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List of Melatonin and group Metabolic Disorder intersectionsRows: 133■ Human ■ Animal ■ Risk ■ Review

SubstanceConditionSeqSrc
PMID
Dtl
Title
Melatonin Diabetes Type 2
18
PM
38851097📋Protective effect of melatonin against metabolic disorders and neuropsychiatric injuries in type 2 diabetes mellitus mice
Melatonin Diabetes Type 2
17
PM
37722934📋Monoamines' role in islet cell function and type 2 diabetes risk
Melatonin Diabetes Type 2
16
PM
37627494📋Melatonin Improves Skeletal Muscle Structure and Oxidative Phenotype by Regulating Mitochondrial Dynamics and Autophagy in Zücker Diabetic Fatty Rat
Melatonin Diabetes Type 2
14
PM
36692817📋A novel combination of sitagliptin and melatonin ameliorates T2D manifestations: studies on experimental diabetic models
Melatonin Diabetes Type 2
13
PM
36475359📋Inhibition of miR-146a-5p and miR-8114 in Insulin- Secreting Cells Contributes to the Protection of Melatonin against Stearic Acid-Induced Cellular Senescence by Targeting Mafa
Melatonin Diabetes Type 2
11
PM
36092489📋Effects of melatonin supplementation in patients with type 2 diabetes mellitus and chronic periodontitis under nonsurgical periodontal therapy: A double-blind randomized controlled trial
Melatonin Diabetes Type 2
9
PM
35455066📋Anti-Inflammatory Effects of Melatonin in Rats with Induced Type 2 Diabetes Mellitus
Melatonin Diabetes Type 2
7
PM
35247789📋The melatonin MT 2 receptor is involved in the anti-apoptotic effects of melatonin in rats with type 2 diabetes mellitus
Melatonin Diabetes Type 2
5
PM
35173531📋The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease
Melatonin Diabetes Type 2
3
PM
35007648📋Diabetes mellitus and melatonin: Where are we?
Melatonin Diabetes Type 2
1
PM
34399601📋Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice
Melatonin Diabetes Type 2
15
PM
33766084📋Consumption of melatonin supplement improves cardiovascular disease risk factors and anthropometric indices in type 2 diabetes mellitus patients: a double-blind, randomized, placebo-controlled trial
Melatonin Diabetes Type 2
2
PM
33748504📋Melatonin protects the heart and pancreas by improving glucose homeostasis, oxidative stress, inflammation and apoptosis in T2DM-induced rats
Melatonin Diabetes Type 2
12
PM
33562452📋Study on the Effects of Melatonin on Glycemic Control and Periodontal Parameters in Patients with Type II Diabetes Mellitus and Periodontal Disease
Melatonin Diabetes Type 2
10
PM
33401187📋Melatonin ameliorates diabetes-induced brain injury in rats
Melatonin Diabetes Type 2
4
PM
29275919📋Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial
Melatonin Diabetes Type 2
8
PM
27023908📋Ameliorative effect of melatonin against increased intestinal permeability in diabetic rats: possible involvement of MLCK-dependent MLC phosphorylation
Melatonin Diabetes Type 2
6
PM
23020082📋Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats
Melatonin Excessive Weight
1
PM
34156346📋Long-term melatonin treatment attenuates body weight gain with aging in female mice
Melatonin Glucose Metabolism Disorder
7
PM
38534314📋Melatonin Improves Glucose Homeostasis and Insulin Sensitivity by Mitigating Inflammation and Activating AMPK Signaling in a Mouse Model of Sleep Fragmentation
Melatonin Glucose Metabolism Disorder
6
PM
38111124📋Exogenous Melatonin Alleviates Atrazine-Induced Glucose Metabolism Disorders in Mice Liver via Suppressing Endoplasmic Reticulum Stress
Melatonin Glucose Metabolism Disorder
5
PM
37371675📋Role of Melatonin in the Onset of Metabolic Syndrome in Women
Melatonin Glucose Metabolism Disorder
4
PM
35986482📋Melatonin alleviates PM 2.5 -induced glucose metabolism disorder and lipidome alteration by regulating endoplasmic reticulum stress
Melatonin Glucose Metabolism Disorder
1
PM
34496412📋Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Melatonin Glucose Metabolism Disorder
3
PM
34370338📋Effects of daily administration of melatonin before bedtime on fasting insulin, glucose and insulin sensitivity in healthy adults and patients with metabolic diseases. A systematic review and meta-analysis
Melatonin Glucose Metabolism Disorder
