| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Metformin | Adenomyosis | 1 | PM | 29434812 | 📋 | Combination therapeutic effects of high intensity focused ultrasound and Metformin for the treatment of adenomyosis |
| Metformin | Breast Cancer | 49 | PM | 38543182 | 📋 | Metformin and Breast Cancer: Current Findings and Future Perspectives from Preclinical and Clinical Studies |
| Metformin | Breast Cancer | 48 | PM | 38529589 | 📋 | Metformin Alters Tumor Immune Microenvironment, Improving the Outcomes of Breast Cancer Patients With Type 2 Diabetes Mellitus |
| Metformin | Breast Cancer | 47 | PM | 38196628 | 📋 | The Combined Treatment with Ketogenic Diet and Metformin Slows Tumor Growth in Two Mouse Models of Triple Negative Breast Cancer |
| Metformin | Breast Cancer | 46 | PM | 38167105 | 📋 | Enhancement of targeted therapy in combination with metformin on human breast cancer cell lines |
| Metformin | Breast Cancer | 45 | PM | 38057926 | 📋 | Genetic effect of metformin use on risk of cancers: evidence from Mendelian randomization analysis |
| Metformin | Breast Cancer | 44 | PM | 37842518 | 📋 | Honokiol inhibits the growth of hormone-resistant breast cancer cells: its promising effect in combination with metformin |
| Metformin | Breast Cancer | 43 | PM | 37765157 | 📋 | The Effect of Different Glucose Concentrations on the Antiproliferative Activity of Metformin in MCF-7 Breast Cancer Cells |
| Metformin | Breast Cancer | 42 | PM | 37760498 | 📋 | Inhibition of Dipeptidyl Peptidase-4 Activates Autophagy to Promote Survival of Breast Cancer Cells via the mTOR/HIF-1α Pathway |
| Metformin | Breast Cancer | 40 | PM | 37632970 | 📋 | The Effect of Metformin on Triple-Negative Breast Cancer Cells and Nude Mice |
| Metformin | Breast Cancer | 39 | PM | 37473529 | 📋 | Metformin combined with glucose starvation synergistically suppress triple-negative breast cancer by enhanced unfolded protein response |
| Metformin | Breast Cancer | 38 | PM | 37406485 | 📋 | Metformin ameliorates BMP2 induced adipocyte-like property in breast cancer cells |
| Metformin | Breast Cancer | 31 | PM | 37225011 | 📋 | Combination therapy with PD-1 inhibition plus rapamycin and metformin enhances anti-tumor efficacy in triple negative breast cancer |
| Metformin | Breast Cancer | 30 | PM | 37180606 | 📋 | The antiproliferative potential and mechanism of action of metformin in MCF-7 cells |
| Metformin | Breast Cancer | 29 | PM | 37037091 | 📋 | Metformin and HER2-positive breast cancer: Mechanisms and therapeutic implications |
| Metformin | Breast Cancer | 28 | PM | 36996738 | 📋 | Metformin plays an antitumor role by downregulating inhibitory cells and immune checkpoint molecules while activating protective immune responses in breast cancer |
| Metformin | Breast Cancer | 27 | PM | 36907329 | 📋 | Metformin pretreatment potentiates the antiproliferative action of doxorubicin against breast cancer |
| Metformin | Breast Cancer | 26 | PM | 36849958 | 📋 | Metformin and long non-coding RNAs in breast cancer |
| Metformin | Breast Cancer | 25 | PM | 36766896 | 📋 | Metformin Therapy and Breast Cancer Incidence in the Ha'il Region |
| Metformin | Breast Cancer | 24 | PM | 36703564 | 📋 | Co-drug development of gallic acid and metformin targeting the pro-inflammatory cytokines for the treatment of breast cancer |
| Metformin | Breast Cancer | 23 | PM | 36656142 | 📋 | YAP/TAZ axis was involved in the effects of metformin on breast cancer |
| Metformin | Breast Cancer | 22 | PM | 36641965 | 📋 | Metformin enhances anti-cancer properties of resveratrol in MCF-7 breast cancer cells via induction of apoptosis, autophagy and alteration in cell cycle distribution |
| Metformin | Breast Cancer | 21 | PM | 36581893 | 📋 | Metabolomic profiles of metformin in breast cancer survivors: a pooled analysis of plasmas from two randomized placebo-controlled trials |
| Metformin | Breast Cancer | 20 | PM | 36562831 | 📋 | Effect of metformin as an adjuvant therapy to letrozole on estradiol and other biomarkers involved in the pathogenesis of breast cancer in overweight and obese postmenopausal women: a pilot study |
