| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Metformin | Biliary Tract Cancer | 2 | PM | 38170336 | 📋 | Metformin Increases the Response of Cholangiocarcinoma Cells to Gemcitabine by Suppressing Pyruvate Kinase M2 to Activate Mitochondrial Apoptosis |
| Metformin | Biliary Tract Cancer | 1 | PM | 36708293 | 📋 | Impact of metformin on the incidence of human cholangiocarcinoma in diabetic patients: a systematic review and meta-analysis |
| Metformin | Cholestasis | 1 | PM | 31791444 | 📋 | Metformin ameliorates bile duct ligation-induced acute hepatic injury via regulation of ER stress |
| Metformin | Colitis | 1 | PM | 35645830 | 📋 | Metformin Ameliorates Chronic Colitis-Related Intestinal Fibrosis via Inhibiting TGF-β1/Smad3 Signaling |
| Metformin | Colon Cancer | 5 | PM | 38215022 | 📋 | Association of metformin and statin uses with the prognosis of colon cancer: a meta-analysis |
| Metformin | Colon Cancer | 3 | PM | 37268905 | 📋 | Synergistic apoptosis by combination of metformin and an O-GlcNAcylation inhibitor in colon cancer cells |
| Metformin | Colon Cancer | 2 | PM | 36929658 | 📋 | Metformin and thymoquinone co-treatment enhance 5-fluorouracil cytotoxicity by suppressing the PI3K/mTOR/HIF1α pathway and increasing oxidative stress in colon cancer cells |
| Metformin | Colon Cancer | 1 | PM | 35326689 | 📋 | In Vivo and In Vitro Enhanced Tumoricidal Effects of Metformin, Active Vitamin D 3, and 5-Fluorouracil Triple Therapy against Colon Cancer by Modulating the PI3K/Akt/PTEN/mTOR Network |
| Metformin | Colon Cancer | 4 | PM | 33147367 | 📋 | Cytotoxicity of metformin against HT29 colon cancer cells contributes to mitochondrial Sirt3 upregulation |
| Metformin | Colon Polyps | 1 | PM | 37987968 | 📋 | Is Metformin Associated with a Lower Prevalence of Polyps, Adenomas, and Colorectal Carcinoma in Patients with Diabetes Mellitus? |
| Metformin | Colorectal Cancer | 22 | PM | 38518387 | 📋 | Metformin's role in lowering colorectal cancer risk among individuals with diabetes from the Southern Community Cohort Study |
| Metformin | Colorectal Cancer | 21 | PM | 38347775 | 📋 | Metformin Inhibits NLRP3 Inflammasome Expression and Regulates Inflammatory Microenvironment to Delay the Progression of Colorectal Cancer |
| Metformin | Colorectal Cancer | 20 | PM | 37712263 | 📋 | [Metformin inhibits self-renewal of colorectal cancer stem cells by inhibiting mitochondrial oxidative phosphorylation] |
| Metformin | Colorectal Cancer | 19 | PM | 37601689 | 📋 | Metformin is a metabolic modulator and radiosensitiser in rectal cancer |
| Metformin | Colorectal Cancer | 18 | PM | 37509386 | 📋 | Metformin Treatment Reduces CRC Aggressiveness in a Glucose-Independent Manner: An In Vitro and Ex Vivo Study |
| Metformin | Colorectal Cancer | 17 | PM | 37312884 | 📋 | Metformin Induces a Caspase 3-Unrelated Apoptosis in Human Colorectal Cancer Cell Lines HCT116 and SW620 |
| Metformin | Colorectal Cancer | 15 | PM | 37225730 | 📋 | Association between visceral obesity, metformin use, and recurrence risk in early-stage colorectal cancer |
| Metformin | Colorectal Cancer | 14 | PM | 37195082 | 📋 | Metformin reprograms tryptophan metabolism to stimulate CD8+ T cell function in colorectal cancer |
| Metformin | Colorectal Cancer | 13 | PM | 37132307 | 📋 | Metformin: A Promising Radiosensitizer in Neoadjuvant Rectal Cancer Treatment |
