| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Silibinin | Acute Liver Injury | 1 | PM | 28958806 | 📋 | Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies |
| Silibinin | Biliary Tract Cancer | 1 | PM | 35401195 | 📋 | Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway |
| Silibinin | Chronic Hepatitis | 1 | PM | 26457982 | 📋 | Curcumin, Silybin Phytosome(®) and α-R-Lipoic Acid Mitigate Chronic Hepatitis in Rat by Inhibiting Oxidative Stress and Inflammatory Cytokines Production |
| Silibinin | Colon Cancer | 6 | PM | 36836848 | 📋 | Silybin Showed Higher Cytotoxic, Antiproliferative, and Anti-Inflammatory Activities in the CaCo Cancer Cell Line while Retaining Viability and Proliferation in Normal Intestinal IPEC-1 Cells |
| Silibinin | Colon Cancer | 5 | PM | 35966396 | 📋 | Curcumin, but not its degradation products, in combination with silibinin is primarily responsible for the inhibition of colon cancer cell proliferation |
| Silibinin | Colon Cancer | 1 | PM | 30314650 | 📋 | Synergistic Interaction of Rutin and Silibinin on Human Colon Cancer Cell Line |
| Silibinin | Colon Cancer | 2 | PM | 25846868 | 📋 | Restoration of the anti-proliferative and anti-migratory effects of 1,25-dihydroxyvitamin D by silibinin in vitamin D-resistant colon cancer cells |
| Silibinin | Colon Cancer | 3 | PM | 24740923 | 📋 | Silibinin Modulates Caudal-Type Homeobox Transcription Factor (CDX2), an Intestine Specific Tumor Suppressor to Abrogate Colon Cancer in Experimental Rats |
| Silibinin | Colon Cancer | 4 | PM | 14614451 | 📋 | Silibinin Upregulates the Expression of Cyclin-Dependent Kinase Inhibitors and Causes Cell Cycle Arrest and Apoptosis in Human Colon Carcinoma HT-29 Cells |
| Silibinin | Colon Polyps | 1 | PM | 29072082 | 📋 | Chemoprevention of polyp recurrence with curcumin followed by silibinin in a case of multiple colorectal adenomas |
| Silibinin | Colorectal Cancer | 2 | PM | 34059044 | 📋 | Targeting the hallmarks of cancer: the effects of silibinin on proliferation, cell death, angiogenesis, and migration in colorectal cancer |
| Silibinin | Colorectal Cancer | 1 | PM | 32748663 | 📋 | Cancer Chemopreventive Activities of Silibinin on Colorectal Cancer through Regulation of E-Cadherin/β-Catenin Pathway |
| Silibinin | Colorectal Cancer | 6 | PM | 23530816 | 📋 | Chemoprevention utility of silibinin and Cdk4 pathway inhibition in Apc(-/+) mice |
| Silibinin | Colorectal Cancer | 5 | PM | 23445752 | 📋 | Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries |
| Silibinin | Colorectal Cancer | 4 | PM | 22086675 | 📋 | Effect of silibinin in human colorectal cancer cells: targeting the activation of NF-κB signaling |
| Silibinin | Colorectal Cancer | 3 | PM | 16675592 | 📋 | Pilot Study of Oral Silibinin, a Putative Chemopreventive Agent, in Colorectal Cancer Patients: Silibinin Levels in Plasma, Colorectum, and Liver and Their Pharmacodynamic Consequences |
| Silibinin | Gastric Cancer | 1 | PM | 32603822 | 📋 | The Gastroprotective Potential of Silibinin Against Helicobacter Pylori Infection and Gastric Tumor Cells |
| Silibinin | Gastric Cancer | 3 | PM | 29135096 | 📋 | Silibinin promotes the apoptosis of gastric cancer BGC823 cells through caspase pathway |
| Silibinin | Gastric Cancer | 2 | PM | 22619007 | 📋 | Silibinin triggers apoptosis and cell-cycle arrest of SGC7901 cells |
| Silibinin | Gastritis | 1 | PM | 34258250 | 📋 | Protective Effects of Silibinin on Helicobacter pylori-induced Gastritis: NF-κB and STAT3 as Potential Targets |
| Silibinin | Helicobacter Pylori Infection | 2 | PM | 34258250 | 📋 | Protective Effects of Silibinin on Helicobacter pylori-induced Gastritis: NF-κB and STAT3 as Potential Targets |
| Silibinin | Helicobacter Pylori Infection | 1 | PM | 32603822 | 📋 | The Gastroprotective Potential of Silibinin Against Helicobacter Pylori Infection and Gastric Tumor Cells |
| Silibinin | Hepatic Ischemia-Reperfusion | 9 | PM | 36474574 | 📋 | JNK and p38 gene and protein expression during liver ischemia-reperfusion in a rat model treated with silibinin |