| Metformin | Breast Cancer | 19 | PM | 36482884 | 📋 | Metformin Inducing the Change of Functional and Exhausted Phenotypic Tumor-Infiltrated Lymphocytes and the Correlation with JNK Signal Pathway in Triple-Negative Breast Cancer |
| Metformin | Breast Cancer | 18 | PM | 36458727 | 📋 | The role of PI3K/AKT-related proteins in di(2-ethyl)hexylphthalate-induced BG-1 and MCF-7 cell proliferation, and inhibition by metformin |
| Metformin | Breast Cancer | 17 | PM | 35969285 | 📋 | Dose-dependent relation between metformin and the risk of hormone receptor-positive, her2-negative breast cancer among postmenopausal women with type-2 diabetes |
| Metformin | Breast Cancer | 16 | PM | 35902376 | 📋 | Metformin and testosterone replacement therapy inversely associated with hormone-associated cancers (prostate, colorectal and male breast cancers) among older White and Black men |
| Metformin | Breast Cancer | 15 | PM | 35733940 | 📋 | Metformin Induces PRODH/POX-Dependent Apoptosis in Breast Cancer Cells |
| Metformin | Breast Cancer | 14 | PM | 35693999 | 📋 | Combined treatment with glucagon-like peptide-1 receptor agonist exendin-4 and metformin attenuates breast cancer growth |
| Metformin | Breast Cancer | 12 | PM | 35673919 | 📋 | [Metformin inhibits proliferation and promotes apoptosis of HER-2 positive breast cancer cells possibly through the Hippo-YAP pathway] |
| Metformin | Breast Cancer | 13 | PM | 35672854 | 📋 | Metformin counteracts stimulatory effects induced by insulin in primary breast cancer cells |
| Metformin | Breast Cancer | 9 | PM | 35550195 | 📋 | Metformin-induced downregulation of c-Met is a determinant of sensitivity in MDA-MB-468 breast cancer cells |
| Metformin | Breast Cancer | 10 | PM | 35538143 | 📋 | The impact of metformin use on the outcomes of locally advanced breast cancer patients receiving neoadjuvant chemotherapy: an open-labelled randomized controlled trial |
| Metformin | Breast Cancer | 11 | PM | 35525887 | 📋 | Synergy between sublethal doses of shikonin and metformin fully inhibits breast cancer cell migration and reverses epithelial-mesenchymal transition |
| Metformin | Breast Cancer | 5 | PM | 35125086 | 📋 | Nimbolide, a Neem Limonoid, Inhibits Angiogenesis in Breast Cancer by Abrogating Aldose Reductase Mediated IGF-1/PI3K/Akt Signaling |
| Metformin | Breast Cancer | 6 | PM | 35038549 | 📋 | Metformin inhibits the tumor-promoting effect of low-dose resveratrol, and enhances the anti-tumor activity of high-dose resveratrol by increasing its reducibility in triple negative breast cancer |
| Metformin | Breast Cancer | 3 | PM | 34125254 | 📋 | Enhanced antitumor activity of doxorubicin by naringenin and metformin in breast carcinoma: an experimental study |
| Metformin | Breast Cancer | 2 | PM | 33929675 | 📋 | Crocin and Metformin suppress metastatic breast cancer progression via VEGF and MMP9 downregulations: in vitro and in vivo studies |
| Metformin | Breast Cancer | 7 | PM | 33524703 | 📋 | Tangeretin boosts the anticancer activity of metformin in breast cancer cells via curbing the energy production |
| Metformin | Breast Cancer | 37 | PM | 33164274 | 📋 | Metformin modulates oncogenic expression of HOTAIR gene via promoter methylation and reverses epithelial-mesenchymal transition in MDA-MB-231 cells |
| Metformin | Breast Cancer | 4 | PM | 33157041 | 📋 | Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo |
| Metformin | Breast Cancer | 36 | PM | 32905620 | 📋 | Metformin potentiates the chemotherapeutic effects of doxorubicin on 2-amino-1-methyl-6-phenylimidazo[4,5b] pyridine-induced Mammary Carcinoma in rats |
| Metformin | Breast Cancer | 41 | PM | 30551465 | 📋 | Formononetin and metformin act synergistically to inhibit growth of MCF-7 breast cancer cells in vitro |
| Metformin | Breast Cancer | 1 | PM | 29693804 | 📋 | Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells Through hTERT and Cyclin D1 Suppression |
| Metformin | Breast Cancer | 33 | PM | 29416762 | 📋 | Metformin synergistically suppress tumor growth with doxorubicin and reverse drug resistance by inhibiting the expression and function of P-glycoprotein in MCF7/ADR cells and xenograft models |
