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List of Berberine and group Liver intersectionsRows: 121■ Human ■ Animal ■ Risk ■ Review

SubstanceConditionSeqSrc
PMID
Dtl
Title
Berberine Acute Liver Failure
1
PM
29191769📋Berberine protects acute liver failure in mice through inhibiting inflammation and mitochondria-dependent apoptosis
Berberine Acute Liver Injury
1
PM
31432116📋Berberine Ameliorates CCl4‑induced Liver Injury in Rats Through Regulation of the Nrf2‑Keap1‑ARE and p53 Signaling Pathways
Berberine Alcoholic Liver Disease
2
PM
36870291📋Berberine Ameliorates Abnormal Lipid Metabolism via the Adenosine Monophosphate-Activated Protein Kinase/Sirtuin 1 Pathway in Alcohol-Related Liver Disease
Berberine Alcoholic Liver Disease
1
PM
32790968📋Modulation of gut microbiota mediates berberine-induced expansion of immuno-suppressive cells to against alcoholic liver disease
Berberine Autoimmune Hepatitis
2
PM
38466881📋Berberine alleviates concanavalin A-induced autoimmune hepatitis in mice by modulating the gut microbiota
Berberine Autoimmune Hepatitis
1
PM
29283990📋The Effects of Berberine on Concanavalin A-Induced Autoimmune Hepatitis (AIH) in Mice and the Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase (AMPK) Pathway
Berberine Biliary Tract Cancer
2
PM
36308362📋Low Dose Berberine Suppresses Cholangiocarcinoma Cell Progression as a Multi-Kinase Inhibitor
Berberine Biliary Tract Cancer
1
PM
28566619📋Berberine Induces Cell Cycle Arrest in Cholangiocarcinoma Cell Lines via Inhibition of NF-κB and STAT3 Pathways
Berberine Hepatic Encephalopathy
1
PM
37371422📋Effect of Berberine against Cognitive Deficits in Rat Model of Thioacetamide-Induced Liver Cirrhosis and Hepatic Encephalopathy (Behavioral, Biochemical, Molecular and Histological Evaluations)
Berberine Hepatic Fibrosis
5
PM
37062521📋Berberine attenuates liver fibrosis by autophagy inhibition triggering apoptosis via the miR-30a-5p/ATG5 axis
Berberine Hepatic Fibrosis
4
PM
35308208📋Therapeutic Effects of Berberine on Liver Fibrosis are associated With Lipid Metabolism and Intestinal Flora
Berberine Hepatic Fibrosis
2
PM
34864819📋Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis
Berberine Hepatic Fibrosis
1
PM
30138605📋Antioxidant and Anti-Inflammatory Activities of Berberine Attenuate Hepatic Fibrosis Induced by Thioacetamide Injection in Rats
Berberine Hepatic Fibrosis
6
PM
23734997📋Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression
Berberine Hepatic Fibrosis
7
PM
23190573📋A comparative study on the hepatoprotective action of bear bile and Coptidis Rhizoma aqueous extract on experimental liver fibrosis in rats
Berberine Hepatic Fibrosis
3
PM
19721228📋Berberine Inhibits Hepatic Stellate Cell Proliferation and Prevents Experimental Liver Fibrosis
Berberine Hepatic Ischemia-Reperfusion
1
PM
37780378📋Berberine protects hepatocyte from hypoxia/reoxygenation-induced injury through inhibiting circDNTTIP2
Berberine Hepatic Steatosis
4
PM
35722423📋Methyltransferase SETD2 mediates hepatoprotection of berberine against steatosis
Berberine Hepatic Steatosis
3
PM
34790723📋Berberine attenuates atherosclerotic lesions and hepatic steatosis in ApoE -/- mice by down-regulating PCSK9 via ERK1/2 pathway
Berberine Hepatic Steatosis
2
PM
29477657📋Berberine Induces miR-373 Expression in Hepatocytes to Inactivate Hepatic Steatosis Associated AKT-S6 Kinase Pathway
Berberine Hepatic Steatosis
1
PM
29065221📋Berberine Attenuates Hepatic Steatosis and Enhances Energy Expenditure in Mice by Inducing Autophagy and Fibroblast Growth Factor 21
Berberine Hepatic Steatosis
