| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Grape Seed extract | Celiac Disease | 1 | PM | 34028481 | 📋 | First morphological-level insights into the efficiency of green tea catechins and grape seed procyanidins on a transgenic mouse model of celiac disease enteropathy |
| Grape Seed extract | Colitis | 1 | PM | 32940671 | 📋 | Emu Oil And Grape Seed Extract Reduce Tumour Burden And Disease Parameters In Murine Colitis-Associated Colorectal Cancer |
| Grape Seed extract | Colon Cancer | 2 | PM | 32718061 | 📋 | Flavonoid and Non-Flavonoid Compounds of Autumn Royal and Egnatia Grape Skin Extracts Affect Membrane PUFA's Profile and Cell Morphology in Human Colon Cancer Cell Lines |
| Grape Seed extract | Colon Cancer | 1 | PM | 27506388 | 📋 | Grape Compounds Suppress Colon Cancer Stem Cells in Vitro and in a Rodent Model of Colon Carcinogenesis |
| Grape Seed extract | Colon Cancer | 4 | PM | 23433299 | 📋 | Grape seed extract triggers apoptosis in Caco-2 human colon cancer cells through reactive oxygen species and calcium increase: extracellular signal-regulated kinase involvement |
| Grape Seed extract | Colon Cancer | 3 | PM | 23026853 | 📋 | Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1 |
| Grape Seed extract | Colorectal Cancer | 10 | PM | 35600365 | 📋 | Berberine and Oligomeric Proanthocyanidins Exhibit Synergistic Efficacy Through Regulation of PI3K-Akt Signaling Pathway in Colorectal Cancer |
| Grape Seed extract | Colorectal Cancer | 9 | PM | 32940671 | 📋 | Emu Oil And Grape Seed Extract Reduce Tumour Burden And Disease Parameters In Murine Colitis-Associated Colorectal Cancer |
| Grape Seed extract | Colorectal Cancer | 5 | PM | 31572588 | 📋 | Antiproliferative and Cytotoxic Effects of Grape Pomace and Grape Seed Extracts on Colorectal Cancer Cell Lines |
| Grape Seed extract | Colorectal Cancer | 8 | PM | 31213831 | 📋 | Grape Seed Procyanidin B2 Promotes the Autophagy and Apoptosis in Colorectal Cancer Cells via Regulating PI3K/Akt Signaling Pathway |
| Grape Seed extract | Colorectal Cancer | 3 | PM | 29684110 | 📋 | Mechanistic Insights Into Anticancer Properties of Oligomeric Proanthocyanidins From Grape Seeds in Colorectal Cancer |
| Grape Seed extract | Colorectal Cancer | 4 | PM | 27506388 | 📋 | Grape Compounds Suppress Colon Cancer Stem Cells in Vitro and in a Rodent Model of Colon Carcinogenesis |
| Grape Seed extract | Colorectal Cancer | 6 | PM | 24465501 | 📋 | Grape Seed Extract Dose-Responsively Decreases Disease Severity in a Rat Model of Mucositis; Concomitantly Enhancing Chemotherapeutic Effectiveness in Colon Cancer Cells |
| Grape Seed extract | Colorectal Cancer | 12 | PM | 23639480 | 📋 | Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation |
| Grape Seed extract | Colorectal Cancer | 11 | PM | 23268334 | 📋 | Differential effects of grape seed extract against human colorectal cancer cell lines: the intricate role of death receptors and mitochondria |
| Grape Seed extract | Colorectal Cancer | 7 | PM | 20540818 | 📋 | Apoptosis-inducing Factor and Caspase-Dependent Apoptotic Pathways Triggered by Different Grape Seed Extracts on Human Colon Cancer Cell Line Caco-2 |
| Grape Seed extract | Colorectal Cancer | 1 | PM | 20072658 | 📋 | Dietary Feeding of Grape Seed Extract Prevents Intestinal Tumorigenesis in APCmin/+ Mice |
| Grape Seed extract | Colorectal Cancer | 2 | PM | 17062697 | 📋 | Grape Seed Extract Inhibits in Vitro and in Vivo Growth of Human Colorectal Carcinoma Cells |