| Silibinin | Hepatic Ischemia-Reperfusion | 8 | PM | 34994100 | 📋 | Pro-inflammatory cytokines/chemokines, TNF-α, IL-6 and MCP-1, as biomarkers for the nephro- and pneumoprotective effect of silibinin after hepatic ischemia/reperfusion: confirmation by immunihistochemistry and qRT-PCR |
| Silibinin | Hepatic Ischemia-Reperfusion | 5 | PM | 34755764 | 📋 | Effect of silibinin on the expression of MMP2, MMP3, MMP9 and TIMP2 in kidney and lung after hepatic ischemia/reperfusion injury in an experimental rat model |
| Silibinin | Hepatic Ischemia-Reperfusion | 4 | PM | 34221267 | 📋 | NF-κB and NLRP3 gene expression changes during warm hepatic ischemia-reperfusion in rats with and without silibinin |
| Silibinin | Hepatic Ischemia-Reperfusion | 1 | PM | 33847359 | 📋 | The hepatoprotective effect of silibinin after hepatic ischemia/reperfusion in a rat model is confirmed by immunohistochemistry and qRT-PCR |
| Silibinin | Hepatic Ischemia-Reperfusion | 2 | PM | 32891719 | 📋 | Silibinin-hydroxypropyl-β-cyclodextrin (SLB-HP-β-CD) Complex Prevents Apoptosis in Liver and Kidney after Hepatic Ischemia-Reperfusion Injury |
| Silibinin | Hepatic Ischemia-Reperfusion | 3 | PM | 32373301 | 📋 | Effects of Silibinin on Hepatic Warm Ischemia-Reperfusion Injury in the Rat Model |
| Silibinin | Hepatic Ischemia-Reperfusion | 7 | PM | 32249375 | 📋 | Silibinin treatment results in reducing OPA1&MFN1 genes expression in a rat model hepatic ischemia-reperfusion |
| Silibinin | Hepatic Ischemia-Reperfusion | 6 | PM | 32190775 | 📋 | Glycoprotein non-metastatic melanoma B expression after hepatic ischemia reperfusion and the effect of silibinin |
| Silibinin | Hepatic Ischemia-Reperfusion | 11 | PM | 28952834 | 📋 | Silibinin Effect on Fas/FasL, HMGB1, and CD45 Expressions in a Rat Model Subjected to Liver Ischemia-Reperfusion Injury |
| Silibinin | Hepatic Ischemia-Reperfusion | 10 | PM | 28418711 | 📋 | Silibinin Improves TNF-α and M30 Expression and Histological Parameters in Rat Kidneys After Hepatic Ischemia/Reperfusion |
| Silibinin | Hepatic Steatosis | 1 | PM | 33436935 | 📋 | Effect of silibinin capsules combined with lifestyle modification on hepatic steatosis in patients with chronic hepatitis B |
| Silibinin | Hepatitis B | 1 | PM | 33436935 | 📋 | Effect of silibinin capsules combined with lifestyle modification on hepatic steatosis in patients with chronic hepatitis B |
| Silibinin | Hepatitis C | 2 | PM | 27842532 | 📋 | Silybin Supplementation During HCV Therapy With Pegylated Interferon-α Plus Ribavirin Reduces Depression and Anxiety and Increases Work Ability |
| Silibinin | Hepatitis C | 6 | PM | 23701235 | 📋 | Silibinin inhibits hepatitis C virus entry into hepatocytes by hindering clathrin-dependent trafficking |
| Silibinin | Hepatitis C | 5 | PM | 23322644 | 📋 | Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B |
| Silibinin | Hepatitis C | 4 | PM | 23063567 | 📋 | Intravenous silibinin monotherapy shows significant antiviral activity in HCV-infected patients in the peri-transplantation period |
| Silibinin | Hepatitis C | 1 | PM | 18814247 | 📋 | Treatment With Silybin-Vitamin E-phospholipid Complex in Patients With Hepatitis C Infection |
| Silibinin | Hepatitis C | 3 | PM | 18771667 | 📋 | Silibinin Is a Potent Antiviral Agent in Patients With Chronic Hepatitis C Not Responding to Pegylated Interferon/Ribavirin Therapy |
| Silibinin | Inflammatory Bowel Disease | 1 | PM | 37781701 | 📋 | Silibinin alleviates intestinal inflammation via inhibiting JNK signaling in Drosophila |
| Silibinin | Liver Cancer | 4 | PM | 38222315 | 📋 | Silibinin, a potential fasting mimetic, inhibits hepatocellular carcinoma by triggering extrinsic apoptosis |
| Silibinin | Liver Cancer | 1 | PM | 38204247 | 📋 | Resveratrol Enhances Anticancer Effects of Silybin on HepG2 Cells and H22 Tumor-bearing Mice via Inducing G2/M Phase Arrest and Increasing Bax/Bcl-2 Ratio |
| Silibinin | Liver Cancer | 3 | PM | 34781148 | 📋 | Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/β-catenin, and PI3K/Akt/mTOR signaling pathways |
| Silibinin | Liver Cancer | 5 | PM | 24386256 | 📋 | Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells |
| Silibinin | Liver Cancer | 2 | PM | 19399925 | 📋 | Effects and Mechanisms of Silibinin on Human Hepatocellular Carcinoma Xenografts in Nude Mice |
