| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Fucoidan | Age-Related Cognitive Decline | 1 | PM | 38794753 | 📋 | Fucoidan Improves D-Galactose-Induced Cognitive Dysfunction by Promoting Mitochondrial Biogenesis and Maintaining Gut Microbiome Homeostasis |
| Fucoidan | Alzheimer's Disease | 5 | PM | 36876791 | 📋 | Fucoidans inhibited tau interaction and cellular uptake |
| Fucoidan | Alzheimer's Disease | 2 | PM | 31585867 | 📋 | Fucoidan serves a neuroprotective effect in an Alzheimer's disease model |
| Fucoidan | Alzheimer's Disease | 1 | PM | 29260173 | 📋 | Fucoidan inhibits amyloid-β-induced toxicity in transgenic Caenorhabditis elegans by reducing the accumulation of amyloid-β and decreasing the production of reactive oxygen species |
| Fucoidan | Alzheimer's Disease | 3 | PM | 28300775 | 📋 | Protective Effects of Fucoidan on Aβ25-35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice |
| Fucoidan | Alzheimer's Disease | 4 | PM | 26325676 | 📋 | Fucoidan - An α-amylase inhibitor from Sargassum wightii with relevance to NIDDM |
| Fucoidan | Brain Inflammation | 1 | PM | 19655293 | 📋 | Amelioration of experimental autoimmune encephalomyelitis in Lewis rats treated with fucoidan |
| Fucoidan | Brain Injury | 1 | PM | 33861265 | 📋 | Fucoidan: a promising agent for brain injury and neurodegenerative disease intervention |
| Fucoidan | Chronic Stress | 1 | PM | 23090005 | 📋 | Fucoidan prevents depression-like behavior in rats exposed to repeated restraint stress |
| Fucoidan | Depression | 2 | PM | 31668812 | 📋 | Fucoidan exerts antidepressant-like effects in mice via regulating the stability of surface AMPARs |
| Fucoidan | Depression | 1 | PM | 23090005 | 📋 | Fucoidan prevents depression-like behavior in rats exposed to repeated restraint stress |
| Fucoidan | Encephalomyelitis | 1 | PM | 19655293 | 📋 | Amelioration of experimental autoimmune encephalomyelitis in Lewis rats treated with fucoidan |
| Fucoidan | Glioma | 3 | PM | 38240036 | 📋 | Ultrastructural and immunohistochemical insights on the anti-glioma effects of a dual-drug cocktail in an in vivo experimental model |
| Fucoidan | Glioma | 1 | PM | 31500384 | 📋 | Epigenetic Modification and Differentiation Induction of Malignant Glioma Cells by Oligo-Fucoidan |
| Fucoidan | Glioma | 2 | PM | 22420666 | 📋 | Comparison of the effects of marchantin C and fucoidan on sFlt-1 and angiogenesis in glioma microenvironment |
| Fucoidan | HIV/AIDS | 2 | PM | 26472515 | 📋 | In vitro anti-HIV-1 activity of fucoidan from Sargassum swartzii |
| Fucoidan | HIV/AIDS | 1 | PM | 19107862 | 📋 | Antiretroviral activity of fucoidans extracted from the brown seaweed Adenocystis utricularis |
| Fucoidan | Hyperalgesia | 1 | PM | 24792391 | 📋 | Fucoidan attenuates the existing allodynia and hyperalgesia in a rat model of neuropathic pain |
| Fucoidan | Multiple Sclerosis | 1 | PM | 19655293 | 📋 | Amelioration of experimental autoimmune encephalomyelitis in Lewis rats treated with fucoidan |
| Fucoidan | Neural Damage | 1 | PM | 37182836 | 📋 | Fucoidan (A sulfated polysaccharide) and Cerebroprotein in combination alleviate the neuroinflammation-mediated neural damage and functional deficits in the focal cerebral ischemia model of rat |
| Fucoidan | Neurodegenerative Disease | 3 | PM | 33861265 | 📋 | Fucoidan: a promising agent for brain injury and neurodegenerative disease intervention |
| Fucoidan | Neurodegenerative Disease | 1 | PM | 21570441 | 📋 | Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells |
| Fucoidan | Neurodegenerative Disease | 2 | PM | 19843098 | 📋 | Inhibitory effect of fucoidan on nitric oxide production in lipopolysaccharide-activated primary microglia |