| Grape Seed extract | Diarrhea | 1 | PM | 21534629 | 📋 | Dietary grape-seed procyanidins decreased postweaning diarrhea by modulating intestinal permeability and suppressing oxidative stress in rats |
| Grape Seed extract | Dysbiosis | 5 | PM | 35916585 | 📋 | The effects of grape seed proanthocyanidins in cafeteria diet-induced obese Fischer 344 rats are influenced by faecal microbiota in a photoperiod dependent manner |
| Grape Seed extract | Dysbiosis | 4 | PM | 35794638 | 📋 | Grape seed and skin extract, a potential prebiotic with anti-obesity effect through gut microbiota modulation |
| Grape Seed extract | Dysbiosis | 3 | PM | 35043135 | 📋 | Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a D-galactose-induced aging mouse model by modulating the gut microbiota |
| Grape Seed extract | Dysbiosis | 2 | PM | 34296715 | 📋 | Grape seed proanthocyanidins reduced the overweight of C57BL/6J mice through modulating adipose thermogenesis and gut microbiota |
| Grape Seed extract | Dysbiosis | 1 | PM | 23963706 | 📋 | Dietary Grape Seed Extract Ameliorates Symptoms of Inflammatory Bowel Disease in IL10-deficient Mice |
| Grape Seed extract | Esophageal Cancer | 1 | PM | 30647533 | 📋 | Grape Seed Proanthocyanidin Extract Inhibits Human Esophageal Squamous Cancerous Cell Line ECA109 via the NF- κ B Signaling Pathway |
| Grape Seed extract | Food Poisoning | 1 | PM | 36900445 | 📋 | A Systematic Quantitative Determination of the Antimicrobial Efficacy of Grape Seed Extract against Foodborne Bacterial Pathogens |
| Grape Seed extract | Gastric Cancer | 1 | PM | 33627124 | 📋 | Procyanidin B2 induces apoptosis and autophagy in gastric cancer cells by inhibiting Akt/mTOR signaling pathway |
| Grape Seed extract | Gastric Motility Disorders | 1 | PM | 35693751 | 📋 | Grape seed powder increases gastrointestinal motility |
| Grape Seed extract | Gastric Ulcer | 1 | PM | 23456451 | 📋 | Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats |
| Grape Seed extract | Gastroenteritis | 2 | PM | 37866900 | 📋 | Screening of natural extracts with anti-norovirus effects and analysis of this mechanism in grape seed extract |
| Grape Seed extract | Gastroenteritis | 1 | PM | 36431850 | 📋 | Phenol Derivatives Obtained from Grape Seed Extract Show Virucidal Activity against Murine Norovirus |
| Grape Seed extract | Helicobacter Pylori Infection | 2 | PM | 34208004 | 📋 | Pre-Treatment with Grape Seed Extract Reduces Inflammatory Response and Oxidative Stress Induced by Helicobacter pylori Infection in Human Gastric Epithelial Cells |
| Grape Seed extract | Helicobacter Pylori Infection | 1 | PM | 32993186 | 📋 | Procyanidin-Rich Extract from Grape Seeds as a Putative Tool against Helicobacter pylori |
| Grape Seed extract | Hepatic Fibrosis | 1 | PM | 26308756 | 📋 | Hepatoprotective Effects of Grape Seed Procyanidin B2 in Rats With Carbon Tetrachloride-induced Hepatic Fibrosis |
| Grape Seed extract | Hepatic Fibrosis | 3 | PM | 22863721 | 📋 | Ameliorative effect of grape seed proanthocyanidin extract on thioacetamide-induced mouse hepatic fibrosis |
| Grape Seed extract | Hepatic Fibrosis | 2 | PM | 19891020 | 📋 | Antifibrotic Effects of Green Tea on in Vitro and in Vivo Models of Liver Fibrosis |
| Grape Seed extract | Hepatic Steatosis | 1 | PM | 34195217 | 📋 | Grape Polyphenols Attenuate Diet-Induced Obesity and Hepatic Steatosis in Mice in Association With Reduced Butyrate and Increased Markers of Intestinal Carbohydrate Oxidation |
| Grape Seed extract | Hepatitis A | 1 | PM | 32336357 | 📋 | Heat sensitization of hepatitis A virus and Tulane virus using grape seed extract, gingerol and curcumin |
