| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Piperine | Acute Pancreatitis | 1 | PM | 35963197 | 📋 | Piperine alleviates acute pancreatitis: A possible role for FAM134B and CCPG1 dependent ER-phagy |
| Piperine | Biliary Tract Cancer | 1 | PM | 35600948 | 📋 | Gambogic Acid and Piperine Synergistically Induce Apoptosis in Human Cholangiocarcinoma Cell via Caspase and Mitochondria-Mediated Pathway |
| Piperine | Colitis | 1 | PM | 31835924 | 📋 | Piperine, a Functional Food Alkaloid, Exhibits Inhibitory Potential Against TNBS-induced Colitis via the Inhibition of IκB-α/NF-κB and Induces Tight Junction Protein (claudin-1, Occludin, and ZO-1) Signaling Pathway in Experimental Mice |
| Piperine | Colon Cancer | 6 | PM | 37180710 | 📋 | Cannabinoid compounds in combination with curcumin and piperine display an anti-tumorigenic effect against colon cancer cells |
| Piperine | Colon Cancer | 5 | PM | 33667839 | 📋 | Piperine and Celecoxib synergistically inhibit colon cancer cell proliferation via modulating Wnt/β-catenin signaling pathway |
| Piperine | Colon Cancer | 4 | PM | 33089532 | 📋 | Piperine sensitizes radiation-resistant cancer cells towards radiation and promotes intrinsic pathway of apoptosis |
| Piperine | Colon Cancer | 3 | PM | 24819444 | 📋 | Piperine, an Alkaloid From Black Pepper, Inhibits Growth of Human Colon Cancer Cells via G1 Arrest and Apoptosis Triggered by Endoplasmic Reticulum Stress |
| Piperine | Colon Cancer | 2 | PM | 22531135 | 📋 | Resveratrol and Piperine Enhance Radiosensitivity of Tumor Cells |
| Piperine | Colon Cancer | 1 | PM | 18678136 | 📋 | Growth Inhibition of Human Colon Cancer Cells by Plant Compounds |
| Piperine | Colorectal Cancer | 6 | PM | 35326180 | 📋 | Piperine Attenuates Lithocholic Acid-Stimulated Interleukin-8 by Suppressing Src/EGFR and Reactive Oxygen Species in Human Colorectal Cancer Cells |
| Piperine | Colorectal Cancer | 5 | PM | 32967203 | 📋 | Piperine Regulates Nrf-2/Keap-1 Signalling and Exhibits Anticancer Effect in Experimental Colon Carcinogenesis in Wistar Rats |
| Piperine | Colorectal Cancer | 4 | PM | 32669593 | 📋 | Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells |
| Piperine | Colorectal Cancer | 3 | PM | 32500474 | 📋 | Piperine Inhibits Colorectal Cancer Migration and Invasion by Regulating STAT3/Snail-mediated Epithelial-Mesenchymal Transition |
| Piperine | Colorectal Cancer | 1 | PM | 32117930 | 📋 | Curcumin- And Piperine-Loaded Emulsomes as Combinational Treatment Approach Enhance the Anticancer Activity of Curcumin on HCT116 Colorectal Cancer Model |
| Piperine | Colorectal Cancer | 2 | PM | 29800814 | 📋 | Piperine Potentiates Curcumin-Mediated Repression of mTORC1 Signaling in Human Intestinal Epithelial Cells: Implications for the Inhibition of Protein Synthesis and TNFα Signaling |
| Piperine | Diarrhea | 1 | PM | 38158111 | 📋 | Anti-diarrheal effect of piperine possibly through the interaction with inflammation inducing enzymes: In vivo and in silico studies |
| Piperine | Dysbiosis | 1 | PM | 36110383 | 📋 | Effect of piperine on the mitigation of obesity associated with gut microbiota alteration |
| Piperine | Dyspepsia | 1 | PM | 21918995 | 📋 | Fat Digestion and Absorption in Spice-Pretreated Rats |
| Piperine | Gallstones | 1 | PM | 26335572 | 📋 | Combination of Curcumin and Piperine Prevents Formation of Gallstones in C57BL6 Mice Fed on Lithogenic Diet: Whether NPC1L1/SREBP2 Participates in This Process? |
| Piperine | Gastric Cancer | 3 | PM | 37513459 | 📋 | Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer |
| Piperine | Gastric Cancer | 2 | PM | 34464498 | 📋 | Mechanism of piperine in affecting apoptosis and proliferation of gastric cancer cells via ROS-mitochondria-associated signalling pathway |
| Piperine | Gastric Cancer | 1 | PM | 33382670 | 📋 | Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway |
| Piperine | Gastritis | 1 | PM | 26140520 | 📋 | Anti-Inflammatory Effects of Capsaicin and Piperine on Helicobacter pylori-Induced Chronic Gastritis in Mongolian Gerbils |
| Piperine | Helicobacter Pylori Infection | 2 | PM | 27158376 | 📋 | Piperine Treatment Suppresses Helicobacter Pylori Toxin Entry in to Gastric Epithelium and Minimizes β-Catenin Mediated Oncogenesis and IL-8 Secretion in Vitro |
| Piperine | Helicobacter Pylori Infection | 1 | PM | 26140520 | 📋 | Anti-Inflammatory Effects of Capsaicin and Piperine on Helicobacter pylori-Induced Chronic Gastritis in Mongolian Gerbils |
| Piperine | Hepatic Fibrosis | 3 | PM | 34778375 | 📋 | The Hepatoprotective Effect of Piperine Against Thioacetamide-Induced Liver Fibrosis in Mice: The Involvement of miR-17 and TGF-β/Smads Pathways |