| Metformin | Colorectal Cancer | 12 | PM | 37102105 | 📋 | Overcoming chemoresistance in non-angiogenic colorectal cancer by metformin via inhibiting endothelial apoptosis and vascular immaturity |
| Metformin | Colorectal Cancer | 11 | PM | 37077173 | 📋 | The impact of metformin on survival in diabetes patients with operable colorectal cancer: A nationwide retrospective cohort study |
| Metformin | Colorectal Cancer | 10 | PM | 37042113 | 📋 | Elevated basal AMP-activated protein kinase activity sensitizes colorectal cancer cells to growth inhibition by metformin |
| Metformin | Colorectal Cancer | 9 | PM | 36781298 | 📋 | Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities |
| Metformin | Colorectal Cancer | 8 | PM | 36645225 | 📋 | Novel strategies to reverse chemoresistance in colorectal cancer |
| Metformin | Colorectal Cancer | 7 | PM | 36396820 | 📋 | Metformin abrogates Fusobacterium nucleatum-induced chemoresistance in colorectal cancer by inhibiting miR-361-5p/sonic hedgehog signaling-regulated stemness |
| Metformin | Colorectal Cancer | 6 | PM | 35902376 | 📋 | Metformin and testosterone replacement therapy inversely associated with hormone-associated cancers (prostate, colorectal and male breast cancers) among older White and Black men |
| Metformin | Colorectal Cancer | 5 | PM | 35859114 | 📋 | The effect of metformin on the survival of colorectal cancer patients with type 2 diabetes mellitus |
| Metformin | Colorectal Cancer | 4 | PM | 35780231 | 📋 | Metformin inhibits the development and metastasis of colorectal cancer |
| Metformin | Colorectal Cancer | 3 | PM | 35740547 | 📋 | Tumor-Suppressive Effect of Metformin via the Regulation of M2 Macrophages and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment of Colorectal Cancer |
| Metformin | Colorectal Cancer | 2 | PM | 35731713 | 📋 | Combination of mTOR inhibitor PP242 and AMPK activator metformin exerts enhanced inhibitory effects on colorectal carcinoma cells in vitro by blocking multiple kinase pathways |
| Metformin | Colorectal Cancer | 1 | PM | 35676792 | 📋 | Cytotoxic effect of metformin on butyrate-resistant PMF-K014 colorectal cancer spheroid cells |
| Metformin | Colorectal Cancer | 16 | PM | 32533543 | 📋 | Metformin, Microbiome and Protection Against Colorectal Cancer |
| Metformin | Dysbiosis | 10 | PM | 37795356 | 📋 | Metformin targets intestinal immune system signaling pathways in a high-fat diet-induced mouse model of obesity and insulin resistance |
| Metformin | Dysbiosis | 9 | PM | 37696355 | 📋 | Effects of metformin on the gut microbiota: A systematic review |
| Metformin | Dysbiosis | 8 | PM | 37398234 | 📋 | Changes in the gut mycobiome are associated with Type 2 diabetes mellitus and metformin treatment across populations |
| Metformin | Dysbiosis | 7 | PM | 36593662 | 📋 | Metformin modulates the gut microbiome in a mice model of high-fat diet-induced glycolipid metabolism disorder |
| Metformin | Dysbiosis | 6 | PM | 36465607 | 📋 | Gut microbiota is correlated with gastrointestinal adverse events of metformin in patients with type 2 diabetes |
| Metformin | Dysbiosis | 5 | PM | 35743280 | 📋 | Metformin Influence on the Intestinal Microbiota and Organism of Rats with Metabolic Syndrome |
| Metformin | Dysbiosis | 4 | PM | 34579018 | 📋 | Perilla Seed Oil Alleviates Gut Dysbiosis, Intestinal Inflammation and Metabolic Disturbance in Obese-Insulin-Resistant Rats |
| Metformin | Dysbiosis | 1 | PM | 33716449 | 📋 | Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats |
| Metformin | Dysbiosis | 2 | PM | 33584555 | 📋 | The Therapeutic Efficacy of Curcumin vs. Metformin in Modulating the Gut Microbiota in NAFLD Rats: A Comparative Study |
| Metformin | Dysbiosis | 3 | PM | 33135040 | 📋 | Luteolin cooperated with metformin hydrochloride alleviates lipid metabolism disorders and optimizes intestinal flora compositions of high-fat diet mice |
| Metformin | Esophageal Cancer | 4 | PM | 38474224 | 📋 | Metformin in Esophageal Carcinoma: Exploring Molecular Mechanisms and Therapeutic Insights |
| Metformin | Esophageal Cancer | 3 | PM | 37314979 | 📋 | Diabetes, metformin use and survival in esophageal cancer: a population-based cohort study |
| Metformin | Esophageal Cancer | 1 | PM | 37063031 | 📋 | Is metformin use associated with a reduced risk of oesophageal cancer? A systematic review and meta-analysis |
| Metformin | Esophageal Cancer | 2 | PM | 29435022 | 📋 | Metformin inhibits the migration and invasion of esophageal squamous cell carcinoma cells by downregulating the protein kinase B signaling pathway |
| Metformin | Familial Adenomatous Polyposis | 2 | PM | 38403687 | 📋 | Clinical efficacy of metformin in familial adenomatous polyposis and the effect of intestinal flora |
| Metformin | Familial Adenomatous Polyposis | 1 | PM | 36595813 | 📋 | Metformin combined with endoscopic therapy in patients with familial polyposis associated with carcinoma: A case report |
| Metformin | Gallbladder Cancer | 1 | PM | 29110119 | 📋 | Metformin synergistically enhances antitumor activity of cisplatin in gallbladder cancer via the PI3K/AKT/ERK pathway |
| Metformin | Gastric Cancer | 11 | PM | 38167385 | 📋 | Metformin suppresses proliferation and glycolysis of gastric cancer by modulating ADAMTS12 |
| Metformin | Gastric Cancer | 10 | PM | 37937302 | 📋 | Metformin induces autophagy of cisplatin-resistant human gastric cancer cells in addition to apoptosis |
| Metformin | Gastric Cancer | 9 | PM | 37627162 | 📋 | Association of Metformin Treatment with Risk for Death in Diabetic Patients with Concomitant Gastric Cancer |
| Metformin | Gastric Cancer | 8 | PM | 37600406 | 📋 | Metformin promotes cGAS/STING signaling pathway activation by blocking AKT phosphorylation in gastric cancer |
| Metformin | Gastric Cancer | 7 | PM | 37526857 | 📋 | Effect of Metformin Use on Survival and Recurrence Rate of Gastric Cancer After Gastrectomy in Diabetic Patients: A Systematic Review and Meta-analysis of Observational Studies |
| Metformin | Gastric Cancer | 5 | PM | 37213670 | 📋 | Synergistic Effect of Metformin and Lansoprazole Against Gastric Cancer through Growth Inhibition |
| Metformin | Gastric Cancer | 4 | PM | 36915376 | 📋 | Effect of Metformin on the Prognosis of Gastric Cancer Patients with Type 2 Diabetes Mellitus: A Meta-Analysis Based on Retrospective Cohort Studies |
| Metformin | Gastric Cancer | 3 | PM | 36430639 | 📋 | Mechanism Underlying Metformin Action and Its Potential to Reduce Gastric Cancer Risk |
| Metformin | Gastric Cancer | 2 | PM | 35704903 | 📋 | Combination of metformin and oxaliplatin inhibits gastric cancer cell proliferation and induces apoptosis |
| Metformin | Gastric Cancer | 1 | PM | 34924899 | 📋 | Synergistic effects of metformin and curcumin on cytotoxicity of chemotherapy drugs using a gastric cancer cell line model |
| Metformin | Gastric Cancer | 6 | PM | 29391902 | 📋 | Metformin use and its effect on gastric cancer in patients with type 2 diabetes: A systematic review of observational studies |
