| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Lycopene | Benign Prostatic Hyperplasia | 13 | PM | 37446563 | 📋 | Combination of Lycopene and Curcumin Synergistically Alleviates Testosterone-Propionate-Induced Benign Prostatic Hyperplasia in Sprague Dawley Rats via Modulating Inflammation and Proliferation |
| Lycopene | Benign Prostatic Hyperplasia | 12 | PM | 35215508 | 📋 | Are We Sentenced to Pharmacotherapy? Promising Role of Lycopene and Vitamin A in Benign Urologic Conditions |
| Lycopene | Benign Prostatic Hyperplasia | 5 | PM | 34185339 | 📋 | Therapeutic effect of iodised serum milk protein, lycopene and their combination on benign prostatic hyperplasia induced in rats |
| Lycopene | Benign Prostatic Hyperplasia | 3 | PM | 33421040 | 📋 | Effects of Lycopene-enriched, Organic, Extra Virgin Olive Oil on Benign Prostatic Hyperplasia: A Pilot Study |
| Lycopene | Benign Prostatic Hyperplasia | 6 | PM | 33345482 | 📋 | [Clinical application of common botanical preparations in the treatment of benign prostatic hyperplasia] |
| Lycopene | Benign Prostatic Hyperplasia | 1 | PM | 32233234 | 📋 | [Efficacy and Safety of Lycopene in the Treatment of Benign Prostatic Hyperplasia With Lower Urinary Tract Symptoms] |
| Lycopene | Benign Prostatic Hyperplasia | 16 | PM | 28635053 | 📋 | Protective Effects of Lepidium meyenii (Maca) Aqueous Extract and Lycopene on Testosterone Propionate-Induced Prostatic Hyperplasia in Mice |
| Lycopene | Benign Prostatic Hyperplasia | 9 | PM | 28327526 | 📋 | Survivin and NAIP in Human Benign Prostatic Hyperplasia: Protective Role of the Association of Serenoa repens, Lycopene and Selenium from the Randomized Clinical Study |
| Lycopene | Benign Prostatic Hyperplasia | 8 | PM | 25154739 | 📋 | Serenoa repens, lycopene and selenium versus tamsulosin for the treatment of LUTS/BPH. An Italian multicenter double-blinded randomized study between single or combination therapy (PROCOMB trial) |
| Lycopene | Benign Prostatic Hyperplasia | 7 | PM | 24606563 | 📋 | Inhibitors of apoptosis proteins in experimental benign prostatic hyperplasia: effects of serenoa repens, selenium and lycopene |
| Lycopene | Benign Prostatic Hyperplasia | 15 | PM | 23683667 | 📋 | Effects of Serenoa repens, selenium and lycopene (Profluss®) on chronic inflammation associated with benign prostatic hyperplasia: results of "FLOG" (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study |
| Lycopene | Benign Prostatic Hyperplasia | 10 | PM | 23642948 | 📋 | A phase II randomised double-blind placebo-controlled clinical trial investigating the efficacy and safety of ProstateEZE Max: a herbal medicine preparation for the management of symptoms of benign prostatic hypertrophy |
| Lycopene | Benign Prostatic Hyperplasia | 14 | PM | 23432584 | 📋 | Serenoa Repens, lycopene and selenium: a triple therapeutic approach to manage benign prostatic hyperplasia |
| Lycopene | Benign Prostatic Hyperplasia | 11 | PM | 21855911 | 📋 | The combination of Serenoa repens, selenium and lycopene is more effective than serenoa repens alone to prevent hormone dependent prostatic growth |
| Lycopene | Benign Prostatic Hyperplasia | 2 | PM | 21109292 | 📋 | Effect of Serenoa Repens, Lycopene, and Selenium on Proinflammatory Phenotype Activation: An in Vitro and in Vivo Comparison Study |
| Lycopene | Benign Prostatic Hyperplasia | 4 | PM | 18156403 | 📋 | Lycopene inhibits disease progression in patients with benign prostate hyperplasia |
