| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Sulforaphane | Acoustic Neuroma | 1 | PM | 27805058 | 📋 | Sulforaphane, a natural component of broccoli, inhibits vestibular schwannoma growth in vitro and in vivo |
| Sulforaphane | Age-Related Cognitive Decline | 3 | PM | 35960458 | 📋 | Long-term sulforaphane-treatment restores redox homeostasis and prevents cognitive decline in middleaged female and male rats, but cannot revert previous damage in old animals |
| Sulforaphane | Age-Related Cognitive Decline | 2 | PM | 35955572 | 📋 | Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice |
| Sulforaphane | Age-Related Cognitive Decline | 1 | PM | 34033847 | 📋 | Sulforaphane enhances long-term potentiation and ameliorate scopolamine-induced memory impairment |
| Sulforaphane | Alzheimer's Disease | 13 | PM | 38791068 | 📋 | Possible Prophylactic Effects of Sulforaphane on LPS-Induced Recognition Memory Impairment Mediated by Regulating Oxidative Stress and Neuroinflammatory Proteins in the Prefrontal Cortex Region of the Brain |
| Sulforaphane | Alzheimer's Disease | 12 | PM | 36539049 | 📋 | Sulforaphane attenuates microglia-mediated neuronal damage by down-regulating the ROS/autophagy/NLRP3 signal axis in fibrillar Aβ-activated microglia |
| Sulforaphane | Alzheimer's Disease | 11 | PM | 36508924 | 📋 | Sulforaphene, a CDK5 Inhibitor, attenuates cognitive deficits in a transgenic mouse model of Alzheimer's disease via reducing Aβ Deposition, tau hyperphosphorylation and synaptic dysfunction |
| Sulforaphane | Alzheimer's Disease | 10 | PM | 34699582 | 📋 | Sulforaphane inhibits the production of Aβ partially through the activation of Nrf2-regulated oxidative stress |
| Sulforaphane | Alzheimer's Disease | 9 | PM | 33805772 | 📋 | Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer's Disease |
| Sulforaphane | Alzheimer's Disease | 8 | PM | 33023225 | 📋 | Discovery of Sulforaphane as a Potent BACE1 Inhibitor Based on Kinetics and Computational Studies |
| Sulforaphane | Alzheimer's Disease | 1 | PM | 32925042 | 📋 | Sulforaphane Reverses the Amyloid-β Oligomers Induced Depressive-Like Behavior |
| Sulforaphane | Alzheimer's Disease | 5 | PM | 29714053 | 📋 | Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease |
| Sulforaphane | Alzheimer's Disease | 3 | PM | 29614663 | 📋 | Sulforaphane Inhibits the Generation of Amyloid-β Oligomer and Promotes Spatial Learning and Memory in Alzheimer's Disease (PS1V97L) Transgenic Mice |
| Sulforaphane | Alzheimer's Disease | 2 | PM | 29530050 | 📋 | Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages |
| Sulforaphane | Alzheimer's Disease | 4 | PM | 27255600 | 📋 | Cognition Enhancing Activity of Sulforaphane Against Scopolamine Induced Cognitive Impairment in Zebra Fish (Danio rerio) |
| Sulforaphane | Alzheimer's Disease | 7 | PM | 26827637 | 📋 | Sulforaphane exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages |
| Sulforaphane | Alzheimer's Disease | 6 | PM | 19183883 | 📋 | Protection against amyloid beta cytotoxicity by sulforaphane: role of the proteasome |
| Sulforaphane | Brain Edema | 1 | PM | 16211562 | 📋 | Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury |
| Sulforaphane | Brain Inflammation | 1 | PM | 32715644 | 📋 | Acute antioxidant and cytoprotective effects of sulforaphane in brain endothelial cells and astrocytes during inflammation and excitotoxicity |
| Sulforaphane | Brain Inflammation | 4 | PM | 30813369 | 📋 | Anti-Inflammatory Effect of Sulforaphane on LPS-Activated Microglia Potentially through JNK/AP-1/NF-κB Inhibition and Nrf2/HO-1 Activation |
| Sulforaphane | Brain Inflammation | 2 | PM | 26433376 | 📋 | Sulforaphane Ameliorates Okadaic Acid-Induced Memory Impairment in Rats by Activating the Nrf2/HO-1 Antioxidant Pathway |
| Sulforaphane | Brain Inflammation | 3 | PM | 19924513 | 📋 | Sulforaphane suppresses LPS-induced inflammation in primary rat microglia |
| Sulforaphane | Brain Injury | 2 | PM | 37860845 | 📋 | Effect and molecular mechanism of Sulforaphane alleviates brain damage caused by acute carbon monoxide poisoning:Network pharmacology analysis, molecular docking, and experimental evidence |
