| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Baicalin | Age-Related Cognitive Decline | 1 | PM | 19191093 | 📋 | Scutellaria Flavonoid Supplementation Reverses Ageing-Related Cognitive Impairment and Neuronal Changes in Aged Rats |
| Baicalin | Alzheimer's Disease | 4 | PM | 37719746 | 📋 | An interventional study of baicalin on neuronal pentraxin-1, neuronal pentraxin-2, and C-reactive protein in Alzheimer's disease rat model |
| Baicalin | Alzheimer's Disease | 3 | PM | 35528169 | 📋 | Baicalin Attenuated A β 1-42-Induced Apoptosis in SH-SY5Y Cells by Inhibiting the Ras-ERK Signaling Pathway |
| Baicalin | Alzheimer's Disease | 2 | PM | 35103832 | 📋 | Baicalin attenuates amyloid β oligomers induced memory deficits and mitochondria fragmentation through regulation of PDE-PKA-Drp1 signalling |
| Baicalin | Alzheimer's Disease | 1 | PM | 17480132 | 📋 | Alzheimer's Disease Drug Discovery From Herbs: Neuroprotectivity From Beta-Amyloid (1-42) Insult |
| Baicalin | Brain Edema | 2 | PM | 12212190 | 📋 | [Protective Effects of Baicalin, Mannitol and Dexamethasone on Infective Brain Edema in Rats] |
| Baicalin | Brain Edema | 1 | PM | 11038818 | 📋 | [The Protective Effects of Baicalin on Pertussis Bacilli-Induced Brain Edema in Rats] |
| Baicalin | Brain Inflammation | 1 | PM | 17204294 | 📋 | The Flavonoid Baicalin Protects Against Cerebrovascular Dysfunction and Brain Inflammation in Experimental Heatstroke |
| Baicalin | Chronic Stress | 1 | PM | 36642102 | 📋 | Baicalin attenuates chronic unpredictable mild stress-induced hippocampal neuronal apoptosis through regulating SIRT1/PARP1 signaling pathway |
| Baicalin | Dementia | 2 | PM | 35528169 | 📋 | Baicalin Attenuated A β 1-42-Induced Apoptosis in SH-SY5Y Cells by Inhibiting the Ras-ERK Signaling Pathway |
| Baicalin | Dementia | 1 | PM | 16129477 | 📋 | Scutellaria Flavonoid Reduced Memory Dysfunction and Neuronal Injury Caused by Permanent Global Ischemia in Rats |
| Baicalin | Demyelinating Disease | 2 | PM | 36707260 | 📋 | Baicalin facilitates remyelination and suppresses neuroinflammation in rats with chronic cerebral hypoperfusion by activating Wnt/β-catenin and inhibiting NF-κB signaling |
| Baicalin | Demyelinating Disease | 1 | PM | 35105686 | 📋 | Baicalin Promotes CNS Remyelination via PPARγ Signal Pathway |
| Baicalin | Depression | 12 | PM | 37820491 | 📋 | Widely targeted metabolomics unveils baicalin-induced hippocampal metabolic alternations in a rat model of chronic unpredictable mild stress |
| Baicalin | Depression | 11 | PM | 36642102 | 📋 | Baicalin attenuates chronic unpredictable mild stress-induced hippocampal neuronal apoptosis through regulating SIRT1/PARP1 signaling pathway |
| Baicalin | Depression | 10 | PM | 36607586 | 📋 | Baicalin Ameliorates Corticosterone-Induced Depression by Promoting Neurodevelopment of Hippocampal via mTOR/GSK3 β Pathway |
| Baicalin | Depression | 9 | PM | 36531636 | 📋 | Baicalin improves the energy levels in the prefrontal cortex of mice exposed to chronic unpredictable mild stress |
| Baicalin | Depression | 8 | PM | 36463946 | 📋 | Baicalin ameliorates CUMS-induced depression-like behaviors through activating AMPK/PGC-1α pathway and enhancing NIX-mediated mitophagy in mice |
| Baicalin | Depression | 7 | PM | 35432561 | 📋 | Baicalin Attenuates Continuous Activation of β-Catenin Induced by Lipopolysaccharide (LPS) and Depression Complicated by Infertility in Male Rats |
| Baicalin | Depression | 5 | PM | 34280458 | 📋 | Baicalin Ameliorates Chronic Unpredictable Mild Stress-Induced Depression through the BDNF/ERK/CREB Signaling Pathway |
| Baicalin | Depression | 4 | PM | 33964281 | 📋 | Baicalin promotes hippocampal neurogenesis via the Wnt/β-catenin pathway in a chronic unpredictable mild stress-induced mouse model of depression |
| Baicalin | Depression | 3 | PM | 33025359 | 📋 | A New Perspective on Ameliorating Depression-Like Behaviors: Suppressing Neuroinflammation by Upregulating PGC-1α |
