| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Astragalosides | Allergic Asthma | 1 | PM | 24731407 | 📋 | Astragaloside IV attenuates allergic inflammation by regulation Th1/Th2 cytokine and enhancement CD4(+)CD25(+)Foxp3 T cells in ovalbumin-induced asthma |
| Astragalosides | Allergic Rhinitis | 2 | PM | 34482800 | 📋 | Astragaloside IV suppresses histamine-induced inflammatory factors and mucin 5 subtype AC overproduction in nasal epithelial cells via regulation of inflammation-related genes |
| Astragalosides | Allergic Rhinitis | 1 | PM | 28586019 | 📋 | Protective Effects of Astragaloside IV Against Ovalbumin-Induced Allergic Rhinitis Are Mediated by T-box Protein Expressed in T cells/GATA-3 and Forkhead Box Protein 3/retinoic Acid-Related Orphan Nuclear Receptor γt |
| Astragalosides | Allergies | 1 | PM | 27917896 | 📋 | Astragaloside IV Ameliorates Allergic Inflammation by Inhibiting Key Initiating Factors in the Initial Stage of Sensitization |
| Astragalosides | Atopic Disease | 1 | PM | 36411656 | 📋 | Research progress of astragaloside IV in the treatment of atopic diseases |
| Astragalosides | Autoimmune Disease | 1 | PM | 30385269 | 📋 | Astragaloside IV Regulates Differentiation and Induces Apoptosis of Activated CD4 + T Cells in the Pathogenesis of Experimental Autoimmune Encephalomyelitis |
| Astragalosides | Cytokine Storm Syndrome | 1 | PM | 32108899 | 📋 | Astragaloside IV Attenuates IL-1β Secretion by Enhancing Autophagy in H1N1 Infection |
| Astragalosides | Immune System Regulation | 6 | PM | 38648891 | 📋 | Exploration of the underlying mechanism of Astragaloside III in attenuating immunosuppression via network pharmacology and vitro/vivo pharmacological validation |
| Astragalosides | Immune System Regulation | 2 | PM | 37515271 | 📋 | Astragaloside IV Regulates cGAS-STING Signaling Pathway to Alleviate Immunosuppression Caused by PRRSV Infection |
| Astragalosides | Immune System Regulation | 1 | PM | 37100262 | 📋 | Systems pharmacology reveals the mechanism of Astragaloside IV in improving immune activity on cyclophosphamide-induced immunosuppressed mice |
| Astragalosides | Immune System Regulation | 5 | PM | 28550733 | 📋 | Immune regulation mechanism of Astragaloside IV on RAW264.7 cells through activating the NF-κB/MAPK signaling pathway |
| Astragalosides | Immune System Regulation | 3 | PM | 23524573 | 📋 | Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity |
| Astragalosides | Immune System Regulation | 4 | PM | 22981502 | 📋 | The effect of Astragaloside IV on immune function of regulatory T cell mediated by high mobility group box 1 protein in vitro |
| Astragalosides | Inflammation | 1 | PM | 38762925 | 📋 | Astragaloside IV ameliorates indomethacin-induced intestinal inflammation in rats through inhibiting the activation of NLRP3 inflammasome |
| Astragalosides | Inflammation | 14 | PM | 37493767 | 📋 | Astragaloside IV alleviates lung inflammation in Klebsiella pneumonia rats by suppressing TGF-β1/Smad pathway |
| Astragalosides | Inflammation | 13 | PM | 36246793 | 📋 | Review of the pharmacological effects of astragaloside IV and its autophagic mechanism in association with inflammation |
| Astragalosides | Inflammation | 12 | PM | 36103112 | 📋 | Astragaloside IV Regulates Insulin Resistance and Inflammatory Response of Adipocytes via Modulating CTRP3 and PI3K/AKT Signaling |
| Astragalosides | Inflammation | 11 | PM | 33894036 | 📋 | Astragaloside prevents UV induced keratinocyte injury by regulating TLR4/NF-κB pathway |
| Astragalosides | Inflammation | 9 | PM | 33561643 | 📋 | Induction of autophagy via the TLR4/NF-κB signaling pathway by astragaloside Ⅳ contributes to the amelioration of inflammation in RAW264.7 cells |
| Astragalosides | Inflammation | 8 | PM | 32855769 | 📋 | Transcriptomic Analysis Reveals the Protection of Astragaloside IV against Diabetic Nephropathy by Modulating Inflammation |