| Metformin | Breast Cancer | 8 | PM | 25997252 | 📋 | Synergistic antitumor activity of vitamin D3 combined with metformin in human breast carcinoma MDA-MB-231 cells involves m-TOR related signaling pathways |
| Metformin | Breast Cancer | 34 | PM | 24338509 | 📋 | Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle |
| Metformin | Breast Cancer | 35 | PM | 24322659 | 📋 | Metformin selectively targets tumor-initiating cells in ErbB2-overexpressing breast cancer models |
| Metformin | Breast Cancer | 32 | PM | 24096736 | 📋 | Metformin reverses multidrug resistance and epithelial-mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells |
| Metformin | Cervical Cancer | 4 | PM | 37679230 | 📋 | Radiosensitising Effects of Metformin Added to Concomitant Chemoradiotherapy with Cisplatin in Cervical Cancer |
| Metformin | Cervical Cancer | 3 | PM | 37371530 | 📋 | Potential Mechanisms of Metformin-Induced Apoptosis in HeLa Cells |
| Metformin | Cervical Cancer | 2 | PM | 36604960 | 📋 | Metformin and Cervical Cancer Risk in Patients with Newly Diagnosed Type 2 Diabetes: A Population-Based Study in Korea |
| Metformin | Cervical Cancer | 1 | PM | 36037303 | 📋 | A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer |
| Metformin | Choriocarcinoma | 1 | PM | 36464174 | 📋 | Metformin regulates autophagy via LGMN to inhibit choriocarcinoma |
| Metformin | Endometrial Cancer | 8 | PM | 37415671 | 📋 | Progestin plus metformin improves outcomes in patients with endometrial hyperplasia and early endometrial cancer more than progestin alone: a meta-analysis |
| Metformin | Endometrial Cancer | 4 | PM | 37171945 | 📋 | MET Inhibits the Proliferation of EC Cells by Increasing MPA Sensitivity |
| Metformin | Endometrial Cancer | 3 | PM | 36226249 | 📋 | Metformin Exhibits an Attractive Antineoplastic Effect on Human Endometrial Cancer by Regulating the Hippo Signaling Pathway |
| Metformin | Endometrial Cancer | 2 | PM | 35898873 | 📋 | Association Between Metformin Use and the Risk, Prognosis of Gynecologic Cancer |
| Metformin | Endometrial Cancer | 1 | PM | 35820883 | 📋 | Metformin attenuates the production and proliferative effects of prolactin induced by medroxyprogesterone acetate during fertility-sparing treatment for endometrial cancer |
| Metformin | Endometrial Cancer | 7 | PM | 29182407 | 📋 | Metformin is associated with reduced cell proliferation in human endometrial cancer by inbibiting PI3K/AKT/mTOR signaling |
| Metformin | Endometrial Cancer | 6 | PM | 24269517 | 📋 | Metformin is associated with improved survival in endometrial cancer |
| Metformin | Endometrial Cancer | 5 | PM | 24189334 | 📋 | Metformin use and endometrial cancer survival |
| Metformin | Endometrial Hyperplasia | 5 | PM | 37415671 | 📋 | Progestin plus metformin improves outcomes in patients with endometrial hyperplasia and early endometrial cancer more than progestin alone: a meta-analysis |
| Metformin | Endometrial Hyperplasia | 2 | PM | 35846327 | 📋 | A Prospective Cohort Study of Metformin as an Adjuvant Therapy for Infertile Women With Endometrial Complex Hyperplasia/Complex Atypical Hyperplasia and Their Subsequent Assisted Reproductive Technology Outcomes |
| Metformin | Endometrial Hyperplasia | 1 | PM | 35552758 | 📋 | Role of metformin in functional endometrial hyperplasia and polycystic ovary syndrome involves the regulation of MEG3/miR‑223/GLUT4 and SNHG20/miR‑4486/GLUT4 signaling |
| Metformin | Endometrial Hyperplasia | 3 | PM | 32652300 | 📋 | The impact of adjunctive metformin to progesterone for the treatment of non-atypical endometrial hyperplasia in a randomized fashion, a placebo-controlled, double blind clinical trial |
| Metformin | Endometrial Hyperplasia | 4 | PM | 29179590 | 📋 | Induction of apoptosis by metformin and progesterone in estrogen-induced endometrial hyperplasia in rats: involvement of the bcl-2 family proteins |
| Metformin | Endometriosis | 5 | PM | 37905623 | 📋 | Metformin Inhibits the Estrogen-mediated Epithelial-Mesenchymal Transition of Ectopic Endometrial Stromal Cells in Endometriosis |
| Metformin | Endometriosis | 4 | PM | 36381355 | 📋 | Metformin as a potential agent for modulating the faulty endometriotic mesenchymal stem cells: A case-control study |