| Metformin | Gastric Ulcer | 1 | PM | 35946894 | 📋 | The Effect of Metformin on Ethanol- and Indomethacin-Induced Gastric Ulcers in Rats |
| Metformin | Gastric Ulcer | 2 | PM | 33345855 | 📋 | The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway |
| Metformin | Helicobacter Pylori Infection | 3 | PM | 38192437 | 📋 | Antibacterial and Immunoregulatory Effects of Metformin against Helicobacter pylori Infection in Rat Model |
| Metformin | Helicobacter Pylori Infection | 2 | PM | 35974929 | 📋 | Effect of metformin on the eradication of H.Pylori infection in 25 -75 years old patients referring Loghman Hakim Hospital |
| Metformin | Helicobacter Pylori Infection | 1 | PM | 35731346 | 📋 | Helicobacter pylori-mediated gastric pathogenesis is attenuated by treatment of 2-deoxyglucose and metformin |
| Metformin | Hepatic Encephalopathy | 1 | PM | 37491245 | 📋 | Gallic acid and metformin co-administration reduce oxidative stress, apoptosis and inflammation via Fas/caspase-3 and NF-κB signaling pathways in thioacetamide-induced acute hepatic encephalopathy in rats |
| Metformin | Hepatic Failure | 1 | PM | 38097010 | 📋 | Metformin treatment is associated with improved survival in diabetic patients hospitalized with acute heart failure: A prospective observational study using the Korean acute heart failure registry data |
| Metformin | Hepatic Fibrosis | 5 | PM | 38288020 | 📋 | Metformin exerts anti-liver fibrosis effect based on the regulation of gut microbiota homeostasis and multi-target synergy |
| Metformin | Hepatic Fibrosis | 4 | PM | 37451514 | 📋 | Metformin ameliorates liver fibrosis induced by congestive hepatopathy via the mTOR/HIF-1α signaling pathway |
| Metformin | Hepatic Fibrosis | 3 | PM | 36893671 | 📋 | Metformin alleviates liver fibrosis in mice by enriching Lactobacillus sp. MF-1 in the gut microbiota |
| Metformin | Hepatic Fibrosis | 2 | PM | 36716817 | 📋 | Metformin induces mitochondrial fission and reduces energy metabolism by targeting respiratory chain complex I in hepatic stellate cells to reverse liver fibrosis |
| Metformin | Hepatic Fibrosis | 1 | PM | 35093389 | 📋 | Metformin versus Silymarin as Hepatoprotective Agents in Mice Fibrotic Model Caused by Carbon Tetrachloride |
| Metformin | Hepatic Steatosis | 7 | PM | 38116565 | 📋 | Hepatic Steatosis Alleviated by a Novel Metformin and Quercetin Combination Activating Autophagy Through the cAMP/AMPK/SIRT1 Pathway |
| Metformin | Hepatic Steatosis | 4 | PM | 37075944 | 📋 | The combination of metformin with morin alleviates hepatic steatosis via modulating hepatic lipid metabolism, hepatic inflammation, brown adipose tissue thermogenesis, and white adipose tissue browning in high-fat diet-fed mice |
| Metformin | Hepatic Steatosis | 3 | PM | 36120597 | 📋 | Exercise and Metformin Intervention Prevents Lipotoxicity-Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK/Nrf2/HO-1 Signaling Pathway in db/db Mice |
| Metformin | Hepatic Steatosis | 2 | PM | 35893386 | 📋 | Metformin Improves the Hepatic Steatosis Index in Non-Obese Patients with Polycystic Ovary Syndrome |
| Metformin | Hepatic Steatosis | 1 | PM | 35056941 | 📋 | The Beneficial Additive Effect of Silymarin in Metformin Therapy of Liver Steatosis in a Pre-Diabetic Model |
| Metformin | Hepatic Steatosis | 6 | PM | 25111690 | 📋 | Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes |
| Metformin | Hepatic Steatosis | 5 | PM | 24253218 | 📋 | Metformin prevents hepatic steatosis by regulating the expression of adipose differentiation-related protein |