| Grape Seed extract | Hepatitis C | 1 | PM | 28066241 | 📋 | Grape Seed Extract Attenuates Hepatitis C Virus Replication and Virus-Induced Inflammation |
| Grape Seed extract | Inflammatory Bowel Disease | 3 | PM | 38205677 | 📋 | Grape seed proanthocyanidin extract alleviates inflammation in experimental colitis mice by inhibiting NF-κB signaling pathway |
| Grape Seed extract | Inflammatory Bowel Disease | 2 | PM | 32189068 | 📋 | Protective Properties of Grape-Seed Proanthocyanidins in Human Ex Vivo Acute Colonic Dysfunction Induced by Dextran Sodium Sulfate |
| Grape Seed extract | Inflammatory Bowel Disease | 1 | PM | 23963706 | 📋 | Dietary Grape Seed Extract Ameliorates Symptoms of Inflammatory Bowel Disease in IL10-deficient Mice |
| Grape Seed extract | Intestinal Permeability | 1 | PM | 32492806 | 📋 | Proanthocyanidin-Rich Grape Seed Extract Reduces Inflammation and Oxidative Stress and Restores Tight Junction Barrier Function in Caco-2 Colon Cells |
| Grape Seed extract | Intestinal Permeability | 4 | PM | 28218448 | 📋 | Chronic supplementation with dietary proanthocyanidins protects from diet-induced intestinal alterations in obese rats |
| Grape Seed extract | Intestinal Permeability | 3 | PM | 23146776 | 📋 | Chronic administration of dietary grape seed extract increases colonic expression of gut tight junction protein occludin and reduces fecal calprotectin: a secondary analysis of healthy Wistar Furth rats |
| Grape Seed extract | Intestinal Permeability | 2 | PM | 21534629 | 📋 | Dietary grape-seed procyanidins decreased postweaning diarrhea by modulating intestinal permeability and suppressing oxidative stress in rats |
| Grape Seed extract | Irritable Bowel Syndrome | 1 | PM | 31689935 | 📋 | Grape Seed Extract Eliminates Visceral Allodynia and Colonic Hyperpermeability Induced by Repeated Water Avoidance Stress in Rats |
| Grape Seed extract | Liver Cancer | 2 | PM | 31817589 | 📋 | Grape Seed Proanthocyanidins Induce Autophagy and Modulate Survivin in HepG2 Cells and Inhibit Xenograft Tumor Growth in Vivo |
| Grape Seed extract | Liver Cancer | 1 | PM | 29352129 | 📋 | Molecular Characterization of the Grape Seeds Extract's Effect Against Chemically Induced Liver Cancer: In Vivo and in Vitro Analyses |
| Grape Seed extract | Liver Cancer | 3 | PM | 28747012 | 📋 | Immunohistochemical and biochemical alterations following administration of proanthocyanidin extract in rats hepatocellular carcinoma |
| Grape Seed extract | Liver Damage | 1 | PM | 35990272 | 📋 | Dietary Grape Seed Proanthocyanidin Alleviates the Liver Injury Induced by Long-Term High-Fat Diets in Sprague Dawley Rats |
| Grape Seed extract | Liver Damage | 6 | PM | 33851294 | 📋 | Grape seed extract ameliorated Ehrlich solid tumor-induced hepatic tissue and DNA damage with reduction of PCNA and P53 protein expression in mice |
| Grape Seed extract | Liver Disease | 1 | PM | 32815169 | 📋 | Proteomic analysis of liver mitochondria of db/db mice treated with grape seed procyanidin B2 |
| Grape Seed extract | MAFLD | 3 | PM | 38755622 | 📋 | The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study |
| Grape Seed extract | MAFLD | 2 | PM | 38419408 | 📋 | Grape seed extract supplementation in non-alcoholic fatty liver disease |
| Grape Seed extract | MAFLD | 1 | PM | 34403877 | 📋 | A botanical dietary supplement from white peony and licorice attenuates nonalcoholic fatty liver disease by modulating gut microbiota and reducing inflammation |
