| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Ginsenosides | Age-Related Cognitive Decline | 1 | PM | 25724866 | 📋 | Chronic Treatment With Ginsenoside Rg1 Promotes Memory and Hippocampal Long-Term Potentiation in Middle-Aged Mice |
| Ginsenosides | Age-Related Cognitive Decline | 2 | PM | 23833204 | 📋 | Long-term ginsenoside Rg1 supplementation improves age-related cognitive decline by promoting synaptic plasticity associated protein expression in C57BL/6J mice |
| Ginsenosides | Alzheimer's Disease | 69 | PM | 38593704 | 📋 | Total ginsenosides decrease Aβ production through activating PPARγ |
| Ginsenosides | Alzheimer's Disease | 68 | PM | 38539843 | 📋 | Ginsenosides Rg1 and Rg2 Activate Autophagy and Attenuate Oxidative Stress in Neuroblastoma Cells Overexpressing Aβ(1-42) |
| Ginsenosides | Alzheimer's Disease | 67 | PM | 38434355 | 📋 | Mechanisms with network pharmacology approach of Ginsenosides in Alzheimer's disease |
| Ginsenosides | Alzheimer's Disease | 66 | PM | 38230845 | 📋 | Unraveling the therapeutic potential of ginsenoside compound Mc1 in Alzheimer's disease: Exploring the role of AMPK/SIRT1/NF-κB signaling pathway and mitochondrial function |
| Ginsenosides | Alzheimer's Disease | 65 | PM | 38125359 | 📋 | Ginsenoside Rg1 promotes β‑amyloid peptide degradation through inhibition of the ERK/PPARγ phosphorylation pathway in an Alzheimer's disease neuronal model |
| Ginsenosides | Alzheimer's Disease | 64 | PM | 38063180 | 📋 | Notoginsenoside R1 ameliorates the inflammation induced by amyloid‑β by suppressing SphK1‑mediated NF‑κB activation in PC12 cells |
| Ginsenosides | Alzheimer's Disease | 63 | PM | 37981117 | 📋 | Ginsenoside RK3 promotes neurogenesis in Alzheimer's disease through activation of the CREB/BDNF pathway |
| Ginsenosides | Alzheimer's Disease | 62 | PM | 37925892 | 📋 | Ginsenoside RK1 improves cognitive impairments and pathological changes in Alzheimer's disease via stimulation of the AMPK/Nrf2 signaling pathway |
| Ginsenosides | Alzheimer's Disease | 61 | PM | 37805189 | 📋 | Ginsenoside Rg2 alleviates neurovascular damage in 3xTg-AD mice with Alzheimer's disease through the MAPK-ERK pathway |
| Ginsenosides | Alzheimer's Disease | 60 | PM | 37676640 | 📋 | Ginsenoside Rh4 Alleviates Amyloid β Plaque and Tau Hyperphosphorylation by Regulating Neuroinflammation and the Glycogen Synthase Kinase 3β Signaling Pathway |
| Ginsenosides | Alzheimer's Disease | 59 | PM | 37536646 | 📋 | Ginsenoside Rg1, lights up the way for the potential prevention of Alzheimer's disease due to its therapeutic effects on the drug-controllable risk factors of Alzheimer's disease |
| Ginsenosides | Alzheimer's Disease | 55 | PM | 37239965 | 📋 | Structural-Activity Relationship of Rare Ginsenosides from Red Ginseng in the Treatment of Alzheimer's Disease |
| Ginsenosides | Alzheimer's Disease | 53 | PM | 36873999 | 📋 | Ginsenoside ompound K reduces neuronal damage and improves neuronal synaptic dysfunction by targeting Aβ |
| Ginsenosides | Alzheimer's Disease | 52 | PM | 36764334 | 📋 | The Neuroprotective Effect of Ginsenoside Rb1 on the Cerebral Cortex Changes Induced by Aluminium Chloride in a Mouse Model of Alzheimer's Disease: A Histological, Immunohistochemical, and Biochemical Study |
| Ginsenosides | Alzheimer's Disease | 51 | PM | 36588689 | 📋 | Ginsenoside Rd protects transgenic Caenorhabditis elegans from β-amyloid toxicity by activating oxidative resistant |
