| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Ellagic Acid | Age-Related Cognitive Decline | 1 | PM | 33109788 | 📋 | Combination of ellagic acid and trans-cinnamaldehyde alleviates aging-induced cognitive impairment via modulation of mitochondrial function and inflammatory and apoptotic mediators in the prefrontal cortex of aged rats |
| Ellagic Acid | Alzheimer's Disease | 6 | PM | 38842699 | 📋 | Ellagic Acid Reverses Alterations in the Expression of AMPA Receptor and Its Scaffolding Proteins in the Cerebral Cortex and Memory Decline in STZ-sporadic Alzheimer' s Disease Mouse Model |
| Ellagic Acid | Alzheimer's Disease | 4 | PM | 35983489 | 📋 | Identification of ellagic acid and urolithins as natural inhibitors of Aβ 25-35-induced neurotoxicity and the mechanism predication using network pharmacology analysis and molecular docking |
| Ellagic Acid | Alzheimer's Disease | 3 | PM | 34944019 | 📋 | Ellagic Acid Modulates the Amyloid Precursor Protein Gene via Superoxide Dismutase Regulation in the Entorhinal Cortex in an Experimental Alzheimer's Model |
| Ellagic Acid | Alzheimer's Disease | 2 | PM | 33183192 | 📋 | Neuroprotective Effects of Ellagic Acid in Alzheimer's Disease: Focus on Underlying Molecular Mechanisms of Therapeutic Potential |
| Ellagic Acid | Alzheimer's Disease | 1 | PM | 32830209 | 📋 | Destabilization potential of phenolics on Aβ fibrils: mechanistic insights from molecular dynamics simulation |
| Ellagic Acid | Alzheimer's Disease | 5 | PM | 28303372 | 📋 | Ellagic acid ameliorates learning and memory deficits in a rat model of Alzheimer's disease: an exploration of underlying mechanisms |
| Ellagic Acid | Brain Edema | 1 | PM | 32742603 | 📋 | Ellagic acid attenuates post-cerebral ischemia and reperfusion behavioral deficits by decreasing brain tissue inflammation in rats |
| Ellagic Acid | Brain Inflammation | 1 | PM | 32742603 | 📋 | Ellagic acid attenuates post-cerebral ischemia and reperfusion behavioral deficits by decreasing brain tissue inflammation in rats |
| Ellagic Acid | Brain Inflammation | 2 | PM | 28804609 | 📋 | Therapeutic effects of ellagic acid on memory, hippocampus electrophysiology deficits, and elevated TNF-α level in brain due to experimental traumatic brain injury |
| Ellagic Acid | Brain Inflammation | 3 | PM | 25637685 | 📋 | Ellagic acid prevents cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury |
| Ellagic Acid | Chronic Pain | 1 | PM | 23528359 | 📋 | Central and peripheral antinociceptive effects of ellagic acid in different animal models of pain |
| Ellagic Acid | Dementia | 4 | PM | 36305148 | 📋 | Ellagic acid prevents oxidative stress and memory deficits in a rat model of scopolamine-induced Alzheimer's disease |
| Ellagic Acid | Dementia | 1 | PM | 28778589 | 📋 | A novel DSC approach for evaluating protectant drugs efficacy against dementia |
| Ellagic Acid | Dementia | 3 | PM | 28499310 | 📋 | Ellagic Acid Administration Negated the Development of Streptozotocin-Induced Memory Deficit in Rats |
| Ellagic Acid | Dementia | 2 | PM | 26828763 | 📋 | Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments |
| Ellagic Acid | Depression | 4 | PM | 37151621 | 📋 | Ellagic acid through attenuation of neuro-inflammatory response exerted antidepressant-like effects in socially isolated mice |
| Ellagic Acid | Depression | 3 | PM | 35600992 | 📋 | Pomegranate and Its Components, Punicalagin and Ellagic Acid, Promote Antidepressant, Antioxidant, and Free Radical-Scavenging Activity in Ovariectomized Rats |
| Ellagic Acid | Depression | 1 | PM | 32786855 | 📋 | Serum metabonomic study on the antidepressant-like effects of ellagic acid in a chronic unpredictable mild stress-induced (CUMS) mouse model |
