| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Grape Seed extract | AGE Products | 1 | PM | 19502731 | 📋 | Effects of grape seed proanthocyanidin extracts on aortic pulse wave velocity in streptozocin induced diabetic rats |
| Grape Seed extract | AGE Products | 2 | PM | 18030059 | 📋 | Cardioprotective effects of grape seed proanthocyanidins extracts in streptozocin induced diabetic rats |
| Grape Seed extract | Diabetes Type 2 | 3 | PM | 38367173 | 📋 | Grape Seed Proanthocyanidins Protect Pancreatic β Cells Against Ferroptosis via the Nrf2 Pathway in Type 2 Diabetes |
| Grape Seed extract | Diabetes Type 2 | 2 | PM | 23161660 | 📋 | Grape seed proanthocyanidin extracts alleviate oxidative stress and ER stress in skeletal muscle of low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats |
| Grape Seed extract | Diabetes Type 2 | 1 | PM | 19646193 | 📋 | Effects of Grape Seed Extract in Type 2 Diabetic Subjects at High Cardiovascular Risk: A Double Blind Randomized Placebo Controlled Trial Examining Metabolic Markers, Vascular Tone, Inflammation, Oxidative Stress and Insulin Sensitivity |
| Grape Seed extract | Excessive Weight | 2 | PM | 36839395 | 📋 | Grape-Seed Proanthocyanidins Modulate Adipose Tissue Adaptations to Obesity in a Photoperiod-Dependent Manner in Fischer 344 Rats |
| Grape Seed extract | Excessive Weight | 1 | PM | 34296715 | 📋 | Grape seed proanthocyanidins reduced the overweight of C57BL/6J mice through modulating adipose thermogenesis and gut microbiota |
| Grape Seed extract | Excessive Weight | 4 | PM | 31398921 | 📋 | Proanthocyanidins Limit Adipose Accrual Induced by a Cafeteria Diet, Several Weeks after the End of the Treatment |
| Grape Seed extract | Excessive Weight | 3 | PM | 27039093 | 📋 | A specific dose of grape seed-derived proanthocyanidins to inhibit body weight gain limits food intake and increases energy expenditure in rats |
| Grape Seed extract | Glucose Metabolism Disorder | 2 | PM | 23215023 | 📋 | Procyanidins modulate microRNA expression in pancreatic islets |
| Grape Seed extract | Glucose Metabolism Disorder | 1 | PM | 22444499 | 📋 | Procyanidins modify insulinemia by affecting insulin production and degradation |
| Grape Seed extract | Hypercholesterolemia | 7 | PM | 37375586 | 📋 | Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial |
| Grape Seed extract | Hypercholesterolemia | 4 | PM | 34067538 | 📋 | Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations-A Systematic Review of the Literature |
| Grape Seed extract | Hypercholesterolemia | 3 | PM | 33793875 | 📋 | Grape seed extract improved the fertility-enhancing effect of atorvastatin in high-fat diet-induced testicular injury in rats: involvement of antioxidant and anti-apoptotic effects |
| Grape Seed extract | Hypercholesterolemia | 2 | PM | 33456610 | 📋 | Grape Seed Extract Reduces the Degree of Atherosclerosis in Ligature-Induced Periodontitis in Rats - An Experimental Study |
| Grape Seed extract | Hypercholesterolemia | 5 | PM | 31317709 | 📋 | Subject Profile Assessment of Cases Recommended with Nutritional Supplement Containing Red Yeast Rice, Grape Seed Extract and Black Pepper Extract: A Prospective, Multicentric, Post-marketing Study |
| Grape Seed extract | Hypercholesterolemia | 8 | PM | 27240545 | 📋 | Use of metabolomics and lipidomics to evaluate the hypocholestreolemic effect of Proanthocyanidins from grape seed in a pig model |
| Grape Seed extract | Hypercholesterolemia | 6 | PM | 27143594 | 📋 | ESSENS dyslipidemia: A placebo-controlled, randomized study of a nutritional supplement containing red yeast rice in subjects with newly diagnosed dyslipidemia |
