| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Astragalosides | Age-Related Cognitive Decline | 1 | PM | 34217517 | 📋 | Astragaloside IV prevents memory impairment in D-galactose-induced aging rats via the AGEs/RAGE/ NF-κB axis |
| Astragalosides | Alzheimer's Disease | 13 | PM | 38412923 | 📋 | Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation |
| Astragalosides | Alzheimer's Disease | 11 | PM | 37598923 | 📋 | Astragaloside IV against Alzheimer's disease via microglia-mediated neuroinflammation using network pharmacology and experimental validation |
| Astragalosides | Alzheimer's Disease | 10 | PM | 36820018 | 📋 | Astragaloside IV attenuates neuroinflammation and ameliorates cognitive impairment in Alzheimer's disease via inhibiting NF-κB signaling pathway |
| Astragalosides | Alzheimer's Disease | 9 | PM | 35262870 | 📋 | Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction |
| Astragalosides | Alzheimer's Disease | 7 | PM | 34616501 | 📋 | Depichering the Effects of Astragaloside IV on AD-Like Phenotypes: A Systematic and Experimental Investigation |
| Astragalosides | Alzheimer's Disease | 6 | PM | 34433707 | 📋 | Astragaloside IV ameliorates cognitive impairment and neuroinflammation in an oligomeric Aβ induced Alzheimer's disease mouse model via inhibition of microglial activation and NADPH oxidase expression |
| Astragalosides | Alzheimer's Disease | 5 | PM | 32739157 | 📋 | Astragaloside IV prevents Aβ 1-42 oligomers-induced memory impairment and hippocampal cell apoptosis by promoting PPARγ/BDNF signaling pathway |
| Astragalosides | Alzheimer's Disease | 8 | PM | 31816602 | 📋 | Active compounds of herbs ameliorate impaired cognition in APP/PS1 mouse model of Alzheimer's disease |
| Astragalosides | Alzheimer's Disease | 4 | PM | 30664172 | 📋 | Astragaloside IV Ameliorates Endoplasmic Reticulum stress‑induced Apoptosis of Aβ25‑35‑treated PC12 Cells by Inhibiting the p38 MAPK Signaling Pathway |
| Astragalosides | Alzheimer's Disease | 2 | PM | 29620512 | 📋 | Astragaloside Ⅳ Protects Against Aβ1-42-induced Oxidative Stress, Neuroinflammation and Cognitive Impairment in Rats |
| Astragalosides | Alzheimer's Disease | 1 | PM | 27023226 | 📋 | Astragaloside IV, a Natural PPARγ Agonist, Reduces Aβ Production in Alzheimer's Disease Through Inhibition of BACE1 |
| Astragalosides | Alzheimer's Disease | 3 | PM | 26696494 | 📋 | Beneficial Effect of Astragaloside on Alzheimer's Disease Condition Using Cultured Primary Cortical Cells Under β-amyloid Exposure |
| Astragalosides | Alzheimer's Disease | 12 | PM | 22484447 | 📋 | Protective effects of astragalosides on dexamethasone and Aβ25-35 induced learning and memory impairments due to decrease amyloid precursor protein expression in 12-month male rats |
| Astragalosides | Cognitive Disorders | 3 | PM | 35587259 | 📋 | Astragalus injection ameliorates lipopolysaccharide-induced cognitive decline via relieving acute neuroinflammation and BBB damage and upregulating the BDNF-CREB pathway in mice |
| Astragalosides | Cognitive Disorders | 2 | PM | 32415932 | 📋 | Effect of Astragaloside IV on Cognitive Dysfunction in Rats With Cerebrally Infarcted via TGF-β / Smad Signaling Pathway |
| Astragalosides | Cognitive Disorders | 1 | PM | 30158469 | 📋 | Astragaloside IV Promotes Adult Neurogenesis in Hippocampal Dentate Gyrus of Mouse Through CXCL1/CXCR2 Signaling |
| Astragalosides | Dementia | 1 | PM | 32963600 | 📋 | CGA ameliorates cognitive decline by regulating the PI3K/AKT signaling pathway and neurotransmitter systems in rats with multi-infarct dementia |
| Astragalosides | Depression | 2 | PM | 38064688 | 📋 | Astragaloside IV Alleviates Depression in Rats by Modulating Intestinal Microbiota, T-Immune Balance, and Metabolome |
| Astragalosides | Depression | 1 | PM | 29795356 | 📋 | Astragaloside IV Ameliorates Neuroinflammation-Induced Depressive-Like Behaviors in Mice via the PPARγ/NF-κB/NLRP3 Inflammasome Axis |
| Astragalosides | Diabetic Encephalopathy | 2 | PM | 37097336 | 📋 | Astragaloside IV-mediated inhibition of oxidative stress by upregulation of ghrelin in type 2 diabetes-induced cognitive impairment |
| Astragalosides | Diabetic Encephalopathy | 1 | PM | 36247985 | 📋 | Astragaloside IV supplementation attenuates cognitive impairment by inhibiting neuroinflammation and oxidative stress in type 2 diabetic mice |
| Astragalosides | Post-Stroke Depression | 1 | PM | 36559001 | 📋 | Astragaloside VI Ameliorates Post-Stroke Depression via Upregulating the NRG-1-Mediated MEK/ERK Pathway |
| Astragalosides | Schizophrenia | 1 | PM | 33666843 | 📋 | Anti-anxiety and antidepressant-like effects of astragaloside IV and saponins extracted from Astragalus spinosus against the bisphenol A-induced motor and cognitive impairments in a postnatal rat model of schizophrenia |