| Metformin | Endometriosis | 3 | PM | 36359302 | 📋 | Metformin Prevents Endothelial Dysfunction in Endometriosis through Downregulation of ET-1 and Upregulation of eNOS |
| Metformin | Endometriosis | 2 | PM | 35644046 | 📋 | Effects of metformin, letrozole and atorvastatin on inflammation and apoptosis in experimental peritoneal and ovarian endometriosis in the rat |
| Metformin | Endometriosis | 1 | PM | 33141412 | 📋 | Ameliorative Effects of Quercetin and Metformin and Their Combination Against Experimental Endometriosis in Rats |
| Metformin | Gestational Diabetes | 8 | PM | 38294755 | 📋 | Clinical Impact of Metformin Therapy on Gestational Diabetes Mellitus and Maternal-Infant Health Outcomes |
| Metformin | Gestational Diabetes | 7 | PM | 37765126 | 📋 | Metformin in Gestational Diabetes Mellitus: To Use or Not to Use, That Is the Question |
| Metformin | Gestational Diabetes | 6 | PM | 37725457 | 📋 | Gestational Diabetes Mellitus: Update on Screening, Diagnosis, and Management |
| Metformin | Gestational Diabetes | 4 | PM | 37248332 | 📋 | Prophylactic administration of metformin reduces gestational diabetes mellitus incidence in the high-risk populations: a meta-analysis : Metformin for gestational diabetes prevention |
| Metformin | Gestational Diabetes | 3 | PM | 36593391 | 📋 | Short-term neonatal outcomes in women with gestational diabetes treated using metformin versus insulin: a systematic review and meta-analysis of randomized controlled trials |
| Metformin | Gestational Diabetes | 2 | PM | 36540507 | 📋 | Prediction and Prevention of Gestational Diabetes Mellitus and Its Sequelae by Administering Metformin in the Early Weeks of Pregnancy |
| Metformin | Gestational Diabetes | 1 | PM | 35834091 | 📋 | Efficacy and safety of metformin compared to insulin in gestational diabetes: a systemic review and meta-analysis of Chinese randomized controlled trials |
| Metformin | Gestational Diabetes | 5 | PM | 31558075 | 📋 | Metformin versus insulin for gestational diabetes: a systematic review and meta-analysis |
| Metformin | Infertility Female | 3 | PM | 37364632 | 📋 | Beneficial effects of metformin on mice female fertility after a high-fat diet intake |
| Metformin | Infertility Female | 2 | PM | 36393869 | 📋 | Metformin promotes in vitro maturation of oocytes from aged mice by attenuating mitochondrial oxidative stress via SIRT3-dependent SOD2ac |
| Metformin | Infertility Female | 1 | PM | 35854762 | 📋 | Metformin in Combination with Progesterone Improves the Pregnancy Rate for Patients with Early Endometrial Cancer |
| Metformin | Ovarian Cancer | 15 | PM | 38489280 | 📋 | Evaluating synergistic effects of metformin and simvastatin on ovarian cancer cells |
| Metformin | Ovarian Cancer | 14 | PM | 38203494 | 📋 | Enhancing Immunotherapy in Ovarian Cancer: The Emerging Role of Metformin and Statins |
| Metformin | Ovarian Cancer | 13 | PM | 38004379 | 📋 | Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer |
| Metformin | Ovarian Cancer | 7 | PM | 36458727 | 📋 | The role of PI3K/AKT-related proteins in di(2-ethyl)hexylphthalate-induced BG-1 and MCF-7 cell proliferation, and inhibition by metformin |
| Metformin | Ovarian Cancer | 6 | PM | 36361682 | 📋 | Metformin Improves Ovarian Cancer Sensitivity to Paclitaxel and Platinum-Based Drugs: A Review of In Vitro Findings |
| Metformin | Ovarian Cancer | 5 | PM | 36046821 | 📋 | Metformin anticancer: Reverses tumor hypoxia induced by bevacizumab and reduces the expression of cancer stem cell markers CD44/CD117 in human ovarian cancer SKOV3 cells |
| Metformin | Ovarian Cancer | 4 | PM | 36004387 | 📋 | CCNE1 is a potential target of Metformin for tumor suppression of ovarian high-grade serous carcinoma |
| Metformin | Ovarian Cancer | 3 | PM | 35950370 | 📋 | Metformin inhibits the proliferation and invasion of ovarian cancer cells by suppressing TRIM37-induced TRAF2 ubiquitination |
| Metformin | Ovarian Cancer | 2 | PM | 35898873 | 📋 | Association Between Metformin Use and the Risk, Prognosis of Gynecologic Cancer |
| Metformin | Ovarian Cancer | 1 | PM | 35565427 | 📋 | Shifting the Soil: Metformin Treatment Decreases the Protumorigenic Tumor Microenvironment in Epithelial Ovarian Cancer |