| Ellagic Acid | Depression | 5 | PM | 29017372 | 📋 | The antidepressant-like activity of ellagic acid and its effect on hippocampal brain derived neurotrophic factor levels in mouse depression models |
| Ellagic Acid | Depression | 2 | PM | 23087132 | 📋 | Antidepressant-like activity of ellagic acid in unstressed and acute immobilization-induced stressed mice |
| Ellagic Acid | Diabetic Encephalopathy | 1 | PM | 30943382 | 📋 | Ellagic acid protects against diabetes-associated behavioral deficits in rats: Possible involved mechanisms |
| Ellagic Acid | Diabetic Neuropathy | 2 | PM | 37085061 | 📋 | Evaluation of the effects of sinapic acid and ellagic acid on sciatic nerve in experimental diabetic rats by immunohistochemical and stereological methods |
| Ellagic Acid | Diabetic Neuropathy | 1 | PM | 35693147 | 📋 | The Anti-nociceptive Effect of Ellagic Acid in Streptozotocin-induced Hyperglycemic Rats by Oxidative Stress Involvement |
| Ellagic Acid | Epilepsy | 2 | PM | 36608161 | 📋 | Allopurinol and ellagic acid decrease epileptiform activity and the severity of convulsive behavior in a model of status epilepticus |
| Ellagic Acid | Epilepsy | 1 | PM | 35171306 | 📋 | Ellagic acid and allopurinol decrease H 2 O 2 concentrations, epileptiform activity and astrogliosis after status epilepticus in the hippocampus of adult rats |
| Ellagic Acid | Glioblastoma | 1 | PM | 28035411 | 📋 | Ellagic acid inhibits human glioblastoma growth in vitro and in vivo |
| Ellagic Acid | Glioblastoma | 2 | PM | 26959625 | 📋 | Ellagic acid inhibits proliferation and induces apoptosis in human glioblastoma cells |
| Ellagic Acid | Glioma | 1 | PM | 35946772 | 📋 | Antitumor activity of irinotecan with ellagic acid in C6 glioma cells |
| Ellagic Acid | HIV/AIDS | 1 | PM | 29480632 | 📋 | Ellagic acid inhibits HIV-1 infection in vitro: Potential role as a novel microbicide |
| Ellagic Acid | HIV/AIDS | 2 | PM | 23640562 | 📋 | Ellagic acid & gallic acid from Lagerstroemia speciosa L. inhibit HIV-1 infection through inhibition of HIV-1 protease & reverse transcriptase activity |
| Ellagic Acid | Huntington's Disease | 2 | PM | 36209926 | 📋 | Anti-inflammatory effects of ellagic acid and vanillic acid against quinolinic acid-induced rat model of Huntington's disease by targeting IKK-NF-κB pathway |
| Ellagic Acid | Huntington's Disease | 1 | PM | 34061228 | 📋 | Ellagic acid prevents 3-nitropropionic acid induced symptoms of Huntington's disease |
| Ellagic Acid | Hyperalgesia | 1 | PM | 35693147 | 📋 | The Anti-nociceptive Effect of Ellagic Acid in Streptozotocin-induced Hyperglycemic Rats by Oxidative Stress Involvement |
| Ellagic Acid | Hyperalgesia | 2 | PM | 23743057 | 📋 | Topical anti-inflammatory and analgesic activities of standardized pomegranate rind extract in comparison with its marker compound ellagic acid in vivo |
| Ellagic Acid | Ischemic Stroke | 1 | PM | 28388366 | 📋 | Ellagic acid protects against neuron damage in ischemic stroke through regulating the ratio of Bcl-2/Bax expression |
| Ellagic Acid | Multiple Sclerosis | 4 | PM | 37806153 | 📋 | The effects of Ellagic acid supplementation on neurotrophic, inflammation, and oxidative stress factors, and indoleamine 2, 3-dioxygenase gene expression in multiple sclerosis patients with mild to moderate depressive symptoms: A randomized, triple-blind, placebo-controlled trial |
| Ellagic Acid | Multiple Sclerosis | 3 | PM | 37794975 | 📋 | Ellagic acid effects on disease severity, levels of cytokines and T-bet, RORγt, and GATA3 genes expression in multiple sclerosis patients: a multicentral-triple blind randomized clinical trial |
| Ellagic Acid | Multiple Sclerosis | 2 | PM | 33217488 | 📋 | Ellagic acid ameliorates neuroinflammation and demyelination in experimental autoimmune encephalomyelitis: Involvement of NLRP3 and pyroptosis |