| Astragalosides | Inflammation | 5 | PM | 31906765 | 📋 | Astragaloside IV Protects ATDC5 Cells From Lipopolysaccharide-Caused Damage Through Regulating miR-203/MyD88 |
| Astragalosides | Inflammation | 10 | PM | 31675186 | 📋 | Dual regulation of microglia and neurons by Astragaloside IV-mediated mTORC1 suppression promotes functional recovery after acute spinal cord injury |
| Astragalosides | Inflammation | 7 | PM | 31318999 | 📋 | Astragaloside IV Attenuates Inflammatory Injury and Promotes Odontoblastic Differentiation in Lipopolysaccharide-Stimulated MDPC-23 Cells and Rat Pulpitis |
| Astragalosides | Inflammation | 3 | PM | 30669661 | 📋 | Protective Effects of Astragaloside IV Against LPS-Induced Endometritis in Mice Through Inhibiting Activation of the NF-κB, p38 and JNK Signaling Pathways |
| Astragalosides | Inflammation | 4 | PM | 30628687 | 📋 | Astragaloside IV Prevents High glucose‑induced Cell Apoptosis and Inflammatory Reactions Through Inhibition of the JNK Pathway in Human Umbilical Vein Endothelial Cells |
| Astragalosides | Inflammation | 6 | PM | 28641278 | 📋 | Astragaloside-IV Alleviates Heat-Induced Inflammation by Inhibiting Endoplasmic Reticulum Stress and Autophagy |
| Astragalosides | Inflammation | 2 | PM | 27564970 | 📋 | Astragaloside IV Attenuates Inflammatory Reaction via Activating Immune Function of Regulatory T-cells Inhibited by HMGB1 in Mice |
| Astragalosides | Leukemia | 1 | PM | 21875462 | 📋 | [Mechanism of apoptosis in human leukemia NB4 cells induced by total astragalosides] |
| Astragalosides | Sepsis | 11 | PM | 38124410 | 📋 | Astragaloside IV reduces lung injury in lethal sepsis via promoting treg cells expansion and inhibiting inflammatory responses |
| Astragalosides | Sepsis | 9 | PM | 37113780 | 📋 | Astragaloside IV attenuates lipopolysaccharide induced liver injury by modulating Nrf2-mediated oxidative stress and NLRP3-mediated inflammation |
| Astragalosides | Sepsis | 8 | PM | 36586273 | 📋 | Astragaloside IV alleviates sepsis-induced muscle atrophy by inhibiting the TGF-β1/Smad signaling pathway |
| Astragalosides | Sepsis | 7 | PM | 36302499 | 📋 | Astragaloside IV ameliorates sepsis-induced myocardial dysfunction by regulating NOX4/JNK/BAX pathway |
| Astragalosides | Sepsis | 4 | PM | 35587259 | 📋 | Astragalus injection ameliorates lipopolysaccharide-induced cognitive decline via relieving acute neuroinflammation and BBB damage and upregulating the BDNF-CREB pathway in mice |
| Astragalosides | Sepsis | 3 | PM | 34432200 | 📋 | Astragaloside IV Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction in Rats via IKK/NF-κB Pathway |
| Astragalosides | Sepsis | 2 | PM | 31835087 | 📋 | Astragaloside IV Attenuates Sepsis-Induced Intestinal Barrier Dysfunction via Suppressing RhoA/NLRP3 Inflammasome Signaling |
| Astragalosides | Sepsis | 10 | PM | 26375505 | 📋 | Astragaloside IV protects against polymicrobial sepsis through inhibiting inflammatory response and apoptosis of lymphocytes |
| Astragalosides | Septic Acute Kidney Injury | 4 | PM | 38237511 | 📋 | Astragaloside Ⅳ negatively regulates Gpr97-TPL2 signaling to protect against hyperhomocysteine-exacerbated sepsis associated acute kidney injury |
| Astragalosides | Septic Acute Kidney Injury | 1 | PM | 36056848 | 📋 | Astragaloside IV protects sepsis-induced acute kidney injury by attenuating mitochondrial dysfunction and apoptosis in renal tubular epithelial cells |
| Astragalosides | Septic Acute Kidney Injury | 2 | PM | 35859295 | 📋 | Protective effect of Astragalus membranaceus and Astragaloside IV in sepsis-induced acute kidney injury |
| Astragalosides | Septic Acute Kidney Injury | 3 | PM | 28328867 | 📋 | Astragaloside IV Alleviates Lipopolysaccharide-Induced Acute Kidney Injury Through Down-Regulating Cytokines, CCR5 and p-ERK, and Elevating Anti-Oxidative Ability |
| Astragalosides | Septic Acute Lung Injury | 1 | PM | 27275126 | 📋 | Protective Effect of Astragaloside IV Against Sepsis-Induced Acute Lung Injury in Rats |
