| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Melatonin | Age-Related Cognitive Decline | 5 | PM | 38791160 | 📋 | The Vital Role of Melatonin and Its Metabolites in the Neuroprotection and Retardation of Brain Aging |
| Melatonin | Age-Related Cognitive Decline | 4 | PM | 38613097 | 📋 | The Positive Association between Melatonin-Containing Food Consumption and Older Adult Life Satisfaction, Psychoemotional State, and Cognitive Function |
| Melatonin | Age-Related Cognitive Decline | 3 | PM | 31678348 | 📋 | Nicotinamide Mononucleotide and Melatonin Alleviate Aging-induced Cognitive Impairment via Modulation of Mitochondrial Function and Apoptosis in the Prefrontal Cortex and Hippocampus |
| Melatonin | Age-Related Cognitive Decline | 1 | PM | 26052727 | 📋 | Physiological Levels of Melatonin Relate to Cognitive Function and Depressive Symptoms: The HEIJO-KYO Cohort |
| Melatonin | Age-Related Cognitive Decline | 2 | PM | 25550330 | 📋 | Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential |
| Melatonin | Alzheimer's Disease | 54 | PM | 38791263 | 📋 | Melatonin Inhibits Hypoxia-Induced Alzheimer's Disease Pathogenesis by Regulating the Amyloidogenic Pathway in Human Neuroblastoma Cells |
| Melatonin | Alzheimer's Disease | 53 | PM | 38561619 | 📋 | The Therapeutic Potential of Melatonin in Alzheimer's Disease: A Comprehensive Review |
| Melatonin | Alzheimer's Disease | 52 | PM | 38390232 | 📋 | Melatonin-mediated calcineurin inactivation attenuates amyloid beta-induced apoptosis |
| Melatonin | Alzheimer's Disease | 50 | PM | 38259379 | 📋 | Neuroprotective Potential of Melatonin: Evaluating Therapeutic Efficacy in Alzheimer's and Parkinson's Diseases |
| Melatonin | Alzheimer's Disease | 49 | PM | 37857668 | 📋 | The role of melatonin in amyloid beta-induced inflammation mediated by inflammasome signaling in neuronal cell lines |
| Melatonin | Alzheimer's Disease | 48 | PM | 36926592 | 📋 | Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer's disease model |
| Melatonin | Alzheimer's Disease | 15 | PM | 36602704 | 📋 | Regulatory role of melatonin in Notch1 signaling pathway in cerebral cortex of Aβ1-42-induced Alzheimer's disease rat model |
| Melatonin | Alzheimer's Disease | 47 | PM | 36160083 | 📋 | Potential Effects of Melatonin on TRPA1 Channels in the Prevention and Treatment of Alzheimer's Disease |
| Melatonin | Alzheimer's Disease | 46 | PM | 36116555 | 📋 | Effect and Mechanism of Exogenous Melatonin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic review and Meta-analysis |
| Melatonin | Alzheimer's Disease | 45 | PM | 36056839 | 📋 | Genetic Causes of Alzheimer's Disease and the Neuroprotective Role of Melatonin in its Management |
| Melatonin | Alzheimer's Disease | 44 | PM | 35983247 | 📋 | Melatonin Ameliorates the Progression of Alzheimer's Disease by Inducing TFEB Nuclear Translocation, Promoting Mitophagy, and Regulating NLRP3 Inflammasome Activity |
| Melatonin | Alzheimer's Disease | 43 | PM | 35527277 | 📋 | Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer's disease |
| Melatonin | Alzheimer's Disease | 42 | PM | 35526705 | 📋 | Melatonin and zinc supplements with physical and mental activities subside neurodegeneration and hepatorenal injury induced by aluminum chloride in rats: Inclusion of GSK-3β-Wnt/β-catenin signaling pathway |
| Melatonin | Alzheimer's Disease | 39 | PM | 35450525 | 📋 | The Dose- and Duration-Dependent Association between Melatonin Treatment and Overall Cognition in Alzheimer's Dementia: A Network Meta-Analysis of Randomized Placebo-Controlled Trials |
| Melatonin | Alzheimer's Disease | 41 | PM | 35173531 | 📋 | The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease |
| Melatonin | Alzheimer's Disease | 40 | PM | 35167824 | 📋 | Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies |
| Melatonin | Alzheimer's Disease | 38 | PM | 34899707 | 📋 | Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in AD and Rosacea |
| Melatonin | Alzheimer's Disease | 37 | PM | 34884567 | 📋 | The Role of Melatonin on Behavioral Changes and Concomitant Oxidative Stress in icvAβ 1-42 Rat Model with Pinealectomy |
| Melatonin | Alzheimer's Disease | 35 | PM | 34617321 | 📋 | Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer's disease |
| Melatonin | Alzheimer's Disease | 36 | PM | 34514491 | 📋 | Mechanisms of melatonin binding and destabilizing the protofilament and filament of tau R3-R4 domains revealed by molecular dynamics simulation |
| Melatonin | Alzheimer's Disease | 34 | PM | 34428352 | 📋 | Melatonin binds with high affinity and specificity to beta-amyloid: LC-MS provides insight into Alzheimer disease treatment |
| Melatonin | Alzheimer's Disease | 33 | PM | 34202125 | 📋 | Regulation of Melatonin and Neurotransmission in Alzheimer's Disease |
| Melatonin | Alzheimer's Disease | 32 | PM | 33986623 | 📋 | Melatonin Improves Short-Term Spatial Memory in a Mouse Model of Alzheimer's Disease |
| Melatonin | Alzheimer's Disease | 31 | PM | 33957167 | 📋 | Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: a systematic review and meta-analysis of randomized controlled trials |
| Melatonin | Alzheimer's Disease | 29 | PM | 33769811 | 📋 | Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects In Vitro and Neuroprotective Effects in a Pharmacological Alzheimer's Disease Mouse Model |
| Melatonin | Alzheimer's Disease | 30 | PM | 33610813 | 📋 | Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer's disease neuropathology |
| Melatonin | Alzheimer's Disease | 28 | PM | 33417994 | 📋 | Effects of Melatonin and Resveratrol on Recognition Memory and Passive Avoidance Performance in a Mouse Model of Alzheimer's Disease |
| Melatonin | Alzheimer's Disease | 27 | PM | 33342257 | 📋 | Melatonin Reduces GSK3β-Mediated Tau Phosphorylation, Enhances Nrf2 Nuclear Translocation and Anti-Inflammation |
| Melatonin | Alzheimer's Disease | 26 | PM | 33254429 | 📋 | Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer's disease |
| Melatonin | Alzheimer's Disease | 25 | PM | 33157120 | 📋 | Melatonin alters fluid phase co-existence in POPC/DPPC/cholesterol membranes |
| Melatonin | Alzheimer's Disease | 24 | PM | 33130240 | 📋 | Aluminum chloride-induced amyloid β accumulation and endoplasmic reticulum stress in rat brain are averted by melatonin |
| Melatonin | Alzheimer's Disease | 23 | PM | 33063739 | 📋 | Melatonin ameliorates microvessel abnormalities in the cerebral cortex and hippocampus in a rat model of Alzheimer's disease |
| Melatonin | Alzheimer's Disease | 22 | PM | 32950104 | 📋 | Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation |
| Melatonin | Alzheimer's Disease | 6 | PM | 32703954 | 📋 | ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy |
| Melatonin | Alzheimer's Disease | 5 | PM | 32619650 | 📋 | Long-term Oral Melatonin Alleviates Memory Deficits, Reduces amyloid-β Deposition Associated With Downregulation of BACE1 and Mitophagy in APP/PS1 Transgenic Mice |
| Melatonin | Alzheimer's Disease | 4 | PM | 32579500 | 📋 | Melatonin Prevents Neddylation Dysfunction in Aβ42-exposed SH-SY5Y Neuroblastoma Cells by Regulating the Amyloid Precursor ProteinBinding Protein 1 Pathway |
| Melatonin | Alzheimer's Disease | 3 | PM | 32470495 | 📋 | Therapeutic Effects of Melatonin-Treated Bone Marrow Mesenchymal Stem Cells (BMSC) in a Rat Model of Alzheimer's Disease |
| Melatonin | Alzheimer's Disease | 2 | PM | 32376818 | 📋 | Dietary Melatonin Therapy Alleviates the Lamina Cribrosa Damages in Patients With Mild Cognitive Impairments: A Double-Blinded, Randomized Controlled Study |
| Melatonin | Alzheimer's Disease | 12 | PM | 31726088 | 📋 | Melatonin attenuates streptozotocin-induced Alzheimer-like features in hyperglycemic rats |
| Melatonin | Alzheimer's Disease | 17 | PM | 31640239 | 📋 | The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease |
| Melatonin | Alzheimer's Disease | 18 | PM | 29322615 | 📋 | Melatonin protects against Aβ-induced neurotoxicity in primary neurons via miR-132/PTEN/AKT/FOXO3a pathway |
| Melatonin | Alzheimer's Disease | 51 | PM | 28994117 | 📋 | Melatonin ameliorates Aβ1-42 -induced Alzheimer's cognitive deficits in mouse model |
| Melatonin | Alzheimer's Disease | 21 | PM | 28294066 | 📋 | Mechanisms of Melatonin in Alleviating Alzheimer's Disease |
| Melatonin | Alzheimer's Disease | 11 | PM | 27068758 | 📋 | Melatonin administration reverses the alteration of amyloid precursor protein-cleaving secretases expression in aged mouse hippocampus |
| Melatonin | Alzheimer's Disease | 8 | PM | 26402759 | 📋 | Melatonin Attenuates Memory Impairment, Amyloid-β Accumulation, and Neurodegeneration in a Rat Model of Sporadic Alzheimer's Disease |
| Melatonin | Alzheimer's Disease | 14 | PM | 26159703 | 📋 | Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPP(swe)/PS1 mice |
| Melatonin | Alzheimer's Disease | 20 | PM | 26081146 | 📋 | Subthreshold Concentrations of Melatonin and Galantamine Improves Pathological AD-Hallmarks in Hippocampal Organotypic Cultures |
| Melatonin | Alzheimer's Disease | 7 | PM | 26052727 | 📋 | Physiological Levels of Melatonin Relate to Cognitive Function and Depressive Symptoms: The HEIJO-KYO Cohort |
| Melatonin | Alzheimer's Disease | 13 | PM | 25988948 | 📋 | Melatonin attenuates impairments of structural hippocampal neuroplasticity in OXYS rats during active progression of Alzheimer's disease-like pathology |
| Melatonin | Alzheimer's Disease | 16 | PM | 21358972 | 📋 | Clinical aspects of melatonin intervention in Alzheimer's disease progression |
| Melatonin | Alzheimer's Disease | 1 | PM | 20944813 | 📋 | Melatonin Potentiates the Neuroprotective Properties of Resveratrol Against Beta-Amyloid-Induced Neurodegeneration by Modulating AMP-Activated Protein Kinase Pathways |
| Melatonin | Alzheimer's Disease | 9 | PM | 18705649 | 📋 | Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model |
| Melatonin | Alzheimer's Disease | 10 | PM | 12753069 | 📋 | Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease |
| Melatonin | Alzheimer's Disease | 19 | PM | 12019347 | 📋 | The use of melatonin in Alzheimer's disease |
| Melatonin | Amyotrophic Lateral Sclerosis | 3 | PM | 35606613 | 📋 | Melatonin Induces Autophagy in Amyotrophic Lateral Sclerosis Mice via Upregulation of SIRT1 |
| Melatonin | Amyotrophic Lateral Sclerosis | 2 | PM | 33428242 | 📋 | Melatonin may slow disease progression in amyotrophic lateral sclerosis: Findings from the Pooled Resource Open-Access ALS Clinic Trials database |
| Melatonin | Amyotrophic Lateral Sclerosis | 1 | PM | 17014688 | 📋 | Reduced oxidative damage in ALS by high-dose enteral melatonin treatment |
| Melatonin | Brain Aneurysm | 1 | PM | 27865517 | 📋 | Effects of melatonin in the treatment of asthenia in aneurysmal subarachnoid hemorrhage |
| Melatonin | Brain Edema | 1 | PM | 28351378 | 📋 | Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins |
| Melatonin | Brain Edema | 2 | PM | 27152411 | 📋 | Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition |
| Melatonin | Brain Inflammation | 2 | PM | 34547676 | 📋 | Inflammatory Cytokines are in Action: Brain Plasticity and Recovery after Brain Ischemia Due to Delayed Melatonin Administration |
| Melatonin | Brain Inflammation | 1 | PM | 32821085 | 📋 | Melatonin Plays a Protective Role by Regulating miR-26a-5p-NRSF and JAK2-STAT3 Pathway to Improve Autophagy, Inflammation and Oxidative Stress of Cerebral Ischemia-Reperfusion Injury |
| Melatonin | Brain Inflammation | 3 | PM | 32705396 | 📋 | Melatonin Attenuates Thrombin-induced Inflammation in BV2 Cells and Then Protects HT22 Cells from Apoptosis |
| Melatonin | Brain Inflammation | 6 | PM | 27441728 | 📋 | Melatonin modulates neonatal brain inflammation through endoplasmic reticulum stress, autophagy, and miR-34a/silent information regulator 1 pathway |
| Melatonin | Brain Inflammation | 9 | PM | 27117839 | 📋 | Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy |
| Melatonin | Brain Inflammation | 4 | PM | 26094939 | 📋 | Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling |
| Melatonin | Brain Inflammation | 8 | PM | 25988948 | 📋 | Melatonin attenuates impairments of structural hippocampal neuroplasticity in OXYS rats during active progression of Alzheimer's disease-like pathology |
| Melatonin | Brain Inflammation | 7 | PM | 20856166 | 📋 | Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke |
| Melatonin | Brain Injury | 3 | PM | 37973931 | 📋 | Prophylactic supplement with melatonin prevented the brain injury after cardiac arrest in rats |
| Melatonin | Brain Injury | 4 | PM | 33102250 | 📋 | Melatonin Prevents Brain Damage and Neurocognitive Impairment Induced by Plasmodium Berghei ANKA Infection in Murine Model of Cerebral Malaria |
| Melatonin | Brain Injury | 2 | PM | 32545820 | 📋 | Role and Therapeutic Potential of Melatonin in the Central Nervous System and Cancers |
| Melatonin | Brain Injury | 5 | PM | 29088788 | 📋 | Melatonin attenuated the brain damage and cognitive impairment partially through MT2 melatonin receptor in mice with chronic cerebral hypoperfusion |
| Melatonin | Brain Injury | 6 | PM | 26094939 | 📋 | Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling |
| Melatonin | Brain Injury | 1 | PM | 21073519 | 📋 | Melatonin Synergistically Increases Resveratrol-Induced Heme oxygenase-1 Expression Through the Inhibition of Ubiquitin-Dependent Proteasome Pathway: A Possible Role in Neuroprotection |
| Melatonin | Cerebral Palsy | 1 | PM | 33692754 | 📋 | Effects of Melatonin on Neurobehavior and Cognition in a Cerebral Palsy Model of plppr5-/- Mice |
| Melatonin | Chronic Pain | 1 | PM | 32455582 | 📋 | Analgesic Efficacy of Melatonin: A Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials |
| Melatonin | Chronic Pain | 3 | PM | 32413745 | 📋 | Melatonin Alleviates Morphine Analgesic Tolerance in Mice by Decreasing NLRP3 Inflammasome Activation |
| Melatonin | Chronic Pain | 4 | PM | 27698681 | 📋 | Pain Control by Melatonin: Physiological and Pharmacological Effects |
| Melatonin | Chronic Pain | 2 | PM | 26984272 | 📋 | Melatonin in Chronic Pain Syndromes |
| Melatonin | Chronic Stress | 4 | PM | 38538614 | 📋 | Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats |
| Melatonin | Chronic Stress | 3 | PM | 32417342 | 📋 | Melatonin Reverses the Depression-Associated Behaviour and Regulates Microglia, Fractalkine Expression and Neurogenesis in Adult Mice Exposed to Chronic Mild Stress |
| Melatonin | Chronic Stress | 2 | PM | 28533888 | 📋 | Neuroprotective Effects of Melatonin Administration Against Chronic Immobilization Stress in Rats |
| Melatonin | Chronic Stress | 1 | PM | 28189148 | 📋 | Anxiety and Hyperlocomotion Induced by Chronic Unpredictable Mild Stress Can Be Moderated With Melatonin Treatment |
| Melatonin | Delirium | 16 | PM | 37776484 | 📋 | Prophylactic effect of exogenous melatonin and melatonin receptor agonists on postoperative delirium in elderly patients: a systemic review and meta-analysis of randomized controlled trials |
| Melatonin | Delirium | 15 | PM | 36160675 | 📋 | The effect of melatonin on prevention of postoperative delirium after lower limb fracture surgery in elderly patients: a randomized double blind clinical trial |
| Melatonin | Delirium | 14 | PM | 35801323 | 📋 | Performance of Melatonin as Prophylaxis in Geriatric Patients with Multifactorial Risk for Postoperative Delirium Development: A Randomized Comparative Study |
| Melatonin | Delirium | 13 | PM | 35665270 | 📋 | Melatonin and Its Analogs for Prevention of Post-cardiac Surgery Delirium: A Systematic Review and Meta-Analysis |
| Melatonin | Delirium | 12 | PM | 35647160 | 📋 | Melatonin intervention to prevent delirium in hospitalized patients: A meta-analysis |
| Melatonin | Delirium | 11 | PM | 35238305 | 📋 | Effects of Melatonin for Delirium in Elderly Acute Heart Failure Patients: A Randomized, Single-Center, Double-Blind, and Placebo-Controlled Trial |
| Melatonin | Delirium | 10 | PM | 34749057 | 📋 | Melatonin and melatonin-receptor agonists to prevent delirium in hospitalized older adults: An umbrella review |
| Melatonin | Delirium | 9 | PM | 34730495 | 📋 | Effects of Melatonin on Postoperative Delirium After PCI in Elderly Patients: A Randomized, Single-Center, Double-Blind, Placebo-Controlled Trial |
| Melatonin | Delirium | 8 | PM | 34175857 | 📋 | As part of multimodal anxiolysis oral melatonin but not midazolam decreases emergence delirium in children: A randomised, double-blind, placebo-controlled study |
| Melatonin | Delirium | 7 | PM | 33753956 | 📋 | Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial |
| Melatonin | Delirium | 6 | PM | 33657679 | 📋 | Delirium REduction after Administration of Melatonin in acute ischemic Stroke (DREAMS): A Propensity Score Matched Analysis |
| Melatonin | Delirium | 5 | PM | 33348252 | 📋 | Melatonin for delirium prevention in hospitalized patients: A systematic review and meta-analysis |
| Melatonin | Delirium | 2 | PM | 31619178 | 📋 | Melatonin for the prevention of postoperative delirium in older adults: a systematic review and meta-analysis |
| Melatonin | Delirium | 4 | PM | 29376051 | 📋 | Melatonin and the Prevention and Management of Delirium: A Scoping Study |
| Melatonin | Delirium | 3 | PM | 28154742 | 📋 | Loss of melatonin daily rhythmicity is asociated with delirium development in hospitalized older adults |
| Melatonin | Delirium | 1 | PM | 26189834 | 📋 | Exogenous Melatonin for Delirium Prevention: a Meta-analysis of Randomized Controlled Trials |
| Melatonin | Dementia | 1 | PM | 28419991 | 📋 | Effect of Melatonin and Resveratrol Against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia |
| Melatonin | Demyelinating Disease | 1 | PM | 20856166 | 📋 | Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke |
| Melatonin | Depression | 27 | PM | 38538614 | 📋 | Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats |
| Melatonin | Depression | 26 | PM | 37802998 | 📋 | Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization |
| Melatonin | Depression | 25 | PM | 37686181 | 📋 | Melatonin Prevents Depression but Not Anxiety-like Behavior Produced by the Chemotherapeutic Agent Temozolomide: Implication of Doublecortin Cells and Hilar Oligodendrocytes |
| Melatonin | Depression | 24 | PM | 36162616 | 📋 | Melatonin attenuates chronic stress-induced hippocampal inflammatory response and apoptosis by inhibiting ADAM17/TNF-α axis |
| Melatonin | Depression | 23 | PM | 36080418 | 📋 | Antidepressant Low Doses of Ketamine and Melatonin in Combination Produce Additive Neurogenesis in Human Olfactory Neuronal Precursors |
| Melatonin | Depression | 22 | PM | 35884835 | 📋 | Gut Bless Your Pain-Roles of the Gut Microbiota, Sleep, and Melatonin in Chronic Orofacial Pain and Depression |
| Melatonin | Depression | 21 | PM | 35008730 | 📋 | Associations between Melatonin, Neuroinflammation, and Brain Alterations in Depression |
| Melatonin | Depression | 20 | PM | 34929236 | 📋 | Antidepressant actions of melatonin and melatonin receptor agonist: Focus on pathophysiology and treatment |
| Melatonin | Depression | 19 | PM | 34794022 | 📋 | Melatonin alleviates hippocampal GR inhibition and depression-like behavior induced by constant light exposure in mice |
| Melatonin | Depression | 18 | PM | 34502152 | 📋 | Low Doses of Ketamine and Melatonin in Combination Produce Additive Antidepressant-like Effects in Mice |
| Melatonin | Depression | 17 | PM | 33490672 | 📋 | Melatonin attenuated the behavioral despair induced by acute neurogenic stress through blockade of N-methyl D-aspartate receptors in mice |
| Melatonin | Depression | 16 | PM | 33165196 | 📋 | Melatonin ameliorated CUMS-induced depression-like behavior via restoring endoplasmic reticulum stress in rat hippocampus |
| Melatonin | Depression | 2 | PM | 32417342 | 📋 | Melatonin Reverses the Depression-Associated Behaviour and Regulates Microglia, Fractalkine Expression and Neurogenesis in Adult Mice Exposed to Chronic Mild Stress |
