| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Metformin | Alzheimer's Disease | 14 | PM | 38842663 | 📋 | Beneficial effect of lupeol and metformin in mouse model of intracerebroventricular streptozotocin induced dementia |
| Metformin | Alzheimer's Disease | 13 | PM | 38582410 | 📋 | The role of the cholinergic system in the memory-protecting effects of metformin in a model of scopolamine-induced memory impairment in aged rats |
| Metformin | Alzheimer's Disease | 12 | PM | 38333746 | 📋 | Metformin improves memory via AMPK/mTOR-dependent route in a rat model of Alzheimer's disease |
| Metformin | Alzheimer's Disease | 11 | PM | 37985011 | 📋 | Alzheimer's disease-related brain insulin resistance and the prospective therapeutic impact of metformin |
| Metformin | Alzheimer's Disease | 10 | PM | 37780174 | 📋 | Exploring the mechanism of metformin action in Alzheimer's disease and type 2 diabetes based on network pharmacology, molecular docking, and molecular dynamic simulation |
| Metformin | Alzheimer's Disease | 9 | PM | 37483818 | 📋 | Metformin restores cognitive dysfunction and histopathological deficits in an animal model of sporadic Alzheimer's disease |
| Metformin | Alzheimer's Disease | 7 | PM | 36723832 | 📋 | Metformin mitigates amyloid β1-40-induced cognitive decline via attenuation of oxidative/nitrosative stress and neuroinflammation |
| Metformin | Alzheimer's Disease | 6 | PM | 36464874 | 📋 | Effects of metformin on modulating the expression of brain-related genes of APP/PS1 transgenic mice based on Single Cell Sequencing |
| Metformin | Alzheimer's Disease | 5 | PM | 36422837 | 📋 | Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice |
| Metformin | Alzheimer's Disease | 4 | PM | 35902387 | 📋 | Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer's disease risk in the general population: a Mendelian randomisation study |
| Metformin | Alzheimer's Disease | 3 | PM | 35802659 | 📋 | Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin |
| Metformin | Alzheimer's Disease | 2 | PM | 35395244 | 📋 | Intranasal metformin treatment ameliorates cognitive functions via insulin signaling pathway in ICV-STZ-induced mice model of Alzheimer's disease |
| Metformin | Alzheimer's Disease | 1 | PM | 34657937 | 📋 | Metformin and cyanidin 3- O-galactoside from Aronia melanocarpa synergistically alleviate cognitive impairment in SAMP8 mice |
| Metformin | Alzheimer's Disease | 8 | PM | 29253574 | 📋 | Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice |
| Metformin | Duchenne Muscular Dystrophy | 1 | PM | 37928155 | 📋 | Mechanisms and effects of metformin on skeletal muscle disorders |
| Metformin | Familial Adenomatous Polyposis | 2 | PM | 38403687 | 📋 | Clinical efficacy of metformin in familial adenomatous polyposis and the effect of intestinal flora |
| Metformin | Familial Adenomatous Polyposis | 1 | PM | 36595813 | 📋 | Metformin combined with endoscopic therapy in patients with familial polyposis associated with carcinoma: A case report |
| Metformin | Fragile X Syndrome | 1 | PM | 37286070 | 📋 | Novel Presynaptic Assay System Revealed That Metformin Ameliorates Exaggerated Synaptic Release and Munc18-1 Accumulation in Presynapses of Neurons from Fragile X Mouse Model |
| Metformin | Fragile X Syndrome | 2 | PM | 28436599 | 📋 | Metformin as targeted treatment in fragile X syndrome |
| Metformin | Huntington's Disease | 1 | PM | 35367225 | 📋 | Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder |
| Metformin | Polycystic Ovary Syndrome | 73 | PM | 38735598 | 📋 | Spirulina versus metformin for controlling some insulin signaling pathway genes in induced polycystic ovary syndrome rat model |