| Ginsenosides | Alzheimer's Disease | 50 | PM | 36587558 | 📋 | Ginsenoside Rk3 ameliorates Aβ-induced neurotoxicity in APP/PS1 model mice via AMPK signaling pathway |
| Ginsenosides | Alzheimer's Disease | 49 | PM | 36467099 | 📋 | Pharmacological effects of natural medicine ginsenosides against Alzheimer's disease |
| Ginsenosides | Alzheimer's Disease | 48 | PM | 36367174 | 📋 | Ginsenoside Rg1 alleviates learning and memory impairments and Aβ disposition through inhibiting NLRP1 inflammasome and autophagy dysfunction in APP/PS1 mice |
| Ginsenosides | Alzheimer's Disease | 47 | PM | 35667236 | 📋 | New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer's disease |
| Ginsenosides | Alzheimer's Disease | 46 | PM | 35313087 | 📋 | Ginsenoside Rg1 improves Alzheimer's disease by regulating oxidative stress, apoptosis and neuroinflammation through Wnt/GSK-3β/β-catenin signaling pathway |
| Ginsenosides | Alzheimer's Disease | 45 | PM | 35306001 | 📋 | Ginsenoside Rf inhibits human tau proteotoxicity and causes specific LncRNA, miRNA and mRNA expression changes in Caenorhabditis elegans model of tauopathy |
| Ginsenosides | Alzheimer's Disease | 44 | PM | 35178993 | 📋 | [Ginsenoside Rg_1 protects PC12 cells against Aβ-induced injury through promotion of mitophagy by PINK1/parkin activation] |
| Ginsenosides | Alzheimer's Disease | 43 | PM | 35054451 | 📋 | Ginsenoside F1 Protects the Brain against Amyloid Beta-Induced Toxicity by Regulating IDE and NEP |
| Ginsenosides | Alzheimer's Disease | 42 | PM | 34987593 | 📋 | Ginsenoside Rd Attenuates Tau Phosphorylation in Olfactory Bulb, Spinal Cord, and Telencephalon by Regulating Glycogen Synthase Kinase 3 β and Cyclin-Dependent Kinase 5 |
| Ginsenosides | Alzheimer's Disease | 41 | PM | 34968779 | 📋 | Ginsenoside compound K acts via LRP1 to alleviate Amyloid β 42-induced neuroinflammation in microglia by suppressing NF-κB |
| Ginsenosides | Alzheimer's Disease | 40 | PM | 34764721 | 📋 | Ginsenoside Rg1 alleviates Aβ deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice |
| Ginsenosides | Alzheimer's Disease | 39 | PM | 34533063 | 📋 | Notoginsenoside R2 reduces A β 25-35-induced neuronal apoptosis and inflammation via miR-27a/SOX8/ β-catenin axis |
| Ginsenosides | Alzheimer's Disease | 38 | PM | 34374655 | 📋 | A therapeutic intervention for Alzheimer's disease using ginsenoside Rg3: its role in M2 microglial activation and non-amyloidogenesis |
| Ginsenosides | Alzheimer's Disease | 37 | PM | 34295207 | 📋 | Ginsenosides attenuate bioenergetics and morphology of mitochondria in cultured PC12 cells under the insult of amyloid beta-peptide |
| Ginsenosides | Alzheimer's Disease | 36 | PM | 33686024 | 📋 | Preclinical systematic review of ginsenoside Rg1 for cognitive impairment in Alzheimer's disease |
| Ginsenosides | Alzheimer's Disease | 35 | PM | 33649817 | 📋 | Ginsenoside Rg1 improves cognitive capability and affects the microbiota of large intestine of tree shrew model for Alzheimer's disease |
| Ginsenosides | Alzheimer's Disease | 34 | PM | 33359145 | 📋 | Ginsenoside Rb1 protected PC12 cells from Aβ 25-35-induced cytotoxicity via PPARγ activation and cholesterol reduction |
| Ginsenosides | Alzheimer's Disease | 33 | PM | 33088260 | 📋 | Notoginsenoside R1-Induced Neuronal Repair in Models of Alzheimer Disease Is Associated With an Alteration in Neuronal Hyperexcitability, Which Is Regulated by Nav |