| Metformin | Ovarian Cancer | 9 | PM | 32522016 | 📋 | Metformin Affects Paclitaxel Sensitivity of Ovarian Cancer Cells Through Autophagy Mediated by Long Noncoding RNASNHG7/miR-3127-5p Axis |
| Metformin | Ovarian Cancer | 12 | PM | 29627688 | 📋 | Chemosensitizing effects of metformin on cisplatin- and paclitaxel-resistant ovarian cancer cell lines |
| Metformin | Ovarian Cancer | 11 | PM | 29423103 | 📋 | Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells |
| Metformin | Ovarian Cancer | 10 | PM | 29423021 | 📋 | Association of p53 and mitochondrial gene with chemosensitization by metformin in ovarian cancer |
| Metformin | Ovarian Cancer | 8 | PM | 29117515 | 📋 | Metformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells |
| Metformin | Ovarian Torsion | 1 | PM | 29144016 | 📋 | What is the protective effect of metformin on rat ovary against ischemia-reperfusion injury? |
| Metformin | Polycystic Ovary Syndrome | 73 | PM | 38735598 | 📋 | Spirulina versus metformin for controlling some insulin signaling pathway genes in induced polycystic ovary syndrome rat model |
| Metformin | Polycystic Ovary Syndrome | 72 | PM | 38484797 | 📋 | Effects of melatonin and metformin on the ovaries of rats with polycystic ovary syndrome |
| Metformin | Polycystic Ovary Syndrome | 71 | PM | 38425153 | 📋 | Efficacy of metformin combined with vitamin D in the treatment of polycystic ovarian syndrome: A meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 70 | PM | 38397951 | 📋 | The Comparative Effects of Myo-Inositol and Metformin Therapy on the Clinical and Biochemical Parameters of Women of Normal Weight Suffering from Polycystic Ovary Syndrome |
| Metformin | Polycystic Ovary Syndrome | 69 | PM | 38155665 | 📋 | Comparative effects of acupuncture and metformin on insulin sensitivity in overweight/obese and lean women with polycystic ovary syndrome and insulin resistance: a post hoc analysis of a randomized trial |
| Metformin | Polycystic Ovary Syndrome | 68 | PM | 38131036 | 📋 | Action Mechanisms of Metformin Combined with Exenatide and Metformin Only in the Treatment of PCOS in Obese Patients |
| Metformin | Polycystic Ovary Syndrome | 67 | PM | 37931721 | 📋 | Lavender and metformin effectively propagate progesterone levels in patients with polycystic ovary syndrome: A randomized, double-blind clinical trial |
| Metformin | Polycystic Ovary Syndrome | 66 | PM | 37791160 | 📋 | Role of Metformin in Polycystic Ovary Syndrome (PCOS)-Related Infertility |
| Metformin | Polycystic Ovary Syndrome | 65 | PM | 37736515 | 📋 | Investigation of the effects of astaxanthin in experimental polycystic ovary syndrome (PCOS) in rats |
| Metformin | Polycystic Ovary Syndrome | 64 | PM | 37575860 | 📋 | Myoinositol Versus Metformin in the Treatment of Polycystic Ovarian Syndrome: A Systematic Review |
| Metformin | Polycystic Ovary Syndrome | 63 | PM | 37554096 | 📋 | Metformin and combined oral contraceptive pills in the management of polycystic ovary syndrome: a systematic review and meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 62 | PM | 37536294 | 📋 | The impact of metformin with or without lifestyle modification versus placebo on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials |
| Metformin | Polycystic Ovary Syndrome | 61 | PM | 37406658 | 📋 | Low dose of liraglutide combined with metformin leads to a significant weight loss in Chinese Han women with polycystic ovary syndrome: a retrospective study |
| Metformin | Polycystic Ovary Syndrome | 60 | PM | 37381009 | 📋 | The effects of metformin on anti-Müllerian hormone levels in patients with polycystic ovary syndrome: a systematic review and meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 59 | PM | 37354674 | 📋 | METFORMIN EFFECTS ON NEUREGULIN-1 IN POLYCYSTIC OVARIAN WOMEN |
| Metformin | Polycystic Ovary Syndrome | 58 | PM | 37354673 | 📋 | METFORMIN EFFECTS ON BLOOD LEVELS OF GREMLIN-1 IN POLYCYSTIC OVARIAN WOMEN |
| Metformin | Polycystic Ovary Syndrome | 52 | PM | 37275752 | 📋 | Protective effect of astaxanthin and metformin in the liver of rats in which the polycystic ovary syndrome model was formed by giving letrozole |