2
PM
22411259📋Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8)
Melatonin Hypercholesterolemia
2
PM
33156709📋The effects of melatonin against atherosclerosis-induced endothelial dysfunction and inflammation in hypercholesterolemic rats
Melatonin Hypercholesterolemia
1
PM
32708001📋Effects of Melatonin on Lipid Metabolism and Circulating Irisin in Sprague-Dawley Rats with Diet-Induced Obesity
Melatonin Hypercholesterolemia
3
PM
29191493📋Effects of melatonin supplementation on blood lipid concentrations: A systematic review and meta-analysis of randomized controlled trials
Melatonin Hyperglycemia
8
PM
37975141📋Melatonin and probiotic administration ameliorated hyperglycaemia, oxidative stress, and enhanced cytoprotective effect on beta-cells of diabetic rats
Melatonin Hyperglycemia
7
PM
35707823📋Melatonin relieves diabetic complications and regenerates pancreatic beta cells by the reduction in NF-kB expression in streptozotocin induced diabetic rats
Melatonin Hyperglycemia
6
PM
35178208📋Effect of melatonin on stress-induced hyperglycemia and insulin resistance in critically-ill patients: A randomized double-blind, placebo-controlled clinical trial
Melatonin Hyperglycemia
5
PM
33713326📋Melatonin Attenuates High Glucose-Induced Changes in Beta Amyloid Precursor Protein Processing in Human Neuroblastoma Cells
Melatonin Hyperglycemia
4
PM
32753840📋Melatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats
Melatonin Hyperglycemia
2
PM
32673151📋Melatonin protects INS-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity
Melatonin Hyperglycemia
1
PM
32547319📋Melatonin Protects Human Renal Proximal Tubule Epithelial Cells Against High Glucose-Mediated Fibrosis via the Cellular Prion Protein-TGF-β-Smad Signaling Axis
Melatonin Hyperglycemia
3
PM
26832833📋Effects of Melatonin on Oxidative Stress Index and Alveolar Bone Loss in Diabetic Rats With Periodontitis
Melatonin Hyperhomocysteinaemia
3
PM
34439426📋Melatonin as a Reducer of Neuro- and Vasculotoxic Oxidative Stress Induced by Homocysteine
Melatonin Hyperhomocysteinaemia
1
PM
32592115📋Melatonin and Vitamin E Alleviate Homocysteine-Induced Oxidative Injury and Apoptosis in Endothelial Cells
Melatonin Hyperhomocysteinaemia
2
PM
17803518📋Melatonin inhibits oxidative stress and apoptosis in fetal brains of hyperhomocysteinemic rat dams
Melatonin Hyperlipidemia
2
PM
35707823📋Melatonin relieves diabetic complications and regenerates pancreatic beta cells by the reduction in NF-kB expression in streptozotocin induced diabetic rats
Melatonin Hyperlipidemia
1
PM
33486831📋Effect of melatonin on visceral fat deposition, lipid metabolism and hepatic lipo-metabolic gene expression in male rats
Melatonin Hypertriglyceridemia
1
PM
29191493📋Effects of melatonin supplementation on blood lipid concentrations: A systematic review and meta-analysis of randomized controlled trials
Melatonin Insulin Resistance
12
PM
37804870📋Melatonin protects HT-22 cells against palmitic acid-induced glucolipid metabolic dysfunction and cell injuries: Involved in the regulation of synaptic plasticity and circadian rhythms
Melatonin Insulin Resistance
11
PM
36207302📋Suppression of obesity by melatonin through increasing energy expenditure and accelerating lipolysis in mice fed a high-fat diet
Melatonin Insulin Resistance
10
PM
35343087📋Daily injection of melatonin inhibits insulin resistance induced by chronic mealtime shift
Melatonin Insulin Resistance
9
PM
35178208📋Effect of melatonin on stress-induced hyperglycemia and insulin resistance in critically-ill patients: A randomized double-blind, placebo-controlled clinical trial
Melatonin Insulin Resistance
8
PM
34582575📋The effect of melatonin on glucose tolerance, insulin sensitivity and lipid profiles after a late evening meal in healthy young males
Melatonin Insulin Resistance
7
PM
34496412📋Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Melatonin Insulin Resistance
6
PM
34370338📋Effects of daily administration of melatonin before bedtime on fasting insulin, glucose and insulin sensitivity in healthy adults and patients with metabolic diseases. A systematic review and meta-analysis