| Metformin | Polycystic Ovary Syndrome | 72 | PM | 38484797 | 📋 | Effects of melatonin and metformin on the ovaries of rats with polycystic ovary syndrome |
| Metformin | Polycystic Ovary Syndrome | 71 | PM | 38425153 | 📋 | Efficacy of metformin combined with vitamin D in the treatment of polycystic ovarian syndrome: A meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 70 | PM | 38397951 | 📋 | The Comparative Effects of Myo-Inositol and Metformin Therapy on the Clinical and Biochemical Parameters of Women of Normal Weight Suffering from Polycystic Ovary Syndrome |
| Metformin | Polycystic Ovary Syndrome | 69 | PM | 38155665 | 📋 | Comparative effects of acupuncture and metformin on insulin sensitivity in overweight/obese and lean women with polycystic ovary syndrome and insulin resistance: a post hoc analysis of a randomized trial |
| Metformin | Polycystic Ovary Syndrome | 68 | PM | 38131036 | 📋 | Action Mechanisms of Metformin Combined with Exenatide and Metformin Only in the Treatment of PCOS in Obese Patients |
| Metformin | Polycystic Ovary Syndrome | 67 | PM | 37931721 | 📋 | Lavender and metformin effectively propagate progesterone levels in patients with polycystic ovary syndrome: A randomized, double-blind clinical trial |
| Metformin | Polycystic Ovary Syndrome | 66 | PM | 37791160 | 📋 | Role of Metformin in Polycystic Ovary Syndrome (PCOS)-Related Infertility |
| Metformin | Polycystic Ovary Syndrome | 65 | PM | 37736515 | 📋 | Investigation of the effects of astaxanthin in experimental polycystic ovary syndrome (PCOS) in rats |
| Metformin | Polycystic Ovary Syndrome | 64 | PM | 37575860 | 📋 | Myoinositol Versus Metformin in the Treatment of Polycystic Ovarian Syndrome: A Systematic Review |
| Metformin | Polycystic Ovary Syndrome | 63 | PM | 37554096 | 📋 | Metformin and combined oral contraceptive pills in the management of polycystic ovary syndrome: a systematic review and meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 62 | PM | 37536294 | 📋 | The impact of metformin with or without lifestyle modification versus placebo on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials |
| Metformin | Polycystic Ovary Syndrome | 61 | PM | 37406658 | 📋 | Low dose of liraglutide combined with metformin leads to a significant weight loss in Chinese Han women with polycystic ovary syndrome: a retrospective study |
| Metformin | Polycystic Ovary Syndrome | 60 | PM | 37381009 | 📋 | The effects of metformin on anti-Müllerian hormone levels in patients with polycystic ovary syndrome: a systematic review and meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 59 | PM | 37354674 | 📋 | METFORMIN EFFECTS ON NEUREGULIN-1 IN POLYCYSTIC OVARIAN WOMEN |
| Metformin | Polycystic Ovary Syndrome | 58 | PM | 37354673 | 📋 | METFORMIN EFFECTS ON BLOOD LEVELS OF GREMLIN-1 IN POLYCYSTIC OVARIAN WOMEN |
| Metformin | Polycystic Ovary Syndrome | 52 | PM | 37275752 | 📋 | Protective effect of astaxanthin and metformin in the liver of rats in which the polycystic ovary syndrome model was formed by giving letrozole |
| Metformin | Polycystic Ovary Syndrome | 51 | PM | 37265016 | 📋 | A randomized controlled trial comparing myoinositol with metformin versus metformin monotherapy in polycystic ovary syndrome |
| Metformin | Polycystic Ovary Syndrome | 50 | PM | 37244286 | 📋 | Metformin inhibits ovarian granular cell pyroptosis through the miR-670-3p/NOX2/ROS pathway |
| Metformin | Polycystic Ovary Syndrome | 49 | PM | 37166881 | 📋 | THE THERAPEUTIC EFFECT OF ORAL INSULIN SENSITIZER METFORMIN ON LIPID PROFILE IN WOMEN WITH POLYCYSTIC OVARY SYNDROME |