| Melatonin | Depression | 1 | PM | 32375205 | 📋 | Melatonin Prevents Neuroinflammation and Relieves Depression by Attenuating Autophagy Impairment Through FOXO3a Regulation |
| Melatonin | Depression | 4 | PM | 31726890 | 📋 | Melatonin Reverses Depressive and Anxiety Like-Behaviours Induced by Diabetes: Involvement of Oxidative Stress, Age, Rage and S100B Levels in the Hippocampus and Prefrontal Cortex of Rats |
| Melatonin | Depression | 14 | PM | 31640239 | 📋 | The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease |
| Melatonin | Depression | 12 | PM | 29458118 | 📋 | Neuroprotective effect of melatonin against lipopolysaccharide-induced depressive-like behavior in mice |
| Melatonin | Depression | 8 | PM | 29086908 | 📋 | Melatonin Augments the Effects of Fluoxetine on Depression-Like Behavior and Hippocampal BDNF-TrkB Signaling |
| Melatonin | Depression | 3 | PM | 28189148 | 📋 | Anxiety and Hyperlocomotion Induced by Chronic Unpredictable Mild Stress Can Be Moderated With Melatonin Treatment |
| Melatonin | Depression | 13 | PM | 28160436 | 📋 | Role of the MT 1 and MT 2 melatonin receptors in mediating depressive- and anxiety-like behaviors in C3H/HeN mice |
| Melatonin | Depression | 11 | PM | 28082153 | 📋 | Melatonin produces a rapid onset and prolonged efficacy in reducing depression-like behaviors in adult rats exposed to chronic unpredictable mild stress |
| Melatonin | Depression | 10 | PM | 27499503 | 📋 | Melatonin mediated antidepressant-like effect in the hippocampus of chronic stress-induced depression rats: Regulating vesicular monoamine transporter 2 and monoamine oxidase A levels |
| Melatonin | Depression | 9 | PM | 27398923 | 📋 | Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System |
| Melatonin | Depression | 15 | PM | 26321393 | 📋 | The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders |
| Melatonin | Depression | 7 | PM | 26052727 | 📋 | Physiological Levels of Melatonin Relate to Cognitive Function and Depressive Symptoms: The HEIJO-KYO Cohort |
| Melatonin | Depression | 6 | PM | 24756186 | 📋 | Effect of melatonin on depressive symptoms and anxiety in patients undergoing breast cancer surgery: a randomized, double-blind, placebo-controlled trial |
| Melatonin | Depression | 5 | PM | 21199966 | 📋 | Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial |
| Melatonin | Diabetic Encephalopathy | 6 | PM | 36348200 | 📋 | The protective effects of melatonin in high glucose environment by alleviating autophagy and apoptosis on primary cortical neurons |
| Melatonin | Diabetic Encephalopathy | 5 | PM | 34007273 | 📋 | Association of Serum Melatonin Level with Mild Cognitive Impairment in Type 2 Diabetic Patients: A Cross-Sectional Study |
| Melatonin | Diabetic Encephalopathy | 4 | PM | 33709562 | 📋 | Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway |
| Melatonin | Diabetic Encephalopathy | 3 | PM | 33628283 | 📋 | Melatonin suppresses the brain injury after cerebral ischemia/reperfusion in hyperglycaemic rats |
| Melatonin | Diabetic Encephalopathy | 2 | PM | 33401187 | 📋 | Melatonin ameliorates diabetes-induced brain injury in rats |
| Melatonin | Diabetic Encephalopathy | 1 | PM | 31726088 | 📋 | Melatonin attenuates streptozotocin-induced Alzheimer-like features in hyperglycemic rats |
| Melatonin | Diabetic Neuropathy | 5 | PM | 37456910 | 📋 | Melatonin ameliorates high glucose-induced autophagy in Schwann cells |
| Melatonin | Diabetic Neuropathy | 4 | PM | 36120309 | 📋 | The neuroprotective effects of melatonin against diabetic neuropathy: A systematic review of non-clinical studies |
| Melatonin | Diabetic Neuropathy | 3 | PM | 35496279 | 📋 | New Advances on Pathophysiology of Diabetes Neuropathy and Pain Management: Potential Role of Melatonin and DPP-4 Inhibitors |
| Melatonin | Diabetic Neuropathy | 2 | PM | 35008523 | 📋 | Effects of Melatonin on Diabetic Neuropathy and Retinopathy |
| Melatonin | Diabetic Neuropathy | 1 | PM | 34121140 | 📋 | Adjuvant use of melatonin for relieving symptoms of painful diabetic neuropathy: results of a randomized, double-blinded, controlled trial |
| Melatonin | Down Syndrome | 1 | PM | 34400791 | 📋 | Melatonin as an immunomodulator in children with Down syndrome |
| Melatonin | Down Syndrome | 2 | PM | 24147912 | 📋 | Chronic melatonin treatment rescues electrophysiological and neuromorphological deficits in a mouse model of Down syndrome |
| Melatonin | Encephalitis | 1 | PM | 27503577 | 📋 | Melatonin decreases brain apoptosis, oxidative stress, and CD200 expression and increased survival rate in mice infected by Venezuelan equine encephalitis virus |
| Melatonin | Encephalitis | 2 | PM | 26168898 | 📋 | Melatonin, minocycline and ascorbic acid reduce oxidative stress and viral titers and increase survival rate in experimental Venezuelan equine encephalitis |
| Melatonin | Epilepsy | 14 | PM | 38417212 | 📋 | Melatonin as an add-on treatment for epilepsy: A systematic review and meta-analysis |
| Melatonin | Epilepsy | 12 | PM | 37909654 | 📋 | Safety and efficacy of melatonin supplementation as an add-on treatment for infantile epileptic spasms syndrome: A randomized, placebo-controlled, double-blind trial |
| Melatonin | Epilepsy | 11 | PM | 37382264 | 📋 | Melatonin regulates microglial polarization to M2 cell via RhoA/ROCK signaling pathway in epilepsy |
| Melatonin | Epilepsy | 10 | PM | 36588283 | 📋 | Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients: Cross-sectional, randomized, double-blind, placebo-controlled clinical trial |
| Melatonin | Epilepsy | 9 | PM | 35851222 | 📋 | Melatonin and Epilepsy |
| Melatonin | Epilepsy | 8 | PM | 35507790 | 📋 | The effects of vitamin D3 and melatonin combination on pentylenetetrazole-induced seizures in mice |
| Melatonin | Epilepsy | 7 | PM | 34699755 | 📋 | Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish |
| Melatonin | Epilepsy | 6 | PM | 34165417 | 📋 | Anti-Convulsive Effect of Thiamine and Melatonin Combination in Mice; Involvement of Oxidative Stress |
| Melatonin | Epilepsy | 5 | PM | 33813829 | 📋 | Melatonin as an Antiepileptic Molecule: Therapeutic Implications via Neuroprotective and Inflammatory Mechanisms |
| Melatonin | Epilepsy | 4 | PM | 33641195 | 📋 | Effect of add-on melatonin on seizure outcome, neuronal damage, oxidative stress, and quality of life in generalized epilepsy with generalized onset motor seizures in adults: A randomized controlled trial |
| Melatonin | Epilepsy | 2 | PM | 27016427 | 📋 | Anticonvulsant activity of melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, in mice |
| Melatonin | Epilepsy | 3 | PM | 26321393 | 📋 | The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders |
| Melatonin | Epilepsy | 13 | PM | 24206906 | 📋 | Melatonin potentiates the anticonvulsant action of phenobarbital in neonatal rats |
| Melatonin | Epilepsy | 1 | PM | 22378657 | 📋 | Effect of melatonin on seizure frequency in intractable epilepsy: a pilot study |
| Melatonin | Glioblastoma | 7 | PM | 36359862 | 📋 | Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma |
| Melatonin | Glioblastoma | 6 | PM | 35388757 | 📋 | Melatonin inhibits the malignant progression of glioblastoma via regulating miR-16-5p/PIM1 |
| Melatonin | Glioblastoma | 5 | PM | 34418770 | 📋 | The role of melatonin in angio-miR-associated inhibition of tumorigenesis and invasion in human glioblastoma tumour spheroids |
| Melatonin | Glioblastoma | 2 | PM | 31870319 | 📋 | Inhibition of autophagy triggers melatonin-induced apoptosis in glioblastoma cells |
| Melatonin | Glioblastoma | 1 | PM | 29925764 | 📋 | Do Anti-Oxidants Vitamin D 3, Melatonin, and Alpha-Lipoic Acid Have Synergistic Effects With Temozolomide on Cultured Glioblastoma Cells? |
| Melatonin | Glioblastoma | 4 | PM | 28255276 | 📋 | Melatonin Inhibits Glioblastoma Stem-like cells through Suppression of EZH2-NOTCH1 Signaling Axis |
| Melatonin | Glioblastoma | 3 | PM | 27121240 | 📋 | Melatonin inhibits tumorigenicity of glioblastoma stem-like cells via the AKT-EZH2-STAT3 signaling axis |
| Melatonin | Glioma | 2 | PM | 33863521 | 📋 | miR-6858 plays a key role in the process of melatonin inhibition of the malignant biological behavior of glioma |
| Melatonin | Glioma | 1 | PM | 29408377 | 📋 | The melatonin-MT1 receptor axis modulates tumor growth in PTEN-mutated gliomas |
| Melatonin | Headache | 4 | PM | 33067764 | 📋 | Safety and Efficacy of Melatonin in Chronic Tension-Type Headache: A Post-Marketing Real-World Surveillance Program |
| Melatonin | Headache | 3 | PM | 27316772 | 📋 | The Role of Melatonin in the Treatment of Primary Headache Disorders |
| Melatonin | Headache | 1 | PM | 27027892 | 📋 | Melatonin 4 mg as prophylactic therapy for primary headaches: a pilot study |
| Melatonin | Headache | 2 | PM | 16548786 | 📋 | Potential therapeutic use of melatonin in migraine and other headache disorders |
| Melatonin | Hemorrhagic Stroke | 1 | PM | 28132129 | 📋 | Neuroprotective Mechanisms of Melatonin in Hemorrhagic Stroke |
| Melatonin | Hepatic Encephalopathy | 2 | PM | 35624703 | 📋 | Hepatic Encephalopathy and Melatonin |
| Melatonin | Hepatic Encephalopathy | 1 | PM | 35289256 | 📋 | Promising effects of naringenin and melatonin against hepatic encephalopathy impairments induced by bile duct ligation in male rats |
| Melatonin | Huntington's Disease | 2 | PM | 33334207 | 📋 | Melatonin and curcumin reestablish disturbed circadian gene expressions and restore locomotion ability and eclosion behavior in Drosophila model of Huntington's disease |
| Melatonin | Huntington's Disease | 1 | PM | 32182222 | 📋 | Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration |
| Melatonin | Hyperalgesia | 1 | PM | 32578137 | 📋 | Melatonin and Selenium Suppress Docetaxel-Induced TRPV1 Activation, Neuropathic Pain and Oxidative Neurotoxicity in Mice |
| Melatonin | Hyperalgesia | 2 | PM | 27546822 | 📋 | Melatonin as a potential counter-effect of hyperalgesia induced by neonatal morphine exposure |
| Melatonin | Hypnic Headache | 1 | PM | 27316772 | 📋 | The Role of Melatonin in the Treatment of Primary Headache Disorders |