| Ellagic Acid | Multiple Sclerosis | 1 | PM | 32640490 | 📋 | The Effect of Ellagic Acid on Spinal Cord and Sciatica Function in a Mice Model of Multiple Sclerosis |
| Ellagic Acid | Neuroblastoma | 2 | PM | 24051122 | 📋 | Ellagic acid induces a dose- and time-dependent depolarization of mitochondria and activation of caspase-9 and -3 in human neuroblastoma cells |
| Ellagic Acid | Neuroblastoma | 1 | PM | 18848760 | 📋 | Effect of ellagic acid on proliferation, cell adhesion and apoptosis in SH-SY5Y human neuroblastoma cells |
| Ellagic Acid | Neurodegenerative Disease | 5 | PM | 38617645 | 📋 | Evaluation of the Binding Mechanism of Dietary Phytochemical, Ellagic Acid, with Human Transferrin: Spectroscopic, Calorimetric, and Computational Approaches Targeting Neurodegenerative Diseases |
| Ellagic Acid | Neurodegenerative Disease | 3 | PM | 36142849 | 📋 | Ellagic Acid and Its Anti-Aging Effects on Central Nervous System |
| Ellagic Acid | Neurodegenerative Disease | 4 | PM | 28447514 | 📋 | Neuroprotective effects of ellagic acid on cuprizone-induced acute demyelination through limitation of microgliosis, adjustment of CXCL12/IL-17/IL-11 axis and restriction of mature oligodendrocytes apoptosis |
| Ellagic Acid | Neurodegenerative Disease | 1 | PM | 27794200 | 📋 | Ellagic acid improves endogenous neural stem cells proliferation and neurorestoration through Wnt/β-catenin signaling in vivo and in vitro |
| Ellagic Acid | Neurodegenerative Disease | 2 | PM | 26806345 | 📋 | Insights Into Effects of Ellagic Acid on the Nervous System: A Mini Review |
| Ellagic Acid | Neuroinflammation | 8 | PM | 38291199 | 📋 | Oral administration of ellagic acid mitigates perioperative neurocognitive disorders, hippocampal oxidative stress, and neuroinflammation in aged mice by restoring IGF-1 signaling |
| Ellagic Acid | Neuroinflammation | 7 | PM | 37340785 | 📋 | Oral ellagic acid attenuated LPS-induced neuroinflammation in rat brain: MEK1 interaction and M2 microglial polarization |
| Ellagic Acid | Neuroinflammation | 6 | PM | 37151621 | 📋 | Ellagic acid through attenuation of neuro-inflammatory response exerted antidepressant-like effects in socially isolated mice |
| Ellagic Acid | Neuroinflammation | 2 | PM | 35911650 | 📋 | Synaptic plasticity and cognitive impairment consequences to acute kidney injury: Protective role of ellagic acid |
| Ellagic Acid | Neuroinflammation | 5 | PM | 33294118 | 📋 | Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia |
| Ellagic Acid | Neuroinflammation | 4 | PM | 33217488 | 📋 | Ellagic acid ameliorates neuroinflammation and demyelination in experimental autoimmune encephalomyelitis: Involvement of NLRP3 and pyroptosis |
| Ellagic Acid | Neuroinflammation | 1 | PM | 32779097 | 📋 | Ellagic Acid Inhibits Neuroinflammation and Cognitive Impairment Induced by Lipopolysaccharides |
| Ellagic Acid | Neuroinflammation | 3 | PM | 32455600 | 📋 | Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion |
| Ellagic Acid | Neurological Disorders | 1 | PM | 33693510 | 📋 | Neuroprotective Potential of Ellagic Acid: A Critical Review |
| Ellagic Acid | Neuronal Damage | 1 | PM | 28388366 | 📋 | Ellagic acid protects against neuron damage in ischemic stroke through regulating the ratio of Bcl-2/Bax expression |
| Ellagic Acid | Neuropathic Pain | 2 | PM | 36811684 | 📋 | Synergistic effect of ellagic acid and gabapentin in a rat model of neuropathic pain |
| Ellagic Acid | Neuropathic Pain | 1 | PM | 34369317 | 📋 | Punicalagin and ellagic acid containing Punica granatum L. fruit rind extract prevents vincristine-induced neuropathic pain in rats: an in silico and in vivo evidence of GABAergic action and cytokine inhibition |
| Ellagic Acid | Neuropathic Pain | 3 | PM | 24499201 | 📋 | Attenuating effect of standardized fruit extract of Punica granatum L in rat model of tibial and sural nerve transection induced neuropathic pain |