| Fucoidan | Neuroinflammation | 1 | PM | 37182836 | 📋 | Fucoidan (A sulfated polysaccharide) and Cerebroprotein in combination alleviate the neuroinflammation-mediated neural damage and functional deficits in the focal cerebral ischemia model of rat |
| Fucoidan | Neuronal Damage | 1 | PM | 36174863 | 📋 | Fucoidan ameliorates LPS-induced neuronal cell damage and cognitive impairment in mice |
| Fucoidan | Neuronal Damage | 2 | PM | 23006515 | 📋 | Fucoidan protects against lipopolysaccharide-induced rat neuronal damage and inhibits the production of proinflammatory mediators in primary microglia |
| Fucoidan | Neuropathic Pain | 1 | PM | 28035379 | 📋 | Antinociceptive effects of fucoidan in rat models of vincristine-induced neuropathic pain |
| Fucoidan | Neuropathic Pain | 2 | PM | 24792391 | 📋 | Fucoidan attenuates the existing allodynia and hyperalgesia in a rat model of neuropathic pain |
| Fucoidan | Neurotoxicity | 1 | PM | 34570347 | 📋 | Fucoidan Modulated Oxidative Stress and Caspase-3 mRNA Expression Induced by Sulfoxaflor in the Brain of Mice |
| Fucoidan | Neurotoxicity | 2 | PM | 29121706 | 📋 | Protective Effect of Fucoidan Extract from Ecklonia cava on Hydrogen Peroxide-Induced Neurotoxicity |
| Fucoidan | Neurotoxicity | 3 | PM | 22222440 | 📋 | Neuroprotective effect of fucoidan on H2O2-induced apoptosis in PC12 cells via activation of PI3K/Akt pathway |
| Fucoidan | Parkinson's Disease | 8 | PM | 32630523 | 📋 | Protective Effect of Fucoidan against MPP +-Induced SH-SY5Y Cells Apoptosis by Affecting the PI3K/Akt Pathway |
| Fucoidan | Parkinson's Disease | 5 | PM | 31480724 | 📋 | Fucoidan Suppresses Mitochondrial Dysfunction and Cell Death against 1-Methyl-4-Phenylpyridinum-Induced Neuronal Cytotoxicity via Regulation of PGC-1α Expression |
| Fucoidan | Parkinson's Disease | 6 | PM | 30700973 | 📋 | The Effect of Fucoidan on Cellular Oxidative Stress and the CatD-Bax Signaling Axis in MN9D Cells Damaged by 1-Methyl-4-Phenypyridinium |
| Fucoidan | Parkinson's Disease | 4 | PM | 30090649 | 📋 | Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson's Disease |
| Fucoidan | Parkinson's Disease | 2 | PM | 26828289 | 📋 | Neuroprotective effect of fucoidan from Turbinaria decurrens in MPTP intoxicated Parkinsonic mice |
| Fucoidan | Parkinson's Disease | 3 | PM | 25399812 | 📋 | Therapeutic effects of fucoidan in 6-hydroxydopamine-lesioned rat model of Parkinson's disease: Role of NADPH oxidase-1 |
| Fucoidan | Parkinson's Disease | 7 | PM | 23006515 | 📋 | Fucoidan protects against lipopolysaccharide-induced rat neuronal damage and inhibits the production of proinflammatory mediators in primary microglia |
| Fucoidan | Parkinson's Disease | 1 | PM | 19545563 | 📋 | Fucoidan protects against dopaminergic neuron death in vivo and in vitro |
| Fucoidan | Peripheral Neuropathy | 1 | PM | 28035379 | 📋 | Antinociceptive effects of fucoidan in rat models of vincristine-induced neuropathic pain |
| Fucoidan | Rheumatoid Arthritis | 1 | PM | 31185702 | 📋 | Fucoidan Prevents RANKL-Stimulated Osteoclastogenesis and LPS-Induced Inflammatory Bone Loss via Regulation of Akt/GSK3β/PTEN/NFATc1 Signaling Pathway and Calcineurin Activity |
| Fucoidan | Rheumatoid Arthritis | 2 | PM | 25787883 | 📋 | Low-Molecular-Weight Fucoidan Inhibits the Viability and Invasiveness and Triggers Apoptosis in IL-1β-Treated Human Rheumatoid Arthritis Fibroblast Synoviocytes |
| Fucoidan | Traumatic Brain Injury | 1 | PM | 26743530 | 📋 | Low-Molecular-Weight Fucoidan Attenuates Mitochondrial Dysfunction and Improves Neurological Outcome After Traumatic Brain Injury in Aged Mice: Involvement of Sirt3 |
| Fucoidan | Vascular Dementia | 1 | PM | 38237671 | 📋 | Fucoidan protects CA1 pyramidal neurons of the hippocampus and preserves the cognitive profile of rats subjected to transient forebrain ischemia |
