| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Paeoniflorin | Alzheimer's Disease | 5 | PM | 38027768 | 📋 | Network pharmacology and in vivo studies reveal the neuroprotective effects of paeoniflorin on Alzheimer's disease |
| Paeoniflorin | Alzheimer's Disease | 4 | PM | 37448137 | 📋 | Paeoniflorin suppresses neuronal ferroptosis to improve the cognitive behaviors in Alzheimer's disease mice |
| Paeoniflorin | Alzheimer's Disease | 3 | PM | 36902268 | 📋 | Paeoniflorin Attenuates Lipopolysaccharide-Induced Cognitive Dysfunction by Inhibition of Amyloidogenesis in Mice |
| Paeoniflorin | Alzheimer's Disease | 2 | PM | 35449815 | 📋 | Multiple Roles of Paeoniflorin in Alzheimer's Disease |
| Paeoniflorin | Alzheimer's Disease | 1 | PM | 33282122 | 📋 | Paeoniflorin ameliorates Aβ-stimulated neuroinflammation via regulation of NF-κB signaling pathway and Aβ degradation in C6 glial cells |
| Paeoniflorin | Depression | 8 | PM | 37315645 | 📋 | Identification of paeoniflorin from Paeonia lactiflora pall. As an inhibitor of tryptophan 2,3-dioxygenase and assessment of its pharmacological effects on depressive mice |
| Paeoniflorin | Depression | 7 | PM | 35770096 | 📋 | Integrating Metabolomics and Network Analysis for Exploring the Mechanism Underlying the Antidepressant Activity of Paeoniflorin in Rats With CUMS-Induced Depression |
| Paeoniflorin | Depression | 6 | PM | 35185541 | 📋 | Network Pharmacology-Based and Experimental Identification of the Effects of Paeoniflorin on Major Depressive Disorder |
| Paeoniflorin | Depression | 3 | PM | 35143936 | 📋 | Efficacy of paeoniflorin on models of depression: A systematic review and meta-analysis of rodent studies |
| Paeoniflorin | Depression | 1 | PM | 34334273 | 📋 | Paeoniflorin: A neuroprotective monoterpenoid glycoside with promising anti-depressive properties |
| Paeoniflorin | Depression | 4 | PM | 33025508 | 📋 | Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway |
| Paeoniflorin | Depression | 5 | PM | 32733578 | 📋 | Antidepression and Prokinetic Effects of Paeoniflorin on Rats in the Forced Swimming Test via Polypharmacology |
| Paeoniflorin | Depression | 2 | PM | 31115613 | 📋 | Paeoniflorin attenuates impairment of spatial learning and hippocampal long-term potentiation in mice subjected to chronic unpredictable mild stress |
| Paeoniflorin | Diabetic Encephalopathy | 1 | PM | 28322909 | 📋 | Paeoniflorin ameliorates cognitive dysfunction via regulating SOCS2/IRS-1 pathway in diabetic rats |
| Paeoniflorin | Diabetic Neuropathy | 1 | PM | 35340203 | 📋 | Paeoniflorin Upregulates Mitochondrial Thioredoxin of Schwann Cells to Improve Diabetic Peripheral Neuropathy Indicated by 4D Label-Free Quantitative Proteomics |
| Paeoniflorin | Glioblastoma | 2 | PM | 35957872 | 📋 | Paeoniflorin Inhibits EMT and Angiogenesis in Human Glioblastoma via K63-Linked C-Met Polyubiquitination-Dependent Autophagic Degradation |
| Paeoniflorin | Glioblastoma | 1 | PM | 29740218 | 📋 | Paeoniflorin inhibits glioblastoma growth in vivo and in vitro: a role for the Triad3A-dependent ubiquitin proteasome pathway in TLR4 degradation |
| Paeoniflorin | Glioma | 1 | PM | 36618071 | 📋 | Paeoniflorin Regulates NEDD4L/STAT3 Pathway to Induce Ferroptosis in Human Glioma Cells |
| Paeoniflorin | Ischemic Stroke | 2 | PM | 38178130 | 📋 | Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke |
| Paeoniflorin | Ischemic Stroke | 1 | PM | 35938509 | 📋 | Combination of paeoniflorin and calycosin-7-glucoside alleviates ischaemic stroke injury via the PI3K/AKT signalling pathway |
| Paeoniflorin | Neurodegenerative Disease | 1 | PM | 36046834 | 📋 | A review for the pharmacological effects of paeoniflorin in the nervous system |
| Paeoniflorin | Neuroinflammation | 4 | PM | 38027768 | 📋 | Network pharmacology and in vivo studies reveal the neuroprotective effects of paeoniflorin on Alzheimer's disease |
| Paeoniflorin | Neuroinflammation | 3 | PM | 37169480 | 📋 | Paeoniflorin, ferulic acid, and atractylenolide III improved LPS-induced neuroinflammation of BV2 microglia cells by enhancing autophagy |