| Ellagic Acid | Neurotoxicity | 3 | PM | 38338554 | 📋 | Evaluation of the Potential Protective Effect of Ellagic Acid against Heavy Metal (Cadmium, Mercury, and Lead) Toxicity in SH-SY5Y Neuroblastoma Cells |
| Ellagic Acid | Neurotoxicity | 1 | PM | 36951984 | 📋 | Intraperitoneal pretreatment of ellagic acid and chrysin alleviate ifosfamide-induced neurotoxicity, but betanin induces death in male wistar rats |
| Ellagic Acid | Neurotoxicity | 2 | PM | 28815802 | 📋 | Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin-induced neurotoxicity in rats |
| Ellagic Acid | Pain | 1 | PM | 35844922 | 📋 | Antinociceptive activity of the Caesalpinia eriostachys Benth. ethanolic extract, fractions, and isolated compounds in mice |
| Ellagic Acid | Parkinson's Disease | 9 | PM | 38201915 | 📋 | Ellagic Acid Prevents α-Synuclein Spread and Mitigates Toxicity by Enhancing Autophagic Flux in an Animal Model of Parkinson's Disease |
| Ellagic Acid | Parkinson's Disease | 7 | PM | 36242848 | 📋 | Ellagic acid activates the Keap1-Nrf2-ARE signaling pathway in improving Parkinson's disease: A review |
| Ellagic Acid | Parkinson's Disease | 6 | PM | 34948195 | 📋 | Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy |
| Ellagic Acid | Parkinson's Disease | 5 | PM | 34506119 | 📋 | Ellagic Acid Modulates Uninduced as well as Mutation and Metal-Induced Aggregation of α-Synuclein: Implications for Parkinson's Disease |
| Ellagic Acid | Parkinson's Disease | 4 | PM | 34015214 | 📋 | Ellagic Acid Inhibits α-Synuclein Aggregation at Multiple Stages and Reduces Its Cytotoxicity |
| Ellagic Acid | Parkinson's Disease | 3 | PM | 33172035 | 📋 | Ellagic Acid Prevents Dopamine Neuron Degeneration from Oxidative Stress and Neuroinflammation in MPTP Model of Parkinson's Disease |
| Ellagic Acid | Parkinson's Disease | 2 | PM | 32657027 | 📋 | Ellagic acid protects dopamine neurons from rotenone-induced neurotoxicity via activation of Nrf2 signalling |
| Ellagic Acid | Parkinson's Disease | 1 | PM | 31935828 | 📋 | Neuroprotective Mechanisms of Three Natural Antioxidants on a Rat Model of Parkinson's Disease: A Comparative Study |
| Ellagic Acid | Parkinson's Disease | 8 | PM | 28238669 | 📋 | Ellagic acid exerts protective effect in intrastriatal 6-hydroxydopamine rat model of Parkinson's disease: Possible involvement of ERβ/Nrf2/HO-1 signaling |
| Ellagic Acid | Prion Diseases | 1 | PM | 33460657 | 📋 | Ellagic acid and pentagalloylglucose are potential inhibitors of prion protein fibrillization |
| Ellagic Acid | Rheumatoid Arthritis | 2 | PM | 34924813 | 📋 | Ellagic Acid Alleviates Rheumatoid Arthritis in Rats through Inhibiting MTA1/HDAC1-Mediated Nur77 Deacetylation |
| Ellagic Acid | Rheumatoid Arthritis | 1 | PM | 30562713 | 📋 | Caffeic acid and ellagic acid ameliorate adjuvant-induced arthritis in rats via targeting inflammatory signals, chitinase-3-like protein-1 and angiogenesis |
| Ellagic Acid | Seizures | 2 | PM | 35600241 | 📋 | The Role of the NMDA Receptor in the Anticonvulsant Effect of Ellagic Acid in Pentylenetetrazole-Induced Seizures in Male Mice |
| Ellagic Acid | Seizures | 1 | PM | 34443428 | 📋 | Effect of Ellagic Acid on Seizure Threshold in Two Acute Seizure Tests in Mice |
| Ellagic Acid | Traumatic Brain Injury | 1 | PM | 28804609 | 📋 | Therapeutic effects of ellagic acid on memory, hippocampus electrophysiology deficits, and elevated TNF-α level in brain due to experimental traumatic brain injury |
| Ellagic Acid | Traumatic Brain Injury | 2 | PM | 27794200 | 📋 | Ellagic acid improves endogenous neural stem cells proliferation and neurorestoration through Wnt/β-catenin signaling in vivo and in vitro |
| Ellagic Acid | Traumatic Brain Injury | 3 | PM | 25637685 | 📋 | Ellagic acid prevents cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury |
