| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Andrographolide | Alzheimer's Disease | 7 | PM | 37179044 | 📋 | Andrographolide exerts a neuroprotective effect by regulating the LRP1-mediated PPARγ/NF-κB pathway |
| Andrographolide | Alzheimer's Disease | 6 | PM | 36029454 | 📋 | Andrographolide Attenuates Short-Term Spatial and Recognition Memory Impairment and Neuroinflammation Induced by a Streptozotocin Rat Model of Alzheimer's Disease |
| Andrographolide | Alzheimer's Disease | 1 | PM | 34824314 | 📋 | Andrographolide promotes hippocampal neurogenesis and spatial memory in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease |
| Andrographolide | Alzheimer's Disease | 2 | PM | 34235591 | 📋 | Protective effect of andrographolide against STZ induced Alzheimer's disease in experimental rats: possible neuromodulation and Aβ (1-42) analysis |
| Andrographolide | Alzheimer's Disease | 3 | PM | 34162168 | 📋 | Andrographolide ameliorates neuroinflammation in APP/PS1 transgenic mice |
| Andrographolide | Alzheimer's Disease | 5 | PM | 31701436 | 📋 | Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus |
| Andrographolide | Alzheimer's Disease | 11 | PM | 31379502 | 📋 | Presymptomatic Treatment With Andrographolide Improves Brain Metabolic Markers and Cognitive Behavior in a Model of Early-Onset Alzheimer's Disease |
| Andrographolide | Alzheimer's Disease | 4 | PM | 30235892 | 📋 | Andrographolide Protects PC12 Cells Against β-Amyloid-Induced Autophagy-Associated Cell Death Through Activation of the Nrf2-Mediated p62 Signaling Pathway |
| Andrographolide | Alzheimer's Disease | 9 | PM | 28373747 | 📋 | Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by A β42 through Nrf2-Related Inflammatory Response |
| Andrographolide | Alzheimer's Disease | 8 | PM | 27505720 | 📋 | Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus) |
| Andrographolide | Alzheimer's Disease | 10 | PM | 25524173 | 📋 | Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice |
| Andrographolide | Chronic Pain | 1 | PM | 37979090 | 📋 | Andrographolide inhibits the activation of spinal microglia and ameliorates mechanical allodynia |
| Andrographolide | Depression | 2 | PM | 31340160 | 📋 | Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice |
| Andrographolide | Depression | 1 | PM | 31181145 | 📋 | Andrographolide Exerts Significant Antidepressant-Like Effects Involving the Hippocampal BDNF System in Mice |
| Andrographolide | Diabetic Encephalopathy | 1 | PM | 26810454 | 📋 | Beneficial effects of an Andrographis paniculata extract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats |
| Andrographolide | Encephalitis | 1 | PM | 34909671 | 📋 | Screening of phytoconstituents of Andrographis paniculata against various targets of Japanese encephalitis virus: An in-silico and in-vitro target-based approach |
| Andrographolide | Epilepsy | 1 | PM | 35333519 | 📋 | Identification of Guaifenesin-Andrographolide as a Novel Combinatorial Drug Therapy for Epilepsy Using Network Virtual Screening and Experimental Validation |
| Andrographolide | Glioblastoma | 1 | PM | 36235222 | 📋 | Andrographolide Induces G2/M Cell Cycle Arrest and Apoptosis in Human Glioblastoma DBTRG-05MG Cell Line via ERK1/2 /c-Myc/p53 Signaling Pathway |
| Andrographolide | Glioblastoma | 3 | PM | 29285298 | 📋 | Andrographolide suppresses the migratory ability of human glioblastoma multiforme cells by targeting ERK1/2-mediated matrix metalloproteinase-2 expression |
| Andrographolide | Glioblastoma | 2 | PM | 22634579 | 📋 | Inactivation of PI3K/Akt signaling mediates proliferation inhibition and G2/M phase arrest induced by andrographolide in human glioblastoma cells |
| Andrographolide | Hyperalgesia | 1 | PM | 35663494 | 📋 | Effect of Diclofenac and Andrographolide Combination on Carrageenan-Induced Paw Edema and Hyperalgesia in Rats |