| Piperine | Hepatic Fibrosis | 2 | PM | 34730139 | 📋 | Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl 4: roles in the activation of the Nrf2 cascade and subsequent suppression of the TGF-β1/Smad axis |
| Piperine | Hepatic Fibrosis | 1 | PM | 22038304 | 📋 | Piperine Attenuates Cardiovascular, Liver and Metabolic Changes in High Carbohydrate, High Fat-Fed Rats |
| Piperine | Hepatic Ischemia-Reperfusion | 1 | PM | 38484898 | 📋 | Piperine attenuates hepatic ischemia/reperfusion injury via suppressing the TLR4 signaling cascade in mice |
| Piperine | Hepatic Steatosis | 1 | PM | 36375392 | 📋 | Piperine attenuates hepatic steatosis and insulin resistance in high-fat diet-induced obesity in Sprague-Dawley rats |
| Piperine | Inflammatory Bowel Disease | 1 | PM | 25907981 | 📋 | The Protective Effect of Piperine on Dextran Sulfate Sodium Induced Inflammatory Bowel Disease and Its Relation With Pregnane X Receptor Activation |
| Piperine | Intestinal Injury | 1 | PM | 36432431 | 📋 | Protective Effects of Piperine on Ethanol-Induced Gastric Mucosa Injury by Oxidative Stress Inhibition |
| Piperine | Intestinal Permeability | 2 | PM | 34591253 | 📋 | Piperine Improves Obesity by Inhibiting Fatty Acid Absorption and Repairing Intestinal Barrier Function |
| Piperine | Intestinal Permeability | 1 | PM | 32851010 | 📋 | Effect of the Single and Combined Use of Curcumin and Piperine on Growth Performance, Intestinal Barrier Function, and Antioxidant Capacity of Weaned Wuzhishan Piglets |
| Piperine | Liver Cancer | 5 | PM | 38809630 | 📋 | Curcumin, Piperine and Taurine Combination Enhances the Efficacy of Transarterial Chemoembolization Therapy in patients with Intermediate Stage Hepatocellular Carcinoma: A Pilot Study |
| Piperine | Liver Cancer | 4 | PM | 36870998 | 📋 | Thymoquinone, piperine, and sorafenib combinations attenuate liver and breast cancers progression: epigenetic and molecular docking approaches |
| Piperine | Liver Cancer | 3 | PM | 33743225 | 📋 | Evaluation of piperine against cancer stem cells (CSCs) of hepatocellular carcinoma: Insights into epithelial-mesenchymal transition (EMT) |
| Piperine | Liver Cancer | 2 | PM | 28341137 | 📋 | Targeting Hepatocellular Carcinoma With Piperine by Radical-Mediated Mitochondrial Pathway of Apoptosis: An in Vitro and in Vivo Study |
| Piperine | Liver Cancer | 1 | PM | 26278679 | 📋 | Synergistic Effect of Curcumin and Piperine in Suppression of DENA-induced Hepatocellular Carcinoma in Rats |
| Piperine | Liver Damage | 2 | PM | 31463384 | 📋 | Piperine Pretreatment Attenuates Renal Ischemia-Reperfusion Induced Liver Injury |
| Piperine | MAFLD | 4 | PM | 38200253 | 📋 | The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial |
| Piperine | MAFLD | 3 | PM | 36799355 | 📋 | Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis: A double-blind, randomized, placebo-controlled clinical trial |
| Piperine | MAFLD | 2 | PM | 34981468 | 📋 | Curcumin and Piperine Combination for the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind Randomized Placebo-Controlled Trial |
| Piperine | MAFLD | 1 | PM | 31168845 | 📋 | Curcuminoids Plus Piperine Improve Nonalcoholic Fatty Liver Disease: A Clinical Trial |
| Piperine | Malabsorption Syndrome | 1 | PM | 20178671 | 📋 | Beneficial Influence of Dietary Spices on the Ultrastructure and Fluidity of the Intestinal Brush Border in Rats |
| Piperine | Non-Alcoholic Steatohepatitis | 1 | PM | 38547097 | 📋 | Piperine alleviates nonalcoholic steatohepatitis by inhibiting NF-κB-mediated hepatocyte pyroptosis |
| Piperine | Oral Cancer | 3 | PM | 37762259 | 📋 | Piperine Induces Apoptosis and Autophagy in HSC-3 Human Oral Cancer Cells by Regulating PI3K Signaling Pathway |
| Piperine | Oral Cancer | 1 | PM | 28426244 | 📋 | Piperine Triggers Apoptosis of Human Oral Squamous Carcinoma Through Cell Cycle Arrest and Mitochondrial Oxidative Stress |
| Piperine | Oral Cancer | 2 | PM | 19296028 | 📋 | Chemopreventive Efficacy of Curcumin and Piperine During 7,12-dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis |
| Piperine | Oral Candidiasis | 2 | PM | 35661216 | 📋 | Biofilm and hyphal inhibitory synergistic effects of phytoactives piperine and cinnamaldehyde against Candida albicans |
| Piperine | Oral Candidiasis | 1 | PM | 32477284 | 📋 | Piperine Impedes Biofilm Formation and Hyphal Morphogenesis of Candida albicans |
| Piperine | Oral Lichen Planus | 1 | PM | 30343451 | 📋 | Black pepper and its bioactive constituent piperine: promising therapeutic strategies for oral lichen planus |
| Piperine | Pancreatitis | 1 | PM | 31485676 | 📋 | Piperine Ameliorates the Severity of Fibrosis via Inhibition of TGF‑β/SMAD Signaling in a Mouse Model of Chronic Pancreatitis |
