| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Nobiletin | Acute Liver Injury | 3 | PM | 37545398 | 📋 | Nobiletin protects against ferroptosis to alleviate sepsis-associated acute liver injury by modulating the gut microbiota |
| Nobiletin | Acute Liver Injury | 1 | PM | 32538091 | 📋 | Nobiletin Protects against Acute Liver Injury via Targeting c-Jun N-Terminal Kinase (JNK)-Induced Apoptosis of Hepatocytes |
| Nobiletin | Acute Liver Injury | 2 | PM | 27878238 | 📋 | Nobiletin attenuates lipopolysaccharide/D‑galactosamine‑induced liver injury in mice by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF‑κB‑mediated cytokine production |
| Nobiletin | Biliary Tract Cancer | 1 | PM | 36263164 | 📋 | Nobiletin suppresses cholangiocarcinoma proliferation via inhibiting GSK3β |
| Nobiletin | Colitis | 5 | PM | 32249565 | 📋 | Nobiletin Attenuates DSS-Induced Intestinal Barrier Damage through the HNF4α-Claudin-7 Signaling Pathway |
| Nobiletin | Colitis | 2 | PM | 29525889 | 📋 | Nobiletin acts anti-inflammatory on murine IL-10 -/- colitis and human intestinal fibroblasts |
| Nobiletin | Colitis | 1 | PM | 28107678 | 📋 | Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression |
| Nobiletin | Colitis | 4 | PM | 26445322 | 📋 | Chemopreventive effects of nobiletin and its colonic metabolites on colon carcinogenesis |
| Nobiletin | Colitis | 3 | PM | 25655748 | 📋 | Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function |
| Nobiletin | Colon Cancer | 6 | PM | 36454256 | 📋 | Nobiletin is capable of regulating certain anti-cancer pathways in a colon cancer cell line |
| Nobiletin | Colon Cancer | 5 | PM | 32144766 | 📋 | Synergistic anticancer effects of curcumin and 3',4'-didemethylnobiletin in combination on colon cancer cells |
| Nobiletin | Colon Cancer | 4 | PM | 28207072 | 📋 | Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis |
| Nobiletin | Colon Cancer | 2 | PM | 28107678 | 📋 | Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression |
| Nobiletin | Colon Cancer | 3 | PM | 26445322 | 📋 | Chemopreventive effects of nobiletin and its colonic metabolites on colon carcinogenesis |
| Nobiletin | Colon Cancer | 1 | PM | 23137376 | 📋 | Multidrug resistance reversal and apoptosis induction in human colon cancer cells by some flavonoids present in citrus plants |
| Nobiletin | Colorectal Cancer | 4 | PM | 34439086 | 📋 | Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy |
| Nobiletin | Colorectal Cancer | 3 | PM | 31234411 | 📋 | Nobiletin and Derivatives: Functional Compounds from Citrus Fruit Peel for Colon Cancer Chemoprevention |
| Nobiletin | Colorectal Cancer | 2 | PM | 30468657 | 📋 | Nobiletin sensitizes colorectal cancer cells to oxaliplatin by PI3K/Akt/MTOR pathway |
| Nobiletin | Colorectal Cancer | 1 | PM | 29313727 | 📋 | Polymethoxylated Flavones from Orange Peels Inhibit Cell Proliferation in a 3D Cell Model of Human Colorectal Cancer |
| Nobiletin | Constipation | 1 | PM | 38387277 | 📋 | Nobiletin, an active component of Wenyang Yiqi formula, alleviates constipation associated depression through targeting MAPT to inhibit the MAPK signaling pathway |
| Nobiletin | Dysbiosis | 2 | PM | 33900329 | 📋 | Bidirectional interaction of nobiletin and gut microbiota in mice fed with a high-fat diet |
| Nobiletin | Dysbiosis | 1 | PM | 33475201 | 📋 | Nobiletin activates thermogenesis of brown and white adipose tissue in high-fat diet-fed C57BL/6 mice by shaping the gut microbiota |
