| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Eicosapentaenoic Acid | Age-Related Cognitive Decline | 1 | PM | 26265727 | 📋 | A High Omega-3 Fatty Acid Multinutrient Supplement Benefits Cognition and Mobility in Older Women: A Randomized, Double-blind, Placebo-controlled Pilot Study |
| Eicosapentaenoic Acid | Alzheimer's Disease | 6 | PM | 38373507 | 📋 | N-3 polyunsaturated fatty acids attenuate amyloid-beta-induced toxicity in AD transgenic Caenorhabditis elegans via promotion of proteasomal activity and activation of PPAR-gamma |
| Eicosapentaenoic Acid | Alzheimer's Disease | 5 | PM | 37150266 | 📋 | Efficacy and acceptability of anti-inflammatory eicosapentaenoic acid for cognitive function in Alzheimer's dementia: a network meta-analysis of randomized, placebo-controlled trials with omega-3 fatty acids and FDA-approved pharmacotherapy |
| Eicosapentaenoic Acid | Alzheimer's Disease | 4 | PM | 36781072 | 📋 | Eicosapentaenoic Acid Protects against Metabolic Impairments in the APPswe/PS1dE9 Alzheimer's Disease Mouse Model |
| Eicosapentaenoic Acid | Alzheimer's Disease | 3 | PM | 33573174 | 📋 | Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer's Dementia in the Oldest Old |
| Eicosapentaenoic Acid | Alzheimer's Disease | 2 | PM | 33456004 | 📋 | Effects of Dietary Supplementation with EPA-enriched Phosphatidylcholine and Phosphatidylethanolamine on Glycerophospholipid Profile in Cerebral Cortex of SAMP8 Mice fed with High-fat Diet |
| Eicosapentaenoic Acid | Alzheimer's Disease | 1 | PM | 26606074 | 📋 | Protective Effects of Dietary Supplementation with a Combination of Nutrients in a Transgenic Mouse Model of Alzheimer's Disease |
| Eicosapentaenoic Acid | Amyotrophic Lateral Sclerosis | 1 | PM | 23620776 | 📋 | The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis |
| Eicosapentaenoic Acid | Brain Aneurysm | 1 | PM | 32331514 | 📋 | Eicosapentaenoic Acid Prevents the Progression of Intracranial Aneurysms in Rats |
| Eicosapentaenoic Acid | Brain Aneurysm | 2 | PM | 18261166 | 📋 | Does eicosapentaenoic acid (EPA) inhibit cerebral vasospasm in patients after aneurysmal subarachnoid hemorrhage? |
| Eicosapentaenoic Acid | Brain Inflammation | 1 | PM | 18424607 | 📋 | Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats |
| Eicosapentaenoic Acid | Demyelinating Disease | 1 | PM | 17941053 | 📋 | Eicosapentaenoic acid stimulates the expression of myelin proteins in rat brain |
| Eicosapentaenoic Acid | Depression | 10 | PM | 38811538 | 📋 | Omega-3 fatty acids and major depression: a Mendelian randomization study |
| Eicosapentaenoic Acid | Depression | 9 | PM | 38479498 | 📋 | Association between eicosapentaenoic acid consumption and the risk of depressive symptoms in US adults: Analyses from NHANES 2005-2018 |
| Eicosapentaenoic Acid | Depression | 8 | PM | 38136199 | 📋 | DHA and EPA Alleviate Epileptic Depression in PTZ-Treated Young Mice Model by Inhibiting Neuroinflammation through Regulating Microglial M2 Polarization and Improving Mitochondrial Metabolism |
| Eicosapentaenoic Acid | Depression | 6 | PM | 36562041 | 📋 | Causal effects of fatty acids on depression: Mendelian randomization study |
| Eicosapentaenoic Acid | Depression | 5 | PM | 33339120 | 📋 | Brain Responses to Emotional Stimuli after Eicosapentaenoic Acid and Docosahexaenoic Acid Treatments in Major Depressive Disorder: Toward Personalized Medicine with Anti-Inflammatory Nutraceuticals |
| Eicosapentaenoic Acid | Depression | 4 | PM | 33316626 | 📋 | Dose- and time-dependent increase in circulating anti-inflammatory and pro-resolving lipid mediators following eicosapentaenoic acid supplementation in patients with major depressive disorder and chronic inflammation |
| Eicosapentaenoic Acid | Depression | 3 | PM | 33255819 | 📋 | Verbal Memory Performance in Depressed Children and Adolescents: Associations with EPA but Not DHA and Depression Severity |
| Eicosapentaenoic Acid | Depression | 1 | PM | 26300645 | 📋 | Combined application of eicosapentaenoic acid and docosahexaenoic acid on depression in women: a meta-analysis of double-blind randomized controlled trials |