| Andrographolide | Ischemic Stroke | 2 | PM | 35602108 | 📋 | URB597 and Andrographolide Improve Brain Microvascular Endothelial Cell Permeability and Apoptosis by Reducing Oxidative Stress and Inflammation Associated with Activation of Nrf2 Signaling in Oxygen-Glucose Deprivation |
| Andrographolide | Ischemic Stroke | 1 | PM | 34368862 | 📋 | Protective effects of andrographolide against cerebral ischemia‑reperfusion injury in mice |
| Andrographolide | Ischemic Stroke | 3 | PM | 26746802 | 📋 | Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats |
| Andrographolide | Multiple Sclerosis | 1 | PM | 32380977 | 📋 | Efficacy of andrographolide in not active progressive multiple sclerosis: a prospective exploratory double-blind, parallel-group, randomized, placebo-controlled trial |
| Andrographolide | Multiple Sclerosis | 2 | PM | 15331658 | 📋 | Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse |
| Andrographolide | Neurodegenerative Disease | 4 | PM | 37571363 | 📋 | The Effects of Andrographis paniculata (Burm.F.) Wall. Ex Nees and Andrographolide on Neuroinflammation in the Treatment of Neurodegenerative Diseases |
| Andrographolide | Neurodegenerative Disease | 1 | PM | 33124061 | 📋 | Andrographolide restores glucose uptake in rat hippocampal neurons |
| Andrographolide | Neurodegenerative Disease | 2 | PM | 26798521 | 📋 | Andrographolide Stimulates Neurogenesis in the Adult Hippocampus |
| Andrographolide | Neurodegenerative Disease | 3 | PM | 25423492 | 📋 | Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: autoregulation of GSK-3β in vivo |
| Andrographolide | Neuroinflammation | 11 | PM | 37571363 | 📋 | The Effects of Andrographis paniculata (Burm.F.) Wall. Ex Nees and Andrographolide on Neuroinflammation in the Treatment of Neurodegenerative Diseases |
| Andrographolide | Neuroinflammation | 6 | PM | 37179044 | 📋 | Andrographolide exerts a neuroprotective effect by regulating the LRP1-mediated PPARγ/NF-κB pathway |
| Andrographolide | Neuroinflammation | 5 | PM | 36873986 | 📋 | Natural product-based bioactive agents in combination attenuate neuroinflammation in a tri-culture model |
| Andrographolide | Neuroinflammation | 4 | PM | 36029454 | 📋 | Andrographolide Attenuates Short-Term Spatial and Recognition Memory Impairment and Neuroinflammation Induced by a Streptozotocin Rat Model of Alzheimer's Disease |
| Andrographolide | Neuroinflammation | 1 | PM | 34162168 | 📋 | Andrographolide ameliorates neuroinflammation in APP/PS1 transgenic mice |
| Andrographolide | Neuroinflammation | 2 | PM | 31701436 | 📋 | Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus |
| Andrographolide | Neuroinflammation | 10 | PM | 31187188 | 📋 | Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion |
| Andrographolide | Neuroinflammation | 3 | PM | 30294256 | 📋 | Andrographolide Alleviates Acute Brain Injury in a Rat Model of Traumatic Brain Injury: Possible Involvement of Inflammatory Signaling |
| Andrographolide | Neuroinflammation | 9 | PM | 29146293 | 📋 | Andrographolide - A promising therapeutic agent, negatively regulates glial cell derived neurodegeneration of prefrontal cortex, hippocampus and working memory impairment |
| Andrographolide | Neuroinflammation | 8 | PM | 28669260 | 📋 | Andrographolide attenuates microglia-mediated Aβ neurotoxicity partially through inhibiting NF-κB and JNK MAPK signaling pathway |
| Andrographolide | Neuroinflammation | 7 | PM | 27663973 | 📋 | Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK |
| Andrographolide | Neurological Disorders | 2 | PM | 35154564 | 📋 | Neurobiological Promises of the Bitter Diterpene Lactone Andrographolide |
| Andrographolide | Neurological Disorders | 1 | PM | 31181444 | 📋 | A review for the neuroprotective effects of andrographolide in the central nervous system |
| Andrographolide | Neurological Disorders | 3 | PM | 29146293 | 📋 | Andrographolide - A promising therapeutic agent, negatively regulates glial cell derived neurodegeneration of prefrontal cortex, hippocampus and working memory impairment |
| Andrographolide | Neuronal Damage | 1 | PM | 32971182 | 📋 | Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease |
| Andrographolide | Neurotoxicity | 2 | PM | 38778607 | 📋 | Safeguarding Neuronal Integrity: Unveiling Possible Role of NFκB in the Neuroprotective Efficacy of Andrographolide Contrary to Aluminium Chloride-induced Neurotoxicity and Associated Spatial Memory Impairments in Rats |
| Andrographolide | Neurotoxicity | 1 | PM | 28669260 | 📋 | Andrographolide attenuates microglia-mediated Aβ neurotoxicity partially through inhibiting NF-κB and JNK MAPK signaling pathway |
| Andrographolide | Parkinson's Disease | 3 | PM | 37239873 | 📋 | Neuroprotection of Andrographolide against Neurotoxin MPP+-Induced Apoptosis in SH-SY5Y Cells via Activating Mitophagy, Autophagy, and Antioxidant Activities |
| Andrographolide | Parkinson's Disease | 1 | PM | 33639218 | 📋 | Andrographolide upregulates protein quality control mechanisms in cell and mouse through upregulation of mTORC1 function |
| Andrographolide | Parkinson's Disease | 2 | PM | 32551381 | 📋 | Phytochemical andrographolide modulates NF-κB and JNK in human neuroblastoma SH-SY5Y cells, a cell model for Parkinson's disease |
| Andrographolide | Parkinson's Disease | 4 | PM | 31389613 | 📋 | Andrographolide alleviates Parkinsonism in MPTP-PD mice via targeting mitochondrial fission mediated by dynamin-related protein 1 |
| Andrographolide | Peripheral Nerve Injury | 2 | PM | 29385888 | 📋 | Andrographolide relieved pathological pain generated by spared nerve injury model in mice |
| Andrographolide | Peripheral Nerve Injury | 1 | PM | 27599453 | 📋 | Pro‑neurogenic effects of andrographolide on RSC96 Schwann cells in vitro |
| Andrographolide | Rheumatoid Arthritis | 1 | PM | 32061742 | 📋 | Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund's adjuvant-induced arthritis |
| Andrographolide | Rheumatoid Arthritis | 2 | PM | 31614480 | 📋 | Andrographolide Ameliorates Rheumatoid Arthritis by Regulating the Apoptosis-NETosis Balance of Neutrophils |
| Andrographolide | Rheumatoid Arthritis | 5 | PM | 28584977 | 📋 | Andrographolide Benefits Rheumatoid Arthritis via Inhibiting MAPK Pathways |
| Andrographolide | Rheumatoid Arthritis | 6 | PM | 26141990 | 📋 | Andrographolide inhibits the migration, invasion and matrix metalloproteinase expression of rheumatoid arthritis fibroblast-like synoviocytes via inhibition of HIF-1α signaling |
| Andrographolide | Rheumatoid Arthritis | 4 | PM | 22012578 | 📋 | Andrographolide induces cell cycle arrest and apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes |
| Andrographolide | Rheumatoid Arthritis | 3 | PM | 19408036 | 📋 | Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial |
| Andrographolide | Schizophrenia | 1 | PM | 34294378 | 📋 | Andrographolide improves PCP-induced schizophrenia-like behaviors through blocking interaction between NRF2 and KEAP1 |
| Andrographolide | Spinal Cord Injury | 1 | PM | 36278181 | 📋 | Andrographolide contributes to spinal cord injury repair via inhibition of apoptosis, oxidative stress and inflammation |
| Andrographolide | Stroke | 1 | PM | 28749412 | 📋 | Multi-Targeting Andrographolide, a Novel NF-κB Inhibitor, as a Potential Therapeutic Agent for Stroke |
| Andrographolide | Subarachnoid Hemorrhage | 1 | PM | 35305248 | 📋 | Andrographolide Attenuates Blood-Brain Barrier Disruption, Neuronal Apoptosis, and Oxidative Stress Through Activation of Nrf2/HO-1 Signaling Pathway in Subarachnoid Hemorrhage |
| Andrographolide | Traumatic Brain Injury | 1 | PM | 30294256 | 📋 | Andrographolide Alleviates Acute Brain Injury in a Rat Model of Traumatic Brain Injury: Possible Involvement of Inflammatory Signaling |
| Andrographolide | Vascular Dementia | 1 | PM | 35397390 | 📋 | Network pharmacology-based strategy to investigate pharmacological mechanisms of Andrographolide for treatment of vascular cognitive impairment |
