| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Metformin | Fibrosis | 3 | PM | 38003450 | 📋 | Metformin Attenuates TGF-β1-Induced Fibrosis in Salivary Gland: A Preliminary Study |
| Metformin | Fibrosis | 2 | PM | 36552855 | 📋 | Deciphering the Antifibrotic Property of Metformin |
| Metformin | Fibrosis | 1 | PM | 35644337 | 📋 | Obesity induces adipose fibrosis and collagen cross-linking through suppressing AMPK and enhancing lysyl oxidase expression |
| Metformin | Hepatic Fibrosis | 5 | PM | 38288020 | 📋 | Metformin exerts anti-liver fibrosis effect based on the regulation of gut microbiota homeostasis and multi-target synergy |
| Metformin | Hepatic Fibrosis | 4 | PM | 37451514 | 📋 | Metformin ameliorates liver fibrosis induced by congestive hepatopathy via the mTOR/HIF-1α signaling pathway |
| Metformin | Hepatic Fibrosis | 3 | PM | 36893671 | 📋 | Metformin alleviates liver fibrosis in mice by enriching Lactobacillus sp. MF-1 in the gut microbiota |
| Metformin | Hepatic Fibrosis | 2 | PM | 36716817 | 📋 | Metformin induces mitochondrial fission and reduces energy metabolism by targeting respiratory chain complex I in hepatic stellate cells to reverse liver fibrosis |
| Metformin | Hepatic Fibrosis | 1 | PM | 35093389 | 📋 | Metformin versus Silymarin as Hepatoprotective Agents in Mice Fibrotic Model Caused by Carbon Tetrachloride |
| Metformin | Kidney Fibrosis | 1 | PM | 35645830 | 📋 | Metformin Ameliorates Chronic Colitis-Related Intestinal Fibrosis via Inhibiting TGF-β1/Smad3 Signaling |
| Metformin | Myocardial Fibrosis | 1 | PM | 35401934 | 📋 | Traditional Chinese Medicine Ginseng Dingzhi Decoction Ameliorates Myocardial Fibrosis and High Glucose-Induced Cardiomyocyte Injury by Regulating Intestinal Flora and Mitochondrial Dysfunction |
| Metformin | Myocardial Fibrosis | 2 | PM | 28230250 | 📋 | Metformin attenuates angiotensin II-induced TGFβ1 expression by targeting hepatocyte nuclear factor-4-α |
| Metformin | Pulmonary Fibrosis | 10 | PM | 38286745 | 📋 | Metformin enhanced the effect of pirfenidone on pulmonary fibrosis in mice |
| Metformin | Pulmonary Fibrosis | 9 | PM | 38149395 | 📋 | [Protective effect of metformin on pulmonary fibrosis caused by paraquat through activating AMP-activated protein kinase pathway] |
| Metformin | Pulmonary Fibrosis | 8 | PM | 38010091 | 📋 | Metformin mitigates sepsis-associated pulmonary fibrosis by promoting AMPK activation and inhibiting Hif-1α-induced aerobic glycolysis |
| Metformin | Pulmonary Fibrosis | 7 | PM | 37530936 | 📋 | Vitamin D3 alleviates lung fibrosis of type 2 diabetic rats via SIRT3 mediated suppression of pyroptosis |
| Metformin | Pulmonary Fibrosis | 5 | PM | 37192555 | 📋 | Activation of AMPK signalling by Metformin: Implication an important molecular mechanism for protecting against mice silicosis via inhibited endothelial cell-to-mesenchymal transition by regulating oxidative stress and apoptosis |
| Metformin | Pulmonary Fibrosis | 4 | PM | 36817136 | 📋 | Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis |
| Metformin | Pulmonary Fibrosis | 3 | PM | 36155331 | 📋 | Metformin alleviates crystalline silica-induced pulmonary fibrosis by remodeling endothelial cells to mesenchymal transition via autophagy signaling |
| Metformin | Pulmonary Fibrosis | 2 | PM | 36147352 | 📋 | Effectiveness and mechanism of metformin in animal models of pulmonary fibrosis: A preclinical systematic review and meta-analysis |
| Metformin | Pulmonary Fibrosis | 1 | PM | 36091775 | 📋 | Metformin suppresses proliferation and differentiation induced by BMP9 via AMPK signaling in human fetal lung fibroblast-1 |
| Metformin | Pulmonary Fibrosis | 6 | PM | 29793317 | 📋 | Metformin alleviates bleomycin-induced pulmonary fibrosis in rats: Pharmacological effects and molecular mechanisms |