| Ginsenosides | Alzheimer's Disease | 32 | PM | 33049344 | 📋 | Protective effects of ginsenoside Rg2 against memory impairment and neuronal death induced by Aβ25-35 in rats |
| Ginsenosides | Alzheimer's Disease | 31 | PM | 32945455 | 📋 | Ginsenoside Rg1 reduces β‑amyloid levels by inhibiting CDΚ5‑induced PPARγ phosphorylation in a neuron model of Alzheimer's disease |
| Ginsenosides | Alzheimer's Disease | 30 | PM | 32819064 | 📋 | [Neuroprotective effect of ginsenoside Rb-1 on a rat model of Alzheimer's disease] |
| Ginsenosides | Alzheimer's Disease | 29 | PM | 32754961 | 📋 | Protective effect of ginsenoside Rh2 on scopolamine-induced memory deficits through regulation of cholinergic transmission, oxidative stress and the ERK-CREB-BDNF signaling pathway |
| Ginsenosides | Alzheimer's Disease | 13 | PM | 31488185 | 📋 | Minor Ginsenoside F1 Improves Memory in APP/PS1 Mice |
| Ginsenosides | Alzheimer's Disease | 18 | PM | 31422666 | 📋 | Ginsenoside Rg3 Prevents Cognitive Impairment by Improving Mitochondrial Dysfunction in the Rat Model of Alzheimer's Disease |
| Ginsenosides | Alzheimer's Disease | 2 | PM | 31364016 | 📋 | Ginsenoside Compound K Ameliorates Alzheimer's Disease in HT22 Cells by Adjusting Energy Metabolism |
| Ginsenosides | Alzheimer's Disease | 21 | PM | 31344860 | 📋 | Ginsenoside Re Inhibits ROS/ASK-1 Dependent Mitochondrial Apoptosis Pathway and Activation of Nrf2-Antioxidant Response in Beta-Amyloid-Challenged SH-SY5Y Cells |
| Ginsenosides | Alzheimer's Disease | 4 | PM | 31217866 | 📋 | Ginsenoside Rb1 Improves Learning and Memory Ability Through Its Anti-Inflammatory Effect in Aβ 1-40 Induced Alzheimer's Disease of Rats |
| Ginsenosides | Alzheimer's Disease | 3 | PM | 30799178 | 📋 | Ginsenoside Compound K Attenuates Cognitive Deficits in Vascular Dementia Rats by Reducing the Aβ Deposition |
| Ginsenosides | Alzheimer's Disease | 25 | PM | 30535776 | 📋 | Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments |
| Ginsenosides | Alzheimer's Disease | 9 | PM | 29926354 | 📋 | Ginsenoside Rg1 and Acori Graminei Rhizoma Attenuates Neuron Cell Apoptosis by Promoting the Expression of miR-873-5p in Alzheimer's Disease |
| Ginsenosides | Alzheimer's Disease | 7 | PM | 29865080 | 📋 | Neuroprotective Effects of Ginsenoside Rf on Amyloid-β-Induced Neurotoxicity in Vitro and in Vivo |
| Ginsenosides | Alzheimer's Disease | 5 | PM | 29636869 | 📋 | Ginsenoside Rb1 Inhibit Apoptosis in Rat Model of Alzheimer's Disease Induced by Aβ 1-40 |
| Ginsenosides | Alzheimer's Disease | 10 | PM | 29204248 | 📋 | Ginsenoside Rg1 Ameliorates Behavioral Abnormalities and Modulates the Hippocampal Proteomic Change in Triple Transgenic Mice of Alzheimer's Disease |
| Ginsenosides | Alzheimer's Disease | 24 | PM | 29021705 | 📋 | Global analysis of ginsenoside Rg1 protective effects in β-amyloid-treated neuronal cells |
| Ginsenosides | Alzheimer's Disease | 23 | PM | 28756148 | 📋 | Ginsenoside Rg2 protects PC12 cells against β-amyloid 25-35-induced apoptosis via the phosphoinositide 3-kinase/Akt pathway |
| Ginsenosides | Alzheimer's Disease | 12 | PM | 27612432 | 📋 | Ginsenosides Attenuate D-Galactose- And AlCl 3-inducedspatial Memory Impairment by Restoring the Dysfunction of the Neurotransmitter Systems in the Rat Model of Alzheimer's Disease |
