| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Ginsenosides | Acute Liver Failure | 1 | PM | 33617946 | 📋 | Gensenoside Rg1 Protects against Lipopolysaccharide- and D-galactose-induced Acute Liver Failure via Suppressing HMGB1-mediated TLR4-NF-κB Pathway |
| Ginsenosides | Acute Liver Failure | 2 | PM | 28482410 | 📋 | [Therapeutic Efficacy and Mechanism of Action of Ginsenoside Rg1 in Treating Acute Hepatic Failure in Mice] |
| Ginsenosides | Acute Liver Failure | 4 | PM | 25431611 | 📋 | Ginsenosides Rg1 From Panax Ginseng: A Potential Therapy for Acute Liver Failure Patients? |
| Ginsenosides | Acute Liver Injury | 12 | PM | 36437551 | 📋 | Ginsenoside Rd Inhibited Ferroptosis to Alleviate CCl4-Induced Acute Liver Injury in Mice via cGAS/STING Pathway |
| Ginsenosides | Acute Liver Injury | 11 | PM | 35836757 | 📋 | Ginsenoside Rb1 Reduces D-GalN/LPS-induced Acute Liver Injury by Regulating TLR4/NF-κB Signaling and NLRP3 Inflammasome |
| Ginsenosides | Acute Liver Injury | 10 | PM | 34930287 | 📋 | Ginsenoside Rg3 alleviates septic liver injury by regulating the lncRNA TUG1/miR-200c-3p/SIRT1 axis |
| Ginsenosides | Acute Liver Injury | 9 | PM | 33628094 | 📋 | Ginsenoside Rg1 alleviates acute liver injury through the induction of autophagy and suppressing NF-κB/NLRP3 inflammasome signaling pathway |
| Ginsenosides | Acute Liver Injury | 8 | PM | 32932915 | 📋 | Minor Ginsenoside Rg2 and Rh1 Attenuates LPS-Induced Acute Liver and Kidney Damages via Downregulating Activation of TLR4-STAT1 and Inflammatory Cytokine Production in Macrophages |
| Ginsenosides | Acute Liver Injury | 4 | PM | 31786947 | 📋 | Ginsenoside Rb1, A Major Saponin From Panax ginseng, Exerts Protective Effects Against Acetaminophen-Induced Hepatotoxicity in Mice |
| Ginsenosides | Acute Liver Injury | 5 | PM | 30662289 | 📋 | Ginsenoside Rk1 Ameliorates Paracetamol-Induced Hepatotoxicity in Mice Through Inhibition of Inflammation, Oxidative Stress, Nitrative Stress and Apoptosis |
| Ginsenosides | Acute Liver Injury | 7 | PM | 30402153 | 📋 | Ginsenoside Rg1 Attenuates Liver Injury Induced by D-galactose in Mice |
| Ginsenosides | Acute Liver Injury | 6 | PM | 30030101 | 📋 | Ginsenoside Rg1 Protects Against Acetaminophen-Induced Liver Injury via Activating Nrf2 Signaling Pathway in Vivo and in Vitro |
| Ginsenosides | Acute Liver Injury | 3 | PM | 29964319 | 📋 | Hepatoprotective Effect of Ginsenoside Rg1 From Panax Ginseng on Carbon Tetrachloride-Induced Acute Liver Injury by Activating Nrf2 Signaling Pathway in Mice |
| Ginsenosides | Acute Liver Injury | 2 | PM | 29902710 | 📋 | Protective Effects of Ginsenoside Rg1 Against lipopolysaccharide/d-galactosamine-induced Acute Liver Injury in Mice Through Inhibiting Toll-Like Receptor 4 Signaling Pathway |
| Ginsenosides | Acute Liver Injury | 1 | PM | 28677756 | 📋 | Protective Effect and Mechanism of Ginsenoside Rg1 on Carbon tetrachloride‑induced Acute Liver Injury |
| Ginsenosides | Aging Liver | 1 | PM | 34523690 | 📋 | Ginsenoside Rg1 ameliorates aging‑induced liver fibrosis by inhibiting the NOX4/NLRP3 inflammasome in SAMP8 mice |
| Ginsenosides | Alcoholic Hepatitis | 1 | PM | 33412392 | 📋 | Hepatoprotection by Ginsenoside Rg1 in alcoholic liver disease |
| Ginsenosides | Alcoholic Liver Disease | 7 | PM | 37842661 | 📋 | Ginsenoside Rk2, a dehydroprotopanaxadiol saponin, alleviates alcoholic liver disease via regulating NLRP3 and NLRP6 inflammasome signaling pathways in mice |
| Ginsenosides | Alcoholic Liver Disease | 6 | PM | 37382340 | 📋 | Attenuation of alcohol-induced hepatocyte damage by ginsenoside Rg1 evaluated using atomic force microscopy |