| Metformin | Polycystic Ovary Syndrome | 48 | PM | 37148410 | 📋 | Effects of myo-inositol vs. metformin on hormonal and metabolic parameters in women with PCOS: a meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 47 | PM | 36916886 | 📋 | Immunomodulatory effects of metformin treatment in pregnant women with PCOS |
| Metformin | Polycystic Ovary Syndrome | 46 | PM | 36763111 | 📋 | Influence of metformin on hyperandrogenism in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials |
| Metformin | Polycystic Ovary Syndrome | 45 | PM | 36755918 | 📋 | Metformin improves polycystic ovary syndrome in mice by inhibiting ovarian ferroptosis |
| Metformin | Polycystic Ovary Syndrome | 44 | PM | 36618831 | 📋 | The effects of melatonin and metformin on histological characteristics of the ovary and uterus in letrozole-induced polycystic ovarian syndrome mice: A stereological study |
| Metformin | Polycystic Ovary Syndrome | 43 | PM | 36351033 | 📋 | Nasturtium officinale L. and metformin alleviate the estradiol -induced polycystic ovary syndrome with synergistic effects through modulation of Bax/Bcl-2/p53/caspase-3 signaling pathway and anti-inflammatory and anti-oxidative effects |
| Metformin | Polycystic Ovary Syndrome | 42 | PM | 36322951 | 📋 | Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells (EECs) via mTOR activation and augmented mitochondrial strength |
| Metformin | Polycystic Ovary Syndrome | 41 | PM | 36299963 | 📋 | A Comparative Study of Luteinizing Hormone Levels in Polycystic Ovarian Syndrome With Hyperandrogenism: Metformin Versus Oral Contraceptive Pills |
| Metformin | Polycystic Ovary Syndrome | 40 | PM | 36285403 | 📋 | Effectiveness of inositol, metformin and their combination in women with PCOS undergoing assisted reproduction: systematic review and meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 39 | PM | 36225721 | 📋 | Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials |
| Metformin | Polycystic Ovary Syndrome | 38 | PM | 36176868 | 📋 | Role of Metformin in the Management of Polycystic Ovarian Syndrome-Associated Acne: A Systematic Review |
| Metformin | Polycystic Ovary Syndrome | 37 | PM | 36147577 | 📋 | Canagliflozin combined with metformin versus metformin monotherapy for endocrine and metabolic profiles in overweight and obese women with polycystic ovary syndrome: A single-center, open-labeled prospective randomized controlled trial |
| Metformin | Polycystic Ovary Syndrome | 36 | PM | 36129662 | 📋 | The Effect of Oral Antidiabetic Drugs on Improving the Endocrine and Metabolic States in Women with Polycystic Ovary Syndrome: A Systematic Review and Network Meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 35 | PM | 36062569 | 📋 | Effect of probiotics combined with metformin on improvement of menstrual and metabolic patterns in women with polycystic ovary syndrome: a randomized clinical trial |
| Metformin | Polycystic Ovary Syndrome | 34 | PM | 35893386 | 📋 | Metformin Improves the Hepatic Steatosis Index in Non-Obese Patients with Polycystic Ovary Syndrome |
| Metformin | Polycystic Ovary Syndrome | 33 | PM | 35822185 | 📋 | Combination of electroacupuncture and pharmacological treatment improves insulin resistance in women with polycystic ovary syndrome: Double-blind randomized clinical trial |
| Metformin | Polycystic Ovary Syndrome | 32 | PM | 35770635 | 📋 | [Metformin improves polycystic ovary syndrome and activates female germline stem cells in mice] |
| Metformin | Polycystic Ovary Syndrome | 31 | PM | 35748536 | 📋 | Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome |
| Metformin | Polycystic Ovary Syndrome | 30 | PM | 35621312 | 📋 | Efficacy and safety of metformin in pregnant women with polycystic ovary syndrome: a systematic review with meta-analysis of randomized and non-randomized controlled trials |
| Metformin | Polycystic Ovary Syndrome | 27 | PM | 35605922 | 📋 | Effects of Rosa damascena on reproductive improvement, metabolic parameters, liver function and insulin-like growth factor-1 gene expression in estradiol valerate induced polycystic ovarian syndrome in Wistar rats |
| Metformin | Polycystic Ovary Syndrome | 15 | PM | 35535444 | 📋 | Effects of N-acetylcysteine and metformin treatment on the stereopathological characteristics of uterus and ovary |
| Metformin | Polycystic Ovary Syndrome | 12 | PM | 35501295 | 📋 | Combination of alpha lipoic acid and metformin supplement improve assisted reproductive technologies outcomes in polycystic ovary syndrome patients |
| Metformin | Polycystic Ovary Syndrome | 23 | PM | 35444350 | 📋 | Histomorphological Changes in a Rat Model of Polycystic Ovary Syndrome and the Contribution of Stevia Leaf Extract in Modulating the Ovarian Fibrosis, VEGF, and TGF-β Immunoexpressions: Comparison with Metformin |
| Metformin | Polycystic Ovary Syndrome | 25 | PM | 35363325 | 📋 | Short period-administration of myo-inositol and metformin on hormonal and glycolipid profiles in patients with polycystic ovary syndrome: a systematic review and updated meta-analysis of randomized controlled trials |
| Metformin | Polycystic Ovary Syndrome | 28 | PM | 35310326 | 📋 | Metformin effects on zonulin level in polycystic ovarian women |
| Metformin | Polycystic Ovary Syndrome | 4 | PM | 35251851 | 📋 | Study on the Effect of Berberine, Myoinositol, and Metformin in Women with Polycystic Ovary Syndrome: A Prospective Randomised Study |
| Metformin | Polycystic Ovary Syndrome | 1 | PM | 35152800 | 📋 | Apigenin exerts protective effect and restores ovarian function in dehydroepiandrosterone induced polycystic ovary syndrome rats: a biochemical and histological analysis |
| Metformin | Polycystic Ovary Syndrome | 29 | PM | 34865304 | 📋 | Gestational weight gain, appetite regulating hormones, and metformin treatment in polycystic ovary syndrome: A longitudinal, placebo-controlled study |
| Metformin | Polycystic Ovary Syndrome | 20 | PM | 34752810 | 📋 | The anti-androgenic effect of quercetin on hyperandrogenism and ovarian dysfunction induced in a dehydroepiandrosterone rat model of polycystic ovary syndrome |
| Metformin | Polycystic Ovary Syndrome | 26 | PM | 34665453 | 📋 | The effect of metformin and myoinositol on metabolic outcomes in women with polycystic ovary syndrome: role of body mass and adiponectin in a randomized controlled trial |
| Metformin | Polycystic Ovary Syndrome | 21 | PM | 34538551 | 📋 | Mechanism of quercetin on the improvement of ovulation disorder and regulation of ovarian CNP/NPR2 in PCOS model rats |
| Metformin | Polycystic Ovary Syndrome | 24 | PM | 34407851 | 📋 | Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 9 | PM | 34298098 | 📋 | Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome |
| Metformin | Polycystic Ovary Syndrome | 10 | PM | 34286169 | 📋 | A Pilot Trial: Fish Oil and Metformin Effects on ApoB-Remnants and Triglycerides in Women With Polycystic Ovary Syndrome |
| Metformin | Polycystic Ovary Syndrome | 19 | PM | 34032731 | 📋 | Therapeutic effects of puerarin on polycystic ovary syndrome: A randomized trial in Chinese women |
| Metformin | Polycystic Ovary Syndrome | 2 | PM | 33876387 | 📋 | The Effect of Astaxanthin and Metformin on Oxidative Stress in Granulosa Cells of BALB C Mouse Model of Polycystic Ovary Syndrome |
