | Spinal Cord Injury | 5 | PM | 28966235 | 📋 | Ginsenoside Rg1 Promotes the Migration of Olfactory Ensheathing Cells via the PI3K/Akt Pathway to Repair Rat Spinal Cord Injury |
| Ginsenosides | Spinal Cord Injury | 8 | PM | 28762191 | 📋 | Inhibition of Autophagy is Involved in the Protective Effects of Ginsenoside Rb1 on Spinal Cord Injury |
| Ginsenosides | Spinal Cord Injury | 6 | PM | 28085110 | 📋 | Ginsenoside Rg3 Improves Recovery From Spinal Cord Injury in Rats via Suppression of Neuronal Apoptosis, Pro-Inflammatory Mediators, and Microglial Activation |
| Ginsenosides | Spinal Cord Injury | 4 | PM | 25374589 | 📋 | Ginsenoside Rd Inhibits Apoptosis Following Spinal Cord ischemia/reperfusion Injury |
| Ginsenosides | Spinal Cord Injury | 7 | PM | 20419536 | 📋 | Ginsenoside Rg1 Promotes Proliferation and Neurotrophin Expression of Olfactory Ensheathing Cells |
| Ginsenosides | Tendinopathy | 1 | PM | 37979397 | 📋 | Therapeutic potential of ginsenoside compound K in managing tenocyte apoptosis and extracellular matrix damage in diabetic tendinopathy |