| Ginsenosides | Alzheimer's Disease | 27 | PM | 27275774 | 📋 | BACE1 molecular docking and anti-Alzheimer's disease activities of ginsenosides |
| Ginsenosides | Alzheimer's Disease | 22 | PM | 27236892 | 📋 | [Effect of Ginsenoside Rg2 and Its Stereoisomers on Oxygen-Glucose Deprivation and Reperfusion Induced Cortical Neuronal Injury Model] |
| Ginsenosides | Alzheimer's Disease | 8 | PM | 27082952 | 📋 | Ginsenoside Rg1 Ameliorates Hippocampal Long-Term Potentiation and Memory in an Alzheimer's Disease Model |
| Ginsenosides | Alzheimer's Disease | 54 | PM | 26210744 | 📋 | A UHPLC-TOF/MS method based metabonomic study of total ginsenosides effects on Alzheimer disease mouse model |
| Ginsenosides | Alzheimer's Disease | 14 | PM | 25714973 | 📋 | Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzheimer's Disease by Up-Regulating Insulin Degrading Enzyme and Inhibiting Aβ Accumulation |
| Ginsenosides | Alzheimer's Disease | 1 | PM | 25317137 | 📋 | Cellular and Molecular Mechanisms Underlying the Action of Ginsenoside Rg1 Against Alzheimer's Disease |
| Ginsenosides | Alzheimer's Disease | 26 | PM | 25206916 | 📋 | Neuroprotective effects of ginsenoside Rb1 on hippocampal neuronal injury and neurite outgrowth |
| Ginsenosides | Alzheimer's Disease | 19 | PM | 25187838 | 📋 | Ginsenoside compound K promotes β-amyloid peptide clearance in primary astrocytes via autophagy enhancement |
| Ginsenosides | Alzheimer's Disease | 20 | PM | 24599032 | 📋 | Ginsenoside Re and Rd enhance the expression of cholinergic markers and neuronal differentiation in Neuro-2a cells |
| Ginsenosides | Alzheimer's Disease | 17 | PM | 24503167 | 📋 | Ginsenoside Rg5 Improves Cognitive Dysfunction and Beta-Amyloid Deposition in STZ-induced Memory Impaired Rats via Attenuating Neuroinflammatory Responses |
| Ginsenosides | Alzheimer's Disease | 57 | PM | 24287922 | 📋 | Ginsenoside Rg1 decreases neurofibrillary tangles accumulation in retina by regulating activities of neprilysin and PKA in retinal cells of AD mice model |
| Ginsenosides | Alzheimer's Disease | 58 | PM | 24137274 | 📋 | Panax notoginsenoside Rb1 ameliorates Alzheimer's disease by upregulating brain-derived neurotrophic factor and downregulating Tau protein expression |
| Ginsenosides | Alzheimer's Disease | 56 | PM | 23723072 | 📋 | Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3 |
| Ginsenosides | Alzheimer's Disease | 6 | PM | 23321003 | 📋 | Ginsenoside Rd Attenuates Beta-Amyloid-Induced Tau Phosphorylation by Altering the Functional Balance of Glycogen Synthase Kinase 3beta and Protein Phosphatase 2A |
| Ginsenosides | Alzheimer's Disease | 16 | PM | 22728092 | 📋 | Effects of Ginsenoside Rg1 or 17β-estradiol on a Cognitively Impaired, Ovariectomized Rat Model of Alzheimer's Disease |
| Ginsenosides | Alzheimer's Disease | 15 | PM | 20157253 | 📋 | Ginsenoside Rg1 Attenuates Amyloid-Beta Content, Regulates PKA/CREB Activity, and Improves Cognitive Performance in SAMP8 Mice |
| Ginsenosides | Alzheimer's Disease | 28 | PM | 19222911 | 📋 | Ginsenoside Rg3 promotes beta-amyloid peptide degradation by enhancing gene expression of neprilysin |
| Ginsenosides | Alzheimer's Disease | 11 | PM | 19035088 | 📋 | [Ginsenoside-Rg1 Inhibits Cell Apoptosis Induced by Beta Amyloid] |
| Ginsenosides | Anhedonia | 1 | PM | 28618657 | 📋 | Antidepressive Effects of Ginsenoside Rg1 via Regulation of HPA and HPG Axis |