| Ginsenosides | Alcoholic Liver Disease | 5 | PM | 36960204 | 📋 | Amelioration of alcohol-induced acute liver injury in C57BL/6 mice by a mixture of TCM phytochemicals and probiotics with antioxidative and anti-inflammatory effects |
| Ginsenosides | Alcoholic Liver Disease | 4 | PM | 36052161 | 📋 | Hepatoprotective Mechanism of Ginsenoside Rg1 against Alcoholic Liver Damage Based on Gut Microbiota and Network Pharmacology |
| Ginsenosides | Alcoholic Liver Disease | 3 | PM | 33716743 | 📋 | Ginsenoside Rb1 Alleviates Alcohol-Induced Liver Injury by Inhibiting Steatosis, Oxidative Stress, and Inflammation |
| Ginsenosides | Alcoholic Liver Disease | 2 | PM | 33192125 | 📋 | Ginsenoside F2 attenuates chronic-binge ethanol-induced liver injury by increasing regulatory T cells and decreasing Th17 cells |
| Ginsenosides | Alcoholic Liver Disease | 1 | PM | 29207044 | 📋 | Ginsenoside Rg1 Inhibits Inflammatory Responses via Modulation of the Nuclear factor‑κB Pathway and Inhibition of Inflammasome Activation in Alcoholic Hepatitis |
| Ginsenosides | Autoimmune Hepatitis | 2 | PM | 38137182 | 📋 | Protective Effect of Ginsenoside CK against Autoimmune Hepatitis Induced by Concanavalin A |
| Ginsenosides | Autoimmune Hepatitis | 1 | PM | 35222444 | 📋 | Ginsenosides Regulates Innate Immunity to Affect Immune Microenvironment of AIH Through Hippo-YAP/TAZ Signaling Pathway |
| Ginsenosides | Cholestasis | 2 | PM | 37634749 | 📋 | Ginsenoside Rg1 alleviates ANIT-induced cholestatic liver injury by inhibiting hepatic inflammation and oxidative stress via SIRT1 activation |
| Ginsenosides | Cholestasis | 1 | PM | 36235592 | 📋 | Ginsenosides Restore Lipid and Redox Homeostasis in Mice with Intrahepatic Cholestasis through SIRT1/AMPK Pathways |
| Ginsenosides | Hepatic Cirrhosis | 1 | PM | 21895415 | 📋 | Ginsenoside Rb1 inhibits cell activation and liver fibrosis in rat hepatic stellate cells |
| Ginsenosides | Hepatic Failure | 2 | PM | 37659296 | 📋 | Activation of ULK1 to trigger FUNDC1-mediated mitophagy in heart failure: Effect of Ginsenoside Rg3 intervention |
| Ginsenosides | Hepatic Failure | 1 | PM | 34428586 | 📋 | Rg3 promotes the SUMOylation of SERCA2a and corrects cardiac dysfunction in heart failure |
| Ginsenosides | Hepatic Fibrosis | 16 | PM | 38784156 | 📋 | Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis |
| Ginsenosides | Hepatic Fibrosis | 15 | PM | 38176269 | 📋 | Ginsenoside Rg3 promotes hepatic stellate cell ferroptosis by epigenetically regulating ACSL4 to suppress liver fibrosis progression |
| Ginsenosides | Hepatic Fibrosis | 14 | PM | 37441987 | 📋 | Ginsenoside Rh2 promotes hepatic stellate cell ferroptosis and inactivation via regulation of IRF1-inhibited SLC7A11 |
| Ginsenosides | Hepatic Fibrosis | 13 | PM | 37397418 | 📋 | Ginsenoside Rg1 Epigenetically Modulates Smad7 Expression in Liver Fibrosis via MicroRNA-152 |
| Ginsenosides | Hepatic Fibrosis | 12 | PM | 37249244 | 📋 | Ginsenoside Rd, a natural production for attenuating fibrogenesis and inflammation in hepatic fibrosis by regulating the ERRα-mediated P2X7r pathway |
| Ginsenosides | Hepatic Fibrosis | 11 | PM | 36644954 | 📋 | Ginsenoside AD-2 Ameliorating Lipopolysaccharide-Induced Activation in HSC-T6 Cells and Carbon Tetrachloride-Induced Hepatic Fibrosis in Mice via Regulation of VD-VDR Axis |
| Ginsenosides | Hepatic Fibrosis | 10 | PM | 35489327 | 📋 | Ginsenoside Rh2 attenuates CDAHFD-induced liver fibrosis in mice by improving intestinal microbial composition and regulating LPS-mediated autophagy |
| Ginsenosides | Hepatic Fibrosis | 9 | PM | 35114912 | 📋 | Notoginsenoside R1, An Active Compound from Panax notoginseng, Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis via MAPK Signaling Pathway |
| Ginsenosides | Hepatic Fibrosis | 8 | PM | 35104139 | 📋 | Ginsenoside Rg2 Ameliorating CDAHFD-Induced Hepatic Fibrosis by Regulating AKT/mTOR-Mediated Autophagy |
| Ginsenosides | Hepatic Fibrosis | 7 | PM | 34822828 | 📋 | Ginsenoside PPD inhibit the activation of HSCs by directly targeting TGFβR1 |
| Ginsenosides | Hepatic Fibrosis | 6 | PM | 34523690 | 📋 | Ginsenoside Rg1 ameliorates aging‑induced liver fibrosis by inhibiting the NOX4/NLRP3 inflammasome in SAMP8 mice |
| Ginsenosides | Hepatic Fibrosis | 5 | PM | 33667840 | 📋 | Ginsenoside-Rg1 acts as an IDO1 inhibitor, protects against liver fibrosis via alleviating IDO1-mediated the inhibition of DCs maturation |
| Ginsenosides | Hepatic Fibrosis | 1 | PM | 32532964 | 📋 | Ginsenoside Rg3 Promotes Regression From Hepatic Fibrosis Through Reducing Inflammation-Mediated Autophagy Signaling Pathway |
| Ginsenosides | Hepatic Fibrosis | 2 | PM | 29929367 | 📋 | Ginsenoside 25-OCH 3-PPD Promotes Activity of LXRs To Ameliorate P2X7R-Mediated NLRP3 Inflammasome in the Development of Hepatic Fibrosis |
| Ginsenosides | Hepatic Fibrosis | 3 | PM | 29761840 | 📋 | Ginsenoside Rg1 Ameliorates Liver Fibrosis via Suppressing Epithelial to Mesenchymal Transition and Reactive Oxygen Species Production in Vitro and in Vivo |
| Ginsenosides | Hepatic Fibrosis | 4 | PM | 20184879 | 📋 | Ginsenoside-Rg1 From Panax Notoginseng Prevents Hepatic Fibrosis Induced by Thioacetamide in Rats |
| Ginsenosides | Hepatic Ischemia-Reperfusion | 2 | PM | 34630612 | 📋 | Ginsenoside Rg1 Alleviates Hepatic Ischemia-Reperfusion Injury in Mice via Activating ER α-Regulating YAP Expression |
| Ginsenosides | Hepatic Ischemia-Reperfusion | 1 | PM | 32603889 | 📋 | The Effect of Ginsenoside Rg1 in Hepatic Ischemia Reperfusion (I/R) Injury Ameliorates Ischemia-Reperfusion-Induced Liver Injury by Inhibiting Apoptosis |
| Ginsenosides | Hepatic Steatosis | 7 | PM | 35818425 | 📋 | Upregulation of adiponectin by Ginsenoside Rb1 contributes to amelioration of hepatic steatosis induced by high fat diet |
| Ginsenosides | Hepatic Steatosis | 5 | PM | 32654591 | 📋 | Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid |
| Ginsenosides | Hepatic Steatosis | 1 | PM | 32387461 | 📋 | Ginsenoside Mc1 Improves Liver Steatosis and Insulin Resistance by Attenuating ER Stress |
| Ginsenosides | Hepatic Steatosis | 3 | PM | 32016448 | 📋 | Ginsenosides Reduce Body Weight and Ameliorate Hepatic Steatosis in High Fat diet‑induced Obese Mice via Endoplasmic Reticulum Stress and p‑STAT3/STAT3 Signaling |
| Ginsenosides | Hepatic Steatosis | 2 | PM | 31002778 | 📋 | Ginsenoside Rg1 Attenuates Hepatic Insulin Resistance Induced by High-Fat and High-Sugar by Inhibiting Inflammation |
| Ginsenosides | Hepatic Steatosis | 4 | PM | 29042402 | 📋 | Ginsenoside Rg3 Ameliorated HFD-induced Hepatic Steatosis Through Downregulation of STAT5-PPARγ |
| Ginsenosides | Hepatic Steatosis | 6 | PM | 27614967 | 📋 | Ginsenosides from stems and leaves of ginseng prevent ethanol-induced lipid accumulation in human L02 hepatocytes |
| Ginsenosides | Hepatitis | 1 | PM | 23666740 | 📋 | Ginsenoside Rg1 attenuates concanavalin A-induced hepatitis in mice through inhibition of cytokine secretion and lymphocyte infiltration |
| Ginsenosides | Hepatitis A | 1 | PM | 23931146 | 📋 | Reduction of hepatitis A virus on FRhK-4 cells treated with Korean red ginseng extract and ginsenosides |
| Ginsenosides | Hepatitis B | 3 | PM | 36950885 | 📋 | Notoginsenoside R1 inhibits hepatitis B virus replication by modulating SIRT1 activity |
| Ginsenosides | Hepatitis B | 2 | PM | 36110238 | 📋 | Selected ginsenosides interfere efficiently with hepatitis B virus mRNA expression levels and suppress viral surface antigen secretion |
| Ginsenosides | Hepatitis B | 1 | PM | 24180280 | 📋 | Stimulation of DDX3 expression by ginsenoside Rg3 through the Akt/p53 pathway activates the innate immune response via TBK1/IKKε/IRF3 signalling |
| Ginsenosides | Hepatitis B | 4 | PM | 24004833 | 📋 | Stimulation of TRAF6/TAK1 degradation and inhibition of JNK/AP-1 signalling by ginsenoside Rg3 attenuates hepatitis B virus replication |
| Ginsenosides | Hepatitis C | 1 | PM | 28329914 | 📋 | Ginsenoside Rg3 restores hepatitis C virus-induced aberrant mitochondrial dynamics and inhibits virus propagation |
| Ginsenosides | Hepatotoxicity | 16 | PM | 38708102 | 📋 | Ameliorative effect of total ginsenosides from heat-treated fresh ginseng against cyclophosphamide-induced liver injury in mice |
| Ginsenosides | Hepatotoxicity | 15 | PM | 38244950 | 📋 | Ginsenoside Rg1 attenuates lipopolysaccharide-induced chronic liver damage by activating Nrf2 signaling and inhibiting inflammasomes in hepatic cells |
| Ginsenosides | Hepatotoxicity | 14 | PM | 36278209 | 📋 | Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity via relieving inflammation and oxidative stress |
| Ginsenosides | Hepatotoxicity | 13 | PM | 36152060 | 📋 | Ros-mediated mitochondrial oxidative stress is involved in the ameliorating effect of ginsenoside GSLS on chlorpyrifos induced hepatotoxicity in mice |
| Ginsenosides | Hepatotoxicity | 12 | PM | 35875589 | 📋 | Gut Microbiota Modulates the Protective Role of Ginsenoside Compound K Against Sodium Valproate-Induced Hepatotoxicity in Rat |
| Ginsenosides | Hepatotoxicity | 11 | PM | 35595219 | 📋 | Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury by inhibiting CYP1A1 through the aryl hydrocarbon receptor |
| Ginsenosides | Hepatotoxicity | 7 | PM | 35046796 | 📋 | Ginsenoside Rb1 Attenuates Triptolide-Induced Cytotoxicity in HL-7702 Cells via the Activation of Keap1/Nrf2/ARE Pathway |
| Ginsenosides | Hepatotoxicity | 1 | PM | 34812491 | 📋 | Ginsenoside Rb1 alleviates liver injury induced by 3-chloro-1,2-propanediol by stimulating autophagic flux |
| Ginsenosides | Hepatotoxicity | 10 | PM | 34397062 | 📋 | Hepatoprotective effects of ginsenoside Rk3 in acetaminophen-induced liver injury in mice by activation of autophagy |
| Ginsenosides | Hepatotoxicity | 8 | PM | 34155666 | 📋 | Ginsenoside Rg1 and ginsenoside Rh1 prevent liver injury induced by acetaminophen in mice |
| Ginsenosides | Hepatotoxicity | 2 | PM | 33793882 | 📋 | Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity by suppressing inflammation and oxidative stress |
| Ginsenosides | Hepatotoxicity | 6 | PM | 33096694 | 📋 | Hepatoprotection by Traditional Essence of Ginseng against Carbon Tetrachloride-Induced Liver Damage |
| Ginsenosides | Hepatotoxicity | 3 | PM | 30608002 | 📋 | Ginsenoside Rg1 Prevents Acetaminophen-Induced Oxidative Stress and Apoptosis via Nrf2/ARE Signaling Pathway |
| Ginsenosides | Hepatotoxicity | 9 | PM | 28965396 | 📋 | Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice |
| Ginsenosides | Hepatotoxicity | 5 | PM | 28429935 | 📋 | Saponins (Ginsenosides) From the Leaves of Panax Quinquefolius Ameliorated Acetaminophen-Induced Hepatotoxicity in Mice |
| Ginsenosides | Hepatotoxicity | 4 | PM | 16162168 | 📋 | Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury |
| Ginsenosides | Liver Cancer | 53 | PM | 38664638 | 📋 | Ginsenoside compound K induces ferroptosis via the FOXO pathway in liver cancer cells |
| Ginsenosides | Liver Cancer | 52 | PM | 38584523 | 📋 | 20(S)-Ginsenoside Rh2 inhibits hepatocellular carcinoma by suppressing angiogenesis and the GPC3-mediated Wnt/β‑catenin signaling pathway |
| Ginsenosides | Liver Cancer | 51 | PM | 38461953 | 📋 | Ginsenoside Rk1 induces autophagy-dependent apoptosis in hepatocellular carcinoma by AMPK/mTOR signaling pathway |
| Ginsenosides | Liver Cancer | 50 | PM | 38027042 | 📋 | Mechanism Research and Application for Ginsenosides in the Treatment of Hepatocellular Carcinoma |
| Ginsenosides | Liver Cancer | 49 | PM | 37843550 | 📋 | Ginsenoside Rh4 inhibits inflammation-related hepatocellular carcinoma progression by targeting HDAC4/IL-6/STAT3 signaling |
| Ginsenosides | Liver Cancer | 48 | PM | 37806155 | 📋 | Ginsenoside Rh2 and its octyl ester derivative inhibited invasion and metastasis of hepatocellular carcinoma via the c-Jun/COX2/PGE2 pathway |
| Ginsenosides | Liver Cancer | 47 | PM | 37666060 | 📋 | A large-scale transcriptional analysis reveals herb-derived ginsenoside F2 suppressing hepatocellular carcinoma via inhibiting STAT3 |
| Ginsenosides | Liver Cancer | 45 | PM | 37305788 | 📋 | Ginsenoside Rk3 is a novel PI3K/AKT-targeting therapeutics agent that regulates autophagy and apoptosis in hepatocellular carcinoma |
| Ginsenosides | Liver Cancer | 44 | PM | 36839713 | 📋 | Ginsenoside Rg3 Reduces the Toxicity of Graphene Oxide Used for pH-Responsive Delivery of Doxorubicin to Liver and Breast Cancer Cells |
| Ginsenosides | Liver Cancer | 43 | PM | 36432152 | 📋 | Ginsenoside Rb1 from Panax notoginseng Suppressed TNF-α-Induced Matrix Metalloproteinase-9 via the Suppression of Double-Strand RNA-Dependent Protein Kinase (PKR)/NF-κB Pathway |
| Ginsenosides | Liver Cancer | 42 | PM | 35719058 | 📋 | Ginsenoside Rg3 and sorafenib combination therapy relieves the hepatocellular carcinomaprogression through regulating the HK2-mediated glycolysis and PI3K/Akt signaling pathway |
| Ginsenosides | Liver Cancer | 41 | PM | 35600776 | 📋 | Ginsenoside Rg3 in combination with artesunate overcomes sorafenib resistance in hepatoma cell and mouse models |
| Ginsenosides | Liver Cancer | 40 | PM | 35568793 | 📋 | 20(s)-ginsenoside Rh2 promotes TRAIL-induced apoptosis by upregulating DR5 in human hepatocellular carcinoma cells |
| Ginsenosides | Liver Cancer | 39 | PM | 35316310 | 📋 | Ginsenoside Rk1 regulates glutamine metabolism in hepatocellular carcinoma through inhibition of the ERK/c-Myc pathway |
| Ginsenosides | Liver Cancer | 38 | PM | 34884975 | 📋 | (20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells |
| Ginsenosides | Liver Cancer | 37 | PM | 34415764 | 📋 | Ginsenoside Rk3 Suppresses Hepatocellular Carcinoma Development through Targeting the Gut-Liver Axis |
| Ginsenosides | Liver Cancer | 36 | PM | 34199025 | 📋 | The Anti-Tumor Effect and Underlying Apoptotic Mechanism of Ginsenoside Rk1 and Rg5 in Human Liver Cancer Cells |
| Ginsenosides | Liver Cancer | 35 | PM | 34130594 | 📋 | Ginsenoside-Rg3 inhibits the proliferation and invasion of hepatoma carcinoma cells via regulating long non-coding RNA HOX antisense intergenic |
| Ginsenosides | Liver Cancer | 34 | PM | 34073155 | 📋 | Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma |
| Ginsenosides | Liver Cancer | 33 | PM | 33793802 | 📋 | Combining combretastatin A4 phosphate with ginsenoside Rd synergistically inhibited hepatocellular carcinoma by reducing HIF-1α via PI3K/AKT/mTOR signalling pathway |
| Ginsenosides | Liver Cancer | 32 | PM | 33363466 | 📋 | Ginsenoside Compound K Regulates HIF-1α-Mediated Glycolysis Through Bclaf1 to Inhibit the Proliferation of Human Liver Cancer Cells |
| Ginsenosides | Liver Cancer | 31 | PM | 33133379 | 📋 | Synergistic anti-liver cancer effects of curcumin and total ginsenosides |
| Ginsenosides | Liver Cancer | 7 | PM | 31814271 | 📋 | Nanoparticle Conjugation of Ginsenoside Rg3 Inhibits Hepatocellular Carcinoma Development and Metastasis |
| Ginsenosides | Liver Cancer | 4 | PM | 31534898 | 📋 | Ginsenoside Rg3 Prolongs Survival of the Orthotopic Hepatocellular Carcinoma Model by Inducing Apoptosis and Inhibiting Angiogenesis |
| Ginsenosides | Liver Cancer | 6 | PM | 31531357 | 📋 | Study on the Effect of Ginsenosides Rb on Blood of Tumor Mice |
| Ginsenosides | Liver Cancer | 22 | PM | 30655855 | 📋 | Ginsenoside Rg3 inhibits the migration and invasion of liver cancer cells by increasing the protein expression of ARHGAP9 |
| Ginsenosides | Liver Cancer | 9 | PM | 30525897 | 📋 | Ginsenoside Rg3 Decreases NHE1 Expression via Inhibiting EGF-EGFR-ERK1/2-HIF-1 [Formula: see text] Pathway in Hepatocellular Carcinoma: A Novel Antitumor Mechanism |
| Ginsenosides | Liver Cancer | 18 | PM | 30093032 | 📋 | Enhanced Cytotoxic and Apoptotic Potential in Hepatic Carcinoma Cells of Chitosan Nanoparticles Loaded With Ginsenoside Compound K |
| Ginsenosides | Liver Cancer | 3 | PM | 29921768 | 📋 | Compound K Induces Endoplasmic Reticulum Stress and Apoptosis in Human Liver Cancer Cells by Regulating STAT3 |
| Ginsenosides | Liver Cancer | 46 | PM | 29193880 | 📋 | Octyl ester of ginsenoside compound K as novel anti-hepatoma compound: Synthesis and evaluation on murine H22 cells in vitro and in vivo |
| Ginsenosides | Liver Cancer | 27 | PM | 29156516 | 📋 | Synergistic anticancer activity of 20(S)-Ginsenoside Rg3 and Sorafenib in hepatocellular carcinoma by modulating PTEN/Akt signaling pathway |
| Ginsenosides | Liver Cancer | 13 | PM | 28963461 | 📋 | The Identification of Molecular Target of (20S) Ginsenoside Rh2 for Its Anti-Cancer Activity |
| Ginsenosides | Liver Cancer | 12 | PM | 28928088 | 📋 | 20(S)-Ginsenoside Rh2 Suppresses Proliferation and Migration of Hepatocellular Carcinoma Cells by Targeting EZH2 to Regulate CDKN2A-2B Gene Cluster Transcription |
| Ginsenosides | Liver Cancer | 28 | PM | 28260016 | 📋 | Effects of R type and S type ginsenoside Rg3 on DNA methylation in human hepatocarcinoma cells |
| Ginsenosides | Liver Cancer | 20 | PM | 27756603 | 📋 | Ginsenoside exhibits concentration-dependent dual effects on HepG2 cell proliferation via regulation of c-Myc and HNF-4α |
| Ginsenosides | Liver Cancer | 11 | PM | 27573179 | 📋 | Anticancer Effect of 20(S)-ginsenoside Rh2 on HepG2 Liver Carcinoma Cells: Activating GSK-3β and Degrading β-catenin |
| Ginsenosides | Liver Cancer | 5 | PM | 27163230 | 📋 | Antitumoral Activity of (20R)- And (20S)-Ginsenoside Rh2 on Transplanted Hepatocellular Carcinoma in Mice |
| Ginsenosides | Liver Cancer | 1 | PM | 26885681 | 📋 | Prospective Study of Transcatheter Arterial Chemoembolization (TACE) With Ginsenoside Rg3 Versus TACE Alone for the Treatment of Patients With Advanced Hepatocellular Carcinoma |
| Ginsenosides | Liver Cancer | 23 | PM | 26783250 | 📋 | Ginsenoside Rh2 inhibits hepatocellular carcinoma through β-catenin and autophagy |
| Ginsenosides | Liver Cancer | 26 | PM | 25515352 | 📋 | Ginsenoside Rg1 attenuates invasion and migration by inhibiting transforming growth factor-β1-induced epithelial to mesenchymal transition in HepG2 cells |
| Ginsenosides | Liver Cancer | 2 | PM | 25364265 | 📋 | Ginsenoside Rg3 Attenuates Hepatoma VEGF Overexpression After Hepatic Artery Embolization in an Orthotopic Transplantation Hepatocellular Carcinoma Rat Model |
| Ginsenosides | Liver Cancer | 24 | PM | 25051397 | 📋 | Effect of ginsenoside Rh2 on the migratory ability of HepG2 liver carcinoma cells: recruiting histone deacetylase and inhibiting activator protein 1 transcription factors |
| Ginsenosides | Liver Cancer | 8 | PM | 25041540 | 📋 | Stereospecificity of Ginsenoside Rg3 in the Promotion of Cellular Immunity in Hepatoma H22-bearing Mice |
| Ginsenosides | Liver Cancer | 10 | PM | 24970805 | 📋 | 20(S)-Ginsenoside Rg3 Is a Novel Inhibitor of Autophagy and Sensitizes Hepatocellular Carcinoma to Doxorubicin |
| Ginsenosides | Liver Cancer | 17 | PM | 24804620 | 📋 | Compound K-induced Apoptosis of Human Hepatocellular Carcinoma MHCC97-H Cells in Vitro |
| Ginsenosides | Liver Cancer | 25 | PM | 23053497 | 📋 | Sensitization of TRAIL-induced cell death by 20(S)-ginsenoside Rg3 via CHOP-mediated DR5 upregulation in human hepatocellular carcinoma cells |
| Ginsenosides | Liver Cancer | 29 | PM | 22634290 | 📋 | Reactive oxygen species mediated ginsenoside Rg3- and Rh2-induced apoptosis in hepatoma cells through mitochondrial signaling pathways |
| Ginsenosides | Liver Cancer | 15 | PM | 22366885 | 📋 | Antitumor Effects of Ginsenoside Rg3 on Human Hepatocellular Carcinoma Cells |
| Ginsenosides | Liver Cancer | 21 | PM | 21987607 | 📋 | Ginsenoside Rg3 inhibit hepatocellular carcinoma growth via intrinsic apoptotic pathway |
| Ginsenosides | Liver Cancer | 30 | PM | 21982435 | 📋 | Anti-metastatic effects of ginsenoside Rd via inactivation of MAPK signaling and induction of focal adhesion formation |
| Ginsenosides | Liver Cancer | 19 | PM | 20979019 | 📋 | Ginsenoside Compound K Attenuates Metastatic Growth of Hepatocellular Carcinoma, Which Is Associated With the Translocation of Nuclear factor-κB p65 and Reduction of Matrix metalloproteinase-2/9 |
| Ginsenosides | Liver Cancer | 16 | PM | 19809182 | 📋 | Autophagy Inhibition Enhances Apoptosis Induced by Ginsenoside Rk1 in Hepatocellular Carcinoma Cells |
| Ginsenosides | Liver Cancer | 14 | PM | 18451501 | 📋 | Anti-tumor Activity of the Ginsenoside Rk1 in Human Hepatocellular Carcinoma Cells Through Inhibition of Telomerase Activity and Induction of Apoptosis |
| Ginsenosides | Liver Damage | 2 | PM | 38244950 | 📋 | Ginsenoside Rg1 attenuates lipopolysaccharide-induced chronic liver damage by activating Nrf2 signaling and inhibiting inflammasomes in hepatic cells |
| Ginsenosides | Liver Damage | 1 | PM | 36077440 | 📋 | Revealing the Therapeutic Targets and Mechanism of Ginsenoside Rg1 for Liver Damage Related to Anti-Oxidative Stress Using Proteomic Analysis |
| Ginsenosides | Liver Damage | 10 | PM | 32733933 | 📋 | Ginsenoside Rb1 Alleviated High-Fat-Diet-Induced Hepatocytic Apoptosis via Peroxisome Proliferator-Activated Receptor γ |
| Ginsenosides | Liver Damage | 8 | PM | 30342195 | 📋 | Reversing effects of ginsenosides on LPS-induced hepatic CYP3A11/3A4 dysfunction through the pregnane X receptor |
| Ginsenosides | Liver Disease | 2 | PM | 38465219 | 📋 | The pharmacological role of Ginsenoside Rg3 in liver diseases: A review on molecular mechanisms |
| Ginsenosides | Liver Disease | 1 | PM | 28427912 | 📋 | Hepataprotective Effects of Ginsenoside Rg1 - A Review |
| Ginsenosides | MAFLD | 18 | PM | 38542753 | 📋 | Ginsenoside Rg5 Activates the LKB1/AMPK/mTOR Signaling Pathway and Modifies the Gut Microbiota to Alleviate Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet |
| Ginsenosides | MAFLD | 17 | PM | 37599957 | 📋 | Harnessing the Therapeutic Potential of Ginsenoside Rd for Activating SIRT6 in Treating a Mouse Model of Nonalcoholic Fatty Liver Disease |
| Ginsenosides | MAFLD | 16 | PM | 37444230 | 📋 | Ginsenoside Rh4 Improves Hepatic Lipid Metabolism and Inflammation in a Model of NAFLD by Targeting the Gut Liver Axis and Modulating the FXR Signaling Pathway |
| Ginsenosides | MAFLD | 14 | PM | 37252282 | 📋 | Ginsenoside Rg3-enriched Korean Red Ginseng extract attenuates Non-Alcoholic Fatty Liver Disease by way of suppressed VCAM-1 expression in liver sinusoidal endothelium |
| Ginsenosides | MAFLD | 13 | PM | 37252281 | 📋 | Ginsenosides Rc, as a novel SIRT6 activator, protects mice against high fat diet induced NAFLD |
| Ginsenosides | MAFLD | 12 | PM | 36759837 | 📋 | Ginsenoside Rg1 attenuates the NASH phenotype by regulating the miR-375-3p/ATG2B/PTEN-AKT axis to mediate autophagy and pyroptosis |
| Ginsenosides | MAFLD | 11 | PM | 35358801 | 📋 | Bioinformatics study of the potential therapeutic effects of ginsenoside Rf in reversing nonalcoholic fatty liver disease |
| Ginsenosides | MAFLD | 10 | PM | 35322862 | 📋 | Ginsenoside Rg1 exerts anti‑apoptotic effects on non‑alcoholic fatty liver cells by downregulating the expression of SGPL1 |
| Ginsenosides | MAFLD | 9 | PM | 35018944 | 📋 | Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo |
| Ginsenosides | MAFLD | 8 | PM | 34659439 | 📋 | Ginsenoside Re Improves Inflammation and Fibrosis in Hepatic Tissue by Upregulating PPAR γ Expression and Inhibiting Oxidative Stress in db/db Mice |
| Ginsenosides | MAFLD | 7 | PM | 33679403 | 📋 | Ginsenosides Improve Nonalcoholic Fatty Liver Disease via Integrated Regulation of Gut Microbiota, Inflammation and Energy Homeostasis |
| Ginsenosides | MAFLD | 6 | PM | 33385408 | 📋 | Transcriptome analysis reveals the efficacy of ginsenoside-Rg1 in the treatment of nonalcoholic fatty liver disease |
| Ginsenosides | MAFLD | 3 | PM | 32455208 | 📋 | Ginsenoside Rg1 Regulates Liver Lipid Factor Metabolism in NAFLD Model Rats |
| Ginsenosides | MAFLD | 1 | PM | 32437790 | 📋 | Ginsenoside Rg1 Protects Against D-Galactose Induced Fatty Liver Disease in a Mouse Model via FOXO1 Transcriptional Factor |
| Ginsenosides | MAFLD | 4 | PM | 30135326 | 📋 | Ginsenoside Rg1 Protects Against Non-alcoholic Fatty Liver Disease by Ameliorating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammasome Activation |
| Ginsenosides | MAFLD | 5 | PM | 28534819 | 📋 | Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK |
| Ginsenosides | MAFLD | 15 | PM | 28142230 | 📋 | Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent pathways in type 2 diabetic OLETF rats |
| Ginsenosides | MAFLD | 2 | PM | 28106137 | 📋 | Ameliorative Effects of Compound K and Ginsenoside Rh1 on Non-Alcoholic Fatty Liver Disease in Rats |
| Ginsenosides | Non-Alcoholic Steatohepatitis | 4 | PM | 38223828 | 📋 | Ginsenoside F2 Restrains Hepatic Steatosis and Inflammation by Altering the Binding Affinity of Liver X Receptor Coregulators |
| Ginsenosides | Non-Alcoholic Steatohepatitis | 3 | PM | 38176268 | 📋 | Ginsenoside Rg5 inhibits lipid accumulation and hepatocyte apoptosis via the Notch1 signaling pathway in NASH mice |
| Ginsenosides | Non-Alcoholic Steatohepatitis | 2 | PM | 37288986 | 📋 | Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice |
| Ginsenosides | Non-Alcoholic Steatohepatitis | 1 | PM | 33050067 | 📋 | Pharmaceutical Efficacy of Gypenoside LXXV on Non-Alcoholic Steatohepatitis (NASH) |
