| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Melatonin | Acute Liver Injury | 2 | PM | 38051589 | 📋 | Hepatoprotective actions of melatonin by mainly modulating oxidative status and apoptosis rate in lipopolysaccharide-induced liver damage |
| Melatonin | Acute Liver Injury | 1 | PM | 36058048 | 📋 | Melatonin arrests excessive inflammatory response and apoptosis in lipopolysaccharide-damaged rat liver: A deeper insight into its mechanism of action |
| Melatonin | Aging Liver | 1 | PM | 37886973 | 📋 | Effects of Melatonin on Liver of D-Galactose-Induced Aged Mouse Model |
| Melatonin | Alcoholic Liver Disease | 4 | PM | 38247468 | 📋 | Melatonin Prevents Alcohol- and Metabolic Dysfunction- Associated Steatotic Liver Disease by Mitigating Gut Dysbiosis, Intestinal Barrier Dysfunction, and Endotoxemia |
| Melatonin | Alcoholic Liver Disease | 3 | PM | 36815038 | 📋 | Melatonin alleviates alcoholic liver disease via EGFR-BRG1-TERT axis regulation |
| Melatonin | Alcoholic Liver Disease | 2 | PM | 36166594 | 📋 | Melatonin Prevents against Ethanol-Induced Liver Injury by Mitigating Ferroptosis via Targeting Brain and Muscle ARNT-like 1 in Mice Liver and HepG2 Cells |
| Melatonin | Alcoholic Liver Disease | 1 | PM | 26564773 | 📋 | Melatonin Upregulates the Activity of AMPK and Attenuates Lipid Accumulation in Alcohol-induced Rats |
| Melatonin | Biliary Tract Cancer | 1 | PM | 33445767 | 📋 | Melatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review |
| Melatonin | Cholestasis | 3 | PM | 38047407 | 📋 | Melatonin improves cholestatic liver disease via the gut-liver axis |
| Melatonin | Cholestasis | 2 | PM | 36869985 | 📋 | Melatonin attenuates cholestatic liver injury via inhibition of the inflammatory response |
| Melatonin | Cholestasis | 1 | PM | 34373700 | 📋 | iTRAQ-based quantitative proteomics analysis of the hepatoprotective effect of melatonin on ANIT-induced cholestasis in rats |
| Melatonin | Cholestasis | 4 | PM | 23095487 | 📋 | Melatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in rats |
| Melatonin | Hepatic Cirrhosis | 3 | PM | 34146550 | 📋 | Sarcopenia, oxidative stress and inflammatory process in muscle of cirrhotic rats - Action of melatonin and physical exercise |
| Melatonin | Hepatic Cirrhosis | 2 | PM | 32782966 | 📋 | Low-dose melatonin for sleep disturbances in early-stage cirrhosis: A randomized, placebo-controlled, cross-over trial |
| Melatonin | Hepatic Cirrhosis | 1 | PM | 27801960 | 📋 | Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells |
| Melatonin | Hepatic Encephalopathy | 2 | PM | 35624703 | 📋 | Hepatic Encephalopathy and Melatonin |
| Melatonin | Hepatic Encephalopathy | 1 | PM | 35289256 | 📋 | Promising effects of naringenin and melatonin against hepatic encephalopathy impairments induced by bile duct ligation in male rats |
| Melatonin | Hepatic Fibrosis | 10 | PM | 38246330 | 📋 | Melatonin ameliorates hepatic fibrosis via the melatonin receptor 2-mediated upregulation of BMAL1 and anti-oxidative enzymes |
| Melatonin | Hepatic Fibrosis | 9 | PM | 37992643 | 📋 | Melatonin alleviates particulate matter-induced liver fibrosis by inhibiting ROS-mediated mitophagy and inflammation via Nrf2 activation |
| Melatonin | Hepatic Fibrosis | 8 | PM | 36942808 | 📋 | Melatonin attenuates thioacetamide-induced liver fibrosis in male rats through modulation of interleukin-6, interleukin-4, apoptosis and urokinase plasminogen activator receptor-associated protein/Endo180 |
| Melatonin | Hepatic Fibrosis | 7 | PM | 36375715 | 📋 | Sustained systemic inflammation increases autophagy and induces EMT/fibrotic changes in mouse liver cells: Protection by melatonin |