| Melatonin | Hypnic Headache | 2 | PM | 16548786 | 📋 | Potential therapeutic use of melatonin in migraine and other headache disorders |
| Melatonin | Intracerebral Hemorrhage | 4 | PM | 33503014 | 📋 | Efficacy of melatonin in animal models of intracerebral hemorrhage: a systematic review and meta-analysis |
| Melatonin | Intracerebral Hemorrhage | 3 | PM | 32753840 | 📋 | Melatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats |
| Melatonin | Intracerebral Hemorrhage | 2 | PM | 32705396 | 📋 | Melatonin Attenuates Thrombin-induced Inflammation in BV2 Cells and Then Protects HT22 Cells from Apoptosis |
| Melatonin | Intracerebral Hemorrhage | 1 | PM | 32699918 | 📋 | The effect of melatonin on reduction in the need for sedative agents and duration of mechanical ventilation in traumatic intracranial hemorrhage patients: a randomized controlled trial |
| Melatonin | Intracerebral Hemorrhage | 5 | PM | 28766251 | 📋 | Melatonin Alleviates Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via Suppressing Apoptosis, Inflammation, Oxidative Stress, DNA Damage, and Mitochondria Injury |
| Melatonin | Ischemic Stroke | 19 | PM | 38791263 | 📋 | Melatonin Inhibits Hypoxia-Induced Alzheimer's Disease Pathogenesis by Regulating the Amyloidogenic Pathway in Human Neuroblastoma Cells |
| Melatonin | Ischemic Stroke | 18 | PM | 38289595 | 📋 | Melatonin improves stroke through MDM2-mediated ubiquitination of ACSL4 |
| Melatonin | Ischemic Stroke | 17 | PM | 38205686 | 📋 | Melatonin alleviates ischemic stroke by inhibiting ferroptosis through the CYP1B1/ACSL4 pathway |
| Melatonin | Ischemic Stroke | 16 | PM | 37301531 | 📋 | Melatonin regulates microglial polarization and protects against ischemic stroke-induced brain injury in mice |
| Melatonin | Ischemic Stroke | 15 | PM | 36181629 | 📋 | Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule |
| Melatonin | Ischemic Stroke | 14 | PM | 35307786 | 📋 | Delayed Therapeutic Administration of Melatonin Enhances Neuronal Survival Through AKT and MAPK Signaling Pathways Following Focal Brain Ischemia in Mice |
| Melatonin | Ischemic Stroke | 13 | PM | 34547676 | 📋 | Inflammatory Cytokines are in Action: Brain Plasticity and Recovery after Brain Ischemia Due to Delayed Melatonin Administration |
| Melatonin | Ischemic Stroke | 12 | PM | 34520636 | 📋 | Melatonin supplementation in the subacute phase after ischemia alleviates postischemic sleep disturbances in rats |
| Melatonin | Ischemic Stroke | 11 | PM | 34196879 | 📋 | Modulation of α7nAchR by Melatonin Alleviates Ischemia and Reperfusion-Compromised Integrity of Blood-Brain Barrier Through Inhibiting HMGB1-Mediated Microglia Activation and CRTC1-Mediated Neuronal Loss |
| Melatonin | Ischemic Stroke | 10 | PM | 34120482 | 📋 | Melatonin Protects Against Ischemic Brain Injury by Modulating PI3K/AKT Signaling Pathway via Suppression of PTEN Activity |
| Melatonin | Ischemic Stroke | 9 | PM | 33657679 | 📋 | Delirium REduction after Administration of Melatonin in acute ischemic Stroke (DREAMS): A Propensity Score Matched Analysis |
| Melatonin | Ischemic Stroke | 8 | PM | 33563490 | 📋 | Melatonin decreases circulating levels of galectin-3 and cytokines, motor activity, and anxiety following acute global cerebral ischemia in male rats |
| Melatonin | Ischemic Stroke | 7 | PM | 32973495 | 📋 | A Potent Antioxidant Endogenous Neurohormone Melatonin, Rescued MCAO by Attenuating Oxidative Stress-Associated Neuroinflammation |
| Melatonin | Ischemic Stroke | 6 | PM | 32962330 | 📋 | Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke |
| Melatonin | Ischemic Stroke | 1 | PM | 32729676 | 📋 | Melatonin against acute ischaemic stroke dependently via suppressing both inflammatory and oxidative stress downstream signallings |
| Melatonin | Ischemic Stroke | 3 | PM | 31793209 | 📋 | Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti-inflammatory phenotype through STAT3 pathway |
| Melatonin | Ischemic Stroke | 4 | PM | 28178380 | 📋 | Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings |
| Melatonin | Ischemic Stroke | 5 | PM | 26435711 | 📋 | Melatonin and Ischemic Stroke: Mechanistic Roles and Action |
| Melatonin | Ischemic Stroke | 2 | PM | 22330064 | 📋 | Melatonin ameliorates neural function by promoting endogenous neurogenesis through the MT2 melatonin receptor in ischemic-stroke mice |
| Melatonin | Meningitis | 1 | PM | 33808027 | 📋 | The Potentials of Melatonin in the Prevention and Treatment of Bacterial Meningitis Disease |
| Melatonin | Migraine | 12 | PM | 38751874 | 📋 | The Effect of Melatonin on Reducing the Frequency and Severity of Migraine Attacks: A Double-Blind, Randomized Clinical Trial |
| Melatonin | Migraine | 11 | PM | 36479001 | 📋 | Administration in Efficacy of Melatonin Reducing Headaches in Children With Migraines and Sleep Disorders: A Randomized Clinical Trial Study |
| Melatonin | Migraine | 10 | PM | 36445912 | 📋 | Efficacy and Safety of Melatonin as Prophylaxis for Migraine in Adults: A Meta-analysis |
| Melatonin | Migraine | 9 | PM | 36014841 | 📋 | The Pathogenetic Role of Melatonin in Migraine and Its Theoretic Implications for Pharmacotherapy: A Brief Overview of the Research |
| Melatonin | Migraine | 8 | PM | 33008513 | 📋 | Therapeutic role of melatonin in migraine prophylaxis: Is there a link between sleep and migraine? |
| Melatonin | Migraine | 7 | PM | 32965037 | 📋 | Melatonin for Acute Treatment of Migraine in Children and Adolescents: A Pilot Randomized Trial |
| Melatonin | Migraine | 1 | PM | 32352572 | 📋 | Endogenous Melatonin Levels and Therapeutic Use of Exogenous Melatonin in Migraine: Systematic Review and Meta-Analysis |
| Melatonin | Migraine | 2 | PM | 29379562 | 📋 | A Randomized Clinical Trial Comparing the Efficacy of Melatonin and Amitriptyline in Migraine Prophylaxis of Children |
| Melatonin | Migraine | 6 | PM | 28459893 | 📋 | PURLs: Consider melatonin for migraine prevention |
| Melatonin | Migraine | 5 | PM | 27316772 | 📋 | The Role of Melatonin in the Treatment of Primary Headache Disorders |
| Melatonin | Migraine | 3 | PM | 27165014 | 📋 | Randomised clinical trial comparing melatonin 3 mg, amitriptyline 25 mg and placebo for migraine prevention |
| Melatonin | Migraine | 4 | PM | 16548786 | 📋 | Potential therapeutic use of melatonin in migraine and other headache disorders |
| Melatonin | Movement Disorders | 1 | PM | 35708140 | 📋 | Effect of melatonin intake on postural balance, functional mobility and fall risk in persons with multiple sclerosis: a pilot study |
| Melatonin | Multiple Sclerosis | 13 | PM | 38428060 | 📋 | Effects of a nighttime melatonin ingestion on dynamic postural balance and muscle strength the following morning in people living with multiple sclerosis: A preliminary study |
| Melatonin | Multiple Sclerosis | 11 | PM | 38252220 | 📋 | The effects of melatonin supplementation on neurobehavioral outcomes and clinical severity in rodent models of multiple sclerosis; a systematic review and meta-analysis |
| Melatonin | Multiple Sclerosis | 10 | PM | 36153399 | 📋 | Melatonin ameliorates disease severity in a mouse model of multiple sclerosis by modulating the kynurenine pathway |
| Melatonin | Multiple Sclerosis | 9 | PM | 35807462 | 📋 | Beneficial Effect of Melatonin Alone or in Combination with Glatiramer Acetate and Interferon β-1b on Experimental Autoimmune Encephalomyelitis |
| Melatonin | Multiple Sclerosis | 8 | PM | 35708140 | 📋 | Effect of melatonin intake on postural balance, functional mobility and fall risk in persons with multiple sclerosis: a pilot study |
| Melatonin | Multiple Sclerosis | 7 | PM | 35665873 | 📋 | Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action |
| Melatonin | Multiple Sclerosis | 6 | PM | 35038645 | 📋 | Protective effects of melatonin on changes occurring in the experimental autoimmune encephalomyelitis model of multiple sclerosis |
| Melatonin | Multiple Sclerosis | 1 | PM | 32706187 | 📋 | Melatonin improves memory defects in a mouse model of multiple sclerosis by up-regulating cAMP-response element-binding protein and synapse-associated proteins in the prefrontal cortex |
| Melatonin | Multiple Sclerosis | 3 | PM | 30595364 | 📋 | Efficacy of Melatonin on Serum Pro-inflammatory Cytokines and Oxidative Stress Markers in Relapsing Remitting Multiple Sclerosis |
| Melatonin | Multiple Sclerosis | 12 | PM | 29193274 | 📋 | Melatonin therapy reduces the risk of osteoporosis and normalizes bone formation in multiple sclerosis |
| Melatonin | Multiple Sclerosis | 2 | PM | 27226183 | 📋 | Effect of melatonin supplementation on plasma lipid hydroperoxides, homocysteine concentration and chronic fatigue syndrome in multiple sclerosis patients treated with interferons-beta and mitoxantrone |
| Melatonin | Multiple Sclerosis | 5 | PM | 26359987 | 📋 | Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses |
| Melatonin | Multiple Sclerosis | 4 | PM | 26130320 | 📋 | Melatonin controls experimental autoimmune encephalomyelitis by altering the T effector/regulatory balance |
| Melatonin | Neonatal Encephalopathy | 11 | PM | 38775315 | 📋 | Melatonin reduces brain injury following inflammation-amplified hypoxia-ischemia in a translational newborn piglet study of neonatal encephalopathy |
| Melatonin | Neonatal Encephalopathy | 9 | PM | 37668036 | 📋 | [Research research on the use of melatonin in combination with therapeutic hypothermia for the treatment of neonatal hypoxic-ischemic encephalopathy] |
| Melatonin | Neonatal Encephalopathy | 8 | PM | 37627625 | 📋 | Melatonin as a Therapy for Preterm Brain Injury: What Is the Evidence? |
| Melatonin | Neonatal Encephalopathy | 7 | PM | 37321183 | 📋 | Melatonin Alters Innate Immune Function in Infants with Neonatal Encephalopathy |
| Melatonin | Neonatal Encephalopathy | 6 | PM | 36770769 | 📋 | Melatonin: A Potential Candidate for the Treatment of Experimental and Clinical Perinatal Asphyxia |
| Melatonin | Neonatal Encephalopathy | 5 | PM | 35413154 | 📋 | Efficacy of melatonin in term neonatal models of perinatal hypoxia-ischaemia |