| Grape Seed extract | Hypercholesterolemia | 1 | PM | 11508317 | 📋 | Effects of Niacin-Bound Chromium and Grape Seed Proanthocyanidin Extract on the Lipid Profile of Hypercholesterolemic Subjects: A Pilot Study |
| Grape Seed extract | Hyperglycemia | 3 | PM | 31880030 | 📋 | The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: A systematic review and meta-analysis of randomized controlled trials |
| Grape Seed extract | Hyperglycemia | 2 | PM | 28944891 | 📋 | Thioredoxin Is Implicated in the Anti‑apoptotic Effects of Grape Seed Proanthocyanidin Extract During Hyperglycemia |
| Grape Seed extract | Hyperglycemia | 1 | PM | 24026800 | 📋 | Grape Seed Proanthocyanidins and Metformin Act by Different Mechanisms to Promote Insulin Signaling in Rats Fed High Calorie Diet |
| Grape Seed extract | Hyperlipidemia | 8 | PM | 38007734 | 📋 | Effect of Grape Seed Procyanidins Combined with Allicin on Lipid Levels in Hyperlipidemic Rats |
| Grape Seed extract | Hyperlipidemia | 3 | PM | 32447624 | 📋 | Grape Seed Proanthocyanidin Extract Ameliorates Hepatic Lipid Accumulation and Inflammation in Grass Carp (Ctenopharyngodon Idella) |
| Grape Seed extract | Hyperlipidemia | 5 | PM | 31880030 | 📋 | The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: A systematic review and meta-analysis of randomized controlled trials |
| Grape Seed extract | Hyperlipidemia | 4 | PM | 31175811 | 📋 | Grape Seed Proanthocyanidin Affects Lipid Metabolism via Changing Gut Microflora and Enhancing Propionate Production in Weaned Pigs |
| Grape Seed extract | Hyperlipidemia | 2 | PM | 31092996 | 📋 | Grape Seed Extract Alleviates Dexamethasone-Induced Hyperlipidemia, Lipid Peroxidation, and Hematological Alteration in Rats |
| Grape Seed extract | Hyperlipidemia | 1 | PM | 27191247 | 📋 | The Effect of Red Grape Seed Extract on Serum Paraoxonase Activity in Patients With Mild to Moderate Hyperlipidemia |
| Grape Seed extract | Hyperlipidemia | 7 | PM | 23437789 | 📋 | Red grape seed extract improves lipid profiles and decreases oxidized low-density lipoprotein in patients with mild hyperlipidemia |
| Grape Seed extract | Hyperlipidemia | 6 | PM | 22965541 | 📋 | Grape seed proanthocyanidins repress the hepatic lipid regulators miR-33 and miR-122 in rats |
| Grape Seed extract | Hypertriglyceridemia | 4 | PM | 27111442 | 📋 | Grape Seed Procyanidins and Cholestyramine Differentially Alter Bile Acid and Cholesterol Homeostatic Gene Expression in Mouse Intestine and Liver |
| Grape Seed extract | Hypertriglyceridemia | 2 | PM | 26458107 | 📋 | A Grape Seed Procyanidin Extract Ameliorates Fructose-Induced Hypertriglyceridemia in Rats via Enhanced Fecal Bile Acid and Cholesterol Excretion and Inhibition of Hepatic Lipogenesis |
| Grape Seed extract | Hypertriglyceridemia | 3 | PM | 22995387 | 📋 | Grape seed procyanidins improve β-cell functionality under lipotoxic conditions due to their lipid-lowering effect |
| Grape Seed extract | Hypertriglyceridemia | 1 | PM | 18720348 | 📋 | Dietary Procyanidins Lower Triglyceride Levels Signaling Through the Nuclear Receptor Small Heterodimer Partner |
| Grape Seed extract | Insulin Resistance | 4 | PM | 33385766 | 📋 | Effect of 8 weeks' supplementation grape seed extract on insulin resistance in iranian adolescents with metabolic syndrome: A randomized controlled trial |
| Grape Seed extract | Insulin Resistance | 3 | PM | 32560216 | 📋 | Effects of Fish Oil and Grape Seed Extract Combination on Hepatic Endogenous Antioxidants and Bioactive Lipids in Diet-Induced Early Stages of Insulin Resistance in Rats |
| Grape Seed extract | Insulin Resistance | 2 | PM | 24026800 | 📋 | Grape Seed Proanthocyanidins and Metformin Act by Different Mechanisms to Promote Insulin Signaling in Rats Fed High Calorie Diet |
| Grape Seed extract | Insulin Resistance | 1 | PM | 21736810 | 📋 | Grape Seed Extract Supplementation Prevents High-Fructose Diet-Induced Insulin Resistance in Rats by Improving Insulin and Adiponectin Signalling Pathways |
| Grape Seed extract | Iron Overload | 4 | PM | 37832335 | 📋 | Grape seed extract in combination with deferasirox ameliorates iron overload, oxidative stress, inflammation, and liver dysfunction in beta thalassemia children |
| Grape Seed extract | Iron Overload | 2 | PM | 31570250 | 📋 | Protective effects of grape seed proanthocyanidins against iron overload-induced renal oxidative damage in rats |
| Grape Seed extract | Iron Overload | 3 | PM | 31236816 | 📋 | Alleviation Effect of Grape Seed Proanthocyanidins on Neuronal Apoptosis in Rats with Iron Overload |
| Grape Seed extract | Iron Overload | 1 | PM | 29743442 | 📋 | Fluoride-induced Iron Overload Contributes to Hepatic Oxidative Damage in Mouse and the Protective Role of Grape Seed Proanthocyanidin Extract |
| Grape Seed extract | Metabolic Disorders | 11 | PM | 38069379 | 📋 | Abrupt Photoperiod Changes Differentially Modulate Hepatic Antioxidant Response in Healthy and Obese Rats: Effects of Grape Seed Proanthocyanidin Extract (GSPE) |
| Grape Seed extract | Metabolic Disorders | 10 | PM | 37627601 | 📋 | Rhythm and ROS: Hepatic Chronotherapeutic Features of Grape Seed Proanthocyanidin Extract Treatment in Cafeteria Diet-Fed Rats |
| Grape Seed extract | Metabolic Disorders | 9 | PM | 37377055 | 📋 | Metabolism disturbance by light/dark cycle switching depends on the rat health status: the role of grape seed flavanols |
| Grape Seed extract | Metabolic Disorders | 5 | PM | 37110226 | 📋 | Effect of Grape Seed Proanthocyanidins on Fat Metabolism and Adipocytokines in Obese Rats |
| Grape Seed extract | Metabolic Disorders | 4 | PM | 36386937 | 📋 | Grape polyphenols decrease circulating branched chain amino acids in overfed adults |
| Grape Seed extract | Metabolic Disorders | 3 | PM | 35684049 | 📋 | Proanthocyanidins Restore the Metabolic Diurnal Rhythm of Subcutaneous White Adipose Tissue According to Time-Of-Day Consumption |
| Grape Seed extract | Metabolic Disorders | 2 | PM | 35215423 | 📋 | Time-of-Day Circadian Modulation of Grape-Seed Procyanidin Extract (GSPE) in Hepatic Mitochondrial Dynamics in Cafeteria-Diet-Induced Obese Rats |
| Grape Seed extract | Metabolic Disorders | 1 | PM | 34208508 | 📋 | Grape-Seed Proanthocyanidin Extract Reverts Obesity-Related Metabolic Derangements in Aged Female Rats |
| Grape Seed extract | Metabolic Disorders | 7 | PM | 28677803 | 📋 | Grape seed procyanidin B2 ameliorates hepatic lipid metabolism disorders in db/db mice |
| Grape Seed extract | Metabolic Disorders | 8 | PM | 28268123 | 📋 | Brain proteomic modifications associated to protective effect of grape extract in a murine model of obesity |
| Grape Seed extract | Metabolic Disorders | 6 | PM | 27418399 | 📋 | The combined action of omega-3 polyunsaturated fatty acids and grape proanthocyanidins on a rat model of diet-induced metabolic alterations |
| Grape Seed extract | Metabolic Endotoxemia | 1 | PM | 31035432 | 📋 | Grape-Seed Proanthocyanidins are Able to Reverse Intestinal Dysfunction and Metabolic Endotoxemia Induced by a Cafeteria Diet in Wistar Rats |
| Grape Seed extract | Metabolic Syndrome | 1 | PM | 33385766 | 📋 | Effect of 8 weeks' supplementation grape seed extract on insulin resistance in iranian adolescents with metabolic syndrome: A randomized controlled trial |
| Grape Seed extract | Metabolic Syndrome | 2 | PM | 28162106 | 📋 | Chronic administration of grape-seed polyphenols attenuates the development of hypertension and improves other cardiometabolic risk factors associated with the metabolic syndrome in cafeteria diet-fed rats |
| Grape Seed extract | Mitochondrial Dysfunction | 2 | PM | 32266639 | 📋 | Grape Seed Proanthocyanidins Improves Mitochondrial Function and Reduces Oxidative Stress Through an Increase in Sirtuin 3 Expression in EA.hy926 Cells in High Glucose Condition |
| Grape Seed extract | Mitochondrial Dysfunction | 1 | PM | 31943241 | 📋 | Grape Seed Proanthocyanidins Prevent H 2 O 2 -Induced Mitochondrial Dysfunction and Apoptosis via SIRT 1 Activation in Embryonic Kidney Cells |
| Grape Seed extract | Obesity | 21 | PM | 37110226 | 📋 | Effect of Grape Seed Proanthocyanidins on Fat Metabolism and Adipocytokines in Obese Rats |
| Grape Seed extract | Obesity | 20 | PM | 36444031 | 📋 | Proanthocyanidins in grape seeds and their role in gut microbiota-white adipose tissue axis |
| Grape Seed extract | Obesity | 19 | PM | 35916585 | 📋 | The effects of grape seed proanthocyanidins in cafeteria diet-induced obese Fischer 344 rats are influenced by faecal microbiota in a photoperiod dependent manner |
| Grape Seed extract | Obesity | 17 | PM | 35794638 | 📋 | Grape seed and skin extract, a potential prebiotic with anti-obesity effect through gut microbiota modulation |
| Grape Seed extract | Obesity | 16 | PM | 34208508 | 📋 | Grape-Seed Proanthocyanidin Extract Reverts Obesity-Related Metabolic Derangements in Aged Female Rats |
| Grape Seed extract | Obesity | 15 | PM | 34195217 | 📋 | Grape Polyphenols Attenuate Diet-Induced Obesity and Hepatic Steatosis in Mice in Association With Reduced Butyrate and Increased Markers of Intestinal Carbohydrate Oxidation |
| Grape Seed extract | Obesity | 14 | PM | 33905304 | 📋 | Effects of Chronic Dietary Grape Seed Extract Supplementation on Aortic Stiffness and Hemodynamic Responses in Obese/Overweight Males during Submaximal Exercise |
| Grape Seed extract | Obesity | 11 | PM | 33114190 | 📋 | A Mix of Natural Bioactive Compounds Reduces Fat Accumulation and Modulates Gene Expression in the Adipose Tissue of Obese Rats Fed a Cafeteria Diet |
| Grape Seed extract | Obesity | 10 | PM | 33044768 | 📋 | Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals: A randomized, placebo-controlled trial |
| Grape Seed extract | Obesity | 13 | PM | 32114568 | 📋 | Effects of Grape Seed Proanthocyanidin Extract on Obesity |
| Grape Seed extract | Obesity | 1 | PM | 31713941 | 📋 | The Effects of Grape Seed Extract (Vitis Vinifera) Supplement on Inflammatory Markers, Neuropeptide Y, Anthropometric Measures, and Appetite in Obese or Overweight Individuals: A Randomized Clinical Trial |
| Grape Seed extract | Obesity | 9 | PM | 30189642 | 📋 | Grape Seed Proanthocyanidins Improve White Adipose Tissue Expansion During Diet-Induced Obesity Development in Rats |
| Grape Seed extract | Obesity | 5 | PM | 29578242 | 📋 | Proanthocyanidin-Rich Grape Seed Extract Modulates Intestinal Microbiota in Ovariectomized Mice |
| Grape Seed extract | Obesity | 6 | PM | 28903761 | 📋 | Protective Effects of Grape Seed and Skin Extract Against High-Fat-Diet-Induced Lipotoxicity in Rat Lung |
| Grape Seed extract | Obesity | 12 | PM | 28875188 | 📋 | Alterations to metabolically active bacteria in the mucosa of the small intestine predict anti-obesity and anti-diabetic activities of grape seed extract in mice |
| Grape Seed extract | Obesity | 7 | PM | 28500724 | 📋 | Grape Seed Proanthocyanidin Extract Ameliorates Inflammation and Adiposity by Modulating Gut Microbiota in High-Fat Diet Mice |
| Grape Seed extract | Obesity | 8 | PM | 28373675 | 📋 | Grape Seed Proanthocyanidin Supplementation Reduces Adipocyte Size and Increases Adipocyte Number in Obese Rats |
| Grape Seed extract | Obesity | 26 | PM | 28076832 | 📋 | Dietary supplementation of grape seed and skin flour mitigates brain oxidative damage induced by a high-fat diet in rat: Gender dependency |
| Grape Seed extract | Obesity | 25 | PM | 27677620 | 📋 | Proanthocyanidins potentiate hypothalamic leptin/STAT3 signalling and Pomc gene expression in rats with diet-induced obesity |
| Grape Seed extract | Obesity | 3 | PM | 27161420 | 📋 | Grape Seed and Skin Extract as an Adjunct to Xenical Therapy Reduces Obesity, Brain Lipotoxicity and Oxidative Stress in High Fat Diet Fed Rats |
| Grape Seed extract | Obesity | 18 | PM | 25011388 | 📋 | Chronic intake of proanthocyanidins and docosahexaenoic acid improves skeletal muscle oxidative capacity in diet-obese rats |
| Grape Seed extract | Obesity | 24 | PM | 24289079 | 📋 | Grape seed and skin extract mitigates heart and liver oxidative damage induced by a high-fat diet in the rat: gender dependency |
| Grape Seed extract | Obesity | 4 | PM | 24158847 | 📋 | High-fat Diet Induced an Oxidative Stress in White Adipose Tissue and Disturbed Plasma Transition Metals in Rat: Prevention by Grape Seed and Skin Extract |
| Grape Seed extract | Obesity | 23 | PM | 23537016 | 📋 | Grape seed and skin extract alleviates high-fat diet-induced renal lipotoxicity and prevents copper depletion in rat |
| Grape Seed extract | Obesity | 22 | PM | 22584454 | 📋 | Low doses of grape seed procyanidins reduce adiposity and improve the plasma lipid profile in hamsters |
| Grape Seed extract | Obesity | 2 | PM | 21733324 | 📋 | Chronic Dietary Supplementation of Proanthocyanidins Corrects the Mitochondrial Dysfunction of Brown Adipose Tissue Caused by Diet-Induced Obesity in Wistar Rats |
| Grape Seed extract | Overweight | 4 | PM | 34296715 | 📋 | Grape seed proanthocyanidins reduced the overweight of C57BL/6J mice through modulating adipose thermogenesis and gut microbiota |
| Grape Seed extract | Overweight | 3 | PM | 33905304 | 📋 | Effects of Chronic Dietary Grape Seed Extract Supplementation on Aortic Stiffness and Hemodynamic Responses in Obese/Overweight Males during Submaximal Exercise |
| Grape Seed extract | Overweight | 2 | PM | 33044768 | 📋 | Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals: A randomized, placebo-controlled trial |
| Grape Seed extract | Overweight | 1 | PM | 31713941 | 📋 | The Effects of Grape Seed Extract (Vitis Vinifera) Supplement on Inflammatory Markers, Neuropeptide Y, Anthropometric Measures, and Appetite in Obese or Overweight Individuals: A Randomized Clinical Trial |
| Grape Seed extract | Postprandial Hyperglycemia | 1 | PM | 23060692 | 📋 | Postprandial blood glucose response to grape seed extract in healthy participants: A pilot study |
| Grape Seed extract | Postprandial Lipemia | 1 | PM | 23983179 | 📋 | Omega-3 polyunsaturated fatty acids and proanthocyanidins improve postprandial metabolic flexibility in rat |