| Baicalin | Depression | 2 | PM | 32982755 | 📋 | Facilitating Granule Cell Survival and Maturation in Dentate Gyrus With Baicalin for Antidepressant Therapeutics |
| Baicalin | Depression | 1 | PM | 32643091 | 📋 | Baicalin Attenuates Inflammatory Pain Associated Depressive Symptoms via Akt-mediated Adult Hippocampal Neurogenesis |
| Baicalin | Depression | 6 | PM | 31440134 | 📋 | Revealing Antidepressant Mechanisms of Baicalin in Hypothalamus Through Systems Approaches in Corticosterone- Induced Depressed Mice |
| Baicalin | Diabetic Encephalopathy | 1 | PM | 38631145 | 📋 | Upregulation of Nrf2 signaling: A key molecular mechanism of Baicalin's neuroprotective action against diabetes-induced cognitive impairment |
| Baicalin | Diabetic Neuropathy | 1 | PM | 34017440 | 📋 | Effects of baicalin capsules combined with α-lipoic acid on nerve conduction velocity, oxidative stress and inflammatory injury in patients with diabetic peripheral neuropathy |
| Baicalin | Encephalitis | 1 | PM | 17653455 | 📋 | Baicalin Reduces the Severity of Experimental Autoimmune Encephalomyelitis |
| Baicalin | Encephalomyelitis | 1 | PM | 17653455 | 📋 | Baicalin Reduces the Severity of Experimental Autoimmune Encephalomyelitis |
| Baicalin | Epilepsy | 4 | PM | 38778616 | 📋 | Exploring the Therapeutic Potential of Baicalin: Mitigating Anxiety and Depression in Epileptic Rats |
| Baicalin | Epilepsy | 3 | PM | 37771639 | 📋 | Hippocampus protection from apoptosis by Baicalin in a LiCl-pilocarpine-induced rat status epilepticus model through autophagy activation |
| Baicalin | Epilepsy | 2 | PM | 34780748 | 📋 | Baicalin suppresses neuron autophagy and apoptosis by regulating astrocyte polarization in pentylenetetrazol-induced epileptic rats and PC12 cells |
| Baicalin | Epilepsy | 1 | PM | 34321866 | 📋 | Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats |
| Baicalin | Glioblastoma | 1 | PM | 16914050 | 📋 | Anticancer Activity of Extracts Derived From the Mature Roots of Scutellaria Baicalensis on Human Malignant Brain Tumor Cells |
| Baicalin | HIV/AIDS | 1 | PM | 7693133 | 📋 | Inhibition of HIV Infection by Baicalin--A Flavonoid Compound Purified From Chinese Herbal Medicine |
| Baicalin | Hyperalgesia | 1 | PM | 14633550 | 📋 | The Antiinflammatory and Analgesic Effects of Baicalin in Carrageenan-Evoked Thermal Hyperalgesia |
| Baicalin | Intracerebral Hemorrhage | 1 | PM | 33815110 | 📋 | Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage |
| Baicalin | Intracranial Hypertension | 1 | PM | 11783272 | 📋 | [Effect of Baicalin and Tetramethylpyrazine on Intracranial Hypertension of Infectious Brain Edema in Rabbits] |
| Baicalin | Ischemic Stroke | 3 | PM | 36661075 | 📋 | Baicalin Reduces Immune Cell Infiltration by Inhibiting Inflammation and Protecting Tight Junctions in Ischemic Stroke Injury |
| Baicalin | Ischemic Stroke | 2 | PM | 34234667 | 📋 | Baicalin Attenuates Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron-Astrocyte Cocultures |
| Baicalin | Ischemic Stroke | 1 | PM | 32473460 | 📋 | Baicalin combats glutamate excitotoxicity via protecting glutamine synthetase from ROS-induced 20S proteasomal degradation |
| Baicalin | Multiple Sclerosis | 1 | PM | 17653455 | 📋 | Baicalin Reduces the Severity of Experimental Autoimmune Encephalomyelitis |
| Baicalin | Neural Tube Defects | 1 | PM | 32774702 | 📋 | Baicalin rescues hyperglycemia-induced neural tube defects via targeting on retinoic acid signaling |
| Baicalin | Neuroinflammation | 7 | PM | 38715318 | 📋 | Baicalin and baicalein from Scutellaria baicalensis Georgi alleviate aberrant neuronal suppression mediated by GABA from reactive astrocytes |
| Baicalin | Neuroinflammation | 6 | PM | 36707260 | 📋 | Baicalin facilitates remyelination and suppresses neuroinflammation in rats with chronic cerebral hypoperfusion by activating Wnt/β-catenin and inhibiting NF-κB signaling |
| Baicalin | Neuroinflammation | 5 | PM | 36408278 | 📋 | Baicalin Mitigates the Neuroinflammation through the TLR4/MyD88/NF- κ B and MAPK Pathways in LPS-Stimulated BV-2 Microglia |