| Melatonin | Hepatic Fibrosis | 6 | PM | 35583587 | 📋 | Melatonin Alleviates Liver Fibrosis by Inhibiting Autophagy |
| Melatonin | Hepatic Fibrosis | 5 | PM | 35537548 | 📋 | Melatonin relieves liver fibrosis induced by Txnrd3 knockdown and nickel exposure via IRE1/NF-kB/NLRP3 and PERK/TGF-β1 axis activation |
| Melatonin | Hepatic Fibrosis | 4 | PM | 35404472 | 📋 | Beneficial effects of melatonin on liver fibrosis: A systematic review of current biological evidence |
| Melatonin | Hepatic Fibrosis | 3 | PM | 34743371 | 📋 | MT1 but not MT2 melatonin receptor knockout decreases biliary damage and liver fibrosis during cholestatic liver injury |
| Melatonin | Hepatic Fibrosis | 12 | PM | 29180002 | 📋 | Melatonin mitigates thioacetamide-induced hepatic fibrosis via antioxidant activity and modulation of proinflammatory cytokines and fibrogenic genes |
| Melatonin | Hepatic Fibrosis | 11 | PM | 28782839 | 📋 | Post-treatment of melatonin with CCl4 better reduces fibrogenic and oxidative changes in liver than melatonin co-treatment |
| Melatonin | Hepatic Fibrosis | 1 | PM | 28247434 | 📋 | Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice |
| Melatonin | Hepatic Fibrosis | 2 | PM | 26348081 | 📋 | Protective effects of melatonin against thioacetamide-induced liver fibrosis in rats |
| Melatonin | Hepatic Ischemia | 2 | PM | 33760198 | 📋 | Exogenous melatonin alleviates hemorrhagic shock‑induced hepatic ischemic injury in rats by inhibiting the NF‑κB/IκBα signaling pathway |
| Melatonin | Hepatic Ischemia | 1 | PM | 32691975 | 📋 | Hepatic 31 P-magnetic resonance spectroscopy identified the impact of melatonin-pretreated mitochondria in acute liver ischaemia-reperfusion injury |
| Melatonin | Hepatic Ischemia | 5 | PM | 28469765 | 📋 | Melatonin treatment enhances therapeutic effects of exosomes against acute liver ischemia-reperfusion injury |
| Melatonin | Hepatic Ischemia | 4 | PM | 26993080 | 📋 | Melatonin pretreatment enhances the therapeutic effects of exogenous mitochondria against hepatic ischemia-reperfusion injury in rats through suppression of mitochondrial permeability transition |
| Melatonin | Hepatic Ischemia-Reperfusion | 7 | PM | 37509579 | 📋 | Melatonin Preserves Fluidity in Cell and Mitochondrial Membranes against Hepatic Ischemia-Reperfusion |
| Melatonin | Hepatic Ischemia-Reperfusion | 6 | PM | 36436653 | 📋 | Environmental microplastic accumulation exacerbates liver ischemia-reperfusion injury in rat: Protective effects of melatonin |
| Melatonin | Hepatic Ischemia-Reperfusion | 5 | PM | 33947635 | 📋 | Melatonin attenuates hepatic ischemia-reperfusion injury in rats by inhibiting NF-κB signaling pathway |
| Melatonin | Hepatic Ischemia-Reperfusion | 4 | PM | 33751704 | 📋 | Melatonin and its protective role in attenuating warm or cold hepatic ischaemia/reperfusion injury |
| Melatonin | Hepatic Ischemia-Reperfusion | 2 | PM | 27346180 | 📋 | The protective effect of melatonin on remote organ liver ischemia and reperfusion injury following aortic clamping |
| Melatonin | Hepatic Ischemia-Reperfusion | 1 | PM | 27168834 | 📋 | Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury |
| Melatonin | Hepatic Ischemia-Reperfusion | 3 | PM | 26101163 | 📋 | Melatonin attenuates hepatic ischemia through mitogen-activated protein kinase signaling |
| Melatonin | Hepatic Steatosis | 3 | PM | 37652870 | 📋 | Protective Effects of Melatonin in High-Fat Diet-Induced Hepatic Steatosis via Decreased Intestinal Lipid Absorption and Hepatic Cholesterol Synthesis |
| Melatonin | Hepatic Steatosis | 2 | PM | 34399601 | 📋 | Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice |
| Melatonin | Hepatic Steatosis | 1 | PM | 33983041 | 📋 | Effect of Melatonin on the Reduction of Hepatic Steatosis and Intestinal Leptin Expression in Zebrafish Exposed to Fructose |
| Melatonin | Hepatotoxicity | 17 | PM | 38229313 | 📋 | Melatonin attenuates liver injury in arsenic-treated rats: The potential role of the Nrf2/HO-1, apoptosis, and miR-34a/Sirt1/autophagy pathways |
| Melatonin | Hepatotoxicity | 16 | PM | 38179616 | 📋 | The effect of melatonin on capecitabine-induced hepatic and renal toxicity in rats |
| Melatonin | Hepatotoxicity | 15 | PM | 38171107 | 📋 | Insight into the mechanism of melatonin in attenuating PCB126-induced liver injury: Resistance to ROS-dependent NETs formation to alleviate inflammation and lipid metabolism dysfunction |
| Melatonin | Hepatotoxicity | 14 | PM | 38129993 | 📋 | Therapeutic Benefit of Melatonin in 5-Fluorouracil-induced renal and hepatic injury |
| Melatonin | Hepatotoxicity | 9 | PM | 38079620 | 📋 | The role of melatonin in preventing amiodarone induced rat liver damage |
| Melatonin | Hepatotoxicity | 11 | PM | 36890697 | 📋 | Melatonin protects against methotrexate hepatotoxicity in young rats: Impact of PI3K/Akt/mTOR signaling |
| Melatonin | Hepatotoxicity | 10 | PM | 36139801 | 📋 | Effects of the Gut Microbiota and Barrier Function on Melatonin Efficacy in Alleviating Liver Injury |
| Melatonin | Hepatotoxicity | 8 | PM | 35652241 | 📋 | Melatonin mitigates aflatoxin B1-induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice |
| Melatonin | Hepatotoxicity | 7 | PM | 35433098 | 📋 | Melatonin restores zinc levels, activates the Keap1/Nrf2 pathway, and modulates endoplasmic reticular stress and HSP in rats with chronic hepatotoxicity |
| Melatonin | Hepatotoxicity | 1 | PM | 34736034 | 📋 | Protective effect of melatonin against chronic cadmium-induced hepatotoxicity by suppressing oxidative stress, inflammation, and apoptosis in mice |
| Melatonin | Hepatotoxicity | 2 | PM | 33613967 | 📋 | Protective effect of melatonin against herbicides-induced hepatotoxicity in rats |
| Melatonin | Hepatotoxicity | 4 | PM | 33106037 | 📋 | Melatonin modulates oxidative phosphorylation, hepatic and kidney autophagy-caused subclinical endotoxemia and acute ethanol-induced oxidative stress |
| Melatonin | Hepatotoxicity | 6 | PM | 26808084 | 📋 | Melatonin's role in preventing toxin-related and sepsis-mediated hepatic damage: A review |
| Melatonin | Hepatotoxicity | 3 | PM | 26504754 | 📋 | Cytoprotective Effects of Melatonin Against Amitriptyline-Induced Toxicity in Isolated Rat Hepatocytes |
| Melatonin | Hepatotoxicity | 5 | PM | 26348081 | 📋 | Protective effects of melatonin against thioacetamide-induced liver fibrosis in rats |
| Melatonin | Hepatotoxicity | 12 | PM | 24493665 | 📋 | Mechanisms of phenytoin-induced toxicity in freshly isolated rat hepatocytes and the protective effects of taurine and/or melatonin |
| Melatonin | Hepatotoxicity | 13 | PM | 24023050 | 📋 | Mechanisms of trazodone-induced cytotoxicity and the protective effects of melatonin and/or taurine toward freshly isolated rat hepatocytes |
| Melatonin | Hyperbilirubinemia | 1 | PM | 29247156 | 📋 | Melatonin Promotes Brain-Derived Neurotrophic Factor (BDNF) Expression and Anti-Apoptotic Effects in Neonatal Hemolytic Hyperbilirubinemia via a Phospholipase (PLC)-Mediated Mechanism |
| Melatonin | Liver Cancer | 23 | PM | 38618269 | 📋 | Melatonin Mitigates the Progression of Chemically Induced Hepatocellular Carcinoma in Rats via Targeting Wnt/Β-Catenin Pathway, and Small Noncoding miR-let-7b |
| Melatonin | Liver Cancer | 22 | PM | 38356184 | 📋 | Dietary melatonin and liver cancer incidence in Japan: From the Takayama study |
| Melatonin | Liver Cancer | 20 | PM | 38183817 | 📋 | Unraveling the impact of melatonin treatment: Oxidative stress, metabolic responses, and morphological changes in HuH7.5 hepatocellular carcinoma cells |
| Melatonin | Liver Cancer | 19 | PM | 36928762 | 📋 | Anti-proliferative effect of melatonin in human hepatoma HepG2 cells occurs mainly through cell cycle arrest and inflammation inhibition |
| Melatonin | Liver Cancer | 18 | PM | 36863486 | 📋 | Melatonin modulates the Warburg effect and alters the morphology of hepatocellular carcinoma cell line resulting in reduced viability and migratory potential |
| Melatonin | Liver Cancer | 17 | PM | 36651944 | 📋 | Anti-drug resistance, anti-inflammation, and anti-proliferation activities mediated by melatonin in doxorubicin-resistant hepatocellular carcinoma: in vitro investigations |
| Melatonin | Liver Cancer | 16 | PM | 36225557 | 📋 | Melatonin inhibits HCC progression through regulating the alternative splicing of NEMO |
| Melatonin | Liver Cancer | 15 | PM | 35651333 | 📋 | Melatonin inhibits glycolysis in hepatocellular carcinoma cells by downregulating mitochondrial respiration and mTORC1 activity |
| Melatonin | Liver Cancer | 14 | PM | 35141433 | 📋 | Melatonin is a potential oncostatic agent to inhibit HepG2 cell proliferation through multiple pathways |
| Melatonin | Liver Cancer | 13 | PM | 33445767 | 📋 | Melatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review |
| Melatonin | Liver Cancer | 1 | PM | 32630505 | 📋 | Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment |
| Melatonin | Liver Cancer | 12 | PM | 31724939 | 📋 | The potential therapeutic effect for melatonin and mesenchymal stem cells on hepatocellular carcinoma |
| Melatonin | Liver Cancer | 5 | PM | 31523192 | 📋 | Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway |
| Melatonin | Liver Cancer | 8 | PM | 30201903 | 📋 | Melatonin Inhibits the Progression of Hepatocellular Carcinoma through MicroRNA Let7i-3p Mediated RAF1 Reduction |
| Melatonin | Liver Cancer | 10 | PM | 30201872 | 📋 | Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair |
| Melatonin | Liver Cancer | 2 | PM | 28246472 | 📋 | Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation |
| Melatonin | Liver Cancer | 3 | PM | 28178378 | 📋 | Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma |
| Melatonin | Liver Cancer | 11 | PM | 28123844 | 📋 | Targeting NF-κB/AP-2β signaling to enhance antitumor activity of cisplatin by melatonin in hepatocellular carcinoma cells |
| Melatonin | Liver Cancer | 4 | PM | 27696512 | 📋 | Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma |
| Melatonin | Liver Cancer | 6 | PM | 27484637 | 📋 | Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy |
| Melatonin | Liver Cancer | 9 | PM | 27347130 | 📋 | Effects of melatonin on HIF-1α and VEGF expression and on the invasive properties of hepatocarcinoma cells |
| Melatonin | Liver Cancer | 21 | PM | 24117795 | 📋 | Inhibition of matrix metalloproteinase-9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in HepG2 liver cancer cells |
| Melatonin | Liver Cancer | 7 | PM | 19012662 | 📋 | Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line |
| Melatonin | Liver Damage | 1 | PM | 38308199 | 📋 | IP3R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin |
| Melatonin | Liver Damage | 5 | PM | 28333073 | 📋 | Effects of Melatonin on Liver Injuries and Diseases |
| Melatonin | Liver Damage | 4 | PM | 26808084 | 📋 | Melatonin's role in preventing toxin-related and sepsis-mediated hepatic damage: A review |
| Melatonin | Liver Disease | 3 | PM | 34659664 | 📋 | Melatonin effect on platelet count in patients with liver disease |
| Melatonin | Liver Disease | 2 | PM | 28333073 | 📋 | Effects of Melatonin on Liver Injuries and Diseases |
| Melatonin | Liver Disease | 1 | PM | 12531250 | 📋 | Acutely administered melatonin restores hepatic mitochondrial physiology in old mice |
| Melatonin | MAFLD | 12 | PM | 38247468 | 📋 | Melatonin Prevents Alcohol- and Metabolic Dysfunction- Associated Steatotic Liver Disease by Mitigating Gut Dysbiosis, Intestinal Barrier Dysfunction, and Endotoxemia |
| Melatonin | MAFLD | 11 | PM | 38136629 | 📋 | Melatonin as a Repairing Agent in Cadmium- and Free Fatty Acid-Induced Lipotoxicity |
| Melatonin | MAFLD | 10 | PM | 37864588 | 📋 | Assessment of melatonin's therapeutic effectiveness against hepatic steatosis induced by a high-carbohydrate high-fat diet in rats |
| Melatonin | MAFLD | 9 | PM | 37728565 | 📋 | Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model |
| Melatonin | MAFLD | 8 | PM | 37564204 | 📋 | Melatonin Ameliorates Hepatic Ferroptosis in NAFLD by Inhibiting ER Stress via the MT2/cAMP/PKA/IRE1 Signaling Pathway |
| Melatonin | MAFLD | 7 | PM | 37371817 | 📋 | Experimental Data on the Role of Melatonin in the Pathogenesis of Nonalcoholic Fatty Liver Disease |
| Melatonin | MAFLD | 6 | PM | 34399601 | 📋 | Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice |
| Melatonin | MAFLD | 5 | PM | 34365685 | 📋 | Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease |
| Melatonin | MAFLD | 4 | PM | 34221262 | 📋 | Is melatonin associated with pro-inflammatory cytokine activity and liver fibrosis in non-alcoholic fatty liver disease (NAFLD) patients? |
| Melatonin | MAFLD | 3 | PM | 34058202 | 📋 | Effect of melatonin therapy on the non-alcoholic steatohepatitis patients: a systematic review and meta-analysis on clinical trial studies |
| Melatonin | MAFLD | 2 | PM | 32951715 | 📋 | The effect of melatonin on treatment of patients with non-alcoholic fatty liver disease: a randomized double blind clinical trial |
| Melatonin | MAFLD | 1 | PM | 32696189 | 📋 | Melatonin regulates neurodegenerative complications associated with NAFLD via enhanced neurotransmission and cellular integrity: a correlational study |
| Melatonin | MAFLD | 13 | PM | 28981157 | 📋 | Effects of melatonin on fatty liver disease: The role of NR4A1/DNA-PKcs/p53 pathway, mitochondrial fission, and mitophagy |
| Melatonin | Non-Alcoholic Steatohepatitis | 3 | PM | 36356262 | 📋 | Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis |
| Melatonin | Non-Alcoholic Steatohepatitis | 2 | PM | 35668917 | 📋 | Melatonin Suppresses NLRP3 Inflammasome Activation via TLR4/NF-κB and P2X7R Signaling in High-Fat Diet-Induced Murine NASH Model |
| Melatonin | Non-Alcoholic Steatohepatitis | 1 | PM | 35419738 | 📋 | Melatonin Attenuates Inflammation, Oxidative Stress, and DNA Damage in Mice with Nonalcoholic Steatohepatitis Induced by a Methionine- and Choline-Deficient Diet |
| Melatonin | Primary Biliary Cholangitis | 2 | PM | 35110954 | 📋 | Melatonin prevents oxidative stress, inflammatory activity, and DNA damage in cirrhotic rats |
| Melatonin | Primary Biliary Cholangitis | 1 | PM | 33352965 | 📋 | Melatonin Protects Cholangiocytes from Oxidative Stress-Induced Proapoptotic and Proinflammatory Stimuli via miR-132 and miR-34 |
| Melatonin | Primary Sclerosing Cholangitis | 3 | PM | 35863741 | 📋 | Prolonged administration of melatonin ameliorates liver phenotypes in cholestatic murine model |
| Melatonin | Primary Sclerosing Cholangitis | 2 | PM | 35557275 | 📋 | Suppression of MT1 and Melatonin Treatment Improves Liver Phenotypes in Mdr2 -/- mice |
| Melatonin | Primary Sclerosing Cholangitis | 1 | PM | 34743371 | 📋 | MT1 but not MT2 melatonin receptor knockout decreases biliary damage and liver fibrosis during cholestatic liver injury |