| Ginsenosides | Anxiety | 2 | PM | 29773855 | 📋 | The Anxiolytic-Like Effects of Ginsenoside Rg3 on Chronic Unpredictable Stress in Rats |
| Ginsenosides | Anxiety | 1 | PM | 20336484 | 📋 | Ginsenoside rb1 and rg3 Attenuate Glucocorticoid-Induced Neurotoxicity |
| Ginsenosides | Cognitive Disorders | 17 | PM | 37451214 | 📋 | Ginsenoside Rg1 improved learning and memory ability and reduces neuronal apoptosis in epileptic rats through ERK/CREB/BDNF signal pathway |
| Ginsenosides | Cognitive Disorders | 16 | PM | 37252275 | 📋 | Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLC-CN-NFAT1 signaling in T2DM mice |
| Ginsenosides | Cognitive Disorders | 15 | PM | 36367174 | 📋 | Ginsenoside Rg1 alleviates learning and memory impairments and Aβ disposition through inhibiting NLRP1 inflammasome and autophagy dysfunction in APP/PS1 mice |
| Ginsenosides | Cognitive Disorders | 14 | PM | 36139149 | 📋 | Ginsenoside and Its Therapeutic Potential for Cognitive Impairment |
| Ginsenosides | Cognitive Disorders | 13 | PM | 35840016 | 📋 | Ginsenoside Re attenuates memory impairments in aged Klotho deficient mice via interactive modulations of angiotensin II AT1 receptor, Nrf2 and GPx-1 gene |
| Ginsenosides | Cognitive Disorders | 10 | PM | 34764721 | 📋 | Ginsenoside Rg1 alleviates Aβ deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice |
| Ginsenosides | Cognitive Disorders | 11 | PM | 34603030 | 📋 | Notoginsenoside R1 Reverses Abnormal Autophagy in Hippocampal Neurons of Mice With Sleep Deprivation Through Melatonin Receptor 1A |
| Ginsenosides | Cognitive Disorders | 12 | PM | 32682919 | 📋 | Ginsenoside Rd reverses cognitive deficits by modulating BDNF-dependent CREB pathway in chronic restraint stress mice |
| Ginsenosides | Cognitive Disorders | 1 | PM | 30799178 | 📋 | Ginsenoside Compound K Attenuates Cognitive Deficits in Vascular Dementia Rats by Reducing the Aβ Deposition |
| Ginsenosides | Cognitive Disorders | 5 | PM | 30659419 | 📋 | Ginsenoside Rg1 Prevents Chemotherapy-Induced Cognitive Impairment: Associations With Microglia-Mediated Cytokines, Neuroinflammation, and Neuroplasticity |
| Ginsenosides | Cognitive Disorders | 7 | PM | 29544964 | 📋 | Ginsenoside Rh2 Reverses Sleep Deprivation-Induced Cognitive Deficit in Mice |
| Ginsenosides | Cognitive Disorders | 4 | PM | 29147958 | 📋 | Ginsenoside Rg1 Decreases Oxidative Stress and Down-Regulates Akt/mTOR Signalling to Attenuate Cognitive Impairment in Mice and Senescence of Neural Stem Cells Induced by D-Galactose |
| Ginsenosides | Cognitive Disorders | 2 | PM | 28549492 | 📋 | Ginsenoside Rb1 Attenuates Isoflurane/surgery-induced Cognitive Dysfunction via Inhibiting Neuroinflammation and Oxidative Stress |
| Ginsenosides | Cognitive Disorders | 3 | PM | 28314104 | 📋 | Ginsenoside Re Ameliorates Brain Insulin Resistance and Cognitive Dysfunction in High Fat Diet-Induced C57BL/6 Mice |
| Ginsenosides | Cognitive Disorders | 8 | PM | 28078612 | 📋 | Ameliorative Effect of Ginsenoside Rg1 on Lipopolysaccharide-Induced Cognitive Impairment: Role of Cholinergic System |
| Ginsenosides | Cognitive Disorders | 9 | PM | 24503167 | 📋 | Ginsenoside Rg5 Improves Cognitive Dysfunction and Beta-Amyloid Deposition in STZ-induced Memory Impaired Rats via Attenuating Neuroinflammatory Responses |