| Metformin | Hepatitis B | 1 | PM | 24164660 | 📋 | Metformin inhibits hepatitis B virus protein production and replication in human hepatoma cells |
| Metformin | Inflammatory Bowel Disease | 1 | PM | 36099786 | 📋 | Repurposing metformin as a potential treatment for inflammatory bowel disease: Evidence from cell to the clinic |
| Metformin | Intestinal Injury | 2 | PM | 37446172 | 📋 | The Role of Activating Transcription Factor 3 in Metformin's Alleviation of Gastrointestinal Injury Induced by Restraint Stress in Mice |
| Metformin | Intestinal Injury | 1 | PM | 36327871 | 📋 | Metformin ameliorates 5-fluorouracil-induced intestinal injury by inhibiting cellular senescence, inflammation, and oxidative stress |
| Metformin | Intestinal Metaplasia | 1 | PM | 35731346 | 📋 | Helicobacter pylori-mediated gastric pathogenesis is attenuated by treatment of 2-deoxyglucose and metformin |
| Metformin | Intestinal Mucositis | 1 | PM | 36312920 | 📋 | Metformin alleviates irradiation-induced intestinal injury by activation of FXR in intestinal epithelia |
| Metformin | Intestinal Permeability | 5 | PM | 35890109 | 📋 | Metabolic Action of Metformin |
| Metformin | Intestinal Permeability | 4 | PM | 35693534 | 📋 | Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function |
| Metformin | Intestinal Permeability | 3 | PM | 35682612 | 📋 | Metformin Protects the Intestinal Barrier by Activating Goblet Cell Maturation and Epithelial Proliferation in Radiation-Induced Enteropathy |
| Metformin | Intestinal Permeability | 2 | PM | 34579018 | 📋 | Perilla Seed Oil Alleviates Gut Dysbiosis, Intestinal Inflammation and Metabolic Disturbance in Obese-Insulin-Resistant Rats |
| Metformin | Intestinal Permeability | 1 | PM | 33584555 | 📋 | The Therapeutic Efficacy of Curcumin vs. Metformin in Modulating the Gut Microbiota in NAFLD Rats: A Comparative Study |
| Metformin | Liver Cancer | 23 | PM | 38413541 | 📋 | Identification of glucose-independent and reversible metabolic pathways associated with anti-proliferative effect of metformin in liver cancer cells |
| Metformin | Liver Cancer | 22 | PM | 37997519 | 📋 | Metformin reduces hepatocarcinogenesis by inducing downregulation of Cyp26a1 and CD8+ T cells |
| Metformin | Liver Cancer | 21 | PM | 37893061 | 📋 | Regulation of Protein-Induced Apoptosis and Autophagy in Human Hepatocytes Treated with Metformin and Paclitaxel In Silico and In Vitro |
| Metformin | Liver Cancer | 20 | PM | 37760509 | 📋 | Antitumor Activity of Metformin Combined with Locoregional Therapy for Liver Cancer: Evidence and Future Directions |
| Metformin | Liver Cancer | 19 | PM | 37529015 | 📋 | Metformin Induces Lipogenesis and Apoptosis in H4IIE Hepatocellular Carcinoma Cells |
| Metformin | Liver Cancer | 17 | PM | 37370771 | 📋 | The Emerging Role of Metformin in the Treatment of Hepatocellular Carcinoma: Is There Any Value in Repurposing Metformin for HCC Immunotherapy? |
| Metformin | Liver Cancer | 16 | PM | 37326750 | 📋 | Metformin promotes ferroptosis and sensitivity to sorafenib in hepatocellular carcinoma cells via ATF4/STAT3 |
| Metformin | Liver Cancer | 13 | PM | 37208925 | 📋 | Metformin synergistically enhances the antitumour activity of Lenvatinib in hepatocellular carcinoma by altering AKT-FOXO3 signalling pathway |
| Metformin | Liver Cancer | 12 | PM | 36669583 | 📋 | Twist1-YY1-p300 complex promotes the malignant progression of HCC through activation of miR-9 by forming phase-separated condensates at super-enhancers and relieved by metformin |
