| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Melatonin | Acute Lung Injury | 9 | PM | 37224647 | 📋 | Melatonin attenuates lipopolysaccharide-induced immune dysfunction in dendritic cells |
| Melatonin | Acute Lung Injury | 8 | PM | 37199082 | 📋 | Protective effect of melatonin and ascorbic acid combination on sepsis-induced lung injury: An Experimental study |
| Melatonin | Acute Lung Injury | 6 | PM | 36290735 | 📋 | Melatonin Suppresses LPS-Induced Oxidative Stress in Dendritic Cells for Inflammatory Regulation via the Nrf2/HO-1 Axis |
| Melatonin | Acute Lung Injury | 5 | PM | 35468366 | 📋 | Melatonin attenuates LPS-induced pyroptosis in acute lung injury by inhibiting NLRP3-GSDMD pathway via activating Nrf2/HO-1 signaling axis |
| Melatonin | Acute Lung Injury | 4 | PM | 33978073 | 📋 | Melatonin can be, more effective than N-acetylcysteine, protecting acute lung injury induced by intestinal ischemia-reperfusion in rat model |
| Melatonin | Acute Lung Injury | 2 | PM | 33065391 | 📋 | Melatonin prevents LPS-induced epithelial-mesenchymal transition in human alveolar epithelial cells via the GSK-3β/Nrf2 pathway |
| Melatonin | Acute Lung Injury | 1 | PM | 31602989 | 📋 | Melatonin treatment prevents carbon tetrachloride-induced acute lung injury in rats by mitigating tissue antioxidant capacity and inflammatory response |
| Melatonin | Acute Respiratory Distress Syndrome | 2 | PM | 37871834 | 📋 | Melatonin alleviates acute respiratory distress syndrome by inhibiting alveolar macrophage NLRP3 inflammasomes through the ROS/HIF-1α/GLUT1 pathway |
| Melatonin | Acute Respiratory Distress Syndrome | 1 | PM | 32217117 | 📋 | COVID-19: Melatonin as a potential adjuvant treatment |
| Melatonin | Allergic Asthma | 2 | PM | 34522948 | 📋 | Melatonin prevents allergic airway inflammation in epicutaneously sensitized mice |
| Melatonin | Allergic Asthma | 1 | PM | 34146326 | 📋 | Melatonin antagonizes ozone-exacerbated asthma by inhibiting the TRPV1 channel and stabilizing the Nrf2 pathway |
| Melatonin | Asthma | 1 | PM | 33940766 | 📋 | Role of endogenous melatonin in pathophysiologic and oxidative stress responses to personal air pollutant exposures in asthmatic children |
| Melatonin | Bronchopulmonary Dysplasia | 3 | PM | 36928143 | 📋 | Melatonin Protects Against Hyperoxia-Induced Apoptosis in Alveolar Epithelial type II Cells by Activating the MT2/PI3K/AKT/ETS1 Signaling Pathway |
| Melatonin | Bronchopulmonary Dysplasia | 2 | PM | 35286033 | 📋 | Evaluation of melatonin efficacy in prevention of bronchopulmonary dysplasia in preterm newborn infants |
| Melatonin | Bronchopulmonary Dysplasia | 1 | PM | 33583108 | 📋 | Melatonin for the prevention of fetal injury associated with intrauterine inflammation |
| Melatonin | Chronic Rhinosinusitis | 1 | PM | 36840497 | 📋 | Melatonin reduces IL-33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly |
| Melatonin | COPD | 4 | PM | 38678295 | 📋 | Melatonin improves influenza virus infection-induced acute exacerbation of COPD by suppressing macrophage M1 polarization and apoptosis |
| Melatonin | COPD | 3 | PM | 37944829 | 📋 | Melatonin supplementation enhances pulmonary rehabilitation outcomes in COPD: A randomized, double-blind, placebo-controlled study |
| Melatonin | COPD | 2 | PM | 34771000 | 📋 | The Involvement of PDE4 in the Protective Effects of Melatonin on Cigarette-Smoke-Induced Chronic Obstructive Pulmonary Disease |
| Melatonin | COPD | 1 | PM | 32738376 | 📋 | Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice |
| Melatonin | Hyperoxia | 2 | PM | 39183539 | 📋 | Melatonin alleviates hyperoxia-induced lung injury through elevating MSC exosomal miR-18a-5p expression to repress PUM2 signaling |
| Melatonin | Hyperoxia | 1 | PM | 36928143 | 📋 | Melatonin Protects Against Hyperoxia-Induced Apoptosis in Alveolar Epithelial type II Cells by Activating the MT2/PI3K/AKT/ETS1 Signaling Pathway |
