| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| EGCG | Acute Lung Injury | 6 | PM | 38662666 | 📋 | Epigallocatechin gallate regulates the myeloid-specific transcription factor PU.1 in macrophages |
| EGCG | Acute Lung Injury | 5 | PM | 36139034 | 📋 | Preventive Effect of Epigallocatechin Gallate, the Main Component of Green Tea, on Acute Lung Injury Caused by Air Pollutants |
| EGCG | Acute Lung Injury | 4 | PM | 35547130 | 📋 | Epigallocatechin-3-Gallate Ameliorates Acute Lung Damage by Inhibiting Quorum-Sensing-Related Virulence Factors of Pseudomonas aeruginosa |
| EGCG | Acute Lung Injury | 3 | PM | 34040072 | 📋 | EGCG promotes PRKCA expression to alleviate LPS-induced acute lung injury and inflammatory response |
| EGCG | Acute Lung Injury | 2 | PM | 34018522 | 📋 | Epigallocatechin-3-gallate attenuates acute pancreatitis induced lung injury by targeting mitochondrial reactive oxygen species triggered NLRP3 inflammasome activation |
| EGCG | Acute Lung Injury | 1 | PM | 32575718 | 📋 | Epigallocatechin-3-Gallate (EGCG), an Active Compound of Green Tea Attenuates Acute Lung Injury Regulating Macrophage Polarization and Krüpple-Like-Factor 4 (KLF4) Expression |
| EGCG | Airways Inflammation | 2 | PM | 28932196 | 📋 | (-)-Epigallocatechin-3-gallate Reduces Cigarette Smoke-Induced Airway Neutrophilic Inflammation and Mucin Hypersecretion in Rats |
| EGCG | Airways Inflammation | 1 | PM | 24353864 | 📋 | Effect of Epigallocatechin-3-Gallate on PMA-Induced MUC5B Expression in Human Airway Epithelial Cells |
| EGCG | Allergic Asthma | 2 | PM | 35640712 | 📋 | Epigallocatechin gallate relieves asthmatic symptoms in mice by suppressing HIF-1α/VEGFA-mediated M2 skewing of macrophages |
| EGCG | Allergic Asthma | 1 | PM | 22670643 | 📋 | Green Tea (Camelia Sinensis) Mediated Suppression of IgE Production by Peripheral Blood Mononuclear Cells of Allergic Asthmatic Humans |
| EGCG | Asthma | 3 | PM | 31030098 | 📋 | Epigallocatechin Gallate Ameliorates Airway Inflammation by Regulating Treg/Th17 Imbalance in an Asthmatic Mouse Model |
| EGCG | Asthma | 2 | PM | 31003767 | 📋 | Effects of epigallocatechin-3-gallate on the HMGB1/RAGE Pathway in PM 2.5-exposed Asthmatic Rats |
| EGCG | Bronchial Asthma | 1 | PM | 29207033 | 📋 | Epigallocatechin-3-gallate Inhibits Inflammation and Epithelial‑mesenchymal Transition Through the PI3K/AKT Pathway via Upregulation of PTEN in Asthma |
| EGCG | COPD | 1 | PM | 32795541 | 📋 | Epigallocatechin gallate diminishes cigarette smoke-induced oxidative stress, lipid peroxidation, and inflammation in human bronchial epithelial cells |
| EGCG | Cystic Fibrosis | 1 | PM | 27035618 | 📋 | A Novel Treatment of Cystic Fibrosis Acting On-Target: Cysteamine Plus Epigallocatechin Gallate for the Autophagy-Dependent Rescue of Class II-mutated CFTR |
| EGCG | Hypobaric Hypoxia | 3 | PM | 37875765 | 📋 | Protective effects of epigallocatechin-3-gallate counteracting the chronic hypobaric hypoxia-induced myocardial injury in plain-grown rats at high altitude |
| EGCG | Hypobaric Hypoxia | 2 | PM | 36084697 | 📋 | (-)-Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling |
| EGCG | Hypobaric Hypoxia | 1 | PM | 35552996 | 📋 | Epigallocatechin-3-Gallate Ameliorated Iron Accumulation and Apoptosis and Promoted Neuronal Regeneration and Memory/Cognitive Functions in the Hippocampus Induced by Exposure to a Chronic High-Altitude Hypoxia Environment |
| EGCG | Hypoxia | 3 | PM | 35409364 | 📋 | Epigallocatechin Gallate Protects against Hypoxia-Induced Inflammation in Microglia via NF-κB Suppression and Nrf-2/HO-1 Activation |
| EGCG | Hypoxia | 2 | PM | 29115797 | 📋 | Polyphenol epigallocatechin-3-gallate Inhibits Hypoxia/Reoxygenation-Induced H9C2 Cell Apoptosis |
| EGCG | Hypoxia | 1 | PM | 26780211 | 📋 | EGCG Ameliorates the Hypoxia-Induced Apoptosis and Osteogenic Differentiation Reduction of Mesenchymal Stem Cells via Upregulating miR-210 |
| EGCG | Lung Cancer | 33 | PM | 38840243 | 📋 | Epigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer |
| EGCG | Lung Cancer | 32 | PM | 37621136 | 📋 | Epigallocatechin gallate circumvents drug-induced resistance in non-small-cell lung cancer by modulating glucose metabolism and AMPK/AKT/MAPK axis |
| EGCG | Lung Cancer | 31 | PM | 37546685 | 📋 | Therapeutic Targeting of Regulated Signaling Pathways of Non-Small Cell Lung Carcinoma |
| EGCG | Lung Cancer | 30 | PM | 37451475 | 📋 | EGCG Alleviates Obesity-Exacerbated Lung Cancer Progression By STAT1/SLC7A11 Pathway and Gut Microbiota |
| EGCG | Lung Cancer | 23 | PM | 36385933 | 📋 | (-)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase |
| EGCG | Lung Cancer | 22 | PM | 35218280 | 📋 | Low dose epigallocatechin-3-gallate revives doxorubicin responsiveness by a redox-sensitive pathway in A549 lung adenocarcinoma cells |
| EGCG | Lung Cancer | 21 | PM | 34769263 | 📋 | Effect of Epigallocatechin-3-Gallate on EGFR Signaling and Migration in Non-Small Cell Lung Cancer |
| EGCG | Lung Cancer | 20 | PM | 34676878 | 📋 | Effect of EGCG on bronchial epithelial cell premalignant lesions induced by cigarette smoke and on its CYP1A1 expression |
| EGCG | Lung Cancer | 19 | PM | 33125096 | 📋 | Epigallocatechin‑3‑gallate inhibits self‑renewal ability of lung cancer stem‑like cells through inhibition of CLOCK |
| EGCG | Lung Cancer | 18 | PM | 32606686 | 📋 | Enhanced Chemotherapeutic Efficacy of PLGA-Encapsulated Epigallocatechin Gallate (EGCG) Against Human Lung Cancer |
| EGCG | Lung Cancer | 16 | PM | 32438613 | 📋 | Fatty Acid Synthase Inhibitor G28 Shows Anticancer Activity in EGFR Tyrosine Kinase Inhibitor Resistant Lung Adenocarcinoma Models |
| EGCG | Lung Cancer | 11 | PM | 31943177 | 📋 | EGCG Regulates CTR1 Expression Through Its Pro-Oxidative Property in Non-Small-Cell Lung Cancer Cells |
| EGCG | Lung Cancer | 5 | PM | 31777584 | 📋 | Synergistic Inhibition of Lung Cancer Cells by EGCG and NF-κB Inhibitor BAY11-7082 |
| EGCG | Lung Cancer | 4 | PM | 30988640 | 📋 | Epigallocatechin-3-gallate-induced Vascular Normalization in A549-cell Xenograft-Bearing Nude Mice: Therapeutic Efficacy in Combination With Chemotherapy |
| EGCG | Lung Cancer | 14 | PM | 30669618 | 📋 | Next-Generation Sequencing Reveals the Role of Epigallocatechin-3-Gallate in Regulating Putative Novel and Known microRNAs Which Target the MAPK Pathway in Non-Small-Cell Lung Cancer A549 Cells |