| Metformin | Polycystic Ovary Syndrome | 51 | PM | 37265016 | 📋 | A randomized controlled trial comparing myoinositol with metformin versus metformin monotherapy in polycystic ovary syndrome |
| Metformin | Polycystic Ovary Syndrome | 50 | PM | 37244286 | 📋 | Metformin inhibits ovarian granular cell pyroptosis through the miR-670-3p/NOX2/ROS pathway |
| Metformin | Polycystic Ovary Syndrome | 49 | PM | 37166881 | 📋 | THE THERAPEUTIC EFFECT OF ORAL INSULIN SENSITIZER METFORMIN ON LIPID PROFILE IN WOMEN WITH POLYCYSTIC OVARY SYNDROME |
| Metformin | Polycystic Ovary Syndrome | 48 | PM | 37148410 | 📋 | Effects of myo-inositol vs. metformin on hormonal and metabolic parameters in women with PCOS: a meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 47 | PM | 36916886 | 📋 | Immunomodulatory effects of metformin treatment in pregnant women with PCOS |
| Metformin | Polycystic Ovary Syndrome | 46 | PM | 36763111 | 📋 | Influence of metformin on hyperandrogenism in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials |
| Metformin | Polycystic Ovary Syndrome | 45 | PM | 36755918 | 📋 | Metformin improves polycystic ovary syndrome in mice by inhibiting ovarian ferroptosis |
| Metformin | Polycystic Ovary Syndrome | 44 | PM | 36618831 | 📋 | The effects of melatonin and metformin on histological characteristics of the ovary and uterus in letrozole-induced polycystic ovarian syndrome mice: A stereological study |
| Metformin | Polycystic Ovary Syndrome | 43 | PM | 36351033 | 📋 | Nasturtium officinale L. and metformin alleviate the estradiol -induced polycystic ovary syndrome with synergistic effects through modulation of Bax/Bcl-2/p53/caspase-3 signaling pathway and anti-inflammatory and anti-oxidative effects |
| Metformin | Polycystic Ovary Syndrome | 42 | PM | 36322951 | 📋 | Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells (EECs) via mTOR activation and augmented mitochondrial strength |
| Metformin | Polycystic Ovary Syndrome | 41 | PM | 36299963 | 📋 | A Comparative Study of Luteinizing Hormone Levels in Polycystic Ovarian Syndrome With Hyperandrogenism: Metformin Versus Oral Contraceptive Pills |
| Metformin | Polycystic Ovary Syndrome | 40 | PM | 36285403 | 📋 | Effectiveness of inositol, metformin and their combination in women with PCOS undergoing assisted reproduction: systematic review and meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 39 | PM | 36225721 | 📋 | Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials |
| Metformin | Polycystic Ovary Syndrome | 38 | PM | 36176868 | 📋 | Role of Metformin in the Management of Polycystic Ovarian Syndrome-Associated Acne: A Systematic Review |
| Metformin | Polycystic Ovary Syndrome | 37 | PM | 36147577 | 📋 | Canagliflozin combined with metformin versus metformin monotherapy for endocrine and metabolic profiles in overweight and obese women with polycystic ovary syndrome: A single-center, open-labeled prospective randomized controlled trial |
| Metformin | Polycystic Ovary Syndrome | 36 | PM | 36129662 | 📋 | The Effect of Oral Antidiabetic Drugs on Improving the Endocrine and Metabolic States in Women with Polycystic Ovary Syndrome: A Systematic Review and Network Meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 35 | PM | 36062569 | 📋 | Effect of probiotics combined with metformin on improvement of menstrual and metabolic patterns in women with polycystic ovary syndrome: a randomized clinical trial |
| Metformin | Polycystic Ovary Syndrome | 34 | PM | 35893386 | 📋 | Metformin Improves the Hepatic Steatosis Index in Non-Obese Patients with Polycystic Ovary Syndrome |
| Metformin | Polycystic Ovary Syndrome | 33 | PM | 35822185 | 📋 | Combination of electroacupuncture and pharmacological treatment improves insulin resistance in women with polycystic ovary syndrome: Double-blind randomized clinical trial |
| Metformin | Polycystic Ovary Syndrome | 32 | PM | 35770635 | 📋 | [Metformin improves polycystic ovary syndrome and activates female germline stem cells in mice] |
| Metformin | Polycystic Ovary Syndrome | 31 | PM | 35748536 | 📋 | Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome |
| Metformin | Polycystic Ovary Syndrome | 30 | PM | 35621312 | 📋 | Efficacy and safety of metformin in pregnant women with polycystic ovary syndrome: a systematic review with meta-analysis of randomized and non-randomized controlled trials |