| Metformin | Polycystic Ovary Syndrome | 8 | PM | 33861440 | 📋 | Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial |
| Metformin | Polycystic Ovary Syndrome | 3 | PM | 33555077 | 📋 | Synergic effect of bee pollen and metformin on proliferation and apoptosis of granulosa cells: Rat model of polycystic ovary syndrome |
| Metformin | Polycystic Ovary Syndrome | 13 | PM | 32877649 | 📋 | The ameliorative effects of marjoram in dehydroepiandrosterone induced polycystic ovary syndrome in rats |
| Metformin | Polycystic Ovary Syndrome | 6 | PM | 31948119 | 📋 | Both Matricaria chamomilla and Metformin Extract Improved the Function and Histological Structure of Thyroid Gland in Polycystic Ovary Syndrome Rats through Antioxidant Mechanism |
| Metformin | Polycystic Ovary Syndrome | 16 | PM | 31749393 | 📋 | Comparison of the Efficacy Between NAC and Metformin in Treating PCOS Patients: A Meta-Analysis |
| Metformin | Polycystic Ovary Syndrome | 17 | PM | 30814814 | 📋 | Comparison of Metformin and N Acetylcysteine on Clinical, Metabolic Parameter and Hormonal Profile in Women With Polycystic Ovarian Syndrome |
| Metformin | Polycystic Ovary Syndrome | 5 | PM | 30538756 | 📋 | The Effect of Berberine on Polycystic Ovary Syndrome Patients With Insulin Resistance (PCOS-IR): A Meta-Analysis and Systematic Review |
| Metformin | Polycystic Ovary Syndrome | 14 | PM | 30369967 | 📋 | Effects of Moringa oleifera on Insulin Levels and Folliculogenesis in Polycystic Ovary Syndrome Model with Insulin Resistance |
| Metformin | Polycystic Ovary Syndrome | 57 | PM | 29434814 | 📋 | Metformin and pioglitazone combination therapy ameliorate polycystic ovary syndrome through AMPK/PI3K/JNK pathway |
| Metformin | Polycystic Ovary Syndrome | 54 | PM | 28941255 | 📋 | Effects of placebo-controlled insulin-sensitizing drugs on hormonal parameters in polycystic ovary syndrome patients: A network meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 56 | PM | 28834135 | 📋 | The Pharmacogenetics of Metformin in Women with Polycystic Ovary Syndrome: A Randomized Trial |
| Metformin | Polycystic Ovary Syndrome | 7 | PM | 28479753 | 📋 | The Effect of Metformin and Cinnamon on Serum Anti-Mullerian Hormone in Women Having PCOS: A Double-Blind, Randomized, Controlled Trial |
| Metformin | Polycystic Ovary Syndrome | 22 | PM | 27923406 | 📋 | Ameliorative Effects of Rutin Against Metabolic, Biochemical and Hormonal Disturbances in Polycystic Ovary Syndrome in Rats |
| Metformin | Polycystic Ovary Syndrome | 18 | PM | 25482371 | 📋 | N-Acetylcysteine Improves Oocyte and Embryo Quality in Polycystic Ovary Syndrome Patients Undergoing Intracytoplasmic Sperm Injection: An Alternative to Metformin |
| Metformin | Polycystic Ovary Syndrome | 55 | PM | 24196302 | 📋 | Assessment of ovarian stromal blood flow after metformin treatment in women with polycystic ovary syndrome |
| Metformin | Polycystic Ovary Syndrome | 53 | PM | 23869585 | 📋 | The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment |
| Metformin | Polycystic Ovary Syndrome | 11 | PM | 19933994 | 📋 | Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome |
| Metformin | Rett Syndrome | 1 | PM | 36442649 | 📋 | Chronic treatment with the anti-diabetic drug metformin rescues impaired brain mitochondrial activity and selectively ameliorates defective cognitive flexibility in a female mouse model of Rett syndrome |
| Metformin | Tuberous Sclerosis | 1 | PM | 36833359 | 📋 | Tuberous Sclerosis, Type II Diabetes Mellitus and the PI3K/AKT/mTOR Signaling Pathways-Case Report and Literature Review |