| Lycopene | Chronic Prostatitis | 7 | PM | 37839004 | 📋 | [Lycopene for the treatment of chronic prostatitis / chronic pelvic pain syndrome: Effect and mechanism based on network pharmacology and molecular docking] |
| Lycopene | Chronic Prostatitis | 6 | PM | 35215508 | 📋 | Are We Sentenced to Pharmacotherapy? Promising Role of Lycopene and Vitamin A in Benign Urologic Conditions |
| Lycopene | Chronic Prostatitis | 4 | PM | 34914324 | 📋 | [Lycopene combined with quercetin and curcumin for chronic prostatitis/chronic pelvic pain syndrome in rats: Effect and mechanism] |
| Lycopene | Chronic Prostatitis | 2 | PM | 31880092 | 📋 | Lycopene attenuates chronic prostatitis/chronic pelvic pain syndrome by inhibiting oxidative stress and inflammation via the interaction of NF-κB, MAPKs, and Nrf2 signaling pathways in rats |
| Lycopene | Chronic Prostatitis | 1 | PM | 27711089 | 📋 | Serenoa Repens Associated With Selenium and Lycopene Extract and Bromelain and Methylsulfonylmethane Extract Are Able to Improve the Efficacy of Levofloxacin in Chronic Bacterial Prostatitis Patients |
| Lycopene | Chronic Prostatitis | 5 | PM | 20332612 | 📋 | Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus selenium and lycopene (Profluss) versus S. repens alone: an Italian randomized multicenter-controlled study |
| Lycopene | Chronic Prostatitis | 3 | PM | 17920247 | 📋 | Synergistic effect between lycopene and ciprofloxacin on a chronic bacterial prostatitis rat model |
| Lycopene | Erectile Disfunction | 1 | PM | 37038051 | 📋 | Lycopene intake and the risk of erectile dysfunction in US adults: NHANES 2001-2004 |
| Lycopene | Infertility Male | 7 | PM | 37686330 | 📋 | Positive Effects of the Nutraceutical Association of Lycopene and Selenium in Experimental Varicocele |
| Lycopene | Infertility Male | 5 | PM | 36915878 | 📋 | Lycopene alleviates lipopolysaccharide-induced testicular injury in rats by activating the PPAR signaling pathway to integrate lipid metabolism and the inflammatory response |
| Lycopene | Infertility Male | 4 | PM | 34025172 | 📋 | Lycopene is superior to moringa in improving fertility markers in diet-induced obesity male rats |
| Lycopene | Infertility Male | 3 | PM | 31814398 | 📋 | Lycopene Prevents DEHP-Induced Leydig Cell Damage with the Nrf2 Antioxidant Signaling Pathway in Mice |
| Lycopene | Infertility Male | 2 | PM | 31468596 | 📋 | The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double-blind, placebo-controlled clinical trial |
| Lycopene | Infertility Male | 1 | PM | 31002161 | 📋 | Non-hormonal Treatment for Male Infertility: The Potential Role of Serenoa Repens, Selenium and Lycopene |
| Lycopene | Infertility Male | 8 | PM | 24179434 | 📋 | Lycopene supplementation prevents reactive oxygen species mediated apoptosis in Sertoli cells of adult albino rats exposed to polychlorinated biphenyls |
| Lycopene | Infertility Male | 6 | PM | 23446211 | 📋 | Lycopene improves the distorted ratio between AA/DHA in the seminal plasma of infertile males and increases the likelihood of successful pregnancy |
| Lycopene | Prostate Cancer | 19 | PM | 37187350 | 📋 | Orchestration of miRNA patterns by testosterone and dietary tomato carotenoids during early prostate carcinogenesis in TRAMP mice |
| Lycopene | Prostate Cancer | 18 | PM | 36967185 | 📋 | β-Carotene Oxygenase 2 Genotype Modulates the Impact of Dietary Lycopene on Gene Expression during Early TRAMP Prostate Carcinogenesis |
| Lycopene | Prostate Cancer | 20 | PM | 36612074 | 📋 | Plasma Micronutrient Profile of Prostate Cancer Cases Is Altered Relative to Healthy Controls-Results of a Pilot Study in South Australia |
| Lycopene | Prostate Cancer | 17 | PM | 35533600 | 📋 | Lycopene enhances the sensitivity of castration-resistant prostate cancer to enzalutamide through the AKT/EZH2/ androgen receptor signaling pathway |
| Lycopene | Prostate Cancer | 16 | PM | 35278075 | 📋 | Tomatoes, Lycopene, and Prostate Cancer: What Have We Learned from Experimental Models? |
| Lycopene | Prostate Cancer | 15 | PM | 34966715 | 📋 | Insufficient Lycopene Intake Is Associated With High Risk of Prostate Cancer: A Cross-Sectional Study From the National Health and Nutrition Examination Survey (2003-2010) |
| Lycopene | Prostate Cancer | 14 | PM | 34649352 | 📋 | A phase II study of docetaxel plus lycopene in metastatic castrate resistant prostate cancer |
| Lycopene | Prostate Cancer | 4 | PM | 32768949 | 📋 | Potential inhibitory effect of lycopene on prostate cancer |
| Lycopene | Prostate Cancer | 2 | PM | 32368526 | 📋 | The Protective Effect of Lycopene on Prostate Growth Inhibitory Efficacy by Decreasing Insulin Growth Factor-1 in Indonesian Human Prostate Cancer Cells |
| Lycopene | Prostate Cancer | 7 | PM | 32100191 | 📋 | Tomato consumption and intake of lycopene as predictors of the incidence of prostate cancer: the Adventist Health Study-2 |
| Lycopene | Prostate Cancer | 10 | PM | 30198495 | 📋 | Lycopene exerts anti-inflammatory effect to inhibit prostate cancer progression |
| Lycopene | Prostate Cancer | 5 | PM | 28440323 | 📋 | Increased dietary and circulating lycopene are associated with reduced prostate cancer risk: a systematic review and meta-analysis |
| Lycopene | Prostate Cancer | 12 | PM | 28345329 | 📋 | Lycopene Extracts from Different Tomato-Based Food Products Induce Apoptosis in Cultured Human Primary Prostate Cancer Cells and Regulate TP53, Bax and Bcl-2 Transcript Expression |
| Lycopene | Prostate Cancer | 1 | PM | 27406859 | 📋 | Tomato-based Randomized Controlled Trial in Prostate Cancer Patients: Effect on PSA |
| Lycopene | Prostate Cancer | 8 | PM | 26817504 | 📋 | Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression |
| Lycopene | Prostate Cancer | 6 | PM | 26287411 | 📋 | Lycopene and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis |
| Lycopene | Prostate Cancer | 9 | PM | 25315431 | 📋 | Dietary tomato and lycopene impact androgen signaling- and carcinogenesis-related gene expression during early TRAMP prostate carcinogenesis |
| Lycopene | Prostate Cancer | 13 | PM | 24851879 | 📋 | The effect of lycopene on the PI3K/Akt signalling pathway in prostate cancer |
| Lycopene | Prostate Cancer | 23 | PM | 23857058 | 📋 | The potential role of lycopene for the prevention and therapy of prostate cancer: from molecular mechanisms to clinical evidence |
| Lycopene | Prostate Cancer | 22 | PM | 23746934 | 📋 | Lycopene modulates growth and survival associated genes in prostate cancer |
| Lycopene | Prostate Cancer | 21 | PM | 23483004 | 📋 | Effects of lycopene on protein expression in human primary prostatic epithelial cells |
| Lycopene | Prostate Cancer | 11 | PM | 18095570 | 📋 | [Effect of lycopene on proliferation and cell cycle of hormone refractory prostate cancer PC-3 cell line] |
| Lycopene | Prostate Cancer | 3 | PM | 17927495 | 📋 | Lycopene and Soy Isoflavones in the Treatment of Prostate Cancer |
| Lycopene | Reproductive Toxicity Male | 11 | PM | 38268887 | 📋 | Lycopene protects against ionizing radiation-induced testicular damage by inhibition of apoptosis and mitochondrial dysfunction |
| Lycopene | Reproductive Toxicity Male | 10 | PM | 36958386 | 📋 | Role of ROS/JAK2/STAT3 signaling pathway in di-n-butyl phthalate-induced testosterone synthesis inhibition and antagonism of lycopene |
| Lycopene | Reproductive Toxicity Male | 9 | PM | 36104915 | 📋 | Phthalate-induced testosterone/androgen receptor pathway disorder on spermatogenesis and antagonism of lycopene |
| Lycopene | Reproductive Toxicity Male | 8 | PM | 35940575 | 📋 | Lycopene modulates hepatic toxicity and testis injury induced by etoposide in male rats |
| Lycopene | Reproductive Toxicity Male | 7 | PM | 35814917 | 📋 | Comparative Potential of Zinc Sulfate, L-Carnitine, Lycopene, and Coenzyme Q10 on Cadmium-Induced Male Infertility |
| Lycopene | Reproductive Toxicity Male | 2 | PM | 34825328 | 📋 | Testicular toxicity of cisplatin in rats: ameliorative effect of lycopene and N-acetylcysteine |
| Lycopene | Reproductive Toxicity Male | 3 | PM | 34396458 | 📋 | Lycopene Alleviates Titanium Dioxide Nanoparticle-Induced Testicular Toxicity by Inhibiting Oxidative Stress and Apoptosis in Mice |
| Lycopene | Reproductive Toxicity Male | 4 | PM | 31568845 | 📋 | Protective effect of lycopene on testicular toxicity induced by Benzo[a]pyrene intake in rats |
| Lycopene | Reproductive Toxicity Male | 1 | PM | 31319718 | 📋 | Testicular toxicity of gentamicin in adult rats: Ameliorative effect of lycopene |
| Lycopene | Reproductive Toxicity Male | 5 | PM | 30907024 | 📋 | Evaluation of ameliorating effect of lycopene against testicular toxicity due to diethylnitrosamine using biochemical, spermatological and histopathological data |
| Lycopene | Reproductive Toxicity Male | 6 | PM | 29886059 | 📋 | Lycopene abrogates di-(2-ethylhexyl) phthalate induced testicular injury by modulating oxidative, endocrine and inflammatory changes in mice |
| Lycopene | Testicular Disorders | 1 | PM | 37018856 | 📋 | Lycopene ameliorates aflatoxin B1-induced testicular lesion by attenuating oxidative stress and mitochondrial damage with Nrf2 activation in mice |
| Lycopene | Testicular Disorders | 2 | PM | 27882589 | 📋 | Attenuation of the cyproterone acetate-induced testicular hypofunction by a novel nutraceutical lycopene: a genomic approach |
| Lycopene | Varicocele | 5 | PM | 38301353 | 📋 | Lycopene inhibits apoptosis of mouse spermatocytes in varicocele via miR-23a/b-induced downregulation of PROK2 |
| Lycopene | Varicocele | 4 | PM | 35592276 | 📋 | Lycopene improves testicular damage and sperm quality in experimentally induced varicocele: Relationship with apoptosis, hypoxia, and hyperthermia |
| Lycopene | Varicocele | 3 | PM | 34925809 | 📋 | Lycopene protects sperm from oxidative stress in the experimental varicocele model |
| Lycopene | Varicocele | 2 | PM | 34055003 | 📋 | Lycopene Attenuates Hypoxia-Induced Testicular Injury by Inhibiting PROK2 Expression and Activating PI3K/AKT/mTOR Pathway in a Varicocele Adult Rat |
| Lycopene | Varicocele | 1 | PM | 32466161 | 📋 | Nutraceutical Effects of Lycopene in Experimental Varicocele: An "In Vivo" Model to Study Male Infertility |