| Metformin | Polycystic Ovary Syndrome | 27 | PM | 35605922 | 📋 | Effects of Rosa damascena on reproductive improvement, metabolic parameters, liver function and insulin-like growth factor-1 gene expression in estradiol valerate induced polycystic ovarian syndrome in Wistar rats |
| Metformin | Polycystic Ovary Syndrome | 15 | PM | 35535444 | 📋 | Effects of N-acetylcysteine and metformin treatment on the stereopathological characteristics of uterus and ovary |
| Metformin | Polycystic Ovary Syndrome | 12 | PM | 35501295 | 📋 | Combination of alpha lipoic acid and metformin supplement improve assisted reproductive technologies outcomes in polycystic ovary syndrome patients |
| Metformin | Polycystic Ovary Syndrome | 23 | PM | 35444350 | 📋 | Histomorphological Changes in a Rat Model of Polycystic Ovary Syndrome and the Contribution of Stevia Leaf Extract in Modulating the Ovarian Fibrosis, VEGF, and TGF-β Immunoexpressions: Comparison with Metformin |
| Metformin | Polycystic Ovary Syndrome | 25 | PM | 35363325 | 📋 | Short period-administration of myo-inositol and metformin on hormonal and glycolipid profiles in patients with polycystic ovary syndrome: a systematic review and updated meta-analysis of randomized controlled trials |
| Metformin | Polycystic Ovary Syndrome | 28 | PM | 35310326 | 📋 | Metformin effects on zonulin level in polycystic ovarian women |
| Metformin | Polycystic Ovary Syndrome | 4 | PM | 35251851 | 📋 | Study on the Effect of Berberine, Myoinositol, and Metformin in Women with Polycystic Ovary Syndrome: A Prospective Randomised Study |
| Metformin | Polycystic Ovary Syndrome | 1 | PM | 35152800 | 📋 | Apigenin exerts protective effect and restores ovarian function in dehydroepiandrosterone induced polycystic ovary syndrome rats: a biochemical and histological analysis |
| Metformin | Polycystic Ovary Syndrome | 29 | PM | 34865304 | 📋 | Gestational weight gain, appetite regulating hormones, and metformin treatment in polycystic ovary syndrome: A longitudinal, placebo-controlled study |
| Metformin | Polycystic Ovary Syndrome | 20 | PM | 34752810 | 📋 | The anti-androgenic effect of quercetin on hyperandrogenism and ovarian dysfunction induced in a dehydroepiandrosterone rat model of polycystic ovary syndrome |
| Metformin | Polycystic Ovary Syndrome | 26 | PM | 34665453 | 📋 | The effect of metformin and myoinositol on metabolic outcomes in women with polycystic ovary syndrome: role of body mass and adiponectin in a randomized controlled trial |
| Metformin | Polycystic Ovary Syndrome | 21 | PM | 34538551 | 📋 | Mechanism of quercetin on the improvement of ovulation disorder and regulation of ovarian CNP/NPR2 in PCOS model rats |
| Metformin | Polycystic Ovary Syndrome | 24 | PM | 34407851 | 📋 | Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 9 | PM | 34298098 | 📋 | Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome |
| Metformin | Polycystic Ovary Syndrome | 10 | PM | 34286169 | 📋 | A Pilot Trial: Fish Oil and Metformin Effects on ApoB-Remnants and Triglycerides in Women With Polycystic Ovary Syndrome |
| Metformin | Polycystic Ovary Syndrome | 19 | PM | 34032731 | 📋 | Therapeutic effects of puerarin on polycystic ovary syndrome: A randomized trial in Chinese women |
| Metformin | Polycystic Ovary Syndrome | 2 | PM | 33876387 | 📋 | The Effect of Astaxanthin and Metformin on Oxidative Stress in Granulosa Cells of BALB C Mouse Model of Polycystic Ovary Syndrome |
| Metformin | Polycystic Ovary Syndrome | 8 | PM | 33861440 | 📋 | Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial |
| Metformin | Polycystic Ovary Syndrome | 3 | PM | 33555077 | 📋 | Synergic effect of bee pollen and metformin on proliferation and apoptosis of granulosa cells: Rat model of polycystic ovary syndrome |
| Metformin | Polycystic Ovary Syndrome | 13 | PM | 32877649 | 📋 | The ameliorative effects of marjoram in dehydroepiandrosterone induced polycystic ovary syndrome in rats |
| Metformin | Polycystic Ovary Syndrome | 6 | PM | 31948119 | 📋 | Both Matricaria chamomilla and Metformin Extract Improved the Function and Histological Structure of Thyroid Gland in Polycystic Ovary Syndrome Rats through Antioxidant Mechanism |