| Metformin | Liver Cancer | 11 | PM | 36583006 | 📋 | The effect of metformin usage on survival outcomes for hepatocellular carcinoma patients with type 2 diabetes mellitus after curative therapy |
| Metformin | Liver Cancer | 10 | PM | 36411886 | 📋 | Plasma exosomal miR-122 regulates the efficacy of metformin via AMPK in type 2 diabetes and hepatocellular carcinoma |
| Metformin | Liver Cancer | 9 | PM | 36321555 | 📋 | Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis |
| Metformin | Liver Cancer | 8 | PM | 36208843 | 📋 | Metformin reduces hepatocellular carcinoma incidence after successful antiviral therapy in patients with diabetes and chronic hepatitis C in Taiwan |
| Metformin | Liver Cancer | 7 | PM | 36118519 | 📋 | Combination of Metformin and Sorafenib Induces Ferroptosis of Hepatocellular Carcinoma Through p62-Keap1-Nrf2 Pathway |
| Metformin | Liver Cancer | 6 | PM | 35897659 | 📋 | Metformin Enhances the Anti-Cancer Efficacy of Sorafenib via Suppressing MAPK/ERK/Stat3 Axis in Hepatocellular Carcinoma |
| Metformin | Liver Cancer | 5 | PM | 35747976 | 📋 | Recent Insights of Metformin on Hepatocellular Carcinoma (HCC) |
| Metformin | Liver Cancer | 4 | PM | 35679661 | 📋 | Metformin modulate immune fitness in hepatocellular carcinoma: Molecular and cellular approach |
| Metformin | Liver Cancer | 3 | PM | 34779535 | 📋 | Effect of diabetes medications and glycemic control on risk of hepatocellular cancer in patients with nonalcoholic fatty liver disease |
| Metformin | Liver Cancer | 1 | PM | 34536497 | 📋 | In-vitro and in-vivo investigation of amygdalin, metformin, and combination of both against doxorubicin on hepatocellular carcinoma |
| Metformin | Liver Cancer | 18 | PM | 31830378 | 📋 | Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway |
| Metformin | Liver Cancer | 15 | PM | 29117515 | 📋 | Metformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells |
| Metformin | Liver Cancer | 2 | PM | 28833603 | 📋 | Metformin Incombination With Curcumin Inhibits the Growth, Metastasis, and Angiogenesis of Hepatocellular Carcinoma in Vitro and in Vivo |
| Metformin | Liver Cancer | 14 | PM | 24378856 | 📋 | Effect of the anti-diabetic drug metformin in hepatocellular carcinoma in vitro and in vivo |
| Metformin | Liver Damage | 4 | PM | 37255805 | 📋 | Drug repurposing: Metformin's effect against liver tissue damage in diabetes and prostate cancer model |
| Metformin | Liver Damage | 3 | PM | 36315407 | 📋 | Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling |
| Metformin | Liver Damage | 2 | PM | 32371063 | 📋 | NLRP3 Inflammasome Drives Inflammation in High Fructose Fed Diabetic Rat Liver: Effect of Resveratrol and Metformin |
| Metformin | Liver Damage | 1 | PM | 30205096 | 📋 | Malaysian Propolis, Metformin and Their Combination, Exert Hepatoprotective Effect in Streptozotocin-Induced Diabetic Rats |
| Metformin | Liver Disease | 1 | PM | 38192642 | 📋 | Metformin: update on mechanisms of action on liver diseases |
| Metformin | MAFLD | 16 | PM | 38244761 | 📋 | Metformin improves nonalcoholic fatty liver disease in db/db mice by inhibiting ferroptosis |
| Metformin | MAFLD | 14 | PM | 37209153 | 📋 | A novel combination of metformin and resveratrol alleviates hepatic steatosis by activating autophagy through the cAMP/AMPK/SIRT1 signaling pathway |