5
PM
28900305📋Berberine ameliorates fatty acid-induced oxidative stress in human hepatoma cells
Berberine Hepatitis C
1
PM
32276448📋Targeting Autophagy Augments BBR-Mediated Cell Death in Human Hepatoma Cells Harboring Hepatitis C Virus RNA
Berberine Hepatotoxicity
11
PM
38633147📋Ameliorative effects of berberine and selenium against paracetamol-induced hepatic toxicity in rats
Berberine Hepatotoxicity
10
PM
37421530📋Berberine mitigates acetamiprid-induced hepatotoxicity and inflammation via regulating endogenous antioxidants and NF-κB/TNF-α signaling in rats
Berberine Hepatotoxicity
7
PM
36655525📋Evaluation of the Antioxidant Effects of Berberine against Sodium Nitrite-induced Oxidative Injury in the Rat Liver
Berberine Hepatotoxicity
6
PM
35427583📋Berberis integerrima hydro-alcoholic root extract ant its constituent berberine protect against cisplatin-induced nephro- and hepato-toxicity
Berberine Hepatotoxicity
5
PM
34979291📋Berberine improves liver injury induced glucose and lipid metabolic disorders via alleviating ER stress of hepatocytes and modulating gut microbiota in mice
Berberine Hepatotoxicity
2
PM
34258700📋Hepatoprotective effects of phytochemicals berberine and umbelliferone against methotrexate-induced hepatic intoxication: experimental studies and in silico evidence
Berberine Hepatotoxicity
3
PM
31845254📋Hepatoprotective Role of Berberine Against Paraquat-Induced Liver Toxicity in Rat
Berberine Hepatotoxicity
1
PM
29864914📋Hepatoprotective Effects of Berberine on Acetaminophen-Induced Hepatotoxicity in Mice
Berberine Hepatotoxicity
9
PM
29091871📋Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats
Berberine Hepatotoxicity
8
PM
28763751📋Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ, and suppressing oxidative stress and apoptosis in rats
Berberine Hepatotoxicity
4
PM
11449466📋Studies on Preventive and Curative Effects of Berberine on Chemical-Induced Hepatotoxicity in Rodents
Berberine Liver Cancer
34
PM
38750718📋Berberine increases the killing effect of pirarubicin on HCC cells by inhibiting ATG4B-autophagy pathway
Berberine Liver Cancer
33
PM
38693042📋The potential of the nutraceutical berberine in the treatment of hepatocellular carcinoma and other liver diseases such as NAFLD and NASH
Berberine Liver Cancer
32
PM
38301771📋Berberine prevents NAFLD and HCC by modulating metabolic disorders
Berberine Liver Cancer
31
PM
38084140📋Inhibition of hepatocellular carcinoma growth via modulation of the miR-221/SOX11 axis by curcumin and berberine
Berberine Liver Cancer
25
PM
37148713📋Berberine activates PPARδ and promotes gut microbiota-derived butyric acid to suppress hepatocellular carcinoma
Berberine Liver Cancer
24
PM
36191360📋Hepatocellular cancer cell lines, Hep-3B and Hep-G2 display the pleiotropic response to resveratrol and berberine
Berberine Liver Cancer
23
PM
36090480📋Berberine inhibits carcinogenesis through antagonizing the ATX-LPA-LPAR2-p38-leptin axis in a mouse hepatoma model
Berberine Liver Cancer
22
PM
34787617📋Antiproliferative activity of berberine in HepG2 cells via inducing apoptosis and arresting cell cycle
Berberine Liver Cancer
21
PM
34712379📋Berberine Suppresses EMT in Liver and Gastric Carcinoma Cells through Combination with TGF β R Regulating TGF- β/Smad Pathway
Berberine Liver Cancer
20
PM
34460138📋A novel combined resveratrol/berberine phytochemotheraputic using the HePG2 cell line as a model for the treatment of hepatocarcinoma
Berberine Liver Cancer
19
PM
34395446📋Probing Synergistic Targets by Natural Compounds for Hepatocellular Carcinoma
Berberine Liver Cancer
18
PM
34220494📋Berberine Sensitizes Human Hepatoma Cells to Regorafenib via Modulating Expression of Circular RNAs
Berberine Liver Cancer
17
PM
33130557📋Berberine represses β-catenin translation involving 4E-BPs in hepatocellular carcinoma cells
Berberine Liver Cancer
29
PM
32815562📋Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence
Berberine Liver Cancer
16
PM
32606742📋Berberine Inhibits the Apoptosis-Induced Metastasis by Suppressing the iPLA2/LOX-5/LTB4 Pathway in Hepatocellular Carcinoma
Berberine Liver Cancer
15
PM
32276448📋Targeting Autophagy Augments BBR-Mediated Cell Death in Human Hepatoma Cells Harboring Hepatitis C Virus RNA
Berberine Liver Cancer
2
PM
32021249📋Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake
Berberine Liver Cancer
11
PM
31545468📋Exploring the Active Mechanism of Berberine Against HCC by Systematic Pharmacology and Experimental Validation
Berberine Liver Cancer
4
PM
31217846📋Berberine Prevents Non-Alcoholic Steatohepatitis-Derived Hepatocellular Carcinoma by Inhibiting Inflammation and Angiogenesis in Mice
Berberine Liver Cancer
3
PM
30565332📋Synergistic Effect of Berberine and HMQ1611 Impairs Cell Proliferation and Migration by Regulating Wnt Signaling Pathway in Hepatocellular Carcinoma
Berberine Liver Cancer
10
PM
30015938📋Berberine, a Natural Plant Alkaloid, Synergistically Sensitizes Human Liver Cancer Cells to Sorafenib
Berberine Liver Cancer
6
PM
29626488📋Berberine Induced Modulation of PHLPP2-Akt-MST1 Kinase Signaling Is Coupled With Mitochondrial Impairment and Hepatoma Cell Death
Berberine Liver Cancer
5
PM
29360760📋Regulation of Akt/FoxO3a/Skp2 Axis Is Critically Involved in Berberine-Induced Cell Cycle Arrest in Hepatocellular Carcinoma Cells
Berberine Liver Cancer
7
PM
28572744📋Berberine Regulates the Protein Expression of Multiple Tumorigenesis-Related Genes in Hepatocellular Carcinoma Cell Lines
Berberine Liver Cancer
8
PM
28277195📋Induction of Apoptosis by Berberine in Hepatocellular Carcinoma HepG2 Cells via Downregulation of NF-κB
Berberine Liver Cancer
14
PM
27854312📋Berberine Suppresses Cyclin D1 Expression Through Proteasomal Degradation in Human Hepatoma Cells
Berberine Liver Cancer
9
PM
27311637📋Antiproliferation of Berberine Is Mediated by Epigenetic Modification of Constitutive Androstane Receptor (CAR) Metabolic Pathway in Hepatoma Cells
Berberine Liver Cancer
13
PM
27092498📋Up-Regulation of PAI-1 and Down-Regulation of uPA Are Involved in Suppression of Invasiveness and Motility of Hepatocellular Carcinoma Cells by a Natural Compound Berberine
Berberine Liver Cancer
28
PM
23999088📋Berberine and S allyl cysteine mediated amelioration of DEN+CCl4 induced hepatocarcinoma
Berberine Liver Cancer
27
PM
23784371📋Berberine induces apoptosis via the mitochondrial pathway in liver cancer cells
Berberine Liver Cancer
26
PM
23732865📋Berberine induces selective apoptosis through the AMPK‑mediated mitochondrial/caspase pathway in hepatocellular carcinoma
Berberine Liver Cancer
30
PM
21443647📋Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147
Berberine Liver Cancer
12
PM
19724899📋Coptis Chinensis Inhibits Hepatocellular Carcinoma Cell Growth Through Nonsteroidal Anti-Inflammatory Drug-Activated Gene Activation
Berberine Liver Cancer
1
PM
19408145📋Berbamine Induces Fas-mediated Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells and Inhibits Its Tumor Growth in Nude Mice
Berberine Liver Damage
1
PM
35436630📋Hydrochloride Berberine ameliorates alcohol-induced liver injury by regulating inflammation and lipid metabolism
Berberine Liver Damage
6
PM
35078575📋[Berberine hydrochloride attenuates liver injury induced by acute hypoxic exposure by inhibiting TNF-α/caspase-8/caspase-3 signaling pathway]
Berberine Liver Disease
4
PM
38693042📋The potential of the nutraceutical berberine in the treatment of hepatocellular carcinoma and other liver diseases such as NAFLD and NASH
Berberine Liver Disease
3
PM
34056769📋Molecular updates on berberine in liver diseases: Bench to bedside
Berberine Liver Disease
2
PM
33068590📋The pharmacological activity of berberine, a review for liver protection
Berberine Liver Disease
1
PM
32265720📋The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism
Berberine MAFLD
35
PM
38762210📋Berberine directly targets AKR1B10 protein to modulate lipid and glucose metabolism disorders in NAFLD
Berberine MAFLD
34
PM
38723878📋Berberine ameliorates nonalcoholic fatty liver disease-induced bone loss by inhibiting ferroptosis
Berberine MAFLD
33
PM
38673787📋Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature
Berberine MAFLD
32
PM
38429794📋The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review
Berberine MAFLD
31
PM
38301771📋Berberine prevents NAFLD and HCC by modulating metabolic disorders
Berberine MAFLD
28
PM
37293270📋Berberine alleviates non-alcoholic hepatic steatosis partially by promoting SIRT1 deacetylation of CPT1A in mice
Berberine MAFLD
27
PM
36838862📋Berberine Ameliorates Metabolic-Associated Fatty Liver Disease Mediated Metabolism Disorder and Redox Homeostasis by Upregulating Clock Genes: Clock and Bmal1 Expressions
Berberine MAFLD
26
PM
36079717📋Berberine in Non-Alcoholic Fatty Liver Disease-A Review
Berberine MAFLD
25
PM
35873595📋Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota
Berberine MAFLD
24
PM
35726797📋Astragalus mongholicus polysaccharides ameliorate hepatic lipid accumulation and inflammation as well as modulate gut microbiota in NAFLD rats
Berberine MAFLD
23
PM
35722423📋Methyltransferase SETD2 mediates hepatoprotection of berberine against steatosis
Berberine MAFLD
22
PM
35584453📋The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver disease associated with modulation of gut microbiota in rats
Berberine MAFLD
21
PM
35382695📋Effect of berberine and bicyclol on Chinese patients with non-alcoholic fatty liver disease: a retrospective study
Berberine MAFLD
20
PM
35359076📋[Berberine alleviates programmed necrosis of metabolic-associated fatty liver disease via activating Nrf2 pathway in mice]
Berberine MAFLD
19
PM
35250593📋Combined Use of Bicyclol and Berberine Alleviates Mouse Nonalcoholic Fatty Liver Disease
Berberine MAFLD
18
PM
34566663📋Preclinical Evidence of Berberine on Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Animal Studies
Berberine MAFLD
17
PM
34504563📋Berberine ameliorates nonalcoholic fatty liver disease by decreasing the liver lipid content via reversing the abnormal expression of MTTP and LDLR
Berberine MAFLD
16
PM
34094026📋The therapeutic effects of berberine plus sitagliptin in a rat model of fatty liver disease
Berberine MAFLD
15
PM
33831691📋Therapeutic effect of oxyberberine on obese non-alcoholic fatty liver disease rats
Berberine MAFLD
14
PM
33626003📋Berberine inhibits liver damage in rats with non-alcoholic fatty liver disease by regulating TLR4/MyD88/NF-κB pathway
Berberine MAFLD
13
PM
32429849📋Anti-inflammatory Activity of Berberine in Non-Alcoholic Fatty Liver Disease via the Angptl2 Pathway
Berberine MAFLD
12
PM
32403887📋[Discussion on the Curative Effect and Mechanisms of Berberine in Rats With Non-Alcoholic Fatty Liver]
Berberine MAFLD
11
PM
