| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Andrographolide | Acute Lung Injury | 2 | PM | 37275765 | 📋 | Andrographolide alleviates paraquat-induced acute lung injury by activating the Nrf2/HO-1 pathway |
| Andrographolide | Acute Lung Injury | 1 | PM | 31862870 | 📋 | Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis |
| Andrographolide | Acute Lung Injury | 3 | PM | 23437127 | 📋 | Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB |
| Andrographolide | Acute Respiratory Distress Syndrome | 1 | PM | 36523372 | 📋 | Andrographolide Suppresses Expressions of Coagulation and Fibrinolytic Inhibition-Related Factors in LPS-Induced Alveolar Epithelial Cell Type II via NF-κB Signal Pathway In Vitro |
| Andrographolide | Asthma | 1 | PM | 27793052 | 📋 | Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-κB signaling and NLRP3 inflammasome activation |
| Andrographolide | COPD | 5 | PM | 38808326 | 📋 | Andrographolide Attenuates NLRP3 Inflammasome Activation and Airway Inflammation in Exacerbation of Chronic Obstructive Pulmonary Disease |
| Andrographolide | COPD | 1 | PM | 32335896 | 📋 | Restoration of HDAC2 and Nrf2 by andrographolide overcomes corticosteroid resistance in chronic obstructive pulmonary disease |
| Andrographolide | COPD | 3 | PM | 31128153 | 📋 | Andrographolide antagonizes the cigarette smoke-induced epithelial-mesenchymal transition and pulmonary dysfunction through anti-inflammatory inhibiting HOTAIR |
| Andrographolide | COPD | 2 | PM | 30291937 | 📋 | Andrographolide simultaneously augments Nrf2 antioxidant defense and facilitates autophagic flux blockade in cigarette smoke-exposed human bronchial epithelial cells |
| Andrographolide | COPD | 4 | PM | 23146110 | 📋 | Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity |
| Andrographolide | Hypoxia | 1 | PM | 27297870 | 📋 | Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells |
| Andrographolide | Hypoxia | 2 | PM | 26141990 | 📋 | Andrographolide inhibits the migration, invasion and matrix metalloproteinase expression of rheumatoid arthritis fibroblast-like synoviocytes via inhibition of HIF-1α signaling |
| Andrographolide | Lung Cancer | 12 | PM | 38765081 | 📋 | Novel inhaled andrographolide for treatment of lung cancer: In vitr o assessment |
| Andrographolide | Lung Cancer | 4 | PM | 36610134 | 📋 | Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction |
| Andrographolide | Lung Cancer | 1 | PM | 35121394 | 📋 | Andrographolide, a diterpene lactone from the Traditional Chinese Medicine Andrographis paniculate, induces senescence in human lung adenocarcinoma via p53/p21 and Skp2/p27 |
| Andrographolide | Lung Cancer | 2 | PM | 33995110 | 📋 | Andrographolide Induces Noxa-Dependent Apoptosis by Transactivating ATF4 in Human Lung Adenocarcinoma Cells |
| Andrographolide | Lung Cancer | 11 | PM | 28692436 | 📋 | Andrographolide enhances cisplatin-mediated anticancer effects in lung cancer cells through blockade of autophagy |
| Andrographolide | Lung Cancer | 10 | PM | 27639426 | 📋 | Inhibition of autophagy by andrographolide resensitizes cisplatin-resistant non-small cell lung carcinoma cells via activation of the Akt/mTOR pathway |
| Andrographolide | Lung Cancer | 9 | PM | 27159496 | 📋 | Synergistic anticancer effects of andrographolide and paclitaxel against A549 NSCLC cells |
| Andrographolide | Lung Cancer | 8 | PM | 24137258 | 📋 | Andrographolide inhibits the activation of NF-κB and MMP-9 activity in H3255 lung cancer cells |
| Andrographolide | Lung Cancer | 7 | PM | 23997793 | 📋 | Therapeutic Potential of Andrographolide Isolated from the Leaves of Andrographis paniculata Nees for Treating Lung Adenocarcinomas |
| Andrographolide | Lung Cancer | 6 | PM | 23306212 | 📋 | The HLJ1-targeting drug screening identified Chinese herb andrographolide that can suppress tumour growth and invasion in non-small-cell lung cancer |
| Andrographolide | Lung Cancer | 5 | PM | 21134392 | 📋 | Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells |
| Andrographolide | Lung Cancer | 3 | PM | 20097193 | 📋 | Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway |
| Andrographolide | Lung Disease | 1 | PM | 24298938 | 📋 | Andrographolide antagonizes cigarette smoke extract-induced inflammatory response and oxidative stress in human alveolar epithelial A549 cells through induction of microRNA-218 |
| Andrographolide | Lung Inflammation | 2 | PM | 27104764 | 📋 | Cigarette Smoke-Induced Lung Disease Predisposes to More Severe Infection with Nontypeable Haemophilus influenzae: Protective Effects of Andrographolide |
| Andrographolide | Lung Inflammation | 1 | PM | 23629921 | 📋 | Andrographolide protects against cigarette smoke-induced lung inflammation through activation of heme oxygenase-1 |
| Andrographolide | Nasopharyngeal Cancer | 1 | PM | 30223924 | 📋 | Andrographolide inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cell line C666-1 through LKB1-AMPK-dependent signaling pathways |
| Andrographolide | Oral Cancer | 1 | PM | 35624605 | 📋 | Real-Time Monitoring the Cytotoxic Effect of Andrographolide on Human Oral Epidermoid Carcinoma Cells |
| Andrographolide | Oral Cancer | 5 | PM | 28513299 | 📋 | Anti-tumor effect of cisplatin in human oral squamous cell carcinoma was enhanced by andrographolide via upregulation of phospho-p53 in vitro and in vivo |
| Andrographolide | Oral Cancer | 6 | PM | 27926533 | 📋 | Andrographolide impedes cancer stemness and enhances radio-sensitivity in oral carcinomas via miR-218 activation |
| Andrographolide | Oral Cancer | 4 | PM | 27793918 | 📋 | Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata |
| Andrographolide | Oral Cancer | 2 | PM | 23317242 | 📋 | Anti-tumor initiating potential of andrographolide in 7,12-dimethylbenz[a]anthracene induced hamster buccal pouch carcinogenesis |
| Andrographolide | Oral Cancer | 3 | PM | 21841043 | 📋 | Andrographolide inhibits oral squamous cell carcinogenesis through NF-κB inactivation |
| Andrographolide | Pneumonia | 2 | PM | 37560862 | 📋 | Clinical Efficacy and Immune Function of Andrographolide Sulfonate in Children with Mycoplasma Pneumoniae Pneumonia |
| Andrographolide | Pneumonia | 1 | PM | 33070837 | 📋 | Andrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice |
| Andrographolide | Pulmonary Edema | 1 | PM | 34268377 | 📋 | Andrographolide alleviates bleomycin-induced NLRP3 inflammasome activation and epithelial-mesenchymal transition in lung epithelial cells by suppressing AKT/mTOR signaling pathway |
| Andrographolide | Pulmonary Fibrosis | 2 | PM | 34268377 | 📋 | Andrographolide alleviates bleomycin-induced NLRP3 inflammasome activation and epithelial-mesenchymal transition in lung epithelial cells by suppressing AKT/mTOR signaling pathway |
| Andrographolide | Pulmonary Fibrosis | 1 | PM | 31862870 | 📋 | Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis |
| Andrographolide | Pulmonary Fibrosis | 3 | PM | 31706003 | 📋 | Andrographolide ameliorates bleomycin-induced pulmonary fibrosis by suppressing cell proliferation and myofibroblast differentiation of fibroblasts via the TGF-β1-mediated Smad-dependent and -independent pathways |
| Andrographolide | Pulmonary Fibrosis | 6 | PM | 26550147 | 📋 | Andrographolide plays an important role in bleomycin-induced pulmonary fibrosis treatment |
| Andrographolide | Pulmonary Fibrosis | 5 | PM | 24300094 | 📋 | Protective role of andrographolide in bleomycin-induced pulmonary fibrosis in mice |
| Andrographolide | Pulmonary Fibrosis | 4 | PM | 21722520 | 📋 | [Effects of andrographolide on the concentration of cytokines in BALF and the expressions of type I and III collagen mRNA in lung tissue in bleomycin-induced rat pulmonary fibrosis] |
| Andrographolide | Respiratory Disorders | 1 | PM | 27183596 | 📋 | Andrographolide Restores Steroid Sensitivity To Block Lipopolysaccharide/IFN-γ-Induced IL-27 and Airway Hyperresponsiveness in Mice |
| Andrographolide | Respiratory Tract Infection | 2 | PM | 37957849 | 📋 | Andrographolide Attenuates RSV-induced Inflammation by Suppressing Apoptosis and Promoting Pyroptosis after Respiratory Syncytial Virus Infection In Vitro |
| Andrographolide | Respiratory Tract Infection | 1 | PM | 36918433 | 📋 | Andrographolide exerts anti-respiratory syncytial virus activity by up-regulating heme oxygenase-1 independent of interferon responses in human airway epithelial cells |
