| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| EGCG | Acute Liver Injury | 1 | PM | 36548773 | 📋 | Epigallocatechin Gallate and Glutathione Attenuate Aflatoxin B1-Induced Acute Liver Injury in Ducklings via Mitochondria-Mediated Apoptosis and the Nrf2 Signalling Pathway |
| EGCG | Acute Pancreatitis | 2 | PM | 35983712 | 📋 | Epigallocatechin-3-gallate reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis |
| EGCG | Acute Pancreatitis | 1 | PM | 34018522 | 📋 | Epigallocatechin-3-gallate attenuates acute pancreatitis induced lung injury by targeting mitochondrial reactive oxygen species triggered NLRP3 inflammasome activation |
| EGCG | Atrophic Gastritis | 1 | PM | 33628319 | 📋 | Epigallocatechin Gallate Protects against MNNG-Induced Precancerous Lesions of Gastric Carcinoma in Rats via PI3K/Akt/mTOR Pathway |
| EGCG | Biliary Tract Cancer | 2 | PM | 26100134 | 📋 | The Green Tea Catechin Epigallocatechin Gallate Induces Cell Cycle Arrest and Shows Potential Synergism With Cisplatin in Biliary Tract Cancer Cells |
| EGCG | Biliary Tract Cancer | 3 | PM | 24038588 | 📋 | Quercetin and EGCG exhibit chemopreventive effects in cholangiocarcinoma cells via suppression of JAK/STAT signaling pathway |
| EGCG | Biliary Tract Cancer | 1 | PM | 19226332 | 📋 | Epigallocatechin-gallate Modulates Chemotherapy-Induced Apoptosis in Human Cholangiocarcinoma Cells |
| EGCG | Binge Eating | 1 | PM | 27468160 | 📋 | Green Tea (-)-epigallocatechin-3-gallate Counteracts Daytime Overeating Induced by High-Fat Diet in Mice |
| EGCG | Cholestasis of Pregnancy | 1 | PM | 28477356 | 📋 | Epigallocatechin-3-gallate ameliorates intrahepatic cholestasis of pregnancy by inhibiting matrix metalloproteinase-2 and matrix metalloproteinase-9 |
| EGCG | Colitis | 1 | PM | 35779147 | 📋 | Green tea EGCG effectively alleviates experimental colitis in middle-aged male mice by attenuating multiple aspects of oxi-inflammatory stress and cell cycle deregulation |
| EGCG | Colon Cancer | 11 | PM | 36547087 | 📋 | Phosphodiesterase 5 Inhibitor Potentiates Epigallocatechin 3-O-Gallate-Induced Apoptotic Cell Death via Activation of the cGMP Signaling Pathway in Caco-2 Cells |
| EGCG | Colon Cancer | 10 | PM | 36174978 | 📋 | Epigallocatechin-3-gallate suppresses hemin-aggravated colon carcinogenesis through Nrf2-inhibited mitochondrial reactive oxygen species accumulation |
| EGCG | Colon Cancer | 9 | PM | 36112238 | 📋 | Epigallocatechin-3-gallate inhibits the formation of neutrophil extracellular traps and suppresses the migration and invasion of colon cancer cells by regulating STAT3/CXCL8 pathway |
| EGCG | Colon Cancer | 8 | PM | 35358581 | 📋 | Tetranectin targeting by epigallocatechin gallate suppresses colon cancer cell proliferation |
| EGCG | Colon Cancer | 7 | PM | 33754881 | 📋 | Amelioration of N,N'-dimethylhydrazine induced colon toxicity by epigallocatechin gallate in Wistar rats |
| EGCG | Colon Cancer | 6 | PM | 33617370 | 📋 | Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways |
| EGCG | Colon Cancer | 5 | PM | 33357777 | 📋 | Probing the chemoprevention potential of the antidepressant fluoxetine combined with epigallocatechin gallate or kaempferol in rats with induced early stage colon carcinogenesis |
| EGCG | Colon Cancer | 1 | PM | 27167203 | 📋 | Reduction in Promotor Methylation Utilizing EGCG (epigallocatechin-3-gallate) Restores RXRα Expression in Human Colon Cancer Cells |
| EGCG | Colon Cancer | 4 | PM | 26241688 | 📋 | Epigallocatechin Gallate Hinders Human Hepatoma and Colon Cancer Sphere Formation |
| EGCG | Colon Cancer | 15 | PM | 24359816 | 📋 | Antiproliferative activity of tea catechins associated with casein micelles, using HT29 colon cancer cells |
| EGCG | Colon Cancer | 14 | PM | 24324066 | 📋 | Green tea polyphenol epigallocatechin 3-gallate, contributes to the degradation of DNMT3A and HDAC3 in HCT 116 human colon cancer cells |
| EGCG | Colon Cancer | 12 | PM | 24256565 | 📋 | Impact of antioxidants on the ability of phenolic phytochemicals to kill HCT116 colon cancer cells |