| EGCG | Lung Cancer | 8 | PM | 30182373 | 📋 | EGCG Inhibits CSC-like Properties Through Targeting miR-485/CD44 Axis in A549-cisplatin Resistant Cells |
| EGCG | Lung Cancer | 15 | PM | 30126206 | 📋 | Green Tea Catechin Is an Alternative Immune Checkpoint Inhibitor That Inhibits PD-L1 Expression and Lung Tumor Growth |
| EGCG | Lung Cancer | 29 | PM | 29332333 | 📋 | Epigallocatechin gallate from green tea exhibits potent anticancer effects in A-549 non-small lung cancer cells by inducing apoptosis, cell cycle arrest and inhibition of cell migration |
| EGCG | Lung Cancer | 24 | PM | 29230104 | 📋 | Metformin Sensitizes Non-small Cell Lung Cancer Cells to an Epigallocatechin-3-Gallate (EGCG) Treatment by Suppressing the Nrf2/HO-1 Signaling Pathway |
| EGCG | Lung Cancer | 1 | PM | 27224248 | 📋 | Epicatechin-3-gallate Reverses TGF-β1-induced Epithelial-To-Mesenchymal Transition and Inhibits Cell Invasion and Protease Activities in Human Lung Cancer Cells |
| EGCG | Lung Cancer | 7 | PM | 26794417 | 📋 | EGCG Induces Lung Cancer A549 Cell Apoptosis by Regulating Ku70 Acetylation |
| EGCG | Lung Cancer | 2 | PM | 25845434 | 📋 | Epigallocatechin-3-gallate Inhibits Nicotine-Induced Migration and Invasion by the Suppression of Angiogenesis and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer Cells |
| EGCG | Lung Cancer | 3 | PM | 25559244 | 📋 | Gene Regulation Mediated by microRNAs in Response to Green Tea Polyphenol EGCG in Mouse Lung Cancer |
| EGCG | Lung Cancer | 28 | PM | 24366444 | 📋 | Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathway |
| EGCG | Lung Cancer | 26 | PM | 24269590 | 📋 | Mechanism-based inhibition of cancer metastasis with (-)-epigallocatechin gallate |
| EGCG | Lung Cancer | 27 | PM | 24148818 | 📋 | Synergistic inhibition of lung cancer cell lines by (-)-epigallocatechin-3-gallate in combination with clinically used nitrocatechol inhibitors of catechol-O-methyltransferase |
| EGCG | Lung Cancer | 25 | PM | 23892041 | 📋 | Enhancement of (-)-epigallocatechin-3-gallate and theaflavin-3-3'-digallate induced apoptosis by ascorbic acid in human lung adenocarcinoma SPC-A-1 cells and esophageal carcinoma Eca-109 cells via MAPK pathways |
| EGCG | Lung Cancer | 6 | PM | 23725836 | 📋 | Treatment With EGCG in NSCLC Leads to Decreasing Interstitial Fluid Pressure and Hypoxia to Improve Chemotherapy Efficacy Through Rebalance of Ang-1 and Ang-2 |
| EGCG | Lung Cancer | 12 | PM | 21965273 | 📋 | Green Tea Polyphenol EGCG Suppresses Lung Cancer Cell Growth Through Upregulating miR-210 Expression Caused by Stabilizing HIF-1α |
| EGCG | Lung Cancer | 17 | PM | 20606042 | 📋 | New Role of (-)-Epicatechin in Enhancing the Induction of Growth Inhibition and Apoptosis in Human Lung Cancer Cells by Curcumin |
| EGCG | Lung Cancer | 9 | PM | 20159951 | 📋 | Pro-oxidative Activities and Dose-Response Relationship of (-)-epigallocatechin-3-gallate in the Inhibition of Lung Cancer Cell Growth: A Comparative Study in Vivo and in Vitro |
| EGCG | Lung Cancer | 10 | PM | 19406223 | 📋 | Identification of epigallocatechin-3-gallate in Green Tea Polyphenols as a Potent Inducer of p53-dependent Apoptosis in the Human Lung Cancer Cell Line A549 |