| Paeoniflorin | Neuroinflammation | 1 | PM | 33282122 | 📋 | Paeoniflorin ameliorates Aβ-stimulated neuroinflammation via regulation of NF-κB signaling pathway and Aβ degradation in C6 glial cells |
| Paeoniflorin | Neuroinflammation | 2 | PM | 28339077 | 📋 | Paeoniflorin attenuates the neuroinflammatory response in a rat model of chronic constriction injury |
| Paeoniflorin | Neurological Disorders | 1 | PM | 36046834 | 📋 | A review for the pharmacological effects of paeoniflorin in the nervous system |
| Paeoniflorin | Neuronal Damage | 1 | PM | 37448137 | 📋 | Paeoniflorin suppresses neuronal ferroptosis to improve the cognitive behaviors in Alzheimer's disease mice |
| Paeoniflorin | Neuropathic Pain | 2 | PM | 36160378 | 📋 | Combination of paeoniflorin and liquiritin alleviates neuropathic pain by lipid metabolism and calcium signaling coordination |
| Paeoniflorin | Neuropathic Pain | 1 | PM | 28339077 | 📋 | Paeoniflorin attenuates the neuroinflammatory response in a rat model of chronic constriction injury |
| Paeoniflorin | Neurotoxicity | 3 | PM | 38513881 | 📋 | Paeoniflorin ameliorates oxaliplatin-induced peripheral neuropathy via inhibiting neuroinflammation through influence on gut microbiota |
| Paeoniflorin | Neurotoxicity | 2 | PM | 35860525 | 📋 | Paeoniflorin Ameliorates BiPN by Reducing IL6 Levels and Regulating PARKIN-Mediated Mitochondrial Autophagy |
| Paeoniflorin | Neurotoxicity | 1 | PM | 35439856 | 📋 | [Mechanism of paeoniflorin inhibiting apoptosis of hippocampal neurons of rats induced by lead acetate] |
| Paeoniflorin | Pain | 2 | PM | 36707182 | 📋 | Repeated topical paeoniflorin attenuates postoperative pain and accelerates cutaneous fibroblast proliferation in mice |
| Paeoniflorin | Pain | 1 | PM | 34844873 | 📋 | Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway |
| Paeoniflorin | Parkinson's Disease | 3 | PM | 36881748 | 📋 | Paeoniflorin protects 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mice by inhibiting oxidative stress and neuronal apoptosis through activating the Nrf2/HO-1 signaling pathway |
| Paeoniflorin | Parkinson's Disease | 2 | PM | 35489613 | 📋 | The Neuroprotective Effects of Paeoniflorin Against MPP +-induced Damage to Dopaminergic Neurons via the Akt/Nrf2/GPX4 Pathway |
| Paeoniflorin | Parkinson's Disease | 1 | PM | 35230626 | 📋 | Paeoniflorin ameliorates cognitive impairment in Parkinson's disease via JNK/p53 signaling |
| Paeoniflorin | Peripheral Neuropathy | 1 | PM | 35860525 | 📋 | Paeoniflorin Ameliorates BiPN by Reducing IL6 Levels and Regulating PARKIN-Mediated Mitochondrial Autophagy |
| Paeoniflorin | Postpartum Depression | 1 | PM | 36214717 | 📋 | Paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the TSPO and BDNF‑mTOR pathways |
| Paeoniflorin | Rheumatoid Arthritis | 4 | PM | 38726183 | 📋 | Paeoniflorin inhibits the inflammation of rheumatoid arthritis fibroblast-like synoviocytes by downregulating hsa_circ_009012 |
| Paeoniflorin | Rheumatoid Arthritis | 3 | PM | 35851082 | 📋 | [Paeoniflorin inhibits Wnt1/β-catenin pathway and promotes apoptosis of fibroblast-like synoviocytes in patients with rheumatoid arthritis by upregulating lncRNA MALAT1] |
| Paeoniflorin | Rheumatoid Arthritis | 1 | PM | 34423389 | 📋 | Paeoniflorin Suppresses Rheumatoid Arthritis Development via Modulating the Circ-FAM120A/miR-671-5p/MDM4 Axis |
| Paeoniflorin | Rheumatoid Arthritis | 2 | PM | 32172753 | 📋 | The effects of total glucosides of paeony (TGP) and paeoniflorin (Pae) on inflammatory-immune responses in rheumatoid arthritis (RA) |
| Paeoniflorin | Schizophrenia | 1 | PM | 35571896 | 📋 | Paeoniflorin Rescued MK-801-Induced Schizophrenia-Like Behaviors in Mice via Oxidative Stress Pathway |
| Paeoniflorin | Sciatica | 1 | PM | 35499270 | 📋 | Therapeutic effect of paeoniflorin on chronic constriction injury of the sciatic nerve via the inhibition of Schwann cell apoptosis |