| Melatonin | Hypobaric Hypoxia | 2 | PM | 38465746 | 📋 | Melatonin protects oogenesis from hypobaric hypoxia-induced fertility damage in mice |
| Melatonin | Hypobaric Hypoxia | 1 | PM | 35150933 | 📋 | Melatonin treatment during chronic hypoxic gestation improves neonatal cerebrovascular function |
| Melatonin | Hypoxia | 6 | PM | 35274763 | 📋 | Melatonin increased hypoxia-inducible factor (HIF) by inhibiting prolyl hydroxylase: A hypothesis for treating anemia, ischemia, and covid-19 |
| Melatonin | Hypoxia | 5 | PM | 34313039 | 📋 | Melatonin mitigates the adverse effect of hypoxia during myocardial differentiation in mouse embryonic stem cells |
| Melatonin | Hypoxia | 4 | PM | 33766627 | 📋 | Beneficial effects of melatonin on prostanoids pathways in pulmonary hypertensive neonates |
| Melatonin | Hypoxia | 3 | PM | 32846285 | 📋 | Effects of melatonin on the passive mechanical response of arteries in chronic hypoxic newborn lambs |
| Melatonin | Hypoxia | 2 | PM | 28538666 | 📋 | Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats |
| Melatonin | Hypoxia | 1 | PM | 26444711 | 📋 | Melatonin rescues cardiovascular dysfunction during hypoxic development in the chick embryo |
| Melatonin | Intermittent Hypoxia | 2 | PM | 37659335 | 📋 | Melatonin attenuates chronic intermittent hypoxia-induced intestinal barrier dysfunction in mice |
| Melatonin | Intermittent Hypoxia | 1 | PM | 18289174 | 📋 | Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia |
| Melatonin | Lung Cancer | 12 | PM | 39230586 | 📋 | Melatonin downregulates angiogenesis and lymphangiogenesis by regulating tumor-associated macrophages via NLRP3 inflammasomes in lung adenocarcinoma |
| Melatonin | Lung Cancer | 11 | PM | 39074422 | 📋 | Melatonin reverses EGFR-TKI therapeutic resistance by modulating crosstalk between circadian-related gene signature and immune infiltration patterns in patients with COVID-19 and lung adenocarcinoma |
| Melatonin | Lung Cancer | 10 | PM | 35728260 | 📋 | Potential role of melatonin in prevention and treatment of lung cancer |
| Melatonin | Lung Cancer | 9 | PM | 35661247 | 📋 | Melatonin may suppress lung adenocarcinoma progression via regulation of the circular non-coding RNA hsa_circ_0017109/miR-135b-3p/TOX3 axis |
| Melatonin | Lung Cancer | 8 | PM | 35068335 | 📋 | The effect and mechanisms of melatonin on the proliferation and apoptosis of lung cancer cells |
| Melatonin | Lung Cancer | 7 | PM | 34471091 | 📋 | Melatonin enhances radiofrequency-induced NK antitumor immunity, causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development |
| Melatonin | Lung Cancer | 6 | PM | 34396568 | 📋 | Melatonin and its derivative disrupt cancer stem-like phenotypes of lung cancer cells via AKT downregulation |
| Melatonin | Lung Cancer | 5 | PM | 34214200 | 📋 | Melatonin inhibits lung cancer development by reversing the Warburg effect via stimulating the SIRT3/PDH axis |
| Melatonin | Lung Cancer | 4 | PM | 34073318 | 📋 | Melatonin Downregulates PD-L1 Expression and Modulates Tumor Immunity in KRAS-Mutant Non-Small Cell Lung Cancer |
| Melatonin | Lung Cancer | 3 | PM | 33342820 | 📋 | The inhibitory effect of melatonin on the proliferation of irradiated A549 cell line |
| Melatonin | Lung Cancer | 2 | PM | 27102150 | 📋 | Melatonin as a potential anticarcinogen for non-small-cell lung cancer |
| Melatonin | Lung Cancer | 1 | PM | 26672764 | 📋 | Melatonin Inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and Activates caspase/Cyto C Signaling to Enhance the Antitumor Activity of Berberine in Lung Cancer Cells |
| Melatonin | Lung Inflammation | 1 | PM | 30852418 | 📋 | Short-interval exposure to ambient fine particulate matter (PM2.5) exacerbates the susceptibility of pulmonary damage in setting of lung ischemia-reperfusion injury in rodent: Pharmacomodulation of melatonin |
| Melatonin | Lung Injury | 9 | PM | 37716496 | 📋 | Txnrd3 knockout enhancement of lung injury induced by Ni exposure via the VEGF-VEGFR-2 axis and alleviation of this effect by melatonin |