| Sulforaphane | Brain Injury | 1 | PM | 35401114 | 📋 | Sulforaphane Attenuates Chronic Intermittent Hypoxia-Induced Brain Damage in Mice via Augmenting Nrf2 Nuclear Translocation and Autophagy |
| Sulforaphane | Brain Tumor | 2 | PM | 18435488 | 📋 | The diet-derived sulforaphane inhibits matrix metalloproteinase-9-activated human brain microvascular endothelial cell migration and tubulogenesis |
| Sulforaphane | Brain Tumor | 1 | PM | 14670615 | 📋 | Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables |
| Sulforaphane | Depression | 6 | PM | 38438062 | 📋 | Sulforaphane's role in Redefining autophagic Responses in depression associated with polycystic ovarian syndrome: Unveiling the SIRT1/AMPK/LKB1 pathway connection |
| Sulforaphane | Depression | 5 | PM | 34272506 | 📋 | Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription |
| Sulforaphane | Depression | 4 | PM | 34033171 | 📋 | Efficacy and safety of sulforaphane for treatment of mild to moderate depression in patients with history of cardiac interventions: A randomized, double-blind, placebo-controlled clinical trial |
| Sulforaphane | Depression | 1 | PM | 32925042 | 📋 | Sulforaphane Reverses the Amyloid-β Oligomers Induced Depressive-Like Behavior |
| Sulforaphane | Depression | 2 | PM | 27833054 | 📋 | Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation |
| Sulforaphane | Depression | 3 | PM | 26721468 | 📋 | Sulforaphane produces antidepressant- and anxiolytic-like effects in adult mice |
| Sulforaphane | Diabetic Encephalopathy | 3 | PM | 32199985 | 📋 | Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose via regulating endoplasmic reticulum |
| Sulforaphane | Diabetic Encephalopathy | 2 | PM | 29684505 | 📋 | Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity |
| Sulforaphane | Diabetic Encephalopathy | 1 | PM | 27497670 | 📋 | Sulforaphane Prevents Neuronal Apoptosis and Memory Impairment in Diabetic Rats |
| Sulforaphane | Encephalomyelitis | 1 | PM | 31327180 | 📋 | The Anti-Inflammatory Effect of Sulforaphane in Mice with Experimental Autoimmune Encephalomyelitis |
| Sulforaphane | Epilepsy | 3 | PM | 36598650 | 📋 | Protective Effect of Sulforaphane on Oxidative Stress and Mitochondrial Dysfunction Associated with Status Epilepticus in Immature Rats |
| Sulforaphane | Epilepsy | 2 | PM | 35370554 | 📋 | Sulforaphane Ameliorates Metabolic Changes Associated With Status Epilepticus in Immature Rats |
| Sulforaphane | Epilepsy | 1 | PM | 34829573 | 📋 | Induction of the Nrf2 Pathway by Sulforaphane Is Neuroprotective in a Rat Temporal Lobe Epilepsy Model |
| Sulforaphane | Glioblastoma | 6 | PM | 35209084 | 📋 | Treatment of Human Glioblastoma U251 Cells with Sulforaphane and a Peptide Nucleic Acid (PNA) Targeting miR-15b-5p: Synergistic Effects on Induction of Apoptosis |
| Sulforaphane | Glioblastoma | 5 | PM | 34681862 | 📋 | Sulforaphane Causes Cell Cycle Arrest and Apoptosis in Human Glioblastoma U87MG and U373MG Cell Lines under Hypoxic Conditions |
| Sulforaphane | Glioblastoma | 1 | PM | 28059653 | 📋 | Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways |
| Sulforaphane | Glioblastoma | 4 | PM | 27026929 | 📋 | Sulforaphane induces apoptosis and inhibits invasion in U251MG glioblastoma cells |
| Sulforaphane | Glioblastoma | 3 | PM | 25991372 | 📋 | Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/β-catenin signaling in glioblastoma |
| Sulforaphane | Glioblastoma | 2 | PM | 16765523 | 📋 | Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane |
| Sulforaphane | Glioma | 4 | PM | 38221767 | 📋 | Sulforaphane suppresses cell proliferation and induces apoptosis in glioma via the ACTL6A/PGK1 axis |
| Sulforaphane | Glioma | 3 | PM | 26397194 | 📋 | Isothiocyanates inhibit the invasion and migration of C6 glioma cells by blocking FAK/JNK-mediated MMP-9 expression |
| Sulforaphane | Glioma | 2 | PM | 22565590 | 📋 | Effect of sulforaphane on growth inhibition in human brain malignant glioma GBM 8401 cells by means of mitochondrial- and MEK/ERK-mediated apoptosis pathway |
| Sulforaphane | Glioma | 1 | PM | 19685289 | 📋 | Combination Treatment With Resveratrol and Sulforaphane Induces Apoptosis in Human U251 Glioma Cells |
| Sulforaphane | HIV/AIDS | 2 | PM | 37663574 | 📋 | Sulforaphane prevents the reactivation of HIV-1 by suppressing NFκB signaling |
| Sulforaphane | HIV/AIDS | 1 | PM | 27093399 | 📋 | Sulforaphane Inhibits HIV Infection of Macrophages through Nrf2 |
| Sulforaphane | Hyperalgesia | 1 | PM | 34375671 | 📋 | Sulforaphane alleviates hyperalgesia and enhances analgesic potency of morphine in rats with cancer-induced bone pain |
| Sulforaphane | Ischemic Stroke | 2 | PM | 36244590 | 📋 | Sulforaphane promotes white matter plasticity and improves long-term neurological outcomes after ischemic stroke via the Nrf2 pathway |
| Sulforaphane | Ischemic Stroke | 1 | PM | 16233958 | 📋 | Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents |
| Sulforaphane | Medulloblastoma | 1 | PM | 14670615 | 📋 | Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables |
| Sulforaphane | Multiple Sclerosis | 1 | PM | 31327180 | 📋 | The Anti-Inflammatory Effect of Sulforaphane in Mice with Experimental Autoimmune Encephalomyelitis |
| Sulforaphane | Neonatal Encephalopathy | 1 | PM | 35616041 | 📋 | The effect of sulforaphane on perinatal hypoxic-ischemic brain injury in rats |
| Sulforaphane | Neurodegenerative Disease | 9 | PM | 35991296 | 📋 | Sulforaphane Upregulates Cultured Mouse Astrocytic Aquaporin-4 Expression through p38 MAPK Pathway |
| Sulforaphane | Neurodegenerative Disease | 6 | PM | 34033847 | 📋 | Sulforaphane enhances long-term potentiation and ameliorate scopolamine-induced memory impairment |
| Sulforaphane | Neurodegenerative Disease | 8 | PM | 33207780 | 📋 | Efficacy of Sulforaphane in Neurodegenerative Diseases |
| Sulforaphane | Neurodegenerative Disease | 7 | PM | 33160067 | 📋 | The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis |
| Sulforaphane | Neurodegenerative Disease | 1 | PM | 32503075 | 📋 | Sulforaphane and Vitamin E Protect From Glucotoxic Neurodegeneration and Lifespan Reduction In C. Elegans |
| Sulforaphane | Neurodegenerative Disease | 3 | PM | 27735126 | 📋 | Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways |
| Sulforaphane | Neurodegenerative Disease | 2 | PM | 22200890 | 📋 | Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine |
| Sulforaphane | Neurodegenerative Disease | 5 | PM | 20166144 | 📋 | Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes |
| Sulforaphane | Neurodegenerative Disease | 4 | PM | 17664144 | 📋 | Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells |
| Sulforaphane | Neuroinflammation | 6 | PM | 38189401 | 📋 | [Sulforaphane reverses Aβ fiber-mediated M1 type microglia polarization and neuroinflammation-mediated necroptosis of neural stem cells by downregulating the MAPK/NF-κB signaling pathways] |
| Sulforaphane | Neuroinflammation | 5 | PM | 35469083 | 📋 | The isothiocyanate sulforaphane prevents mitochondrial impairment and neuroinflammation in the human dopaminergic SH-SY5Y and in the mouse microglial BV2 cells: role for heme oxygenase-1 |
| Sulforaphane | Neuroinflammation | 4 | PM | 35300301 | 📋 | Sulforaphane Modulates the Inflammation and Delays Neurodegeneration on a Retinitis Pigmentosa Mice Model |
| Sulforaphane | Neuroinflammation | 3 | PM | 33079284 | 📋 | Sulforaphane Induces Glioprotection After LPS Challenge |
| Sulforaphane | Neuroinflammation | 2 | PM | 33010279 | 📋 | Sulforaphane mitigates LPS-induced neuroinflammation through modulation of Cezanne/NF-κB signalling |
| Sulforaphane | Neuroinflammation | 1 | PM | 32859007 | 📋 | Sulforaphane Inhibits MGO-AGE-Mediated Neuroinflammation by Suppressing NF-κB, MAPK, and AGE-RAGE Signaling Pathways in Microglial Cells |
| Sulforaphane | Neurological Disorders | 4 | PM | 33196947 | 📋 | Neuroprotective potential of isothiocyanates in an in vitro model of neuroinflammation |
| Sulforaphane | Neurological Disorders | 2 | PM | 31784171 | 📋 | Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders |
| Sulforaphane | Neurological Disorders | 3 | PM | 31334360 | 📋 | The neuroprotective mechanisms and effects of sulforaphane |