Melatonin Insulin Resistance
5
PM
33411973📋Effects of melatonin on insulin signaling and inflammatory pathways of rats with apical periodontitis
Melatonin Insulin Resistance
4
PM
33150187📋Melatonin Alleviates Glucose and Lipid Metabolism Disorders in Guinea Pigs Caused by Different Artificial Light Rhythms
Melatonin Insulin Resistance
13
PM
25436746📋Beneficial effect of melatonin treatment on age-related insulin resistance and on the development of type 2 diabetes
Melatonin Insulin Resistance
1
PM
23020082📋Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats
Melatonin Insulin Resistance
2
PM
22411259📋Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8)
Melatonin Insulin Resistance
3
PM
22220562📋Melatonin improves metabolic syndrome induced by high fructose intake in rats
Melatonin Iron Overload
4
PM
38146034📋Evaluating the Protective Effects of Melatonin Against Chronic Iron Administration in Male Wistar Rats: a Comparative Analysis of Affective, Cognitive, and Oxidative Stress with EDTA Chelator
Melatonin Iron Overload
2
PM
36703914📋Melatonin Repairs Osteoporotic Bone Defects in Iron-Overloaded Rats through PI3K/AKT/GSK-3 β/P70S6k Signaling Pathway
Melatonin Iron Overload
1
PM
35961513📋Melatonin: Potential avenue for treating iron overload disorders
Melatonin Iron Overload
3
PM
28500782📋Melatonin protects bone marrow mesenchymal stem cells against iron overload-induced aberrant differentiation and senescence
Melatonin Metabolic Disorders
10
PM
37804870📋Melatonin protects HT-22 cells against palmitic acid-induced glucolipid metabolic dysfunction and cell injuries: Involved in the regulation of synaptic plasticity and circadian rhythms
Melatonin Metabolic Disorders
9
PM
36207302📋Suppression of obesity by melatonin through increasing energy expenditure and accelerating lipolysis in mice fed a high-fat diet
Melatonin Metabolic Disorders
8
PM
36139720📋Dose-Dependent Effect of Melatonin on BAT Thermogenesis in Zücker Diabetic Fatty Rat: Future Clinical Implications for Obesity
Melatonin Metabolic Disorders
7
PM
34683825📋Melatonin Improves Levels of Zn and Cu in the Muscle of Diabetic Obese Rats
Melatonin Metabolic Disorders
6
PM
34156346📋Long-term melatonin treatment attenuates body weight gain with aging in female mice
Melatonin Metabolic Disorders
5
PM
33934676📋Effects of melatonin supplementation on eating habits and appetite-regulating hormones: a systematic review of randomized controlled clinical and preclinical trials
Melatonin Metabolic Disorders
4
PM
33486831📋Effect of melatonin on visceral fat deposition, lipid metabolism and hepatic lipo-metabolic gene expression in male rats
Melatonin Metabolic Disorders
3
PM
32802257📋Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats
Melatonin Metabolic Disorders
2
PM
27190797📋Implication of Renal Aquaporin-3 in Fructose-Induced Metabolic Syndrome and Melatonin Protection
Melatonin Metabolic Disorders
1
PM
26044240📋The investigation of melatonin effect on liver antioxidant and oxidant levels in fructose-mediated metabolic syndrome model
Melatonin Metabolic Endotoxemia
3
PM
37989260📋Protective effect of melatonin on blood-brain barrier damage caused by Endotoxemia
Melatonin Metabolic Endotoxemia
2
PM
34873405📋Melatonin Alleviates LPS-Induced Pyroptotic Cell Death in Human Stem Cell-Derived Cardiomyocytes by Activating Autophagy
Melatonin Metabolic Endotoxemia
1
PM
33106037📋Melatonin modulates oxidative phosphorylation, hepatic and kidney autophagy-caused subclinical endotoxemia and acute ethanol-induced oxidative stress
Melatonin Metabolic Syndrome
8
PM
37371675📋Role of Melatonin in the Onset of Metabolic Syndrome in Women
Melatonin Metabolic Syndrome
7
PM
34347240📋Melatonin ameliorates cardiac remodelling in fructose-induced metabolic syndrome rat model by using genes encoding cardiac potassium ion channels
Melatonin Metabolic Syndrome
6
PM
34069820📋Melatonin Ameliorates Autophagy Impairment in a Metabolic Syndrome Model
Melatonin Metabolic Syndrome
5
PM
33346477📋[Treatment of metabolic syndrome in young patients with vitamin D deficiency]
Melatonin Metabolic Syndrome
4
PM
33090894📋Positive Effects of Melatonin on Renal Nitric Oxide-Asymmetric Dimethylarginine Metabolism in Fructose-Fed Rats
Melatonin Metabolic Syndrome
2
PM
32138638📋Dietary Melatonin Protects Against Behavioural, Metabolic, Oxidative, and Organ Morphological Changes in Mice that are Fed High-Fat, High- Sugar Diet
Melatonin Metabolic Syndrome
1
PM
29907916📋The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: a systematic review and meta-analysis of randomized controlled trials
Melatonin Metabolic Syndrome
9
PM
25436751📋Melatonin and diet-induced metabolic syndrome in rats: impact on the hypophysial-testicular axis
Melatonin Metabolic Syndrome
3
PM
22220562📋Melatonin improves metabolic syndrome induced by high fructose intake in rats
Melatonin Mitochondrial Dysfunction
18
PM
38001815📋Melatonin Alleviates the Impairment of Muscle Bioenergetics and Protein Quality Control Systems in Leptin-Deficiency-Induced Obesity
Melatonin Mitochondrial Dysfunction
17
PM
37832908📋Melatonin Improves Mitochondrial Dysfunction and Attenuates Neuropathic Pain by Regulating SIRT1 in Dorsal Root Ganglions
Melatonin Mitochondrial Dysfunction
16
PM
36810730📋Melatonin-mediated FKBP4 downregulation protects against stress-induced neuronal mitochondria dysfunctions by blocking nuclear translocation of GR
Melatonin Mitochondrial Dysfunction
15
PM
35523285📋Melatonin: A mitochondrial resident with a diverse skill set
Melatonin Mitochondrial Dysfunction
13
PM
34668398📋Melatonin ameliorates aging-related impaired angiogenesis in gastric endothelial cells via local actions on mitochondria & VEGF-survivin signaling
Melatonin Mitochondrial Dysfunction
12
PM
33962019📋Melatonin prevents blood-retinal barrier breakdown and mitochondrial dysfunction in high glucose and hypoxia-induced in vitro diabetic macular edema model
Melatonin Mitochondrial Dysfunction
11
PM
33332241📋Melatonin Inhibits Vascular Endothelial Cell Pyroptosis by Improving Mitochondrial Function via UQCRC1 Up-regulation and Demethylation
Melatonin Mitochondrial Dysfunction
10
PM
33260800📋Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging
Melatonin Mitochondrial Dysfunction
9
PM
33088945📋Activation of SIRT1/PGC 1α/SIRT3 pathway by melatonin provides protection against mitochondrial dysfunction in isoproterenol induced myocardial injury
Melatonin Mitochondrial Dysfunction
8
PM
33059742📋Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage
Melatonin Mitochondrial Dysfunction
2
PM
31773776📋Melatonin enhances mitochondrial biogenesis and protects against rotenone-induced mitochondrial deficiency in early porcine embryos
Melatonin Mitochondrial Dysfunction
14
PM
31678348📋Nicotinamide Mononucleotide and Melatonin Alleviate Aging-induced Cognitive Impairment via Modulation of Mitochondrial Function and Apoptosis in the Prefrontal Cortex and Hippocampus
Melatonin Mitochondrial Dysfunction
20
PM
28994117📋Melatonin ameliorates Aβ1-42 -induced Alzheimer's cognitive deficits in mouse model
Melatonin Mitochondrial Dysfunction
4
PM
28247434📋Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice
Melatonin Mitochondrial Dysfunction
3
PM
27555536📋Melatonin reverses H-89 induced spatial memory deficit: Involvement of oxidative stress and mitochondrial function
Melatonin Mitochondrial Dysfunction
6
PM
26087000📋Melatonin: A Potential Anti-Oxidant Therapeutic Agent for Mitochondrial Dysfunctions and Related Disorders
Melatonin Mitochondrial Dysfunction
19
PM
25436750📋Early gender differences in the redox status of the brain mitochondria with age: effects of melatonin therapy
Melatonin Mitochondrial Dysfunction
1
PM
24313280📋Age-related changes in mitochondrial function of mouse colonic smooth muscle: beneficial effects of melatonin
Melatonin Mitochondrial Dysfunction
7
PM
23137057📋Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes
Melatonin Mitochondrial Dysfunction
5
PM
12074097📋Melatonin protects hepatic mitochondrial respiratory chain activity in senescence-accelerated mice
Melatonin Obesity
27
PM
38387135📋Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and male Zücker diabetic fatty rats
Melatonin Obesity
25
PM
37652870📋Protective Effects of Melatonin in High-Fat Diet-Induced Hepatic Steatosis via Decreased Intestinal Lipid Absorption and Hepatic Cholesterol Synthesis
Melatonin Obesity
24
PM
37627494📋Melatonin Improves Skeletal Muscle Structure and Oxidative Phenotype by Regulating Mitochondrial Dynamics and Autophagy in Zücker Diabetic Fatty Rat
Melatonin Obesity
23
PM
36139720📋Dose-Dependent Effect of Melatonin on BAT Thermogenesis in Zücker Diabetic Fatty Rat: Future Clinical Implications for Obesity
Melatonin Obesity
22
PM
35937803📋Therapeutic Target Analysis and Molecular Mechanism of Melatonin - Treated Leptin Resistance Induced Obesity: A Systematic Study of Network Pharmacology
Melatonin Obesity
21
PM
35274657📋Melatonin induces fat browning by transdifferentiation of white adipocytes and de novo differentiation of mesenchymal stem cells
Melatonin Obesity
20
PM
35008644📋Mechanisms of Melatonin in Obesity: A Review
Melatonin Obesity
16
PM
34861097📋The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review
Melatonin Obesity
19
PM
34573114📋Melatonin Enhances the Mitochondrial Functionality of Brown Adipose Tissue in Obese-Diabetic Rats
Melatonin Obesity
18
PM
34563600📋Protective Effects of Melatonin against Obesity-Induced by Leptin Resistance
Melatonin Obesity
17
PM
34490912📋Melatonin ameliorates endocrine dysfunction and defective sperm integrity associated with high-fat diet-induced obesity in male Wistar rats
Melatonin Obesity
4
PM
34423033📋Melatonin Supplementation and Anthropometric Indices: A Randomized Double-Blind Controlled Clinical Trial
Melatonin Obesity
15
PM
33546749📋Melatonin activates ABCA1 via the BiP/NRF1 pathway to suppress high-cholesterol-induced apoptosis of mesenchymal stem cells
Melatonin Obesity
14
PM
33201734📋Comparative Protective Effects of N-Acetylcysteine, and Melatonin against Obesity- Induced Testicular Dysfunction in Rats
Melatonin Obesity
13
PM
33150187📋Melatonin Alleviates Glucose and Lipid Metabolism Disorders in Guinea Pigs Caused by Different Artificial Light Rhythms
Melatonin Obesity
12
PM
33080320📋Melatonin supplementation in the management of obesity and obesity-associated disorders: a review of physiological mechanisms and clinical applications
Melatonin Obesity
3
PM
32708001📋Effects of Melatonin on Lipid Metabolism and Circulating Irisin in Sprague-Dawley Rats with Diet-Induced Obesity
Melatonin Obesity
2
PM
32392192📋[Melatonin Induces Apoptotic Cell Death in 3T3-L1 Preadipocytes]
Melatonin Obesity
8
PM
29900537📋Melatonin expression in periodontitis and obesity: An experimental in-vivo investigation
Melatonin Obesity
9
PM
29405372📋Melatonin increases brown adipose tissue mass and function in Zücker diabetic fatty rats: implications for obesity control
Melatonin Obesity
6
PM
29206172📋Melatonin Efficacy in Obese Leptin-Deficient Mice Heart
Melatonin Obesity
26
PM
29149454📋Melatonin alleviates adipose inflammation through elevating α-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice
Melatonin Obesity
5
PM
29086246📋Melatonin Prevents the Harmful Effects of Obesity on the Brain, Including at the Behavioral Level
Melatonin Obesity
10
PM
28199741📋Melatonin prevents obesity through modulation of gut microbiota in mice
Melatonin Obesity
7
PM
27090356📋Melatonin reduces endoplasmic reticulum stress and autophagy in liver of leptin-deficient mice
Melatonin Obesity
11
PM
26250620📋Melatonin reduces obesity and restores adipokine patterns and metabolism in obese (ob/ob) mice
Melatonin Obesity
1
PM
24134701📋Melatonin administration decreases adipogenesis in the liver of ob/ob mice through autophagy modulation
Melatonin Overweight
1
PM
28339282📋Melatonin for Reducing Weight Gain Following Administration of Atypical Antipsychotic Olanzapine for Adolescents with Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial
Melatonin Postprandial Hyperglycemia
1
PM
34582575📋The effect of melatonin on glucose tolerance, insulin sensitivity and lipid profiles after a late evening meal in healthy young males
Melatonin Prediabetes
1
PM
29206172📋Melatonin Efficacy in Obese Leptin-Deficient Mice Heart
Melatonin Sarcopenic Obesity
1
PM
37047070📋Melatonin and Exercise Counteract Sarcopenic Obesity through Preservation of Satellite Cell Function