| EGCG | Lung Cancer | 13 | PM | 17585882 | 📋 | The Green Tea Polyphenol, epigallocatechin-3-gallate Inhibits Telomerase and Induces Apoptosis in Drug-Resistant Lung Cancer Cells |
| EGCG | Lung Injury | 2 | PM | 31003767 | 📋 | Effects of epigallocatechin-3-gallate on the HMGB1/RAGE Pathway in PM 2.5-exposed Asthmatic Rats |
| EGCG | Lung Injury | 3 | PM | 28198717 | 📋 | Mitochondrial DNA-Induced Inflammatory Responses and Lung Injury in Thermal Injury Rat Model: Protective Effect of Epigallocatechin Gallate |
| EGCG | Lung Injury | 1 | PM | 27020813 | 📋 | Epigallocatechin Gallate Attenuates Cardiopulmonary Bypass-Associated Lung Injury |
| EGCG | Nasal Polyps | 1 | PM | 23512732 | 📋 | Epigallocatechin-3-gallate inhibits collagen production of nasal polyp-derived fibroblasts |
| EGCG | Nasopharyngeal Cancer | 6 | PM | 35548580 | 📋 | EGCG Inhibits Proliferation and Induces Apoptosis Through Downregulation of SIRT1 in Nasopharyngeal Carcinoma Cells |
| EGCG | Nasopharyngeal Cancer | 4 | PM | 32326395 | 📋 | Involvement of MicroRNA-296 in the Inhibitory Effect of Epigallocatechin Gallate Against the Migratory Properties of Anoikis-Resistant Nasopharyngeal Carcinoma Cells |
| EGCG | Nasopharyngeal Cancer | 3 | PM | 31012106 | 📋 | Epigallocatechin-3-gallate Inhibits Migration of Human Nasopharyngeal Carcinoma Cells by Repressing MMP-2 Expression |
| EGCG | Nasopharyngeal Cancer | 1 | PM | 25625511 | 📋 | EGCG Inhibits Proliferation, Invasiveness and Tumor Growth by Up-Regulation of Adhesion Molecules, Suppression of Gelatinases Activity, and Induction of Apoptosis in Nasopharyngeal Carcinoma Cells |
| EGCG | Nasopharyngeal Cancer | 2 | PM | 23110507 | 📋 | Epigallocathechin Gallate, Polyphenol Present in Green Tea, Inhibits Stem-Like Characteristics and Epithelial-Mesenchymal Transition in Nasopharyngeal Cancer Cell Lines |
| EGCG | Nasopharyngeal Cancer | 5 | PM | 15355641 | 📋 | [Epigallocatechin-3-gallate interferes with EBV-encoding AP-1 signal transduction pathway] |
| EGCG | Oral and Dental Health | 1 | PM | 37867423 | 📋 | Epigallocatechin gallate (EGCG) alleviates the inflammatory response and recovers oral microbiota in acetic acid-induced oral inflammation mice |
| EGCG | Oral Cancer | 10 | PM | 37354753 | 📋 | Molecular mechanisms underlying the epigallocatechin-3-gallate-mediated inhibition of oral squamous cell carcinogenesis |
| EGCG | Oral Cancer | 7 | PM | 33930649 | 📋 | A green tea extract and epigallocatechin-3-gallate attenuate the deleterious effects of irinotecan in an oral epithelial cell model |
| EGCG | Oral Cancer | 5 | PM | 32957726 | 📋 | Natural Compounds Modulate Drug Transporter Mediated Oral Cancer Treatment |
| EGCG | Oral Cancer | 4 | PM | 32475087 | 📋 | Epigallocatechin-3-gallate Sensitises Multidrug-Resistant Oral Carcinoma Xenografts to Vincristine Sulphate |
| EGCG | Oral Cancer | 2 | PM | 31188490 | 📋 | Functional and Molecular Effects of a Green Tea Constituent on Oral Cancer Cells |
| EGCG | Oral Cancer | 6 | PM | 28641180 | 📋 | Potential chemotherapeutic effects of diosgenin, zoledronic acid and epigallocatechin-3-gallate on PE/CA-PJ15 oral squamous cancer cell line |