| Silibinin | MAFLD | 13 | PM | 38839561 | 📋 | Silibinin, a commonly used therapeutic agent for non-alcohol fatty liver disease, functions through upregulating intestinal expression of fibroblast growth factor 15/19 |
| Silibinin | MAFLD | 8 | PM | 35705686 | 📋 | Silybin regulates P450s activity by attenuating endoplasmic reticulum stress in mouse nonalcoholic fatty liver disease |
| Silibinin | MAFLD | 7 | PM | 35246007 | 📋 | Quantitative proteomics analysis based on tandem mass tag labeling coupled with labeling coupled with liquid chromatography-tandem mass spectrometry discovers the effect of silibinin on non-alcoholic fatty liver disease in mice |
| Silibinin | MAFLD | 5 | PM | 34671210 | 📋 | Lrp6 Genotype affects Individual Susceptibility to Nonalcoholic Fatty Liver Disease and Silibinin Therapeutic Response via Wnt/β-catenin-Cyp2e1 Signaling |
| Silibinin | MAFLD | 2 | PM | 34183378 | 📋 | Silybin restored CYP3A expression through the SIRT2/NF-κB pathway in mouse nonalcoholic fatty liver disease |
| Silibinin | MAFLD | 4 | PM | 34092291 | 📋 | Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor α |
| Silibinin | MAFLD | 3 | PM | 33760189 | 📋 | Silibinin improves nonalcoholic fatty liver by regulating the expression of miR‑122: An in vitro and in vivo study |
| Silibinin | MAFLD | 1 | PM | 32408667 | 📋 | The Bisphenol A Induced Oxidative Stress in Non-Alcoholic Fatty Liver Disease Male Patients: A Clinical Strategy to Antagonize the Progression of the Disease |
| Silibinin | MAFLD | 9 | PM | 31865143 | 📋 | Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model |
| Silibinin | MAFLD | 12 | PM | 28973994 | 📋 | Silibinin Restores NAD⁺ Levels and Induces the SIRT1/AMPK Pathway in Non-Alcoholic Fatty Liver |
| Silibinin | MAFLD | 6 | PM | 28164196 | 📋 | Preventive effect of Silibinin in combination with Pu-erh tea extract on non-alcoholic fatty liver disease in ob/ob mice |
| Silibinin | MAFLD | 11 | PM | 24036369 | 📋 | Silibinin ameliorates steatosis and insulin resistance during non-alcoholic fatty liver disease development partly through targeting IRS-1/PI3K/Akt pathway |
| Silibinin | MAFLD | 10 | PM | 23532271 | 📋 | Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver |
| Silibinin | Nasopharyngeal Cancer | 1 | PM | 32679194 | 📋 | Silibinin down-regulates PD-L1 expression in nasopharyngeal carcinoma by interfering with tumor cell glycolytic metabolism |
| Silibinin | Non-Alcoholic Steatohepatitis | 5 | PM | 37867498 | 📋 | Beneficial effects of silibinin on serum lipids, bile acids, and gut microbiota in methionine-choline-deficient diet-induced mice |
| Silibinin | Non-Alcoholic Steatohepatitis | 4 | PM | 37731666 | 📋 | Silibinin ameliorates deoxycholic acid-induced pyroptosis in steatotic HepG2 cells by inhibiting NLRP3 inflammasome activation |
| Silibinin | Non-Alcoholic Steatohepatitis | 1 | PM | 31706011 | 📋 | Combinational applicaton of silybin and tangeretin attenuates the progression of non-alcoholic steatohepatitis (NASH) in mice via modulating lipid metabolism |
| Silibinin | Non-Alcoholic Steatohepatitis | 3 | PM | 31384535 | 📋 | Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway |
| Silibinin | Non-Alcoholic Steatohepatitis | 2 | PM | 30248539 | 📋 | Effect of silibinin on CFLAR-JNK pathway in oleic acid-treated HepG2 cells |
| Silibinin | Oral Cancer | 4 | PM | 37476191 | 📋 | Silibinin induces oral cancer cell apoptosis and reactive oxygen species generation by activating the JNK/c-Jun pathway |
| Silibinin | Oral Cancer | 1 | PM | 32711410 | 📋 | Silibinin Triggers the Mitochondrial Pathway of Apoptosis in Human Oral Squamous Carcinoma Cells |
| Silibinin | Oral Cancer | 2 | PM | 32678829 | 📋 | Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model |
| Silibinin | Oral Cancer | 3 | PM | 16498067 | 📋 | Silibinin Inhibits Invasion of Oral Cancer Cells by Suppressing the MAPK Pathway |
| Silibinin | Pancreatic Cancer | 1 | PM | 31351801 | 📋 | Silibinin inhibited autophagy and mitochondrial apoptosis in pancreatic carcinoma by activating JNK/SAPK signaling |
| Silibinin | Pancreatic Cancer | 2 | PM | 23022268 | 📋 | In vitro and in vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and PANC-1 cells |