| Metformin | MAFLD | 13 | PM | 37100305 | 📋 | Combination Therapy of Metformin and p-Coumaric Acid Mitigates Metabolic Dysfunction Associated with Obesity and Non-Alcoholic Fatty Liver Disease in High-Fat Diet Obese C57BL/6 Mice |
| Metformin | MAFLD | 12 | PM | 36815659 | 📋 | Pharmacological Action of Atorvastatin and Metformin on Non-alcoholic Fatty Liver Disease on an Experimental Model of Metabolic Syndrome |
| Metformin | MAFLD | 11 | PM | 36791804 | 📋 | Comparison of the efficacy of pioglitazone and metformin on ultrasound grade and liver enzymes level in patients with non-alcoholic fatty liver disease: A randomized controlled clinical trial |
| Metformin | MAFLD | 10 | PM | 36316840 | 📋 | Effect of metformin on nonalcoholic fatty liver based on meta-analysis and network pharmacology |
| Metformin | MAFLD | 9 | PM | 36103959 | 📋 | Metformin, pioglitazone, dapagliflozin and their combinations ameliorate manifestations associated with NAFLD in rats via anti-inflammatory, anti-fibrotic, anti-oxidant and anti-apoptotic mechanisms |
| Metformin | MAFLD | 8 | PM | 36077467 | 📋 | Reversal of High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Metformin Combined with PGG, an Inducer of Glycine N-Methyltransferase |
| Metformin | MAFLD | 1 | PM | 34533249 | 📋 | The effects of co-administration of artichoke leaf extract supplementation with metformin and vitamin E in patients with nonalcoholic fatty liver disease: A randomized clinical trial |
| Metformin | MAFLD | 7 | PM | 34168429 | 📋 | Metformin in Combination with Malvidin Prevents Progression of Non-Alcoholic Fatty Liver Disease via Improving Lipid and Glucose Metabolisms, and Inhibiting Inflammation in Type 2 Diabetes Rats |
| Metformin | MAFLD | 4 | PM | 33584555 | 📋 | The Therapeutic Efficacy of Curcumin vs. Metformin in Modulating the Gut Microbiota in NAFLD Rats: A Comparative Study |
| Metformin | MAFLD | 3 | PM | 33326684 | 📋 | Combination of metformin and chlorogenic acid attenuates hepatic steatosis and inflammation in high-fat diet fed mice |
| Metformin | MAFLD | 5 | PM | 32956824 | 📋 | Combination of metformin and genistein alleviates non-alcoholic fatty liver disease in high-fat diet-fed mice |
| Metformin | MAFLD | 15 | PM | 24253218 | 📋 | Metformin prevents hepatic steatosis by regulating the expression of adipose differentiation-related protein |
| Metformin | MAFLD | 2 | PM | 23234816 | 📋 | Investigation of the effects of Chlorella vulgaris supplementation in patients with non-alcoholic fatty liver disease: a randomized clinical trial |
| Metformin | MAFLD | 6 | PM | 23087748 | 📋 | Effects of Metformin, Pioglitazone, and Silymarin Treatment on Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Pilot Study |
| Metformin | Nasopharyngeal Cancer | 2 | PM | 37185411 | 📋 | The Association between Metformin and the Cancer-Specific Mortality Rate in Nasopharyngeal Cancer Patients: Real-World Evidence |
| Metformin | Nasopharyngeal Cancer | 1 | PM | 33441838 | 📋 | Effects of different combined regimens of cisplatin, metformin, and quercetin on nasopharyngeal carcinoma cells and subcutaneous xenografts |
| Metformin | Non-Alcoholic Steatohepatitis | 1 | PM | 37652508 | 📋 | Comparing the Influences of Metformin and Berberine on the Intestinal Microbiota of Rats With Nonalcoholic Steatohepatitis |
| Metformin | Oral Cancer | 4 | PM | 37738154 | 📋 | Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma |
| Metformin | Oral Cancer | 2 | PM | 36509195 | 📋 | Metformin inhibits oral squamous cell carcinoma progression through regulating RNA alternative splicing |