| Ginsenosides | Cognitive Disorders | 6 | PM | 23957360 | 📋 | Ginsenoside Rh2 Improves Learning and Memory in Mice |
| Ginsenosides | Dementia | 4 | PM | 35042148 | 📋 | Studies on the mechanism of Panax Ginseng in the treatment of deficiency of vital energy dementia rats based on urine metabolomics |
| Ginsenosides | Dementia | 3 | PM | 32963600 | 📋 | CGA ameliorates cognitive decline by regulating the PI3K/AKT signaling pathway and neurotransmitter systems in rats with multi-infarct dementia |
| Ginsenosides | Dementia | 1 | PM | 30799178 | 📋 | Ginsenoside Compound K Attenuates Cognitive Deficits in Vascular Dementia Rats by Reducing the Aβ Deposition |
| Ginsenosides | Dementia | 2 | PM | 18083315 | 📋 | Panax Ginseng ginsenoside-Rg2 Protects Memory Impairment via Anti-Apoptosis in a Rat Model With Vascular Dementia |
| Ginsenosides | Depression | 40 | PM | 38488514 | 📋 | Ginsenoside Rk3 Regulates Tryptophan Metabolism along the Brain-Gut Axis by Targeting Tryptophan Hydroxylase and Remodeling the Intestinal Microenvironment to Alleviate Depressive-Like Behavior in Mice |
| Ginsenosides | Depression | 39 | PM | 37863415 | 📋 | Ginsenoside Rg1 ameliorates depressive-like behavior by inhibiting NLRP3 inflammasome activation in mice exposed to chronic stress |
| Ginsenosides | Depression | 38 | PM | 37464840 | 📋 | Ginsenoside-Rg1 synergized with voluntary running exercise protects against glial activation and dysregulation of neuronal plasticity in depression |
| Ginsenosides | Depression | 37 | PM | 36614017 | 📋 | Novel Antidepressant Mechanism of Ginsenoside Rg1 in Regulating the Dysfunction of the Glutamatergic System in Astrocytes |
| Ginsenosides | Depression | 36 | PM | 36283312 | 📋 | Ginsenoside Rh4 remodels the periphery microenvironment by targeting the brain-gut axis to alleviate depression-like behaviors |
| Ginsenosides | Depression | 35 | PM | 35848938 | 📋 | Ginsenoside Rh2 administration produces crucial antidepressant-like effects in a CUMS-induced mice model of depression |
| Ginsenosides | Depression | 34 | PM | 35634375 | 📋 | Ginsenosides Rb1 Attenuates Chronic Social Defeat Stress-Induced Depressive Behavior via Regulation of SIRT1-NLRP3/Nrf2 Pathways |
| Ginsenosides | Depression | 33 | PM | 35600767 | 📋 | Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134-mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression |
| Ginsenosides | Depression | 32 | PM | 35370402 | 📋 | Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression |
| Ginsenosides | Depression | 31 | PM | 35230663 | 📋 | Ginsenoside Rg1 Reduced Microglial Activation and Mitochondrial Dysfunction to Alleviate Depression-Like Behaviour Via the GAS5/EZH2/SOCS3/NRF2 Axis |
| Ginsenosides | Depression | 29 | PM | 35035240 | 📋 | Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NF-κB signaling pathway |
| Ginsenosides | Depression | 28 | PM | 34658847 | 📋 | Ginsenoside Rb1 Produces Antidepressant-Like Effects in a Chronic Social Defeat Stress Model of Depression Through the BDNF-Trkb Signaling Pathway |
| Ginsenosides | Depression | 27 | PM | 34421601 | 📋 | Ginsenoside Rg1 Ameliorates Neuroinflammation via Suppression of Connexin43 Ubiquitination to Attenuate Depression |
| Ginsenosides | Depression | 30 | PM | 34372875 | 📋 | Ginsenoside Rb1 induces a pro-neurogenic microglial phenotype via PPARγ activation in male mice exposed to chronic mild stress |
