| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Metformin | Age-Related Cognitive Decline | 2 | PM | 36224264 | 📋 | Metformin alleviates neurocognitive impairment in aging via activation of AMPK/BDNF/PI3K pathway |
| Metformin | Age-Related Cognitive Decline | 1 | PM | 35843348 | 📋 | Metformin use and brain atrophy in nondemented elderly individuals with diabetes |
| Metformin | Alzheimer's Disease | 14 | PM | 38842663 | 📋 | Beneficial effect of lupeol and metformin in mouse model of intracerebroventricular streptozotocin induced dementia |
| Metformin | Alzheimer's Disease | 13 | PM | 38582410 | 📋 | The role of the cholinergic system in the memory-protecting effects of metformin in a model of scopolamine-induced memory impairment in aged rats |
| Metformin | Alzheimer's Disease | 12 | PM | 38333746 | 📋 | Metformin improves memory via AMPK/mTOR-dependent route in a rat model of Alzheimer's disease |
| Metformin | Alzheimer's Disease | 11 | PM | 37985011 | 📋 | Alzheimer's disease-related brain insulin resistance and the prospective therapeutic impact of metformin |
| Metformin | Alzheimer's Disease | 10 | PM | 37780174 | 📋 | Exploring the mechanism of metformin action in Alzheimer's disease and type 2 diabetes based on network pharmacology, molecular docking, and molecular dynamic simulation |
| Metformin | Alzheimer's Disease | 9 | PM | 37483818 | 📋 | Metformin restores cognitive dysfunction and histopathological deficits in an animal model of sporadic Alzheimer's disease |
| Metformin | Alzheimer's Disease | 7 | PM | 36723832 | 📋 | Metformin mitigates amyloid β1-40-induced cognitive decline via attenuation of oxidative/nitrosative stress and neuroinflammation |
| Metformin | Alzheimer's Disease | 6 | PM | 36464874 | 📋 | Effects of metformin on modulating the expression of brain-related genes of APP/PS1 transgenic mice based on Single Cell Sequencing |
| Metformin | Alzheimer's Disease | 5 | PM | 36422837 | 📋 | Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice |
| Metformin | Alzheimer's Disease | 4 | PM | 35902387 | 📋 | Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer's disease risk in the general population: a Mendelian randomisation study |
| Metformin | Alzheimer's Disease | 3 | PM | 35802659 | 📋 | Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin |
| Metformin | Alzheimer's Disease | 2 | PM | 35395244 | 📋 | Intranasal metformin treatment ameliorates cognitive functions via insulin signaling pathway in ICV-STZ-induced mice model of Alzheimer's disease |
| Metformin | Alzheimer's Disease | 1 | PM | 34657937 | 📋 | Metformin and cyanidin 3- O-galactoside from Aronia melanocarpa synergistically alleviate cognitive impairment in SAMP8 mice |
| Metformin | Alzheimer's Disease | 8 | PM | 29253574 | 📋 | Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice |
| Metformin | Anxiety | 3 | PM | 38284725 | 📋 | The Antidiabetic Drug Metformin Attenuated Depressive and Anxietylike Behaviors and Oxidative Stress in the Brain in a Rodent Model of Inflammation Induced by Lipopolysaccharide in Male Rats |
| Metformin | Anxiety | 2 | PM | 37798418 | 📋 | Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons |
| Metformin | Anxiety | 1 | PM | 27581932 | 📋 | Sirtuin 1 and 7 Mediate Resveratrol-Induced Recovery From Hyper-Anxiety in High-Fructose-Fed Prediabetic Rats |
| Metformin | Autism Spectrum Disorder | 1 | PM | 37133558 | 📋 | The comparative effectiveness of metformin and risperidone in a rat model of valproic acid-induced autism, Potential role for enhanced autophagy |
| Metformin | Cognitive Disorders | 4 | PM | 37483818 | 📋 | Metformin restores cognitive dysfunction and histopathological deficits in an animal model of sporadic Alzheimer's disease |
| Metformin | Cognitive Disorders | 3 | PM | 37085892 | 📋 | Extended-release metformin improves cognitive impairment in frail older women with hypertension and diabetes: preliminary results from the LEOPARDESS Study |
| Metformin | Cognitive Disorders | 2 | PM | 36404813 | 📋 | Metformin inhibits cardiometabolic syndrome associated cognitive deficits in high fat diet rats |
| Metformin | Cognitive Disorders | 1 | PM | 34547248 | 📋 | Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations |
| Metformin | Delirium | 1 | PM | 36399107 | 📋 | The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study |