| Melatonin | Neonatal Encephalopathy | 4 | PM | 35165613 | 📋 | Efficacy of Magnesium Sulfate in Addition to Melatonin Therapy in Neonates With Hypoxic-Ischemic Encephalopathy |
| Melatonin | Neonatal Encephalopathy | 1 | PM | 34067448 | 📋 | Melatonin for Neonatal Encephalopathy: From Bench to Bedside |
| Melatonin | Neonatal Encephalopathy | 3 | PM | 34032315 | 📋 | Melatonin augments the neuroprotective effects of hypothermia in lambs following perinatal asphyxia |
| Melatonin | Neonatal Encephalopathy | 2 | PM | 33604569 | 📋 | Melatonin and/or erythropoietin combined with hypothermia in a piglet model of perinatal asphyxia |
| Melatonin | Neonatal Encephalopathy | 10 | PM | 28796402 | 📋 | Protection of melatonin in experimental models of newborn hypoxic-ischemic brain injury through MT1 receptor |
| Melatonin | Neural Damage | 1 | PM | 34925714 | 📋 | Hippocampal Astrocyte Response to Melatonin Following Neural Damage Induction in Rats |
| Melatonin | Neural Tube Defects | 1 | PM | 38062774 | 📋 | Melatonin alleviates valproic acid-induced neural tube defects by modulating Src/PI3K/ERK signaling and oxidative stress |
| Melatonin | Neuralgia | 1 | PM | 26131073 | 📋 | Analgesic effects of melatonin on post-herpetic neuralgia |
| Melatonin | Neuroblastoma | 1 | PM | 28259965 | 📋 | Melatonin inhibits angiogenesis in SH-SY5Y human neuroblastoma cells by downregulation of VEGF |
| Melatonin | Neuroblastoma | 2 | PM | 27155536 | 📋 | Melatonin prevents cytosolic calcium overload, mitochondrial damage and cell death due to toxically high doses of dexamethasone-induced oxidative stress in human neuroblastoma SH-SY5Y cells |
| Melatonin | Neurodegenerative Disease | 29 | PM | 38791160 | 📋 | The Vital Role of Melatonin and Its Metabolites in the Neuroprotection and Retardation of Brain Aging |
| Melatonin | Neurodegenerative Disease | 28 | PM | 37469673 | 📋 | Neuroprotective effects of melatonin in neurodegenerative and autoimmune central nervous system diseases |
| Melatonin | Neurodegenerative Disease | 27 | PM | 36964661 | 📋 | Yet another in vitro evidence that natural compounds introduced by diet have anti-amyloidogenic activities and can counteract neurodegenerative disease depending on aging |
| Melatonin | Neurodegenerative Disease | 26 | PM | 36769340 | 📋 | Oxidative Stress and Aging as Risk Factors for Alzheimer's Disease and Parkinson's Disease: The Role of the Antioxidant Melatonin |
| Melatonin | Neurodegenerative Disease | 25 | PM | 36768703 | 📋 | Melatonin Can Modulate Neurodegenerative Diseases by Regulating Endoplasmic Reticulum Stress |
| Melatonin | Neurodegenerative Disease | 24 | PM | 36602704 | 📋 | Regulatory role of melatonin in Notch1 signaling pathway in cerebral cortex of Aβ1-42-induced Alzheimer's disease rat model |
| Melatonin | Neurodegenerative Disease | 23 | PM | 36080336 | 📋 | Chronic Treatment with Melatonin Improves Hippocampal Neurogenesis in the Aged Brain and Under Neurodegeneration |
| Melatonin | Neurodegenerative Disease | 22 | PM | 36018154 | 📋 | Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis |
| Melatonin | Neurodegenerative Disease | 21 | PM | 35721030 | 📋 | Melatonin as an Anti-Aging Therapy for Age-Related Cardiovascular and Neurodegenerative Diseases |
| Melatonin | Neurodegenerative Disease | 20 | PM | 35316766 | 📋 | Melatonin in ventricular and subarachnoid cerebrospinal fluid: Its function in the neural glymphatic network and biological significance for neurocognitive health |
| Melatonin | Neurodegenerative Disease | 19 | PM | 35015217 | 📋 | Screening the Efficacy of Melatonin on Neurodegeneration Mediated by Endoplasmic Reticulum Stress, Inflammation, and Oxidative Damage |
| Melatonin | Neurodegenerative Disease | 18 | PM | 34933727 | 📋 | Melatonin hormone as a therapeutic weapon against neurodegenerative diseases |
| Melatonin | Neurodegenerative Disease | 17 | PM | 34866924 | 📋 | Melatonin as a Potential Regulator of Oxidative Stress, and Neuroinflammation: Mechanisms and Implications for the Management of Brain Injury-Induced Neurodegeneration |
| Melatonin | Neurodegenerative Disease | 16 | PM | 34769013 | 📋 | Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders |
| Melatonin | Neurodegenerative Disease | 14 | PM | 34607253 | 📋 | Melatonin in neuroskeletal biology |
| Melatonin | Neurodegenerative Disease | 15 | PM | 34573116 | 📋 | Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders |
| Melatonin | Neurodegenerative Disease | 13 | PM | 34418564 | 📋 | Melatonin as a Promising Modulator of Aging Related Neurodegenerative Disorders: Role of microRNAs |
| Melatonin | Neurodegenerative Disease | 12 | PM | 34078880 | 📋 | Melatonin's neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders |
| Melatonin | Neurodegenerative Disease | 11 | PM | 33255515 | 📋 | Melatonin Rescues the Dendrite Collapse Induced by the Pro-Oxidant Toxin Okadaic Acid in Organotypic Cultures of Rat Hilar Hippocampus |
| Melatonin | Neurodegenerative Disease | 10 | PM | 32998479 | 📋 | Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases |
| Melatonin | Neurodegenerative Disease | 4 | PM | 32182222 | 📋 | Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration |
| Melatonin | Neurodegenerative Disease | 1 | PM | 32154907 | 📋 | Melatonin and Cannabinoids: Mitochondrial-Targeted Molecules That May Reduce Inflammaging in Neurodegenerative Diseases |
| Melatonin | Neurodegenerative Disease | 9 | PM | 31718830 | 📋 | Melatonin: A review of its potential functions and effects on neurological diseases |
| Melatonin | Neurodegenerative Disease | 3 | PM | 29907977 | 📋 | Melatonin induces mechanisms of brain resilience against neurodegeneration |
| Melatonin | Neurodegenerative Disease | 7 | PM | 29732485 | 📋 | Role of Melatonin in Aluminum-Related Neurodegenerative Disorders: a Review |
| Melatonin | Neurodegenerative Disease | 5 | PM | 27555536 | 📋 | Melatonin reverses H-89 induced spatial memory deficit: Involvement of oxidative stress and mitochondrial function |
| Melatonin | Neurodegenerative Disease | 8 | PM | 26499395 | 📋 | Effects of melatonin and its analogues on neural stem cells |
| Melatonin | Neurodegenerative Disease | 2 | PM | 26255301 | 📋 | Exogenous melatonin for sleep disorders in neurodegenerative diseases: a meta-analysis of randomized clinical trials |
| Melatonin | Neurodegenerative Disease | 6 | PM | 25988948 | 📋 | Melatonin attenuates impairments of structural hippocampal neuroplasticity in OXYS rats during active progression of Alzheimer's disease-like pathology |
| Melatonin | Neuroinflammation | 19 | PM | 38215799 | 📋 | Astrocyte response to melatonin treatment in rats under high-carbohydrate high-fat diet |
| Melatonin | Neuroinflammation | 18 | PM | 37302429 | 📋 | Melatonin modulates the aggravation of pyroptosis, necroptosis, and neuroinflammation following cerebral ischemia and reperfusion injury in obese rats |
| Melatonin | Neuroinflammation | 17 | PM | 36805045 | 📋 | Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury |
| Melatonin | Neuroinflammation | 16 | PM | 36566971 | 📋 | Melatonin alleviates BDE-209-induced cognitive impairment and hippocampal neuroinflammation by modulating microglia polarization via SIRT1-mediated HMGB1/TLR4/NF-κB pathway |
| Melatonin | Neuroinflammation | 15 | PM | 36538849 | 📋 | Melatonin promotes microglia toward anti-inflammatory phenotype after spinal cord injury |
| Melatonin | Neuroinflammation | 14 | PM | 35750198 | 📋 | Microglial polarization differentially affects neuronal vulnerability to the β-amyloid protein: Modulation by melatonin |
| Melatonin | Neuroinflammation | 13 | PM | 35008730 | 📋 | Associations between Melatonin, Neuroinflammation, and Brain Alterations in Depression |
| Melatonin | Neuroinflammation | 12 | PM | 34866924 | 📋 | Melatonin as a Potential Regulator of Oxidative Stress, and Neuroinflammation: Mechanisms and Implications for the Management of Brain Injury-Induced Neurodegeneration |
| Melatonin | Neuroinflammation | 11 | PM | 34808223 | 📋 | Role of melatonin in Tlr4-mediated inflammatory pathway in the mptp-induced mouse model |
| Melatonin | Neuroinflammation | 10 | PM | 34585328 | 📋 | Melatonin Reduces Neuroinflammation and Improves Axonal Hypomyelination by Modulating M1/M2 Microglia Polarization via JAK2-STAT3-Telomerase Pathway in Postnatal Rats Exposed to Lipopolysaccharide |
| Melatonin | Neuroinflammation | 9 | PM | 34267535 | 📋 | Melatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of Parkinson's Disease |
| Melatonin | Neuroinflammation | 8 | PM | 34144202 | 📋 | Melatonin ameliorates anxiety-like behaviors induced by sleep deprivation in mice: role of oxidative stress, neuroinflammation, autophagy and apoptosis |
| Melatonin | Neuroinflammation | 7 | PM | 33342257 | 📋 | Melatonin Reduces GSK3β-Mediated Tau Phosphorylation, Enhances Nrf2 Nuclear Translocation and Anti-Inflammation |
| Melatonin | Neuroinflammation | 6 | PM | 32973495 | 📋 | A Potent Antioxidant Endogenous Neurohormone Melatonin, Rescued MCAO by Attenuating Oxidative Stress-Associated Neuroinflammation |
| Melatonin | Neuroinflammation | 20 | PM | 32910356 | 📋 | Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis |
| Melatonin | Neuroinflammation | 5 | PM | 32802257 | 📋 | Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats |
| Melatonin | Neuroinflammation | 2 | PM | 32442902 | 📋 | Melatonin Alleviates Intestinal Injury, Neuroinflammation and Cognitive Dysfunction Caused by Intestinal Ischemia/Reperfusion |
| Melatonin | Neuroinflammation | 1 | PM | 32375205 | 📋 | Melatonin Prevents Neuroinflammation and Relieves Depression by Attenuating Autophagy Impairment Through FOXO3a Regulation |
| Melatonin | Neuroinflammation | 4 | PM | 30595364 | 📋 | Efficacy of Melatonin on Serum Pro-inflammatory Cytokines and Oxidative Stress Markers in Relapsing Remitting Multiple Sclerosis |
| Melatonin | Neuroinflammation | 3 | PM | 27012766 | 📋 | Melatonin reverses morphine tolerance by inhibiting microglia activation and HSP27 expression |
| Melatonin | Neurological Disorders | 7 | PM | 38821333 | 📋 | Exploring the impact of melatonin and omega-3, individually and in combination, on cognitive function, histological changes, and oxidant-antioxidant balance in male rats with dorsal CA1 hippocampal lesions |
| Melatonin | Neurological Disorders | 6 | PM | 38518598 | 📋 | Gut microbiota in neurological diseases: Melatonin plays an important regulatory role |
| Melatonin | Neurological Disorders | 4 | PM | 38001870 | 📋 | Melatonin in Neurodevelopmental Disorders: A Critical Literature Review |
| Melatonin | Neurological Disorders | 3 | PM | 36902233 | 📋 | Benefits of the Neurogenic Potential of Melatonin for Treating Neurological and Neuropsychiatric Disorders |
| Melatonin | Neurological Disorders | 2 | PM | 36431847 | 📋 | Melatonin: A Neurotrophic Factor? |
| Melatonin | Neurological Disorders | 1 | PM | 34087957 | 📋 | Melatonin salvages lead-induced neuro-cognitive shutdown, anxiety, and depressive-like symptoms via oxido-inflammatory and cholinergic mechanisms |
| Melatonin | Neurological Disorders | 5 | PM | 28967098 | 📋 | Epigenetic regulation of melatonin receptors in neuropsychiatric disorders |
| Melatonin | Neuronal Damage | 7 | PM | 38683122 | 📋 | Melatonin suppresses TLR4-mediated RSV infection in the central nervous cells by inhibiting NLRP3 inflammasome formation and autophagy |
| Melatonin | Neuronal Damage | 1 | PM | 36361683 | 📋 | Melatonin Attenuates H2O2-Induced Oxidative Injury by Upregulating LncRNA NEAT1 in HT22 Hippocampal Cells |
| Melatonin | Neuronal Damage | 5 | PM | 34925714 | 📋 | Hippocampal Astrocyte Response to Melatonin Following Neural Damage Induction in Rats |
| Melatonin | Neuronal Damage | 4 | PM | 34562506 | 📋 | The involvement of TRPV4 on the hypoxia-induced oxidative neurotoxicity and apoptosis in a neuronal cell line: Protective role of melatonin |
| Melatonin | Neuronal Damage | 3 | PM | 33219756 | 📋 | Melatonin attenuates branch chain fatty acid induced apoptosis mediated neurodegeneration |
| Melatonin | Neuronal Damage | 2 | PM | 32838711 | 📋 | Melatonin Protects HT22 Hippocampal Cells from H2O2-induced Injury by Increasing Beclin1 and Atg Protein Levels to Activate Autophagy |
| Melatonin | Neuronal Damage | 6 | PM | 29183837 | 📋 | Melatonin inhibits rotenone-induced SH-SY5Y cell death via the downregulation of Dynamin-Related Protein 1 expression |
| Melatonin | Neuropathic Pain | 6 | PM | 37978917 | 📋 | Melatonin Relieves Paclitaxel-Induced Neuropathic Pain by Regulating pNEK2-Dependent Epigenetic Pathways in DRG Neurons |
| Melatonin | Neuropathic Pain | 5 | PM | 37832908 | 📋 | Melatonin Improves Mitochondrial Dysfunction and Attenuates Neuropathic Pain by Regulating SIRT1 in Dorsal Root Ganglions |
| Melatonin | Neuropathic Pain | 4 | PM | 36747075 | 📋 | Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis |
| Melatonin | Neuropathic Pain | 1 | PM | 35496279 | 📋 | New Advances on Pathophysiology of Diabetes Neuropathy and Pain Management: Potential Role of Melatonin and DPP-4 Inhibitors |
| Melatonin | Neuropathic Pain | 3 | PM | 33508403 | 📋 | The anti-inflammatory and analgesic effects of intraperitoneal melatonin after spinal nerve ligation are mediated by inhibition of the NF-κB/NLRP3 inflammasome signaling pathway |
| Melatonin | Neuropathic Pain | 2 | PM | 32853748 | 📋 | Melatonin Reduces Neuropathic Pain Behavior and Glial Activation through MT 2 Melatonin Receptor Modulation in a Rat Model of Lysophosphatidylcholine-Induced Demyelination Neuropathy |
| Melatonin | Neurotoxicity | 30 | PM | 38813907 | 📋 | Melatonin mitigates cisplatin-induced cognitive impairment in rats and improves hippocampal dendritic spine density |
| Melatonin | Neurotoxicity | 29 | PM | 38598025 | 📋 | Melatonin is a Neuroprotective and Antioxidant Agent against Neurotoxicity Induced by an Intrahippocampal Injection of Nickel in Rats |
| Melatonin | Neurotoxicity | 28 | PM | 38447734 | 📋 | Melatonin mitigates manganese-induced neural damage via modulation of gut microbiota-metabolism in mice |
| Melatonin | Neurotoxicity | 24 | PM | 38183625 | 📋 | Melatonin ameliorates sevoflurane anesthesia-induced deficits in learning and memory of aged mice through Nrf2 signaling related ferroptosis |
| Melatonin | Neurotoxicity | 23 | PM | 38146034 | 📋 | Evaluating the Protective Effects of Melatonin Against Chronic Iron Administration in Male Wistar Rats: a Comparative Analysis of Affective, Cognitive, and Oxidative Stress with EDTA Chelator |
| Melatonin | Neurotoxicity | 22 | PM | 38036146 | 📋 | Melatonin inhibits atrazine-induced mitochondrial impairment in cerebellum of mice: Modulation of cGAS-STING-NLRP3 axis-dependent cell pyroptosis |
| Melatonin | Neurotoxicity | 21 | PM | 37931809 | 📋 | Melatonin attenuates sevoflurane-induced hippocampal damage and cognitive deficits in neonatal mice by suppressing CypD in parvalbumin neurons |
| Melatonin | Neurotoxicity | 20 | PM | 37915487 | 📋 | Melatonin treatment prevents carbon-tetrachloride induced rat brain injury |
| Melatonin | Neurotoxicity | 19 | PM | 37853305 | 📋 | Melatonin Attenuates Arsenic-Induced Neurotoxicity in Rats Through the Regulation of miR-34a/miR-144 in Sirt1/Nrf2 Pathway |
| Melatonin | Neurotoxicity | 17 | PM | 37042059 | 📋 | Melatonin protects against developmental PBDE-47 neurotoxicity by targeting the AMPK/mitophagy axis |
| Melatonin | Neurotoxicity | 16 | PM | 36896324 | 📋 | Amelioratory Effect of Melatonin on Cognition Dysfunction Induced by Sevoflurane Anesthesia in Aged Mice |
| Melatonin | Neurotoxicity | 15 | PM | 36566971 | 📋 | Melatonin alleviates BDE-209-induced cognitive impairment and hippocampal neuroinflammation by modulating microglia polarization via SIRT1-mediated HMGB1/TLR4/NF-κB pathway |
| Melatonin | Neurotoxicity | 14 | PM | 36515867 | 📋 | Neurotoxicity of Bisphenol A and the Impact of Melatonin Administration on Oxidative Stress, ERK/NF-kB Signaling Pathway, and Behavior in Rats |
| Melatonin | Neurotoxicity | 13 | PM | 36463981 | 📋 | Melatonin and metformin counteract cognitive dysfunction equally in male rats with doxorubicin-induced chemobrain |
| Melatonin | Neurotoxicity | 12 | PM | 36378265 | 📋 | Melatonin Protects Against Titanium Oxide-Induced Neurotoxicity: Neurochemical, Neurobehavioral, and Histopathological Evidences |
| Melatonin | Neurotoxicity | 11 | PM | 36217449 | 📋 | The Combination of Zinc and Melatonin Enhanced Neuroprotection and Attenuated Neuropathy in Oxaliplatin-Induced Neurotoxicity |
| Melatonin | Neurotoxicity | 10 | PM | 36091956 | 📋 | Melatonin attenuates spatial learning and memory dysfunction in developing rats by suppressing isoflurane-induced endoplasmic reticulum stress via the SIRT1/Mfn2/PERK signaling pathway |
| Melatonin | Neurotoxicity | 9 | PM | 36018437 | 📋 | Analysis of Melatonin-Modulating Effects Against Tartrazine-Induced Neurotoxicity in Male Rats: Biochemical, Pathological and Immunohistochemical Markers |
| Melatonin | Neurotoxicity | 8 | PM | 35952951 | 📋 | Neuroprotection by melatonin against acrylamide-induced brain damage in pinealectomized rats |
| Melatonin | Neurotoxicity | 7 | PM | 35873801 | 📋 | Melatonin Attenuates Methotrexate-Induced Reduction of Antioxidant Activity Related to Decreases of Neurogenesis in Adult Rat Hippocampus and Prefrontal Cortex |
| Melatonin | Neurotoxicity | 6 | PM | 35546266 | 📋 | Molecular mechanisms underlying ameliorative impact of melatonin against age-dependent chronic arsenic toxicity in rats' brains |
| Melatonin | Neurotoxicity | 5 | PM | 35451207 | 📋 | Melatonin is effective in attenuating cisplatin-induced neurotoxicity |
| Melatonin | Neurotoxicity | 1 | PM | 35388108 | 📋 | Melatonin reduces the endoplasmic reticulum stress and polyubiquitinated protein accumulation induced by repeated anesthesia exposure in Caenorhabditis elegans |
| Melatonin | Neurotoxicity | 2 | PM | 34120280 | 📋 | The potential neuroprotective effect of allicin and melatonin in acrylamide-induced brain damage in rats |
| Melatonin | Neurotoxicity | 4 | PM | 32738267 | 📋 | Neuroprotective effects of melatonin against neurotoxicity induced by intranasal sodium dimethyldithiocarbamate administration in mice |
| Melatonin | Neurotoxicity | 3 | PM | 32632567 | 📋 | The Protective Effect of Melatonin on Benzo(a)pyrene-Induced Brain Injury: Role of Apoptosis and Autophagy Pathways |
| Melatonin | Neurotoxicity | 27 | PM | 29149481 | 📋 | Neuroprotective effects of melatonin on amphetamine-induced dopaminergic fiber degeneration in the hippocampus of postnatal rats |
| Melatonin | Neurotoxicity | 26 | PM | 28576559 | 📋 | The neuroprotective effect of melatonin on the hippocampus exposed to diclofenac sodium during the prenatal period |
| Melatonin | Neurotoxicity | 25 | PM | 24733834 | 📋 | Protective effect of melatonin on propoxur-induced impairment of memory and oxidative stress in rats |
| Melatonin | Neurotoxicity | 18 | PM | 21986892 | 📋 | Biochemical and genetic alterations of oxidant/antioxidant status of the brain in rats treated with dexamethasone: protective roles of melatonin and acetyl-L-carnitine |
| Melatonin | Orofacial Pain | 2 | PM | 37207745 | 📋 | Melatonin promotes orofacial antinociception in adult zebrafish by modulating TRP channels |
| Melatonin | Orofacial Pain | 1 | PM | 35884835 | 📋 | Gut Bless Your Pain-Roles of the Gut Microbiota, Sleep, and Melatonin in Chronic Orofacial Pain and Depression |
| Melatonin | Pain | 14 | PM | 37720297 | 📋 | Melatonin as preemptive analgesic for intraoperative pain |
| Melatonin | Pain | 13 | PM | 36982488 | 📋 | Modulation of Melatonin in Pain Behaviors Associated with Oxidative Stress and Neuroinflammation Responses in an Animal Model of Central Post-Stroke Pain |
| Melatonin | Pain | 12 | PM | 36475244 | 📋 | The Effect of Preoperative Oral Melatonin on Postoperative Pain after Lumbar Disc Surgery: A Double-Blinded Randomized Clinical Trial |
| Melatonin | Pain | 11 | PM | 36199181 | 📋 | Melatonin synergizes with the antinociceptive effect of N-palmitoylethanolamide and paracetamol |
| Melatonin | Pain | 10 | PM | 36128304 | 📋 | The Effect of Preoperative Sublingual Melatonin on Postoperative Pain Severity in Patients Undergoing Colorectal Surgery: A Triple-Blinded Randomized Trial |
| Melatonin | Pain | 9 | PM | 36122662 | 📋 | Melatonin attenuates bone cancer pain via the SIRT1/HMGB1 pathway |
| Melatonin | Pain | 8 | PM | 35102121 | 📋 | The Effect of Melatonin on Radicular Pain in a Rat Model of Lumbar Disc Herniation |
| Melatonin | Pain | 7 | PM | 34315312 | 📋 | Melatonin Abates TMJOA Chronic Pain by MT 2 R in Trigeminal Ganglion Neurons |
| Melatonin | Pain | 3 | PM | 34040762 | 📋 | Effects of preoperative melatonin on postoperative pain following cesarean section: A randomized clinical trial |
| Melatonin | Pain | 2 | PM | 32925224 | 📋 | The antinociceptive mechanisms of melatonin: role of L-arginine/nitric oxide/cyclic GMP/KATP channel signaling pathway |
| Melatonin | Pain | 4 | PM | 32706079 | 📋 | Involvement of nNOS in the antinociceptive activity of melatonin in inflammatory pain at the level of sensory neurons |
| Melatonin | Pain | 1 | PM | 32413745 | 📋 | Melatonin Alleviates Morphine Analgesic Tolerance in Mice by Decreasing NLRP3 Inflammasome Activation |
| Melatonin | Pain | 5 | PM | 29246003 | 📋 | Exogenous melatonin in the treatment of pain: a systematic review and meta-analysis |
| Melatonin | Pain | 6 | PM | 27697139 | 📋 | The analgesic effects of exogenous melatonin in humans |
| Melatonin | Parkinson's Disease | 18 | PM | 38259379 | 📋 | Neuroprotective Potential of Melatonin: Evaluating Therapeutic Efficacy in Alzheimer's and Parkinson's Diseases |
| Melatonin | Parkinson's Disease | 17 | PM | 37881313 | 📋 | Significant potential of melatonin therapy in Parkinson's disease - a meta-analysis of randomized controlled trials |
| Melatonin | Parkinson's Disease | 16 | PM | 36872990 | 📋 | Melatonin Mitigates Rotenone-Induced Oxidative Stress and Mitochondrial Dysfunction in the Drosophila melanogaster Model of Parkinson's Disease-like Symptoms |
| Melatonin | Parkinson's Disease | 15 | PM | 36223003 | 📋 | The effects of regular swimming exercise and melatonin on the neurons localized in the striatum of hemiparkinsonian rats |
| Melatonin | Parkinson's Disease | 14 | PM | 35810592 | 📋 | Melatonin attenuates MPP +-induced apoptosis via heat shock protein in a Parkinson's disease model |
| Melatonin | Parkinson's Disease | 13 | PM | 35803929 | 📋 | Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway |
| Melatonin | Parkinson's Disease | 12 | PM | 35536495 | 📋 | Effects of melatonin prolonged-release on both sleep and motor symptoms in Parkinson's disease: a preliminary evidence |
| Melatonin | Parkinson's Disease | 11 | PM | 35185525 | 📋 | Melatonin Treatment for Sleep Disorders in Parkinson's Disease: A Meta-Analysis and Systematic Review |
| Melatonin | Parkinson's Disease | 10 | PM | 34707777 | 📋 | Effect of Melatonin Administration on Mitochondrial Activity and Oxidative Stress Markers in Patients with Parkinson's Disease |
| Melatonin | Parkinson's Disease | 9 | PM | 34339012 | 📋 | Melatonin Increases Life Span, Restores the Locomotor Activity, and Reduces Lipid Peroxidation (LPO) in Transgenic Knockdown Parkin Drosophila melanogaster Exposed to Paraquat or Paraquat/Iron |
| Melatonin | Parkinson's Disease | 8 | PM | 34267535 | 📋 | Melatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of Parkinson's Disease |
| Melatonin | Parkinson's Disease | 7 | PM | 33935759 | 📋 | Melatonin as a Chronobiotic and Cytoprotective Agent in Parkinson's Disease |
| Melatonin | Parkinson's Disease | 6 | PM | 33403591 | 📋 | Beneficial Effect of Melatonin on Motor and Memory Disturbances in 6-OHDA-Lesioned Rats |
| Melatonin | Parkinson's Disease | 2 | PM | 32738267 | 📋 | Neuroprotective effects of melatonin against neurotoxicity induced by intranasal sodium dimethyldithiocarbamate administration in mice |
| Melatonin | Parkinson's Disease | 1 | PM | 32417629 | 📋 | Melatonin Supplementation and the Effects on Clinical and Metabolic Status in Parkinson's Disease: A Randomized, Double-Blind, Placebo-Controlled Trial |
| Melatonin | Parkinson's Disease | 3 | PM | 30055549 | 📋 | Melatonin Improves Behavioral and Biochemical Outcomes in a Rotenone-Induced Rat Model of Parkinson's Disease |
| Melatonin | Parkinson's Disease | 19 | PM | 29138117 | 📋 | Melatonin protects against behavioral deficits, dopamine loss and oxidative stress in homocysteine model of Parkinson's disease |
| Melatonin | Parkinson's Disease | 5 | PM | 27159033 | 📋 | Melatonin prevents the dynamin-related protein 1-dependent mitochondrial fission and oxidative insult in the cortical neurons after 1-methyl-4-phenylpyridinium treatment |
| Melatonin | Parkinson's Disease | 4 | PM | 26292069 | 📋 | Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation |
| Melatonin | Peripheral Nerve Injury | 8 | PM | 37832908 | 📋 | Melatonin Improves Mitochondrial Dysfunction and Attenuates Neuropathic Pain by Regulating SIRT1 in Dorsal Root Ganglions |
| Melatonin | Peripheral Nerve Injury | 7 | PM | 36937512 | 📋 | The effects of melatonin in the treatment of acute brachial plexus compression injury in rats |
| Melatonin | Peripheral Nerve Injury | 6 | PM | 36299487 | 📋 | Melatonin signalling in Schwann cells during neuroregeneration |
| Melatonin | Peripheral Nerve Injury | 5 | PM | 35770586 | 📋 | Comparison of the Effects of Electroacupuncture and Melatonin on Nerve Regeneration in Experimentally Nerve-Damaged Rats |
| Melatonin | Peripheral Nerve Injury | 4 | PM | 35765532 | 📋 | Melatonin Induced Schwann Cell Proliferation and Dedifferentiation Through NF-ĸB, FAK-Dependent but Src-Independent Pathways |
| Melatonin | Peripheral Nerve Injury | 3 | PM | 35504358 | 📋 | Melatonin promotes peripheral nerve repair through Parkin-mediated mitophagy |
| Melatonin | Peripheral Nerve Injury | 2 | PM | 32939783 | 📋 | Melatonin promotes regeneration of injured motor axons via MT 1 receptors |
| Melatonin | Peripheral Nerve Injury | 1 | PM | 32934681 | 📋 | Melatonin promotes Schwann cell dedifferentiation and proliferation through the Ras/Raf/ERK and MAPK pathways, and glial cell-derived neurotrophic factor expression |
| Melatonin | Peripheral Neuropathy | 1 | PM | 32578137 | 📋 | Melatonin and Selenium Suppress Docetaxel-Induced TRPV1 Activation, Neuropathic Pain and Oxidative Neurotoxicity in Mice |
| Melatonin | Pituitary Tumor | 1 | PM | 16499559 | 📋 | Inhibitory effects of melatonin on the growth of pituitary prolactin-secreting tumor in rats |
| Melatonin | Pituitary Tumor | 2 | PM | 11150887 | 📋 | Antiproliferative effect and cell cycle modulation by melatonin on GH(3) cells |
| Melatonin | Prion Diseases | 1 | PM | 32526704 | 📋 | Melatonin Regulates Mitochondrial Dynamics and Alleviates Neuron Damage in Prion Diseases |
| Melatonin | Pruritus | 3 | PM | 36267771 | 📋 | Melatonin attenuates acute and chronic itch in mice: the antioxidant and anti-inflammatory effects of melatonin receptors |
| Melatonin | Pruritus | 1 | PM | 35283519 | 📋 | The Association between Melatonin Levels and Sleep Quality in Patients with Pruritus: A Potential Biomarker on a Candidate Future Treatment |
| Melatonin | Pruritus | 2 | PM | 34567175 | 📋 | A Pilot Randomized, Clinical Trial of the Anti-pruritus Effect of Melatonin in Patients with Chronic Liver Disease |
| Melatonin | Psychiatric Disorders | 5 | PM | 36227449 | 📋 | Role of Melatonin in the Management of Sleep and Circadian Disorders in the Context of Psychiatric Illness |
| Melatonin | Psychiatric Disorders | 4 | PM | 34095150 | 📋 | Melatonin Regulates the Neurotransmitter Secretion Disorder Induced by Caffeine Through the Microbiota-Gut-Brain Axis in Zebrafish ( Danio rerio) |
| Melatonin | Psychiatric Disorders | 3 | PM | 34078880 | 📋 | Melatonin's neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders |
| Melatonin | Psychiatric Disorders | 2 | PM | 33349460 | 📋 | Use of immediate release melatonin in psychiatry: BMI impacts the daily-dose |
| Melatonin | Psychiatric Disorders | 1 | PM | 26475510 | 📋 | Administration of N-acetylserotonin and melatonin alleviate chronic ketamine-induced behavioural phenotype accompanying BDNF-independent and dependent converging cytoprotective mechanisms in the hippocampus |
| Melatonin | Psychotic Disorders | 1 | PM | 34605448 | 📋 | Pharmacological and philosophical considerations for the around-the-clock use of scheduled melatonin to promote sedation and reduce aggression in individuals with serious mental illness: a case report |
| Melatonin | Radiculopathy | 1 | PM | 34398134 | 📋 | Melatonin Alleviates Radiculopathy Against Apoptosis and NLRP3 Inflammasomes Via the Parkin-Mediated Mitophagy Pathway |
| Melatonin | Rheumatoid Arthritis | 1 | PM | 28585236 | 📋 | Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes |
| Melatonin | Schizophrenia | 3 | PM | 37383960 | 📋 | Evaluating the Effect of Melatonin on Positive and Negative Symptoms of Schizophrenic Patients: A Randomized Placebo-Controlled Study |
| Melatonin | Schizophrenia | 2 | PM | 34513608 | 📋 | Therapeutic use of melatonin in schizophrenia: A systematic review |
| Melatonin | Schizophrenia | 1 | PM | 27697587 | 📋 | Reversal of schizophrenia-like symptoms and immune alterations in mice by immunomodulatory drugs |
| Melatonin | Sciatic Nerve Injury | 1 | PM | 33022764 | 📋 | Melatonin promotes Schwann cell proliferation and migration via the shh signalling pathway after peripheral nerve injury |
| Melatonin | Sciatica | 1 | PM | 31611748 | 📋 | Comparison of Melatonin and Curcumin Effect at the Light and Dark Periods on Regeneration of Sciatic Nerve Crush Injury in Rats |
| Melatonin | Seizures | 4 | PM | 35507790 | 📋 | The effects of vitamin D3 and melatonin combination on pentylenetetrazole-induced seizures in mice |
| Melatonin | Seizures | 3 | PM | 34165417 | 📋 | Anti-Convulsive Effect of Thiamine and Melatonin Combination in Mice; Involvement of Oxidative Stress |
