| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Grape Seed extract | Age-Related Cognitive Decline | 1 | PM | 33970818 | 📋 | Grape seed extract effects on hippocampal neurogenesis, synaptogenesis and dark neurons production in old mice. Can this extract improve learning and memory in aged animals? |
| Grape Seed extract | Age-Related Cognitive Decline | 2 | PM | 28993969 | 📋 | Grape Seed Proanthocyanidin and Swimming Exercise Protects Against Cognitive Decline: A Study on M1 Acetylcholine Receptors in Aging Male Rat Brain |
| Grape Seed extract | Alzheimer's Disease | 3 | PM | 32681248 | 📋 | Grape Seed Proanthocyanidin Extract Ameliorates Streptozotocin-induced Cognitive and Synaptic Plasticity Deficits by Inhibiting Oxidative Stress and Preserving AKT and ERK Activities |
| Grape Seed extract | Alzheimer's Disease | 4 | PM | 27219682 | 📋 | Non-polyphenolic compounds of a specific kind of dried grape (Maviz) inhibit memory impairments induced by beta-amyloid peptide |
| Grape Seed extract | Alzheimer's Disease | 5 | PM | 24157371 | 📋 | Gallic acid is the major component of grape seed extract that inhibits amyloid fibril formation |
| Grape Seed extract | Alzheimer's Disease | 1 | PM | 21743132 | 📋 | Grape Seed Polyphenolic Extract Specifically Decreases aβ*56 in the Brains of Tg2576 Mice |
| Grape Seed extract | Alzheimer's Disease | 6 | PM | 21196065 | 📋 | Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols |
| Grape Seed extract | Alzheimer's Disease | 2 | PM | 19027755 | 📋 | Grape Seed Polyphenols and Curcumin Reduce Genomic Instability Events in a Transgenic Mouse Model for Alzheimer's Disease |
| Grape Seed extract | Brain Injury | 1 | PM | 28693689 | 📋 | Neuroprotective Effects of Grape Seed Procyanidin Extract on Ischemia-Reperfusion Brain Injury |
| Grape Seed extract | Brain Injury | 2 | PM | 28076832 | 📋 | Dietary supplementation of grape seed and skin flour mitigates brain oxidative damage induced by a high-fat diet in rat: Gender dependency |
| Grape Seed extract | Chronic Stress | 1 | PM | 35411989 | 📋 | Protective effect of grape seed extract against chronic physical stress-induced zona fasciculata injury in male rats: Functional, immunohistochemical and electron microscopic study |
| Grape Seed extract | Depression | 2 | PM | 33427592 | 📋 | Grape seed proanthocyanidins improves depression-like behavior by alleviating oxidative stress and NLRP3 activation in the hippocampus of prenatally-stressed female offspring rats |
| Grape Seed extract | Depression | 1 | PM | 31074515 | 📋 | Grape-derived Polyphenols Produce Antidepressant Effects via VGF- And BDNF-dependent Mechanisms |
| Grape Seed extract | Diabetic Neuropathy | 3 | PM | 24343984 | 📋 | Functional and morphological effects of grape seed proanthocyanidins on peripheral neuropathy in rats with type 2 diabetes mellitus |
| Grape Seed extract | Diabetic Neuropathy | 2 | PM | 24009454 | 📋 | Neuroprotective effects of Vitis vinifera extract on prediabetic mice induced by a high-fat diet |
| Grape Seed extract | Diabetic Neuropathy | 1 | PM | 18797155 | 📋 | Effects of Grape Seed Proanthocyanidin Extracts on Peripheral Nerves in Streptozocin-Induced Diabetic Rats |
| Grape Seed extract | Encephalomyelitis | 1 | PM | 36059517 | 📋 | Antioxidant effect of grape seed extract corrects experimental autoimmune encephalomyelitis behavioral dysfunctions, demyelination, and glial activation |
| Grape Seed extract | Epilepsy | 1 | PM | 34619539 | 📋 | Proanthocyanidin from Vitis vinifera attenuates memory impairment due to convulsive status epilepticus |
| Grape Seed extract | Epilepsy | 2 | PM | 23524183 | 📋 | The involvement of iNOS activity in the anticonvulsant effect of grape seed extract on the penicillin-induced epileptiform activity in rats |
| Grape Seed extract | Glioma | 1 | PM | 19167369 | 📋 | Inhibition of U-87 Human Glioblastoma Cell Proliferation and Formyl Peptide Receptor Function by Oligomer Procyanidins (F2) Isolated From Grape Seeds |
| Grape Seed extract | HIV/AIDS | 2 | PM | 35178129 | 📋 | Polyphenol Extracts from Grape Seeds and Apple Can Reactivate Latent HIV-1 Transcription through Promoting P-TEFb Release from 7SK snRNP |
| Grape Seed extract | HIV/AIDS | 1 | PM | 12462994 | 📋 | Grape Seed Extract Proanthocyanidins Downregulate HIV-1 Entry Coreceptors, CCR2b, CCR3 and CCR5 Gene Expression by Normal Peripheral Blood Mononuclear Cells |
| Grape Seed extract | Ischemic Stroke | 1 | PM | 33485068 | 📋 | Protective effect of grape seed extract and orlistat co-treatment against stroke: Effect on oxidative stress and energy failure |
| Grape Seed extract | Ischemic Stroke | 2 | PM | 30835051 | 📋 | Grape seed proanthocyanidins attenuate apoptosis in ischemic stroke |
| Grape Seed extract | Migraine | 1 | PM | 35295808 | 📋 | Inhibition of Nociception in a Preclinical Episodic Migraine Model by Dietary Supplementation of Grape Seed Extract Involves Activation of Endocannabinoid Receptors |