| Nobiletin | Gastric Cancer | 4 | PM | 38547624 | 📋 | Nobiletin targets SREBP1/ACLY to induce autophagy-dependent cell death of gastric cancer cells through PI3K/Akt/mTOR signaling pathway |
| Nobiletin | Gastric Cancer | 3 | PM | 37270969 | 📋 | Nobiletin inhibits de novo FA synthesis to alleviate gastric cancer progression by regulating endoplasmic reticulum stress |
| Nobiletin | Gastric Cancer | 2 | PM | 32479014 | 📋 | Nobiletin Inhibits Helicobacterium pylori Infection-Induced Gastric Carcinogenic Signaling by Blocking Inflammation, Apoptosis, and Mitogen-Activated Protein Kinase Events in Gastric Epithelial-1 Cells |
| Nobiletin | Gastric Cancer | 1 | PM | 27428937 | 📋 | Nobiletin Induces Protective Autophagy Accompanied by ER-Stress Mediated Apoptosis in Human Gastric Cancer SNU-16 Cells |
| Nobiletin | Gastric Ulcer | 1 | PM | 28948855 | 📋 | The gastroprotective effect of nobiletin against ethanol-induced acute gastric lesions in mice: impact on oxidative stress and inflammation |
| Nobiletin | Helicobacter Pylori Infection | 1 | PM | 32479014 | 📋 | Nobiletin Inhibits Helicobacterium pylori Infection-Induced Gastric Carcinogenic Signaling by Blocking Inflammation, Apoptosis, and Mitogen-Activated Protein Kinase Events in Gastric Epithelial-1 Cells |
| Nobiletin | Hepatic Fibrosis | 2 | PM | 38044268 | 📋 | Nobiletin Alleviated Epithelial-Mesenchymal Transition of Hepatocytes in Liver Fibrosis Based on Autophagy-Hippo/YAP Pathway |
| Nobiletin | Hepatic Fibrosis | 1 | PM | 34695558 | 📋 | Nobiletin mitigates hepatocytes death, liver inflammation, and fibrosis in a murine model of NASH through modulating hepatic oxidative stress and mitochondrial dysfunction |
| Nobiletin | Hepatic Ischemia-Reperfusion | 2 | PM | 31028246 | 📋 | Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1/FOXO3a-mediated autophagy and mitochondrial biogenesis |
| Nobiletin | Hepatic Ischemia-Reperfusion | 1 | PM | 28273635 | 📋 | Nobiletin ameliorates ischemia-reperfusion injury by suppressing the function of Kupffer cells after liver transplantation in rats |
| Nobiletin | Hepatic Steatosis | 3 | PM | 37116815 | 📋 | A Lipidomic Study: Nobiletin ameliorates hepatic steatosis through regulation of lipid alternation |
| Nobiletin | Hepatic Steatosis | 2 | PM | 35997288 | 📋 | The biological clock enhancer nobiletin ameliorates steatosis in obesity by restoring aberrant hepatic circadian rhythm |
| Nobiletin | Hepatic Steatosis | 1 | PM | 31964763 | 📋 | The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK |
| Nobiletin | Hepatitis B | 1 | PM | 31954513 | 📋 | Nobiletin, a novel inhibitor, inhibits HBsAg production and hepatitis B virus replication |
| Nobiletin | Hepatitis C | 1 | PM | 15844836 | 📋 | Anti-hepatitis C virus effect of citrus unshiu peel and its active ingredient nobiletin |
| Nobiletin | Inflammatory Bowel Disease | 1 | PM | 30301267 | 📋 | Citrus aurantium L. and Its Flavonoids Regulate TNBS-Induced Inflammatory Bowel Disease through Anti-Inflammation and Suppressing Isolated Jejunum Contraction |
| Nobiletin | Intestinal Permeability | 2 | PM | 32249565 | 📋 | Nobiletin Attenuates DSS-Induced Intestinal Barrier Damage through the HNF4α-Claudin-7 Signaling Pathway |
| Nobiletin | Intestinal Permeability | 1 | PM | 25655748 | 📋 | Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function |
| Nobiletin | Liver Cancer | 1 | PM | 23537747 | 📋 | Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells |
| Nobiletin | Liver Disease | 1 | PM | 38487166 | 📋 | Nobiletin from citrus peel: a promising therapeutic agent for liver disease-pharmacological characteristics, mechanisms, and potential applications |