| Baicalin | Neuroinflammation | 4 | PM | 33164433 | 📋 | [Effect of baicalin on inflammatory response and TLR4/NF-κB signaling pathway of human brain microvascular endothelial cell after hypoxia-reoxygenation injury] |
| Baicalin | Neuroinflammation | 3 | PM | 33029280 | 📋 | Baicalin Ameliorates Cognitive Impairment and Protects Microglia from LPS-Induced Neuroinflammation via the SIRT1/HMGB1 Pathway |
| Baicalin | Neuroinflammation | 2 | PM | 33025359 | 📋 | A New Perspective on Ameliorating Depression-Like Behaviors: Suppressing Neuroinflammation by Upregulating PGC-1α |
| Baicalin | Neuroinflammation | 1 | PM | 32983956 | 📋 | Baicalin alleviates lipopolysaccharide-induced neuroglial activation and inflammatory factors activation in hippocampus of adult mice |
| Baicalin | Neurological Disorders | 2 | PM | 38503930 | 📋 | The potential of baicalin to enhance neuroprotection and mitochondrial function in a human neuronal cell model |
| Baicalin | Neurological Disorders | 1 | PM | 37764277 | 📋 | Therapeutic Effects of Baicalin on Diseases Related to Gut-Brain Axis Dysfunctions |
| Baicalin | Neuronal Damage | 1 | PM | 32473460 | 📋 | Baicalin combats glutamate excitotoxicity via protecting glutamine synthetase from ROS-induced 20S proteasomal degradation |
| Baicalin | Neuropathic Pain | 2 | PM | 32765762 | 📋 | Baicalin relieves neuropathic pain by regulating α 2-adrenoceptor levels in rats following spinal nerve injury |
| Baicalin | Neuropathic Pain | 1 | PM | 32613759 | 📋 | Baicalin Prevents the Up-Regulation of TRPV1 in Dorsal Root Ganglion and Attenuates Chronic Neuropathic Pain |
| Baicalin | Pain | 4 | PM | 34815689 | 📋 | Transcriptome Sequencing Explores the Mechanism of Baicalin on Bone Cancer Pain |
| Baicalin | Pain | 2 | PM | 32643091 | 📋 | Baicalin Attenuates Inflammatory Pain Associated Depressive Symptoms via Akt-mediated Adult Hippocampal Neurogenesis |
| Baicalin | Pain | 3 | PM | 30311061 | 📋 | Efficacy of a drug composed of herbal extracts on postoperative discomfort after surgical removal of impacted mandibular third molar: a randomized, triple-blind, controlled clinical trial |
| Baicalin | Pain | 1 | PM | 14633550 | 📋 | The Antiinflammatory and Analgesic Effects of Baicalin in Carrageenan-Evoked Thermal Hyperalgesia |
| Baicalin | Parkinson's Disease | 3 | PM | 38016618 | 📋 | Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease |
| Baicalin | Parkinson's Disease | 2 | PM | 34141154 | 📋 | Protective effects of baicalin in a Caenorhabditis elegans model of Parkinson's disease |
| Baicalin | Parkinson's Disease | 1 | PM | 32566108 | 📋 | Baicalin Represses C/EBP β via Its Antioxidative Effect in Parkinson's Disease |
| Baicalin | Pruritus | 1 | PM | 33905439 | 📋 | Extract of Scutellaria baicalensis induces semaphorin 3A production in human epidermal keratinocytes |
| Baicalin | Rheumatoid Arthritis | 2 | PM | 37149276 | 📋 | Bioinformatics analysis of ceRNA regulatory network of baicalin in alleviating pathological joint alterations in CIA rats |
| Baicalin | Rheumatoid Arthritis | 1 | PM | 32945496 | 📋 | Baicalin alleviates collagen‑induced arthritis and suppresses TLR2/MYD88/NF‑κB p65 signaling in rats and HFLS‑RAs |
| Baicalin | Seizures | 1 | PM | 34321866 | 📋 | Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats |
| Baicalin | Spinal Cord Injury | 2 | PM | 34558536 | 📋 | Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury |
| Baicalin | Spinal Cord Injury | 1 | PM | 19519665 | 📋 | Neuroprotective Effect of Scutellaria Baicalensis on Spinal Cord Injury in Rats |
| Baicalin | Stress | 1 | PM | 17639560 | 📋 | Schizandra Chinensis and Scutellaria Baicalensis Counter Stress Behaviors in Mice |
| Baicalin | Stroke | 1 | PM | 16129477 | 📋 | Scutellaria Flavonoid Reduced Memory Dysfunction and Neuronal Injury Caused by Permanent Global Ischemia in Rats |
| Baicalin | Subarachnoid Hemorrhage | 1 | PM | 34704542 | 📋 | Baicalin suppresses autophagy-dependent ferroptosis in early brain injury after subarachnoid hemorrhage |
