| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Pine Bark | Age-Related Cognitive Decline | 1 | PM | 31333448 | 📋 | Assessing the Efficacy and Mechanisms of Pycnogenol ® on Cognitive Aging From In Vitro Animal and Human Studies |
| Pine Bark | Alzheimer's Disease | 2 | PM | 31958081 | 📋 | Pine Bark Polyphenolic Extract Attenuates Amyloid-β and Tau Misfolding in a Model System of Alzheimer's Disease Neuropathology |
| Pine Bark | Alzheimer's Disease | 1 | PM | 30668321 | 📋 | French Maritime Pine Bark Treatment Decelerates Plaque Development and Improves Spatial Memory in Alzheimer's Disease Mice |
| Pine Bark | Back Pain | 1 | PM | 34915691 | 📋 | Primary benign back pain: supplementation with Pycnogenol® |
| Pine Bark | Depression | 2 | PM | 30888217 | 📋 | Pycnogenol supplementation as an adjunct treatment for antidepressant-induced sexual dysfunction |
| Pine Bark | Depression | 1 | PM | 24901001 | 📋 | Pycnogenol Ameliorates Depression-Like Behavior in Repeated Corticosterone-Induced Depression Mice Model |
| Pine Bark | Epilepsy | 1 | PM | 30465512 | 📋 | Pycnogenol Protects Against Pentylenetetrazole-Induced Oxidative Stress and Seizures in Mice |
| Pine Bark | HIV/AIDS | 1 | PM | 18653969 | 📋 | Pycnogenol, a Procyanidin-Rich Extract From French Maritime Pine, Inhibits Intracellular Replication of HIV-1 as Well as Its Binding to Host Cells |
| Pine Bark | Ischemic Stroke | 1 | PM | 32824513 | 📋 | Pycnogenol ® Supplementation Attenuates Memory Deficits and Protects Hippocampal CA1 Pyramidal Neurons via Antioxidative Role in a Gerbil Model of Transient Forebrain Ischemia |
| Pine Bark | Migraine | 3 | PM | 31670494 | 📋 | Episodic Primary Migraine Headache: Prophylaxis With Pycnogenol® Precents Attacks and Controls Oxidative Stress |
| Pine Bark | Migraine | 1 | PM | 23479241 | 📋 | Efficacy of Pinus Radiata Bark Extract and Vitamin C Combination Product as a Prophylactic Therapy for Recalcitrant Migraine and Long-Term Results |
| Pine Bark | Migraine | 2 | PM | 16643582 | 📋 | Use of a Pine Bark Extract and Antioxidant Vitamin Combination Product as Therapy for Migraine in Patients Refractory to Pharmacologic Medication |
| Pine Bark | Neurodegenerative Disease | 1 | PM | 23391521 | 📋 | Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol |
| Pine Bark | Neuroinflammation | 1 | PM | 36039041 | 📋 | Korean Red Pine ( Pinus densiflora) Bark Extract Attenuates Aβ-Induced Cognitive Impairment by Regulating Cholinergic Dysfunction and Neuroinflammation |
| Pine Bark | Parkinson's Disease | 5 | PM | 36153882 | 📋 | Pycnogenol® supplementation alleviates symptoms of Parkinson's disease with mild cognitive impairment |
| Pine Bark | Parkinson's Disease | 4 | PM | 35024909 | 📋 | Pycnogenol ameliorates motor function and gene expressions of NF-ƙB and Nrf2 in a 6-hydroxydopamine-induced experimental model of Parkinson's disease in male NMRI mice |
| Pine Bark | Parkinson's Disease | 1 | PM | 31957998 | 📋 | Supplementary Management With Pycnogenol® in Parkinson's Disease to Prevent Cognitive Impairment |
| Pine Bark | Parkinson's Disease | 2 | PM | 26203556 | 📋 | Pycnogenol Protects Against Rotenone-Induced Neurotoxicity in PC12 Cells Through Regulating NF-κB-iNOS Signaling Pathway |
| Pine Bark | Parkinson's Disease | 3 | PM | 23391521 | 📋 | Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol |
| Pine Bark | Spinal Cord Injury | 1 | PM | 32497471 | 📋 | Pycnogenol Achieves Neuroprotective Effects in Rats With Spinal Cord Injury by Stabilizing the Mitochondrial Membrane Potential |
| Pine Bark | Tinnitus | 1 | PM | 24988090 | 📋 | Improvement in symptoms and cochlear flow with pycnogenol in patients with Meniere's disease and tinnitus |
| Pine Bark | Traumatic Brain Injury | 1 | PM | 34382717 | 📋 | The effect of French maritime pine bark extract supplementation on inflammation, nutritional and clinical status in critically ill patients with traumatic brain injury: A randomized controlled trial |
| Pine Bark | Traumatic Brain Injury | 2 | PM | 26607913 | 📋 | Pycnogenol protects CA3-CA1 synaptic function in a rat model of traumatic brain injury |
| Pine Bark | Traumatic Brain Injury | 4 | PM | 23557184 | 📋 | Dose- and time-dependent neuroprotective effects of Pycnogenol following traumatic brain injury |
| Pine Bark | Traumatic Brain Injury | 3 | PM | 23059456 | 📋 | Neuroprotective effect of Pycnogenol® following traumatic brain injury |