| Metformin | Dementia | 9 | PM | 37878862 | 📋 | Metformin in elderly type 2 diabetes mellitus: dose-dependent dementia risk reduction |
| Metformin | Dementia | 8 | PM | 37878309 | 📋 | Metformin Cessation and Dementia Incidence |
| Metformin | Dementia | 7 | PM | 37869901 | 📋 | Diabetes, antidiabetic medications and risk of dementia: A systematic umbrella review and meta-analysis |
| Metformin | Dementia | 6 | PM | 37830443 | 📋 | Heterogeneous treatment effects of metformin on risk of dementia in patients with type 2 diabetes: A longitudinal observational study |
| Metformin | Dementia | 5 | PM | 37395154 | 📋 | Dementia risk in patients with type 2 diabetes: Comparing metformin with no pharmacological treatment |
| Metformin | Dementia | 4 | PM | 36657564 | 📋 | Metformin adherence reduces the risk of dementia in patients with diabetes: A population-based cohort study |
| Metformin | Dementia | 3 | PM | 36496454 | 📋 | Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia |
| Metformin | Dementia | 2 | PM | 36220195 | 📋 | Use of oral diabetes medications and the risk of incident dementia in US veterans aged ≥60 years with type 2 diabetes |
| Metformin | Dementia | 1 | PM | 35847477 | 📋 | Metformin and the risk of dementia based on an analysis of 396,332 participants |
| Metformin | Depression | 8 | PM | 38286229 | 📋 | Possible role of metformin as an antidepressant in diabetes |
| Metformin | Depression | 7 | PM | 38284725 | 📋 | The Antidiabetic Drug Metformin Attenuated Depressive and Anxietylike Behaviors and Oxidative Stress in the Brain in a Rodent Model of Inflammation Induced by Lipopolysaccharide in Male Rats |
| Metformin | Depression | 6 | PM | 36347837 | 📋 | Are the antidepressant effects of insulin-sensitizing medications related to improvements in metabolic markers? |
| Metformin | Depression | 5 | PM | 36185927 | 📋 | Metformin for the Improvement of Comorbid Depression Symptoms in Diabetic Patients: A Systematic Review |
| Metformin | Depression | 4 | PM | 36108876 | 📋 | Association of metformin and depression in patients with type 2 diabetes |
| Metformin | Depression | 3 | PM | 35931897 | 📋 | Metformin improves depressive-like behavior in experimental Parkinson's disease by inducing autophagy in the substantia nigra and hippocampus |
| Metformin | Depression | 2 | PM | 35338947 | 📋 | Diabetes, antidiabetic medications and risk of depression - A population-based cohort and nested case-control study |
| Metformin | Depression | 1 | PM | 28827076 | 📋 | Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats |
| Metformin | Diabetic Encephalopathy | 3 | PM | 36751729 | 📋 | The effects of endurance exercise and metformin on memory impairment caused by diabetes |
| Metformin | Diabetic Encephalopathy | 2 | PM | 36090264 | 📋 | Metformin use is associated with a reduced risk of cognitive impairment in adults with diabetes mellitus: A systematic review and meta-analysis |
| Metformin | Diabetic Encephalopathy | 1 | PM | 31188777 | 📋 | Trigonella Foenum-Graceum Seed (Fenugreek) Hydroalcoholic Extract Improved the Oxidative Stress Status in a Rat Model of Diabetes-Induced Memory Impairment |
| Metformin | Huntington's Disease | 1 | PM | 35367225 | 📋 | Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder |
| Metformin | Mood Disorders | 1 | PM | 36170869 | 📋 | Metformin is Protective Against the Development of Mood Disorders |
| Metformin | Psychiatric Disorders | 1 | PM | 36191545 | 📋 | The role of metformin as a treatment for neuropsychiatric illness |
| Metformin | Rett Syndrome | 1 | PM | 36442649 | 📋 | Chronic treatment with the anti-diabetic drug metformin rescues impaired brain mitochondrial activity and selectively ameliorates defective cognitive flexibility in a female mouse model of Rett syndrome |
| Metformin | Schizophrenia | 2 | PM | 37821461 | 📋 | Metformin improves cognitive impairment in patients with schizophrenia: associated with enhanced functional connectivity of dorsolateral prefrontal cortex |
| Metformin | Schizophrenia | 1 | PM | 37502816 | 📋 | The potential effect of metformin on cognitive and other symptom dimensions in patients with schizophrenia and antipsychotic-induced weight gain: a systematic review, meta-analysis, and meta-regression |