| Metformin | Polycystic Ovary Syndrome | 16 | PM | 31749393 | 📋 | Comparison of the Efficacy Between NAC and Metformin in Treating PCOS Patients: A Meta-Analysis |
| Metformin | Polycystic Ovary Syndrome | 17 | PM | 30814814 | 📋 | Comparison of Metformin and N Acetylcysteine on Clinical, Metabolic Parameter and Hormonal Profile in Women With Polycystic Ovarian Syndrome |
| Metformin | Polycystic Ovary Syndrome | 5 | PM | 30538756 | 📋 | The Effect of Berberine on Polycystic Ovary Syndrome Patients With Insulin Resistance (PCOS-IR): A Meta-Analysis and Systematic Review |
| Metformin | Polycystic Ovary Syndrome | 14 | PM | 30369967 | 📋 | Effects of Moringa oleifera on Insulin Levels and Folliculogenesis in Polycystic Ovary Syndrome Model with Insulin Resistance |
| Metformin | Polycystic Ovary Syndrome | 57 | PM | 29434814 | 📋 | Metformin and pioglitazone combination therapy ameliorate polycystic ovary syndrome through AMPK/PI3K/JNK pathway |
| Metformin | Polycystic Ovary Syndrome | 54 | PM | 28941255 | 📋 | Effects of placebo-controlled insulin-sensitizing drugs on hormonal parameters in polycystic ovary syndrome patients: A network meta-analysis |
| Metformin | Polycystic Ovary Syndrome | 56 | PM | 28834135 | 📋 | The Pharmacogenetics of Metformin in Women with Polycystic Ovary Syndrome: A Randomized Trial |
| Metformin | Polycystic Ovary Syndrome | 7 | PM | 28479753 | 📋 | The Effect of Metformin and Cinnamon on Serum Anti-Mullerian Hormone in Women Having PCOS: A Double-Blind, Randomized, Controlled Trial |
| Metformin | Polycystic Ovary Syndrome | 22 | PM | 27923406 | 📋 | Ameliorative Effects of Rutin Against Metabolic, Biochemical and Hormonal Disturbances in Polycystic Ovary Syndrome in Rats |
| Metformin | Polycystic Ovary Syndrome | 18 | PM | 25482371 | 📋 | N-Acetylcysteine Improves Oocyte and Embryo Quality in Polycystic Ovary Syndrome Patients Undergoing Intracytoplasmic Sperm Injection: An Alternative to Metformin |
| Metformin | Polycystic Ovary Syndrome | 55 | PM | 24196302 | 📋 | Assessment of ovarian stromal blood flow after metformin treatment in women with polycystic ovary syndrome |
| Metformin | Polycystic Ovary Syndrome | 53 | PM | 23869585 | 📋 | The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment |
| Metformin | Polycystic Ovary Syndrome | 11 | PM | 19933994 | 📋 | Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome |
| Metformin | Preeclampsia | 2 | PM | 38677349 | 📋 | Metformin inhibits activation of NLRP3 inflammasome and inflammatory response in preeclamptic rats |
| Metformin | Preeclampsia | 1 | PM | 37866322 | 📋 | Protective role of metformin in preeclampsia via the regulation of NF-κB/sFlt-1 and Nrf2/HO-1 signaling pathways by activating AMPK |
| Metformin | Pregnancy Complications | 2 | PM | 37409227 | 📋 | Lights and shadows on the use of metformin in pregnancy: from the preconception phase to breastfeeding and beyond |
| Metformin | Pregnancy Complications | 1 | PM | 37401946 | 📋 | Position paper of the Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), and the Italian Study Group of Diabetes in pregnancy: Metformin use in pregnancy |
| Metformin | Premature Ovarian Failure | 3 | PM | 38387407 | 📋 | Metformin improves d-galactose induced premature ovarian insufficiency through PI3K-Akt-FOXO3a pathway |
| Metformin | Premature Ovarian Failure | 2 | PM | 37354386 | 📋 | Metformin Promotes Proliferation of Mouse Female Germline Stem Cells by Histone Acetylation Modification of Traf2 |
| Metformin | Premature Ovarian Failure | 1 | PM | 36054356 | 📋 | Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice |
| Metformin | Reproductive Toxicity Female | 3 | PM | 38484380 | 📋 | Metformin mitigates cisplatin-induced ovarian damage through inhibiting the pyroptosis of granulosa cells via ROS/TXNIP/NLRP3 signaling pathway |
| Metformin | Reproductive Toxicity Female | 2 | PM | 38228655 | 📋 | Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway |
| Metformin | Reproductive Toxicity Female | 1 | PM | 37839107 | 📋 | Salsalate and/or metformin therapy confer beneficial metabolic effects in olanzapine treated female mice |