| Melatonin | Lung Injury | 8 | PM | 35844137 | 📋 | Melatonin counteracts necroptosis and pulmonary edema in cadmium-induced chronic lung injury through the inhibition of angiotensin II |
| Melatonin | Lung Injury | 7 | PM | 35359208 | 📋 | Melatonin ameliorates chronic copper-induced lung injury |
| Melatonin | Lung Injury | 6 | PM | 34364124 | 📋 | Melatonin protects against PM2.5-induced lung injury by inhibiting ferroptosis of lung epithelial cells in a Nrf2-dependent manner |
| Melatonin | Lung Injury | 5 | PM | 33674975 | 📋 | Ameliorating effect of melatonin against nicotine induced lung and heart toxicity in rats |
| Melatonin | Lung Injury | 4 | PM | 33603837 | 📋 | Effects of melatonin on protecting against lung injury (Review) |
| Melatonin | Lung Injury | 2 | PM | 33107683 | 📋 | Protection of melatonin against long-term radon exposure-caused lung injury |
| Melatonin | Lung Injury | 1 | PM | 32737901 | 📋 | Melatonin for prevention of fetal lung injury associated with intrauterine inflammation and for improvement of lung maturation |
| Melatonin | Lung Injury | 3 | PM | 29346581 | 📋 | Melatonin attenuates lung ischaemia-reperfusion injury via inhibition of oxidative stress and inflammation |
| Melatonin | Nasopharyngeal Cancer | 1 | PM | 27600920 | 📋 | Melatonin suppresses TPA-induced metastasis by downregulating matrix metalloproteinase-9 expression through JNK/SP-1 signaling in nasopharyngeal carcinoma |
| Melatonin | Oral Cancer | 12 | PM | 38234969 | 📋 | Potential of melatonin to reverse epigenetic aberrations in oral cancer: new findings |
| Melatonin | Oral Cancer | 11 | PM | 37830217 | 📋 | Melatonin: Emerging Player in the Management of Oral Cancer |
| Melatonin | Oral Cancer | 10 | PM | 37131152 | 📋 | Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS |
| Melatonin | Oral Cancer | 9 | PM | 36958712 | 📋 | Tumor-associated macrophages facilitate oral squamous cell carcinomas migration and invasion by MIF/NLRP3/IL-1β circuit: A crosstalk interrupted by melatonin |
| Melatonin | Oral Cancer | 8 | PM | 34945828 | 📋 | Decreased Circulating Melatonin with Loss of Age-Related Biphasic Change in Patients with Oral Squamous Cell Carcinoma |
| Melatonin | Oral Cancer | 7 | PM | 34576070 | 📋 | Melatonin Suppresses Oral Squamous Cell Carcinomas Migration and Invasion through Blocking FGF19/FGFR 4 Signaling Pathway |
| Melatonin | Oral Cancer | 6 | PM | 34551150 | 📋 | Melatonin enhances cisplatin-induced cell death through inhibition of DERL1 in mesenchymal-like CD44 high OSCC cells |
| Melatonin | Oral Cancer | 5 | PM | 33344223 | 📋 | Melatonin Inhibits the Progression of Oral Squamous Cell Carcinoma via Inducing miR-25-5p Expression by Directly Targeting NEDD9 |
| Melatonin | Oral Cancer | 4 | PM | 32800657 | 📋 | Effects of melatonin to arecoline-induced reactive oxygen species production and DNA damage in oral squamous cell carcinoma |
| Melatonin | Oral Cancer | 1 | PM | 32499868 | 📋 | Pineal Gland Protects Against Chemically Induced Oral Carcinogenesis and Inhibits Tumor Progression in Rats |
| Melatonin | Oral Cancer | 3 | PM | 29312489 | 📋 | Melatonin represses oral squamous cell carcinoma metastasis by inhibiting tumor-associated neutrophils |
| Melatonin | Oral Cancer | 2 | PM | 26980735 | 📋 | Melatonin inhibits TPA-induced oral cancer cell migration by suppressing matrix metalloproteinase-9 activation through the histone acetylation |
| Melatonin | Oral Mucositis | 5 | PM | 38978756 | 📋 | In vitro cytoprotective and in vivo anti-oral mucositis effects of melatonin and its derivatives |
| Melatonin | Oral Mucositis | 4 | PM | 37681910 | 📋 | The Preventive Effect of Melatonin on Radiation-Induced Oral Mucositis |
| Melatonin | Oral Mucositis | 3 | PM | 34212283 | 📋 | Oral Administration of Melatonin or Succinyl Melatonin Niosome Gel Benefits 5-FU-Induced Small Intestinal Mucositis Treatment in Mice |