| Sulforaphane | Neurological Disorders | 1 | PM | 26107664 | 📋 | Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood |
| Sulforaphane | Neuronal Damage | 1 | PM | 34829573 | 📋 | Induction of the Nrf2 Pathway by Sulforaphane Is Neuroprotective in a Rat Temporal Lobe Epilepsy Model |
| Sulforaphane | Neuropathic Pain | 1 | PM | 28054242 | 📋 | Anti-nociceptive and anti-inflammatory actions of sulforaphane in chronic constriction injury-induced neuropathic pain mice |
| Sulforaphane | Parkinson's Disease | 5 | PM | 37429146 | 📋 | Screening of H2S donors with a red emission mitochondria-targetable fluorescent probe: Toward discovering a new therapeutic strategy for Parkinson's disease |
| Sulforaphane | Parkinson's Disease | 4 | PM | 31059012 | 📋 | Sulforaphane prevents PC12 cells from oxidative damage via the Nrf2 pathway |
| Sulforaphane | Parkinson's Disease | 3 | PM | 20166144 | 📋 | Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes |
| Sulforaphane | Parkinson's Disease | 2 | PM | 19780897 | 📋 | Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line |
| Sulforaphane | Parkinson's Disease | 1 | PM | 17259450 | 📋 | Protective effect of sulforaphane against dopaminergic cell death |
| Sulforaphane | Psychiatric Disorders | 2 | PM | 35492261 | 📋 | Biological mechanisms and clinical efficacy of sulforaphane for mental disorders |
| Sulforaphane | Psychiatric Disorders | 1 | PM | 29888232 | 📋 | Sulforaphane Augments Glutathione and Influences Brain Metabolites in Human Subjects: A Clinical Pilot Study |
| Sulforaphane | Rheumatoid Arthritis | 3 | PM | 33592002 | 📋 | The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory cytokines |
| Sulforaphane | Rheumatoid Arthritis | 2 | PM | 24671668 | 📋 | Sulforaphane inhibits IL-1β-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of MMPs, COX-2, and PGE2 |
| Sulforaphane | Rheumatoid Arthritis | 1 | PM | 20039434 | 📋 | Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate |
| Sulforaphane | Schizophrenia | 2 | PM | 26107664 | 📋 | Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood |
| Sulforaphane | Schizophrenia | 1 | PM | 25912539 | 📋 | An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients with Schizophrenia |
| Sulforaphane | Seizures | 1 | PM | 26365487 | 📋 | Sulforaphane is anticonvulsant and improves mitochondrial function |
| Sulforaphane | Spinal Cord Injury | 1 | PM | 22853439 | 📋 | Neuroprotective effects of sulforaphane after contusive spinal cord injury |
| Sulforaphane | Spinal Cord Injury | 2 | PM | 20947810 | 📋 | Sulforaphane attenuates matrix metalloproteinase-9 expression following spinal cord injury in mice |
| Sulforaphane | Stroke | 1 | PM | 29797311 | 📋 | The isothiocyanate sulforaphane modulates platelet function and protects against cerebral thrombotic dysfunction |
| Sulforaphane | Traumatic Brain Injury | 5 | PM | 34638900 | 📋 | Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury |
| Sulforaphane | Traumatic Brain Injury | 3 | PM | 31232487 | 📋 | Sulforaphane administration alleviates diffuse axonal injury (DAI) via regulation signaling pathway of NRF2 and HO-1 |
| Sulforaphane | Traumatic Brain Injury | 4 | PM | 20953205 | 📋 | The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice |
| Sulforaphane | Traumatic Brain Injury | 2 | PM | 19515491 | 📋 | Sulforaphane improves cognitive function administered following traumatic brain injury |
| Sulforaphane | Traumatic Brain Injury | 1 | PM | 16211562 | 📋 | Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury |
| Sulforaphane | Vascular Dementia | 2 | PM | 34294616 | 📋 | Efficacy of Ulinastatin and Sulforaphane Alone or in Combination in Rat Model of Streptozotocin Diabetes Induced Vascular Dementia |
| Sulforaphane | Vascular Dementia | 1 | PM | 29533123 | 📋 | Protective effects of sulforaphane in experimental vascular cognitive impairment: Contribution of the Nrf2 pathway |
| Sulforaphane | Vertigo | 1 | PM | 35441581 | 📋 | Sulforaphane alleviates hypoxic vestibular vertigo (HVV) by increasing NO production via upregulating the expression of NRF2 |