| Eicosapentaenoic Acid | Depression | 7 | PM | 22910528 | 📋 | Eicosapentaenoic acid versus docosahexaenoic acid in mild-to-moderate depression: a randomized, double-blind, placebo-controlled trial |
| Eicosapentaenoic Acid | Depression | 2 | PM | 18247193 | 📋 | Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder |
| Eicosapentaenoic Acid | Diabetic Encephalopathy | 1 | PM | 38680120 | 📋 | Eicosapentaenoic acid activates the P62/KEAP1/NRF2 pathway for the prevention of diabetes-associated cognitive dysfunction |
| Eicosapentaenoic Acid | Epilepsy | 1 | PM | 37755077 | 📋 | A Compared Study of Eicosapentaenoic Acid and Docosahexaenoic Acid in Improving Seizure-Induced Cognitive Deficiency in a Pentylenetetrazol-Kindling Young Mice Model |
| Eicosapentaenoic Acid | Glioblastoma | 1 | PM | 35395232 | 📋 | Eicosapentaenoic acid enhanced apoptotic and oxidant effects of cisplatin via activation of TRPM2 channel in brain tumor cells |
| Eicosapentaenoic Acid | Huntington's Disease | 1 | PM | 30890195 | 📋 | Efficacy of ethyl-EPA as a treatment for Huntington disease: a systematic review and meta-analysis |
| Eicosapentaenoic Acid | Huntington's Disease | 2 | PM | 18831882 | 📋 | Reduction in cerebral atrophy associated with ethyl-eicosapentaenoic acid treatment in patients with Huntington's disease |
| Eicosapentaenoic Acid | Huntington's Disease | 3 | PM | 16043801 | 📋 | Ethyl-EPA in Huntington disease: a double-blind, randomized, placebo-controlled trial |
| Eicosapentaenoic Acid | Intracerebral Hemorrhage | 1 | PM | 35382754 | 📋 | Association of blood eicosapentaenoic acid levels with intracerebral hemorrhage during the COVID-19 pandemic: preliminary experience from a single-center in Japan |
| Eicosapentaenoic Acid | Ischemic Stroke | 1 | PM | 33076354 | 📋 | The Role of Resolvins: EPA and DHA Derivatives Can Be Useful in the Prevention and Treatment of Ischemic Stroke |
| Eicosapentaenoic Acid | Migraine | 2 | PM | 38499208 | 📋 | A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine |
| Eicosapentaenoic Acid | Migraine | 1 | PM | 38110000 | 📋 | Efficacy of high dosage anti-inflammatory EPA/DHA for migraine prophylaxis: a network meta-analysis |
| Eicosapentaenoic Acid | Neuroblastoma | 1 | PM | 26295255 | 📋 | Omega-3 Polyunsaturated Fatty Acids Trigger Cell Cycle Arrest and Induce Apoptosis in Human Neuroblastoma LA-N-1 Cells |
| Eicosapentaenoic Acid | Neuroinflammation | 1 | PM | 38136199 | 📋 | DHA and EPA Alleviate Epileptic Depression in PTZ-Treated Young Mice Model by Inhibiting Neuroinflammation through Regulating Microglial M2 Polarization and Improving Mitochondrial Metabolism |
| Eicosapentaenoic Acid | Neuropathic Pain | 1 | PM | 35858418 | 📋 | Vesicular nucleotide transporter is a molecular target of eicosapentaenoic acid for neuropathic and inflammatory pain treatment |
| Eicosapentaenoic Acid | Pain | 1 | PM | 35858418 | 📋 | Vesicular nucleotide transporter is a molecular target of eicosapentaenoic acid for neuropathic and inflammatory pain treatment |
| Eicosapentaenoic Acid | Parkinson's Disease | 1 | PM | 36555817 | 📋 | The Polyunsaturated Fatty Acid EPA, but Not DHA, Enhances Neurotrophic Factor Expression through Epigenetic Mechanisms and Protects against Parkinsonian Neuronal Cell Death |
| Eicosapentaenoic Acid | Seizures | 1 | PM | 36099650 | 📋 | DHA and EPA Prevent Seizure and Depression-Like Behavior by Inhibiting Ferroptosis and Neuroinflammation via Different Mode-of-actions in a Pentylenetetrazole-Induced Kindling Model in Mice |
| Eicosapentaenoic Acid | Subarachnoid Hemorrhage | 1 | PM | 18261166 | 📋 | Does eicosapentaenoic acid (EPA) inhibit cerebral vasospasm in patients after aneurysmal subarachnoid hemorrhage? |
| Eicosapentaenoic Acid | Traumatic Brain Injury | 1 | PM | 34365584 | 📋 | Systemic Elevation of n-3 Polyunsaturated Fatty Acids (n-3-PUFA) Is Associated with Protection against Visual, Motor, and Emotional Deficits in Mice following Closed-Head Mild Traumatic Brain Injury |