| Grape Seed extract | Multiple Sclerosis | 2 | PM | 36607588 | 📋 | Grape Seed Extract Attenuates Demyelination in Experimental Autoimmune Encephalomyelitis Mice by Inhibiting Inflammatory Response of Immune Cells |
| Grape Seed extract | Multiple Sclerosis | 1 | PM | 36059517 | 📋 | Antioxidant effect of grape seed extract corrects experimental autoimmune encephalomyelitis behavioral dysfunctions, demyelination, and glial activation |
| Grape Seed extract | Neonatal Encephalopathy | 1 | PM | 31147852 | 📋 | Pretreatment of Grape Seed Proanthocyanidin Extract Exerts Neuroprotective Effect in Murine Model of Neonatal Hypoxic-ischemic Brain Injury by Its Antiapoptotic Property |
| Grape Seed extract | Neurodegenerative Disease | 1 | PM | 33401699 | 📋 | Natural Food Supplements Reduce Oxidative Stress in Primary Neurons and in the Mouse Brain, Suggesting Applications in the Prevention of Neurodegenerative Diseases |
| Grape Seed extract | Neurodegenerative Disease | 2 | PM | 33207644 | 📋 | Effects of Grape Polyphenols on the Life Span and Neuroinflammatory Alterations Related to Neurodegenerative Parkinson Disease-Like Disturbances in Mice |
| Grape Seed extract | Neurodegenerative Disease | 3 | PM | 22054871 | 📋 | GSPE interferes with tau aggregation in vivo: implication for treating tauopathy |
| Grape Seed extract | Neuroinflammation | 2 | PM | 35043135 | 📋 | Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a D-galactose-induced aging mouse model by modulating the gut microbiota |
| Grape Seed extract | Neuroinflammation | 1 | PM | 33207644 | 📋 | Effects of Grape Polyphenols on the Life Span and Neuroinflammatory Alterations Related to Neurodegenerative Parkinson Disease-Like Disturbances in Mice |
| Grape Seed extract | Neurological Disorders | 1 | PM | 35343876 | 📋 | The benefits of grape seed extract in neurological disorders and brain aging |
| Grape Seed extract | Neuronal Damage | 2 | PM | 31236816 | 📋 | Alleviation Effect of Grape Seed Proanthocyanidins on Neuronal Apoptosis in Rats with Iron Overload |
| Grape Seed extract | Neuronal Damage | 1 | PM | 21283677 | 📋 | Differential neuroprotective activity of two different grape seed extracts |
| Grape Seed extract | Neuropathic Pain | 1 | PM | 38716504 | 📋 | Grape seed-derived procyanidins decreases neuropathic pain and nerve regeneration by suppression of TLR4-Myd88 signaling |
| Grape Seed extract | Neurotoxicity | 2 | PM | 37042003 | 📋 | Potential protective effects of red grape seed extract in a rat model of malathion-induced neurotoxicity |
| Grape Seed extract | Neurotoxicity | 1 | PM | 35624958 | 📋 | Grape-Seed-Derived Procyanidin Attenuates Chemotherapy-Induced Cognitive Impairment by Suppressing MMP-9 Activity and Related Blood-Brain-Barrier Damage |
| Grape Seed extract | Neurotoxicity | 6 | PM | 33257291 | 📋 | Graded doses of grape seed methanol extract attenuated ataxic movement, cerebellocortical toxicity, and impairment following chronic carbamazepine treatment in male Wistar rats |
| Grape Seed extract | Neurotoxicity | 5 | PM | 27271977 | 📋 | Neuroprotective effect of grape seed extract against cadmium toxicity in male albino rats |
| Grape Seed extract | Neurotoxicity | 4 | PM | 27000838 | 📋 | Neuroprotective Activity of Grape Seed and Skin Extract Against Lithium Exposure Using Proteomic Research |
| Grape Seed extract | Neurotoxicity | 3 | PM | 22116679 | 📋 | Effect of grape seed proanthocyanidin extracts on methylmercury-induced neurotoxicity in rats |
| Grape Seed extract | Orofacial Pain | 1 | PM | 33544064 | 📋 | 5-HT3/7 and GABA B receptors mediate inhibition of trigeminal nociception by dietary supplementation of grape seed extract |
| Grape Seed extract | Parkinson's Disease | 2 | PM | 33207644 | 📋 | Effects of Grape Polyphenols on the Life Span and Neuroinflammatory Alterations Related to Neurodegenerative Parkinson Disease-Like Disturbances in Mice |
| Grape Seed extract | Parkinson's Disease | 1 | PM | 31131731 | 📋 | Neuroprotective Benefits of Grape Seed and Skin Extract in a Mouse Model of Parkinson's Disease |
| Grape Seed extract | Parkinson's Disease | 3 | PM | 25050252 | 📋 | Motor disturbances and thalamic electrical power of frequency bands' improve by grape seed extract in animal model of Parkinson's disease |
| Grape Seed extract | Peripheral Neuropathy | 1 | PM | 24009454 | 📋 | Neuroprotective effects of Vitis vinifera extract on prediabetic mice induced by a high-fat diet |
| Grape Seed extract | Rheumatoid Arthritis | 1 | PM | 36589610 | 📋 | Grape seed proanthocyanidin extract induces apoptotic and autophagic cell death in rheumatoid arthritis fibroblast-like synoviocytes |
| Grape Seed extract | Rheumatoid Arthritis | 2 | PM | 23759204 | 📋 | Grape seed proanthocyanidin extract has potent anti-arthritic effects on collagen-induced arthritis by modifying the T cell balance |
| Grape Seed extract | Spinal Cord Injury | 1 | PM | 35966334 | 📋 | Grape Seed Proanthocyanidins Exert a Neuroprotective Effect by Regulating Microglial M1/M2 Polarisation in Rats with Spinal Cord Injury |