| Grape Seed extract | Nasopharyngeal Cancer | 1 | PM | 27277418 | 📋 | Grape seed proanthocyanidins induce apoptosis through the mitochondrial pathway in nasopharyngeal carcinoma CNE-2 cells |
| Grape Seed extract | Non-Alcoholic Steatohepatitis | 1 | PM | 33457418 | 📋 | Attenuation of Perfluorooctane Sulfonate-Induced Steatohepatitis by Grape Seed Proanthocyanidin Extract in Mice |
| Grape Seed extract | Oral Cancer | 2 | PM | 24243690 | 📋 | Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses |
| Grape Seed extract | Oral Cancer | 1 | PM | 23988171 | 📋 | Induction of Apoptosis by Grape Seed Extract (Vitis Vinifera) in Oral Squamous Cell Carcinoma |
| Grape Seed extract | Pancreatic Cancer | 2 | PM | 24325191 | 📋 | Gallic Acid Is an Active Component for the Anticarcinogenic Action of Grape Seed Procyanidins in Pancreatic Cancer Cells |
| Grape Seed extract | Pancreatic Cancer | 1 | PM | 22905202 | 📋 | Grape Proanthocyanidin Inhibit Pancreatic Cancer Cell Growth in Vitro and in Vivo Through Induction of Apoptosis and by Targeting the PI3K/Akt Pathway |
| Grape Seed extract | Pancreatic Cancer | 3 | PM | 22902508 | 📋 | Grape seed proanthocyanidins inhibit migration potential of pancreatic cancer cells by promoting mesenchymal-to-epithelial transition and targeting NF-κB |
| Grape Seed extract | Pancreatic Disorders | 2 | PM | 27847215 | 📋 | Grape seed and skin extract reduces pancreas lipotoxicity, oxidative stress and inflammation in high fat diet fed rats |
| Grape Seed extract | Pancreatic Disorders | 1 | PM | 27142746 | 📋 | Grape seed proanthocyanidins protects against cadmium induced oxidative pancreatitis in rats by attenuating oxidative stress, inflammation and apoptosis via Nrf-2/HO-1 signaling |
| Grape Seed extract | Scleroderma | 1 | PM | 12420739 | 📋 | Activin, a Grape Seed-Derived Proanthocyanidin Extract, Reduces Plasma Levels of Oxidative Stress and Adhesion Molecules (ICAM-1, VCAM-1 and E-selectin) in Systemic Sclerosis |
| Grape Seed extract | Tongue Cancer | 1 | PM | 29039443 | 📋 | Grape Seed Proanthocyanidins Inhibit the Proliferation, Migration and Invasion of Tongue Squamous Cell Carcinoma Cells Through Suppressing the Protein Kinase B/nuclear factor-κB Signaling Pathway |
| Grape Seed extract | Ulcerative Colitis | 6 | PM | 38205677 | 📋 | Grape seed proanthocyanidin extract alleviates inflammation in experimental colitis mice by inhibiting NF-κB signaling pathway |
| Grape Seed extract | Ulcerative Colitis | 4 | PM | 35692132 | 📋 | Protective Effects of Grape Seed Proanthocyanidin Extract in Preventing DSS Induced Ulcerative Colitis Based on Pharmacodynamic, Pharmacokinetic and Tissue Distribution |
| Grape Seed extract | Ulcerative Colitis | 2 | PM | 33042499 | 📋 | Protective Effect of Vitis vinifera (Black Grape) Seed Extract and Oil on Acetic Acid-Induced Colitis in Rats |
| Grape Seed extract | Ulcerative Colitis | 1 | PM | 32808642 | 📋 | Grape seed proanthocyanidin extract ameliorates dextran sulfate sodium-induced colitis through intestinal barrier improvement, oxidative stress reduction, and inflammatory cytokines and gut microbiota modulation |
| Grape Seed extract | Ulcerative Colitis | 3 | PM | 30862196 | 📋 | Combined Nutraceuticals: A Novel Approach to Colitis-Associated Colorectal Cancer? |
| Grape Seed extract | Ulcerative Colitis | 5 | PM | 23143736 | 📋 | Grape seed extract reduces the severity of selected disease markers in the proximal colon of dextran sulphate sodium-induced colitis in rats |