| EGCG | Oral Cancer | 1 | PM | 27200496 | 📋 | Epigallocatechin Gallate Sensitizes Cisplatin-Resistant Oral Cancer CAR Cell Apoptosis and Autophagy Through Stimulating AKT/STAT3 Pathway and Suppressing Multidrug Resistance 1 Signaling |
| EGCG | Oral Cancer | 9 | PM | 24249144 | 📋 | The role of the mitochondrial oxidative stress in the cytotoxic effects of the green tea catechin, (-)-epigallocatechin-3-gallate, in oral cells |
| EGCG | Oral Cancer | 8 | PM | 23707351 | 📋 | Epigallocatechin-3 gallate inhibits cancer invasion by repressing functional invadopodia formation in oral squamous cell carcinoma |
| EGCG | Oral Cancer | 3 | PM | 9525275 | 📋 | Quantitation of Chemopreventive Synergism Between (-)-epigallocatechin-3-gallate and Curcumin in Normal, Premalignant and Malignant Human Oral Epithelial Cells |
| EGCG | Oral Submucous Fibrosis | 2 | PM | 37106237 | 📋 | Polyphenol-based targeted therapy for oral submucous fibrosis |
| EGCG | Oral Submucous Fibrosis | 1 | PM | 32856877 | 📋 | The Protective Effect of Antioxidants in Areca Nut Extract-Induced Oral Carcinogenesis |
| EGCG | Oral Submucous Fibrosis | 3 | PM | 28720506 | 📋 | Arecoline activates latent transforming growth factor β1 via mitochondrial reactive oxygen species in buccal fibroblasts: Suppression by epigallocatechin-3-gallate |
| EGCG | Pneumonia | 1 | PM | 38580929 | 📋 | Epigallocatechin-3-Gallate attenuates lipopolysacharide-induced pneumonia via modification of inflammation, oxidative stress, apoptosis, and autophagy |
| EGCG | Pulmonary Fibrosis | 6 | PM | 37577522 | 📋 | A fibroblast-dependent TGFβ1/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis |
| EGCG | Pulmonary Fibrosis | 5 | PM | 36776784 | 📋 | (-)‑Epigallocatechin‑3‑ O‑gallate upregulates the expression levels of miR‑6757‑3p, a suppressor of fibrosis‑related gene expression, in extracellular vesicles derived from human umbilical vein endothelial cells |
| EGCG | Pulmonary Fibrosis | 4 | PM | 35707275 | 📋 | Epigallocatechin Gallate Relieved PM2.5-Induced Lung Fibrosis by Inhibiting Oxidative Damage and Epithelial-Mesenchymal Transition through AKT/mTOR Pathway |
| EGCG | Pulmonary Fibrosis | 3 | PM | 33472968 | 📋 | Blocking LOXL2 and TGFβ1 signalling induces collagen I turnover in precision-cut lung slices derived from patients with idiopathic pulmonary fibrosis |
| EGCG | Pulmonary Fibrosis | 1 | PM | 19497426 | 📋 | Epigallocatechin-3-gallate Exhibits Anti-Fibrotic Effect by Attenuating Bleomycin-Induced Glycoconjugates, Lysosomal Hydrolases and Ultrastructural Changes in Rat Model Pulmonary Fibrosis |
| EGCG | Pulmonary Fibrosis | 2 | PM | 12682270 | 📋 | Neutrophil Restraint by Green Tea: Inhibition of Inflammation, Associated Angiogenesis, and Pulmonary Fibrosis |
| EGCG | Respiratory Disorders | 1 | PM | 36009285 | 📋 | Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG): A Time for a New Player in the Treatment of Respiratory Diseases? |
| EGCG | Silicosis | 1 | PM | 36768179 | 📋 | Effects of Green Tea Polyphenol Epigallocatechin-3-Gallate on Markers of Inflammation and Fibrosis in a Rat Model of Pulmonary Silicosis |