32357187📋Berberine Inhibits Free Fatty Acid and LPS-induced Inflammation via Modulating ER Stress Response in Macrophages and Hepatocytes
Berberine MAFLD
1
PM
32194416📋Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis
Berberine MAFLD
7
PM
31226399📋Berberine Attenuates Nonalcoholic Hepatic Steatosis Through the AMPK-SREBP-1c-SCD1 Pathway
Berberine MAFLD
4
PM
30868489📋Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway
Berberine MAFLD
6
PM
30867696📋Berberine Attenuates Hepatic Oxidative Stress in Rats With Non-Alcoholic Fatty Liver Disease via the Nrf2/ARE Signalling Pathway
Berberine MAFLD
3
PM
30848932📋Berberine Alleviates Nonalcoholic Fatty Liver Induced by a High-Fat Diet in Mice by Activating SIRT3
Berberine MAFLD
2
PM
29505790📋Berberine Alleviates Hepatic Lipid Accumulation by Increasing ABCA1 Through the Protein Kinase C δ Pathway
Berberine MAFLD
10
PM
29353208📋Natural Products Berberine and Curcumin Exhibited Better Ameliorative Effects on Rats With Non-Alcohol Fatty Liver Disease Than Lovastatin
Berberine MAFLD
29
PM
29200733📋Amelioration of Intestinal Barrier Dysfunction by Berberine in the Treatment of Nonalcoholic Fatty Liver Disease in Rats
Berberine MAFLD
8
PM
26936230📋Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue Inflammation in Mice With Diet-induced Obesity
Berberine MAFLD
9
PM
26857750📋Berberine Prevents Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis by Reducing Endoplasmic Reticulum Stress
Berberine MAFLD
5
PM
26252777📋Efficacy of Berberine in Patients With Non-Alcoholic Fatty Liver Disease
Berberine MAFLD
30
PM
21839075📋Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (NAFLD) rat liver
Berberine Non-Alcoholic Steatohepatitis
10
PM
37652508📋Comparing the Influences of Metformin and Berberine on the Intestinal Microbiota of Rats With Nonalcoholic Steatohepatitis
Berberine Non-Alcoholic Steatohepatitis
9
PM
34686466📋Berberine mitigates nonalcoholic hepatic steatosis by downregulating SIRT1-FoxO1-SREBP2 pathway for cholesterol synthesis
Berberine Non-Alcoholic Steatohepatitis
8
PM
34603061📋Berberine Alleviates Non-alcoholic Steatohepatitis Through Modulating Gut Microbiota Mediated Intestinal FXR Activation
Berberine Non-Alcoholic Steatohepatitis
7
PM
34566663📋Preclinical Evidence of Berberine on Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Animal Studies
Berberine Non-Alcoholic Steatohepatitis
6
PM
33494295📋Berberine Prevents Disease Progression of Nonalcoholic Steatohepatitis through Modulating Multiple Pathways
Berberine Non-Alcoholic Steatohepatitis
5
PM
32524150📋Berberine Attenuates Non-Alcoholic Steatohepatitis by Regulating chemerin/CMKLR1 Signalling Pathway and Treg/Th17 Ratio
Berberine Non-Alcoholic Steatohepatitis
2
PM
32194416📋Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis
Berberine Non-Alcoholic Steatohepatitis
4
PM
31217846📋Berberine Prevents Non-Alcoholic Steatohepatitis-Derived Hepatocellular Carcinoma by Inhibiting Inflammation and Angiogenesis in Mice
Berberine Non-Alcoholic Steatohepatitis
3
PM
29075339📋Berberine Ameliorates Non-Alcoholic Steatohepatitis in ApoE -/- Mice
Berberine Non-Alcoholic Steatohepatitis
1
PM
26923892📋Modulation of Gut Microbiota by Berberine Improves Steatohepatitis in High-Fat Diet-Fed BALB/C Mice
Berberine Primary Sclerosing Cholangitis
2
PM
38332450📋Berberine ameliorates the progression of primary sclerosing cholangitis by activating farnesoid X receptor
Berberine Primary Sclerosing Cholangitis
1
PM
38273376📋Therapeutic potential of berberine in attenuating cholestatic liver injury: insights from a PSC mouse model