| Melatonin | Oral Mucositis | 2 | PM | 33738704 | 📋 | Randomized placebo-controlled phase II trial of high-dose melatonin mucoadhesive oral gel for the prevention and treatment of oral mucositis in patients with head and neck cancer undergoing radiation therapy concurrent with systemic treatment |
| Melatonin | Oral Mucositis | 1 | PM | 31869853 | 📋 | Efficacy of Melatonin in prevention of radiation-induced oral mucositis: A randomized clinical trial |
| Melatonin | Pneumonia | 1 | PM | 38665558 | 📋 | Melatonin-induced upregulation of telomerase activity interferes with macrophage mitochondrial metabolism and suppresses NLRP3 inflammasome activation in the treatment of Pneumonia |
| Melatonin | Pulmonary Edema | 1 | PM | 36069203 | 📋 | Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by α-naphthylthiourea |
| Melatonin | Pulmonary Fibrosis | 4 | PM | 38688425 | 📋 | Melatonin prevents pulmonary fibrosis caused by PM2.5 exposure by targeting epithelial-mesenchymal transition |
| Melatonin | Pulmonary Fibrosis | 3 | PM | 36333557 | 📋 | Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression |
| Melatonin | Pulmonary Fibrosis | 2 | PM | 34146555 | 📋 | The role of melatonin on radiation-induced pneumonitis and lung fibrosis: A systematic review |
| Melatonin | Pulmonary Fibrosis | 1 | PM | 33065391 | 📋 | Melatonin prevents LPS-induced epithelial-mesenchymal transition in human alveolar epithelial cells via the GSK-3β/Nrf2 pathway |
| Melatonin | Pulmonary Hypertension | 7 | PM | 39128482 | 📋 | Alamandin and especially melatonin attenuate pulmonary arterial hypertension induced by monocrotalin |
| Melatonin | Pulmonary Hypertension | 6 | PM | 39002930 | 📋 | Melatonin effects on oxidative stress and on TLR4/NF-kβ inflammatory pathway in the right ventricle of rats with pulmonary arterial hypertension |
| Melatonin | Pulmonary Hypertension | 5 | PM | 37583483 | 📋 | Gut microbiota crosstalk mechanisms are key in pulmonary hypertension: The involvement of melatonin is instrumental too |
| Melatonin | Pulmonary Hypertension | 4 | PM | 36100129 | 📋 | Melatonin activates the Mst1-Nrf2 signaling to alleviate cardiac hypertrophy in pulmonary arterial hypertension |
| Melatonin | Pulmonary Hypertension | 3 | PM | 33766627 | 📋 | Beneficial effects of melatonin on prostanoids pathways in pulmonary hypertensive neonates |
| Melatonin | Pulmonary Hypertension | 1 | PM | 31774487 | 📋 | Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension |
| Melatonin | Pulmonary Hypertension | 2 | PM | 28538666 | 📋 | Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats |
| Melatonin | Respiratory Disorders | 2 | PM | 35251337 | 📋 | Role of melatonin in respiratory diseases (Review) |
| Melatonin | Respiratory Disorders | 1 | PM | 33761613 | 📋 | The melatonergic pathway and its interactions in modulating respiratory system disorders |
| Melatonin | Respiratory Tract Infection | 1 | PM | 38683122 | 📋 | Melatonin suppresses TLR4-mediated RSV infection in the central nervous cells by inhibiting NLRP3 inflammasome formation and autophagy |
| Melatonin | Septic Acute Lung Injury | 4 | PM | 38203627 | 📋 | Melatonin as a Promising Anti-Inflammatory Agent in an In Vivo Animal Model of Sepsis-Induced Rat Liver Damage |
| Melatonin | Septic Acute Lung Injury | 1 | PM | 37719362 | 📋 | Melatonin Attenuates Sepsis-Induced Acute Lung Injury via Inhibiting Excessive Mitophagy |
| Melatonin | Septic Acute Lung Injury | 2 | PM | 36449070 | 📋 | A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2 |
| Melatonin | Septic Acute Lung Injury | 3 | PM | 33362546 | 📋 | Melatonin Attenuates Sepsis-Induced Acute Lung Injury Through Improvement of Epithelial Sodium Channel-Mediated Alveolar Fluid Clearance Via Activation of SIRT1/SGK1/Nedd4-2 Signaling Pathway |
| Melatonin | Sleep Apnea | 1 | PM | 18289174 | 📋 | Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia |
