| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Fucoidan | Diabetes Type 2 | 10 | PM | 37253360 | 📋 | Fucoidan derived from Sargassum pallidum alleviates metabolism disorders associated with improvement of cardiac injury and oxidative stress in diabetic mice |
| Fucoidan | Diabetes Type 2 | 8 | PM | 36613249 | 📋 | Fucoidan from Laminaria japonica Ameliorates Type 2 Diabetes Mellitus in Association with Modulation of Gut Microbiota and Metabolites in Streptozocin-Treated Mice |
| Fucoidan | Diabetes Type 2 | 4 | PM | 35841956 | 📋 | Low molecular weight fucoidan alleviates cerebrovascular damage by promoting angiogenesis in type 2 diabetes mice |
| Fucoidan | Diabetes Type 2 | 3 | PM | 35170612 | 📋 | Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats |
| Fucoidan | Diabetes Type 2 | 2 | PM | 35077745 | 📋 | Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats |
| Fucoidan | Diabetes Type 2 | 9 | PM | 33900346 | 📋 | Sargassum fusiforme fucoidan modifies gut microbiota and intestinal metabolites during alleviation of hyperglycemia in type 2 diabetic mice |
| Fucoidan | Diabetes Type 2 | 6 | PM | 32070744 | 📋 | Fucoidan from Ecklonia maxima is a powerful inhibitor of the diabetes-related enzyme, α-glucosidase |
| Fucoidan | Diabetes Type 2 | 7 | PM | 30732817 | 📋 | In vitro and in silico inhibition properties of fucoidan against α-amylase and α-D-glucosidase with relevance to type 2 diabetes mellitus |
| Fucoidan | Diabetes Type 2 | 1 | PM | 28387741 | 📋 | Effects of Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin on Glucose Homeostasis, Lipid Metabolism, and Liver Function in a Mouse Model of Type II Diabetes |
| Fucoidan | Diabetes Type 2 | 5 | PM | 22580164 | 📋 | Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice |
| Fucoidan | Glucose Metabolism Disorder | 2 | PM | 35170612 | 📋 | Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats |
| Fucoidan | Glucose Metabolism Disorder | 3 | PM | 35077745 | 📋 | Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats |
| Fucoidan | Glucose Metabolism Disorder | 1 | PM | 33440853 | 📋 | Fucoidan Structure and Its Impact on Glucose Metabolism: Implications for Diabetes and Cancer Therapy |
| Fucoidan | Glucose Metabolism Disorder | 4 | PM | 28387741 | 📋 | Effects of Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin on Glucose Homeostasis, Lipid Metabolism, and Liver Function in a Mouse Model of Type II Diabetes |
| Fucoidan | Hypercholesterolemia | 1 | PM | 24611906 | 📋 | Effect of fucoidan administration on insulin secretion and insulin resistance in overweight or obese adults |
| Fucoidan | Hyperglycemia | 1 | PM | 32971911 | 📋 | Fucoidan from Ascophyllum nodosum Suppresses Postprandial Hyperglycemia by Inhibiting Na +/Glucose Cotransporter 1 Activity |
| Fucoidan | Hyperglycemia | 2 | PM | 22580164 | 📋 | Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice |
| Fucoidan | Hyperlipidemia | 8 | PM | 38738998 | 📋 | A comparative study of the hypolipidemic effects and mechanisms of action of Laminaria japonica- and Ascophyllum nodosum-derived fucoidans in apolipoprotein E-deficient mice |
| Fucoidan | Hyperlipidemia | 7 | PM | 38410655 | 📋 | Hypolipidemic effect of brown seaweed ( Sargassum crassifolium) extract in vivo (Study of histopathology, mRNA expression, and immunohistochemistry (IHC) with VCAM-1, ICAM-1, and MCP-1 parameters) |
| Fucoidan | Hyperlipidemia | 6 | PM | 38375358 | 📋 | Laminaria japonica Aresch-Derived Fucoidan Ameliorates Hyperlipidemia by Upregulating LXRs and Suppressing SREBPs |
| Fucoidan | Hyperlipidemia | 5 | PM | 31381913 | 📋 | Hypolipidemic effects of fucoidan fractions from Saccharina sculpera (Laminariales, Phaeophyceae) |
| Fucoidan | Hyperlipidemia | 4 | PM | 31364648 | 📋 | The fucoidan from the brown seaweed Ascophyllum nodosum ameliorates atherosclerosis in apolipoprotein E-deficient mice |
| Fucoidan | Hyperlipidemia | 2 | PM | 31100394 | 📋 | The fucoidan A3 from the seaweed Ascophyllum nodosum enhances RCT-related genes expression in hyperlipidemic C57BL/6J mice |
| Fucoidan | Hyperlipidemia | 1 | PM | 31055921 | 📋 | Fucoidan A2 from the Brown Seaweed Ascophyllum nodosum Lowers Lipid by Improving Reverse Cholesterol Transport in C57BL/6J Mice Fed a High-Fat Diet |
| Fucoidan | Hyperlipidemia | 3 | PM | 27094367 | 📋 | Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulation |
| Fucoidan | Insulin Resistance | 7 | PM | 35077745 | 📋 | Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats |
| Fucoidan | Insulin Resistance | 6 | PM | 34374401 | 📋 | Sargassum fusiforme fucoidan alleviates diet-induced insulin resistance by inhibiting colon-derived ceramide biosynthesis |
| Fucoidan | Insulin Resistance | 5 | PM | 32866006 | 📋 | Sargassum fusiforme Fucoidan Alleviates High-Fat Diet-Induced Obesity and Insulin Resistance Associated with the Improvement of Hepatic Oxidative Stress and Gut Microbiota Profile |
| Fucoidan | Insulin Resistance | 2 | PM | 31547311 | 📋 | Anti-Metabolic Syndrome Effects of Fucoidan from Fucus vesiculosus via Reactive Oxygen Species-Mediated Regulation of JNK, Akt, and AMPK Signaling |
| Fucoidan | Insulin Resistance | 4 | PM | 29393871 | 📋 | Combination Treatment of Deep Sea Water and Fucoidan Attenuates High Glucose-Induced Insulin-Resistance in HepG2 Hepatocytes |
| Fucoidan | Insulin Resistance | 3 | PM | 26498267 | 📋 | Fucoidan ameliorates steatohepatitis and insulin resistance by suppressing oxidative stress and inflammatory cytokines in experimental non-alcoholic fatty liver disease |
| Fucoidan | Insulin Resistance | 1 | PM | 24611906 | 📋 | Effect of fucoidan administration on insulin secretion and insulin resistance in overweight or obese adults |
| Fucoidan | Iron Overload | 1 | PM | 36076527 | 📋 | Protective effect of fucoidan against iron overload and ferroptosis-induced liver injury in rats exposed to alcohol |
| Fucoidan | Metabolic Disorders | 4 | PM | 38825316 | 📋 | Fucoidan alleviates high sucrose-induced metabolic disorders and enhances intestinal homeostasis through modulation of Notch signaling |
| Fucoidan | Metabolic Disorders | 3 | PM | 34374401 | 📋 | Sargassum fusiforme fucoidan alleviates diet-induced insulin resistance by inhibiting colon-derived ceramide biosynthesis |
| Fucoidan | Metabolic Disorders | 2 | PM | 33300146 | 📋 | Structure-function relationship analysis of fucoidan from sea cucumber (Holothuria tubulosa) on ameliorating metabolic inflammation |
| Fucoidan | Metabolic Disorders | 1 | PM | 32866006 | 📋 | Sargassum fusiforme Fucoidan Alleviates High-Fat Diet-Induced Obesity and Insulin Resistance Associated with the Improvement of Hepatic Oxidative Stress and Gut Microbiota Profile |
| Fucoidan | Metabolic Endotoxemia | 1 | PM | 24492521 | 📋 | Fucoidan extracted from Fucus evanescens prevents endotoxin-induced damage in a mouse model of endotoxemia |
| Fucoidan | Mitochondrial Dysfunction | 2 | PM | 31480724 | 📋 | Fucoidan Suppresses Mitochondrial Dysfunction and Cell Death against 1-Methyl-4-Phenylpyridinum-Induced Neuronal Cytotoxicity via Regulation of PGC-1α Expression |
| Fucoidan | Mitochondrial Dysfunction | 1 | PM | 26743530 | 📋 | Low-Molecular-Weight Fucoidan Attenuates Mitochondrial Dysfunction and Improves Neurological Outcome After Traumatic Brain Injury in Aged Mice: Involvement of Sirt3 |
| Fucoidan | Obesity | 15 | PM | 38284513 | 📋 | Effect of in vitro simulated digestion on the physicochemical properties and pancreatic lipase inhibitory activity of fucoidan |
| Fucoidan | Obesity | 14 | PM | 36828168 | 📋 | Fucoidan from Sargassum thunbergii obtained via step gradient ethanol precipitation indicate potential anti-obesity and anti-hepatic steatosis in vitro 3T3-L1 and HepG2 cells and in vivo high-fat diet-induced obesity mice |
| Fucoidan | Obesity | 13 | PM | 36034923 | 📋 | Preclinical insights into fucoidan as a nutraceutical compound against perfluorooctanoic acid-associated obesity via targeting endoplasmic reticulum stress |
| Fucoidan | Obesity | 12 | PM | 35907465 | 📋 | Sargassum fusiforme fucoidan ameliorates diet-induced obesity through enhancing thermogenesis of adipose tissues and modulating gut microbiota |
| Fucoidan | Obesity | 11 | PM | 35593392 | 📋 | Anti-obesity effects of Laminaria japonica fucoidan in high-fat diet-fed mice vary with the gut microbiota structure |
| Fucoidan | Obesity | 10 | PM | 35157925 | 📋 | Dietary fucoidan from a brown marine algae (Ecklonia cava) attenuates lipid accumulation in differentiated 3T3-L1 cells and alleviates high-fat diet-induced obesity in mice |
| Fucoidan | Obesity | 9 | PM | 34668763 | 📋 | Fucoidan Protects Against High-Fat Diet-Induced Obesity and Modulates Gut Microbiota in Institute of Cancer Research Mice |
| Fucoidan | Obesity | 8 | PM | 33495425 | 📋 | Fucoidan antagonizes diet-induced obesity and inflammation in mice |
| Fucoidan | Obesity | 5 | PM | 30696078 | 📋 | Antioxidant Properties of Fucoidan Alleviate Acceleration and Exacerbation of Hippocampal Neuronal Death Following Transient Global Cerebral Ischemia in High-Fat Diet-Induced Obese Gerbils |
| Fucoidan | Obesity | 3 | PM | 29447962 | 📋 | Low molecular weight fucoidan attenuates liver injury via SIRT1/AMPK/PGC1α axis in db/db mice |
| Fucoidan | Obesity | 1 | PM | 24611906 | 📋 | Effect of fucoidan administration on insulin secretion and insulin resistance in overweight or obese adults |
| Fucoidan | Obesity | 2 | PM | 23580241 | 📋 | Fucoidan prevents high-fat diet-induced obesity in animals by suppression of fat accumulation |
| Fucoidan | Obesity | 6 | PM | 21892350 | 📋 | Fucoidan from Marine Brown Algae Inhibits Lipid Accumulation |
| Fucoidan | Obesity | 7 | PM | 20346961 | 📋 | Fucoidan, a sulfated polysaccharide, inhibits adipogenesis through the mitogen-activated protein kinase pathway in 3T3-L1 preadipocytes |
| Fucoidan | Obesity | 4 | PM | 19067076 | 📋 | Inhibitory effects of Fucoidan in 3T3-L1 adipocyte differentiation |
| Fucoidan | Overweight | 1 | PM | 24611906 | 📋 | Effect of fucoidan administration on insulin secretion and insulin resistance in overweight or obese adults |
| Fucoidan | Overweight | 2 | PM | 21892350 | 📋 | Fucoidan from Marine Brown Algae Inhibits Lipid Accumulation |
| Fucoidan | Postprandial Hyperglycemia | 1 | PM | 35159577 | 📋 | Fucoidan Regulates Starch Digestion: In Vitro and Mechanistic Study |