| Metformin | Oral Cancer | 1 | PM | 36077722 | 📋 | Inhibition of Autophagy Promotes the Anti-Tumor Effect of Metformin in Oral Squamous Cell Carcinoma |
| Metformin | Oral Cancer | 3 | PM | 28618017 | 📋 | Curcumin and metformin-mediated chemoprevention of oral cancer is associated with inhibition of cancer stem cells |
| Metformin | Oral Mucositis | 2 | PM | 37131014 | 📋 | The Effect of Metformin on Chemotherapy-Induced Toxicities in Non-diabetic Breast Cancer Patients: A Randomised Controlled Study |
| Metformin | Oral Mucositis | 1 | PM | 35405270 | 📋 | Metformin protects 5-Fu-induced chemotherapy oral mucositis by reducing endoplasmic reticulum stress in mice |
| Metformin | Pancreatic Cancer | 11 | PM | 38530777 | 📋 | Metformin boosts anti-tumor immunity and improves prognosis in upfront resected pancreatic cancer: an observational study |
| Metformin | Pancreatic Cancer | 10 | PM | 37752238 | 📋 | Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice |
| Metformin | Pancreatic Cancer | 7 | PM | 37293149 | 📋 | Anti-cancer effects of metformin in a 3D co-culture model of pancreatic ductal adenocarcinoma |
| Metformin | Pancreatic Cancer | 6 | PM | 37030634 | 📋 | Metformin inhibits neutrophil extracellular traps-promoted pancreatic carcinogenesis in obese mice |
| Metformin | Pancreatic Cancer | 5 | PM | 36829129 | 📋 | The relationship between the use of metformin and the risk of pancreatic cancer in patients with diabetes: a systematic review and meta-analysis |
| Metformin | Pancreatic Cancer | 4 | PM | 36678613 | 📋 | Metformin Induces Apoptosis in Human Pancreatic Cancer (PC) Cells Accompanied by Changes in the Levels of Histone Acetyltransferases (Particularly, p300/CBP-Associated Factor (PCAF) Protein Levels) |
| Metformin | Pancreatic Cancer | 3 | PM | 36583563 | 📋 | Anticancer Benefit of Metformin in Patients With Early-Stage Pancreatic Cancer: A Retrospective Cohort Study |
| Metformin | Pancreatic Cancer | 2 | PM | 36428689 | 📋 | The NAMPT Inhibitor FK866 Increases Metformin Sensitivity in Pancreatic Cancer Cells |
| Metformin | Pancreatic Cancer | 9 | PM | 29434877 | 📋 | Metformin synergizes with rapamycin to inhibit the growth of pancreatic cancer in vitro and in vivo |
| Metformin | Pancreatic Cancer | 8 | PM | 28875433 | 📋 | Crucial microRNAs and genes in metformin's anti-pancreatic cancer effect explored by microRNA-mRNA integrated analysis |
| Metformin | Pancreatic Cancer | 1 | PM | 26709750 | 📋 | Bulk Pancreatic Cancer Cells Can Convert Into Cancer Stem cells(CSCs) in Vitro and 2 Compounds Can Target These CSCs |
| Metformin | Peritoneal Adhesions | 1 | PM | 35703816 | 📋 | Effect of Metformin on HIF-1α Signaling and Postoperative Adhesion Formation |
| Metformin | Primary Biliary Cholangitis | 1 | PM | 37307826 | 📋 | The inhibition of YAP Signaling Prevents Chronic Biliary Fibrosis in the Abcb4-/- Model by Modulation of Hepatic Stellate Cell and Bile Duct Epithelium Cell Pathophysiology |
| Metformin | Ulcerative Colitis | 1 | PM | 35724510 | 📋 | Combining the HSP90 inhibitor TAS-116 with metformin effectively degrades the NLRP3 and attenuates inflammasome activation in rats: A new management paradigm for ulcerative colitis |
| Metformin | Ulcerative Colitis | 2 | PM | 29653414 | 📋 | New insights on the modulatory roles of metformin or alpha-lipoic acid versus their combination in dextran sulfate sodium-induced chronic colitis in rats |