| Melatonin | Seizures | 2 | PM | 34165162 | 📋 | Treatment with melatonin ameliorates febrile convulsion via modulating the MEG3/miR‑223/PTEN/AKT signaling pathway |
| Melatonin | Seizures | 1 | PM | 33641195 | 📋 | Effect of add-on melatonin on seizure outcome, neuronal damage, oxidative stress, and quality of life in generalized epilepsy with generalized onset motor seizures in adults: A randomized controlled trial |
| Melatonin | Spinal Cord Injury | 16 | PM | 38125360 | 📋 | Melatonin exerts neuroprotective effects in mice with spinal cord injury by activating the Nrf2/Keap1 signaling pathway via the MT2 receptor |
| Melatonin | Spinal Cord Injury | 15 | PM | 37865165 | 📋 | Melatonin protects injured spinal cord neurons from apoptosis by inhibiting mitochondrial damage via the SIRT1/Drp1 signaling pathway |
| Melatonin | Spinal Cord Injury | 14 | PM | 37786299 | 📋 | Melatonin Exerts an Anti-Panoptoic Role in Spinal Cord Ischemia-Reperfusion Injured Rats |
| Melatonin | Spinal Cord Injury | 13 | PM | 37691830 | 📋 | Melatonin, a natural antioxidant therapy in spinal cord injury |
| Melatonin | Spinal Cord Injury | 12 | PM | 36538849 | 📋 | Melatonin promotes microglia toward anti-inflammatory phenotype after spinal cord injury |
| Melatonin | Spinal Cord Injury | 11 | PM | 36139384 | 📋 | Melatonin Attenuates Spinal Cord Injury in Mice by Activating the Nrf2/ARE Signaling Pathway to Inhibit the NLRP3 Inflammasome |
| Melatonin | Spinal Cord Injury | 10 | PM | 35095480 | 📋 | Melatonin Synergizes With Methylprednisolone to Ameliorate Acute Spinal Cord Injury |
| Melatonin | Spinal Cord Injury | 9 | PM | 33497543 | 📋 | Role of melatonin in the dynamics of acute spinal cord injury in rats |
| Melatonin | Spinal Cord Injury | 8 | PM | 33380311 | 📋 | Intrathecal Administration of Melatonin Ameliorates the Neuroinflammation-mediated Sensory and Motor Dysfunction in a rat Model of Compression Spinal Cord Injury |
| Melatonin | Spinal Cord Injury | 7 | PM | 32893892 | 📋 | The effect of the "segment" of spinal cord injury on the activity of the nucleotide-binding domain-like receptor protein 3 inflammasome and response to hormonal therapy |
| Melatonin | Spinal Cord Injury | 1 | PM | 32514788 | 📋 | Neuroprotection of Melatonin on Spinal Cord Injury by Activating Autophagy and Inhibiting Apoptosis via SIRT1/AMPK Signaling Pathway |
| Melatonin | Spinal Cord Injury | 5 | PM | 31902595 | 📋 | Melatonin exerts neuroprotective effects by attenuating astro- and microgliosis and suppressing inflammatory response following spinal cord injury |
| Melatonin | Spinal Cord Injury | 6 | PM | 30693824 | 📋 | Melatonin Treatment Alleviates Spinal Cord Injury-Induced Gut Dysbiosis in Mice |
| Melatonin | Spinal Cord Injury | 2 | PM | 16231427 | 📋 | Dose-dependent neuroprotective effects of melatonin on experimental spinal cord injury in rats |
| Melatonin | Spinal Cord Injury | 3 | PM | 15232723 | 📋 | Effect of combined treatment with melatonin and methylprednisolone on neurological recovery after experimental spinal cord injury |
| Melatonin | Spinal Cord Injury | 4 | PM | 10879762 | 📋 | Comparison of the effects of melatonin and methylprednisolone in experimental spinal cord injury |
| Melatonin | Stress | 1 | PM | 34289399 | 📋 | Melatonin improves learning and memory of mice with chronic social isolation stress via an interaction between microglia polarization and BDNF/TrkB/CREB signaling pathway |
| Melatonin | Stress | 5 | PM | 33165196 | 📋 | Melatonin ameliorated CUMS-induced depression-like behavior via restoring endoplasmic reticulum stress in rat hippocampus |
| Melatonin | Stress | 4 | PM | 26528359 | 📋 | Melatonin is more effective than ascorbic acid and β-carotene in improvement of gastric mucosal damage induced by intensive stress |
| Melatonin | Stroke | 4 | PM | 36465183 | 📋 | Melatonin as an Antioxidant Agent in Stroke: An Updated Review |
| Melatonin | Stroke | 3 | PM | 35948118 | 📋 | Modulation of autophagy by melatonin via sirtuins in stroke: From mechanisms to therapies |
| Melatonin | Stroke | 5 | PM | 32910356 | 📋 | Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis |
| Melatonin | Stroke | 1 | PM | 32513932 | 📋 | Melatonin-induced ApoE Expression in Mouse Astrocytes Protects Endothelial Cells From OGD-R Induced Injuries |
| Melatonin | Stroke | 2 | PM | 26497887 | 📋 | Melatonin as an Antioxidant for Stroke Neuroprotection |
| Melatonin | Subarachnoid Hemorrhage | 8 | PM | 37717795 | 📋 | Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage |
| Melatonin | Subarachnoid Hemorrhage | 7 | PM | 35572137 | 📋 | Melatonin as a Potential Neuroprotectant: Mechanisms in Subarachnoid Hemorrhage-Induced Early Brain Injury |
| Melatonin | Subarachnoid Hemorrhage | 6 | PM | 35170388 | 📋 | Melatonin affects hypoxia-inducible factor 1α and ameliorates delayed brain injury following subarachnoid hemorrhage via H19/miR-675/HIF1A/TLR4 |
| Melatonin | Subarachnoid Hemorrhage | 5 | PM | 34539547 | 📋 | Efficacy of Melatonin in Animal Models of Subarachnoid Hemorrhage: A Systematic Review and Stratified Meta-Analysis |
| Melatonin | Subarachnoid Hemorrhage | 1 | PM | 32705666 | 📋 | Melatonin Attenuate White Matter Injury via Reducing Oligodendrocyte Apoptosis After Subarachnoid Hemorrhage in Mice |
| Melatonin | Subarachnoid Hemorrhage | 3 | PM | 30210141 | 📋 | Melatonin Upregulates Nuclear Factor Erythroid-2 Related Factor 2 (Nrf2) and Mediates Mitophagy to Protect Against Early Brain Injury After Subarachnoid Hemorrhage |
| Melatonin | Subarachnoid Hemorrhage | 4 | PM | 30174621 | 📋 | Antioxidant Melatonin: Potential Functions in Improving Cerebral Autoregulation After Subarachnoid Hemorrhage |
| Melatonin | Subarachnoid Hemorrhage | 2 | PM | 27865517 | 📋 | Effects of melatonin in the treatment of asthenia in aneurysmal subarachnoid hemorrhage |
| Melatonin | Subarachnoid Hemorrhage | 9 | PM | 24033352 | 📋 | Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage |
| Melatonin | Tinnitus | 1 | PM | 21859051 | 📋 | Melatonin: can it stop the ringing? |
| Melatonin | Tinnitus | 2 | PM | 16455366 | 📋 | The effects of melatonin on tinnitus and sleep |
| Melatonin | Tinnitus | 3 | PM | 9504599 | 📋 | Effect of melatonin on tinnitus |
| Melatonin | Traumatic Brain Injury | 19 | PM | 38531791 | 📋 | Melatonin's Protective Effects on Neurons in an in Vitro Cell Injury Model |
| Melatonin | Traumatic Brain Injury | 17 | PM | 36805045 | 📋 | Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury |
| Melatonin | Traumatic Brain Injury | 16 | PM | 36157079 | 📋 | Protective effects and regulatory pathways of melatonin in traumatic brain injury mice model: Transcriptomics and bioinformatics analysis |
| Melatonin | Traumatic Brain Injury | 15 | PM | 35753614 | 📋 | Melatonin mitigates traumatic brain injury-induced depression-like behaviors through HO-1/CREB signal in rats |
| Melatonin | Traumatic Brain Injury | 14 | PM | 35261620 | 📋 | Melatonin alleviates traumatic brain injury-induced anxiety-like behaviors in rats: Roles of the protein kinase A/cAMP-response element binding signaling pathway |
| Melatonin | Traumatic Brain Injury | 13 | PM | 34925714 | 📋 | Hippocampal Astrocyte Response to Melatonin Following Neural Damage Induction in Rats |
| Melatonin | Traumatic Brain Injury | 12 | PM | 34883251 | 📋 | A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of traumatic brain injury |
| Melatonin | Traumatic Brain Injury | 11 | PM | 34866924 | 📋 | Melatonin as a Potential Regulator of Oxidative Stress, and Neuroinflammation: Mechanisms and Implications for the Management of Brain Injury-Induced Neurodegeneration |
| Melatonin | Traumatic Brain Injury | 9 | PM | 34659987 | 📋 | Melatonin in Traumatic Brain Injury and Cognition |
| Melatonin | Traumatic Brain Injury | 8 | PM | 34607259 | 📋 | Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation |
| Melatonin | Traumatic Brain Injury | 10 | PM | 33766734 | 📋 | Androgen is responsible for enhanced susceptibility of melatonin against traumatic brain injury in females |
| Melatonin | Traumatic Brain Injury | 7 | PM | 33370520 | 📋 | Effect of melatonin on regeneration of cortical neurons in rats with traumatic brain injury |
| Melatonin | Traumatic Brain Injury | 6 | PM | 32959092 | 📋 | Melatonin ameliorates spatial memory and motor deficits via preserving the integrity of cortical and hippocampal dendritic spine morphology in mice with neurotrauma |
| Melatonin | Traumatic Brain Injury | 18 | PM | 32468441 | 📋 | Melatonin Provides Neuroprotection Following Traumatic Brain Injury-Promoted Mitochondrial Perturbation in Wistar Rat |
| Melatonin | Traumatic Brain Injury | 1 | PM | 29901413 | 📋 | Melatonin as a Treatment after Traumatic Brain Injury: A Systematic Review and Meta-Analysis of the Pre-Clinical and Clinical Literature |
| Melatonin | Traumatic Brain Injury | 2 | PM | 27159133 | 📋 | Melatonin attenuates neuronal apoptosis through up-regulation of K(+) -Cl(-) cotransporter KCC2 expression following traumatic brain injury in rats |
| Melatonin | Traumatic Brain Injury | 5 | PM | 27152411 | 📋 | Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition |
| Melatonin | Traumatic Brain Injury | 4 | PM | 27117839 | 📋 | Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy |
| Melatonin | Traumatic Brain Injury | 3 | PM | 25206769 | 📋 | Melatonin reduces traumatic brain injury-induced oxidative stress in the cerebral cortex and blood of rats |
| Melatonin | Uremic Pruritus | 1 | PM | 33492303 | 📋 | Evaluation of Antipruritic Effect of Melatonin on Hemodialysis Patients with Uremic Pruritus, A Double-Blind, Randomized, Crossover Trial |
| Melatonin | Vascular Dementia | 2 | PM | 37017851 | 📋 | Melatonin suppresses inflammation and blood‒brain barrier disruption in rats with vascular dementia possibly by activating the SIRT1/PGC-1α/PPARγ signaling pathway |
| Melatonin | Vascular Dementia | 1 | PM | 29088788 | 📋 | Melatonin attenuated the brain damage and cognitive impairment partially through MT2 melatonin receptor in mice with chronic cerebral hypoperfusion |