| Nobiletin | MAFLD | 11 | PM | 38474489 | 📋 | Involvement of Bile Acid Metabolism and Gut Microbiota in the Amelioration of Experimental Metabolism-Associated Fatty Liver Disease by Nobiletin |
| Nobiletin | MAFLD | 10 | PM | 38073108 | 📋 | Nobiletin Ameliorates Hepatic Lipid Deposition, Oxidative Stress, and Inflammation by Mechanisms That Involve the Nrf2/NF-κB Axis in Nonalcoholic Fatty Liver Disease |
| Nobiletin | MAFLD | 9 | PM | 37139957 | 📋 | Nobiletin Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Gut Microbiota and Myristoleic Acid Metabolism |
| Nobiletin | MAFLD | 8 | PM | 36985541 | 📋 | Nobiletin Intake Attenuates Hepatic Lipid Profiling and Oxidative Stress in HFD-Induced Nonalcoholic-Fatty-Liver-Disease Mice |
| Nobiletin | MAFLD | 7 | PM | 36111578 | 📋 | Nobiletin mitigates NAFLD via lipophagy and inflammation |
| Nobiletin | MAFLD | 6 | PM | 35997288 | 📋 | The biological clock enhancer nobiletin ameliorates steatosis in obesity by restoring aberrant hepatic circadian rhythm |
| Nobiletin | MAFLD | 5 | PM | 34349877 | 📋 | Efficacy of nobiletin in improving hypercholesterolemia and nonalcoholic fatty liver disease in high-cholesterol diet-fed mice |
| Nobiletin | MAFLD | 4 | PM | 33096235 | 📋 | Nobiletin alleviates high-fat diet-induced non-alcoholic fatty liver disease by modulating AdipoR1 and gp91 phox expression in rats |
| Nobiletin | MAFLD | 3 | PM | 30387829 | 📋 | Nobiletin alleviates palmitic acid‑induced NLRP3 inflammasome activation in a sirtuin 1‑dependent manner in AML‑12 cells |
| Nobiletin | MAFLD | 2 | PM | 29552085 | 📋 | Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase |
| Nobiletin | MAFLD | 1 | PM | 28116779 | 📋 | Long-term dietary supplementation with low-dose nobiletin ameliorates hepatic steatosis, insulin resistance, and inflammation without altering fat mass in diet-induced obesity |
| Nobiletin | Nasopharyngeal Cancer | 2 | PM | 30918653 | 📋 | Nobiletin induces growth inhibition and apoptosis in human nasopharyngeal carcinoma C666-1 cells through regulating PARP-2/SIRT1/AMPK signaling pathway |
| Nobiletin | Nasopharyngeal Cancer | 1 | PM | 25563790 | 📋 | Nobiletin inhibits invasion and migration of human nasopharyngeal carcinoma cell lines by involving ERK1/2 and transcriptional inhibition of MMP-2 |
| Nobiletin | Non-Alcoholic Steatohepatitis | 2 | PM | 34695558 | 📋 | Nobiletin mitigates hepatocytes death, liver inflammation, and fibrosis in a murine model of NASH through modulating hepatic oxidative stress and mitochondrial dysfunction |
| Nobiletin | Non-Alcoholic Steatohepatitis | 1 | PM | 34093242 | 📋 | Nobiletin Alleviates Non-alcoholic Steatohepatitis in MCD-Induced Mice by Regulating Macrophage Polarization |
| Nobiletin | Oral Cancer | 1 | PM | 32868254 | 📋 | Nobiletin selectively inhibits oral cancer cell growth by promoting apoptosis and DNA damage in vitro |
| Nobiletin | Oral Cancer | 2 | PM | 32724614 | 📋 | Nobiletin inhibits cell growth through restraining aerobic glycolysis via PKA-CREB pathway in oral squamous cell carcinoma |
| Nobiletin | Pancreatic Cancer | 1 | PM | 32521908 | 📋 | Nobiletin flavone inhibits the growth and metastasis of human pancreatic cancer cells via induction of autophagy, G0/G1 cell cycle arrest and inhibition of NF-kB signalling pathway |
| Nobiletin | Ulcerative Colitis | 1 | PM | 31220438 | 📋 | Flavonoids from Citrus aurantium ameliorate TNBS-induced ulcerative colitis through protecting colonic mucus layer integrity |