| Ginsenosides | Depression | 26 | PM | 34087399 | 📋 | Novel antidepressant mechanism of ginsenoside Rg1: Regulating biosynthesis and degradation of connexin43 |
| Ginsenosides | Depression | 25 | PM | 34049474 | 📋 | Berberine and Ginsenoside Rb1 Ameliorate Depression-Like Behavior in Diabetic Rats |
| Ginsenosides | Depression | 24 | PM | 34025135 | 📋 | The effect of ginsenosides on depression in preclinical studies: A systematic review and meta-analysis |
| Ginsenosides | Depression | 22 | PM | 33478610 | 📋 | Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test |
| Ginsenosides | Depression | 21 | PM | 33359924 | 📋 | Ginsenoside Rb1 exerts antidepressant-like effects via suppression inflammation and activation of AKT pathway |
| Ginsenosides | Depression | 20 | PM | 32768191 | 📋 | Ginsenoside Rk1 alleviates LPS-induced depression-like behavior in mice by promoting BDNF and suppressing the neuroinflammatory response |
| Ginsenosides | Depression | 1 | PM | 32617040 | 📋 | Antidepressant Effects of Ginsenoside Rf on Behavioral Change in the Glial Degeneration Model of Depression by Reversing Glial Loss |
| Ginsenosides | Depression | 5 | PM | 32464121 | 📋 | Ginsenoside 20(S)-protopanaxadiol Attenuates Depressive-Like Behaviour and Neuroinflammation in Chronic Unpredictable Mild Stress-Induced Depressive Rats |
| Ginsenosides | Depression | 2 | PM | 32273940 | 📋 | Ginsenoside-Rg1 Rescues Stress-Induced Depression-Like Behaviors via Suppression of Oxidative Stress and Neural Inflammation in Rats |
| Ginsenosides | Depression | 23 | PM | 31572200 | 📋 | Rb1, the Primary Active Ingredient in Panax ginseng C.A. Meyer, Exerts Antidepressant-Like Effects via the BDNF-Trkb-CREB Pathway |
| Ginsenosides | Depression | 6 | PM | 31373969 | 📋 | Ginsenoside Rg1 Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Effect via Regulating NF-κB/NLRP3 Pathway in Rats |
| Ginsenosides | Depression | 14 | PM | 30581440 | 📋 | Neuroprotective Effects of Ginsenoside-Rg1 Against Depression-Like Behaviors via Suppressing Glial Activation, Synaptic Deficits, and Neuronal Apoptosis in Rats |
| Ginsenosides | Depression | 8 | PM | 30121663 | 📋 | Ginsenoside Rg1 Prevents Chronic Stress-Induced Depression-Like Behaviors and Neuronal Structural Plasticity in Rats |
| Ginsenosides | Depression | 9 | PM | 29329879 | 📋 | MiR-134 Modulates Chronic Stress-Induced Structural Plasticity and Depression-Like Behaviors via Downregulation of Limk1/cofilin Signaling in Rats |
| Ginsenosides | Depression | 10 | PM | 28842305 | 📋 | Antidepressant-like Effects of Ginsenoside Rg2 in a Chronic Mild Stress Model of Depression |
| Ginsenosides | Depression | 12 | PM | 28762741 | 📋 | Suppressive Effect of Ginsenoside Rg3 Against Lipopolysaccharide-Induced Depression-Like Behavior and Neuroinflammation in Mice |
| Ginsenosides | Depression | 19 | PM | 28642095 | 📋 | Ginsenoside Rg1 alleviates corticosterone-induced dysfunction of gap junctions in astrocytes |
| Ginsenosides | Depression | 15 | PM | 28618657 | 📋 | Antidepressive Effects of Ginsenoside Rg1 via Regulation of HPA and HPG Axis |
| Ginsenosides | Depression | 18 | PM | 28461003 | 📋 | Ginsenoside Rg3 Exerts Anti-Depressive Effect on an NMDA-treated Cell Model and a Chronic Mild Stress Animal Model |
| Ginsenosides | Depression | 13 | PM | 28257788 | 📋 | Antidepressant-like Effects of Ginsenoside Rg5 in Mice: Involving of Hippocampus BDNF Signaling Pathway |
| Ginsenosides | Depression | 11 | PM | 28013484 | 📋 | Antidepressant-like Effects of Ginsenoside Rg3 in Mice via Activation of the Hippocampal BDNF Signaling Cascade |
| Ginsenosides | Depression | 4 | PM | 27586978 | 📋 | [Effect of Ginsenoside Pre-Treatment on 5-hydroxytryptamine System in SD Rats With Myocardial Infarction and Depression] |
| Ginsenosides | Depression | 16 | PM | 27062560 | 📋 | Ginsenoside Rg1 Reverses Stress-Induced Depression-Like Behaviours and Brain-Derived Neurotrophic Factor Expression Within the Prefrontal Cortex |
| Ginsenosides | Depression | 17 | PM | 26926964 | 📋 | The Effects of Ginsenoside Rg1 on Chronic Stress Induced Depression-Like Behaviors, BDNF Expression and the Phosphorylation of PKA and CREB in Rats |
| Ginsenosides | Depression | 3 | PM | 26528894 | 📋 | Antidepressant-like Effects of Ginsenosides: A Comparison of Ginsenoside Rb3 and Its Four Deglycosylated Derivatives, Rg3, Rh2, Compound K, and 20(S)-protopanaxadiol in Mice Models of Despair |
| Ginsenosides | Depression | 7 | PM | 23311165 | 📋 | [Effect of Ginsenoside Rg1 on Behaviors and Hippocampal Amino Acids in Depressive-Like Rats] |
| Ginsenosides | Diabetic Encephalopathy | 1 | PM | 29886506 | 📋 | Ginsenoside Ameliorates Cognitive Dysfunction in Type 2 Diabetic Goto-Kakizaki Rats |
| Ginsenosides | Huntington's Disease | 4 | PM | 35818427 | 📋 | Ginsenoside compound K reduces the progression of Huntington's disease via the inhibition of oxidative stress and overactivation of the ATM/AMPK pathway |
| Ginsenosides | Huntington's Disease | 3 | PM | 34128157 | 📋 | Therapeutic potential of ginsenoside Rg3 and Rf for Huntington's disease |
| Ginsenosides | Huntington's Disease | 2 | PM | 33214696 | 📋 | Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington's disease via suppressing MAPKs and NF-κB pathways in the striatum |
| Ginsenosides | Huntington's Disease | 1 | PM | 19185022 | 📋 | Ginsenosides Protect Striatal Neurons in a Cellular Model of Huntington's Disease |
| Ginsenosides | Insomnia | 1 | PM | 32052003 | 📋 | Ginsenoside Rg5/Rk1 ameliorated sleep via regulating the GABAergic/serotoninergic signaling pathway in a rodent model |
| Ginsenosides | Mild Cognitive Impairment | 1 | PM | 36312734 | 📋 | Target engagement of ginsenosides in mild cognitive impairment using mass spectrometry-based drug affinity responsive target stability |
| Ginsenosides | Post-Traumatic Stress Disorder | 2 | PM | 35982366 | 📋 | Ginsenoside Rg3 modulates spatial memory and fear memory extinction by the HPA axis and BDNF-TrkB pathway in a rat post-traumatic stress disorder |
| Ginsenosides | Post-Traumatic Stress Disorder | 1 | PM | 33215390 | 📋 | Ginsenoside Rg1 Prevents PTSD-Like Behaviors in Mice Through Promoting Synaptic Proteins, Reducing Kir4.1 and TNF-α in the Hippocampus |
| Ginsenosides | Psychiatric Disorders | 3 | PM | 38469409 | 📋 | The protective role of ginsenoside Rg3 in heart diseases and mental disorders |
| Ginsenosides | Psychiatric Disorders | 1 | PM | 35745252 | 📋 | The Untapped Potential of Ginsenosides and American Ginseng Berry in Promoting Mental Health via the Gut-Brain Axis |
| Ginsenosides | Psychiatric Disorders | 2 | PM | 24161284 | 📋 | Peripheral immunomodulation with ginsenoside Rg1 ameliorates neuroinflammation-induced behavioral deficits in rats |