| EGCG | Colon Cancer | 16 | PM | 24179522 | 📋 | Pro-apoptotic and migration-suppressing potential of EGCG, and the involvement of AMPK in the p53-mediated modulation of VEGF and MMP-9 expression |
| EGCG | Colon Cancer | 13 | PM | 23954321 | 📋 | Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells |
| EGCG | Colon Cancer | 2 | PM | 17571968 | 📋 | Comparison of White Tea, Green Tea, epigallocatechin-3-gallate, and Caffeine as Inhibitors of PhIP-induced Colonic Aberrant Crypts |
| EGCG | Colon Cancer | 3 | PM | 17487093 | 📋 | A Comparison of 5-fluorouracil and Natural Chemotherapeutic Agents, EGCG and Thymoquinone, Delivered by Sustained Drug Delivery on Colon Cancer Cells |
| EGCG | Colorectal Cancer | 22 | PM | 38189882 | 📋 | Dichotomic Role of Low-Concentration EGCG in the Oxaliplatin Sensitivity of Colorectal Cancer Cells |
| EGCG | Colorectal Cancer | 21 | PM | 37516013 | 📋 | NADPH oxidase 1: A target in the capacity of dimeric ECG and EGCG procyanidins to inhibit colorectal cancer cell invasion |
| EGCG | Colorectal Cancer | 18 | PM | 37168333 | 📋 | Improving the anti-tumor effect of EGCG in colorectal cancer cells by blocking EGCG-induced YAP activation |
| EGCG | Colorectal Cancer | 17 | PM | 36147440 | 📋 | EGCG Enhances the Chemosensitivity of Colorectal Cancer to Irinotecan through GRP78-MediatedEndoplasmic Reticulum Stress |
| EGCG | Colorectal Cancer | 16 | PM | 36009495 | 📋 | Plant-Derived Bioactive Compounds in Colorectal Cancer: Insights from Combined Regimens with Conventional Chemotherapy to Overcome Drug-Resistance |
| EGCG | Colorectal Cancer | 6 | PM | 35243817 | 📋 | Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells |
| EGCG | Colorectal Cancer | 15 | PM | 35029285 | 📋 | Epigallocatechin‑3‑gallate hinders metabolic coupling to suppress colorectal cancer malignancy through targeting aerobic glycolysis in cancer‑associated fibroblasts |
| EGCG | Colorectal Cancer | 14 | PM | 34495165 | 📋 | Enhancement of Annexin V in response to combination of epigallocatechin gallate and quercetin as a potent arrest the cell cycle of colorectal cancer |
| EGCG | Colorectal Cancer | 13 | PM | 34132471 | 📋 | EGCG synergizes the therapeutic effect of irinotecan through enhanced DNA damage in human colorectal cancer cells |
| EGCG | Colorectal Cancer | 12 | PM | 33747527 | 📋 | Tea polyphenol EGCG inhibited colorectal-cancer-cell proliferation and migration via downregulation of STAT3 |
| EGCG | Colorectal Cancer | 10 | PM | 32536775 | 📋 | Epigallocatechin Gallate Inhibits Dimethylhydrazine-Induced Colorectal Cancer in Rats |
| EGCG | Colorectal Cancer | 9 | PM | 32512070 | 📋 | Integrated Transcriptomic and Metabolomic Analyses to Characterize the Anti-Cancer Effects of (-)-epigallocatechin-3-gallate in Human Colon Cancer Cells |
| EGCG | Colorectal Cancer | 7 | PM | 32280356 | 📋 | Iron Chelation Properties of Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Analysis on Tfr/Fth Regulations and Molecular Docking |
| EGCG | Colorectal Cancer | 3 | PM | 29429153 | 📋 | Cancer Prevention With Green Tea and Its Principal Constituent, EGCG: From Early Investigations to Current Focus on Human Cancer Stem Cells |
| EGCG | Colorectal Cancer | 20 | PM | 29290650 | 📋 | Structural shift of gut microbiota during chemo-preventive effects of epigallocatechin gallate on colorectal carcinogenesis in mice |
| EGCG | Colorectal Cancer | 5 | PM | 28967875 | 📋 | Combination Curcumin and (-)-epigallocatechin-3-gallate Inhibits Colorectal Carcinoma Microenvironment-Induced Angiogenesis by JAK/STAT3/IL-8 Pathway |
| EGCG | Colorectal Cancer | 19 | PM | 28925507 | 📋 | (-)-Epigallocatechin-3-gallate and EZH2 inhibitor GSK343 have similar inhibitory effects and mechanisms of action on colorectal cancer cells |
| EGCG | Colorectal Cancer | 2 | PM | 26930714 | 📋 | Epigallocatechin-3-gallate Targets Cancer Stem-Like Cells and Enhances 5-fluorouracil Chemosensitivity in Colorectal Cancer |
| EGCG | Colorectal Cancer | 11 | PM | 24337301 | 📋 | (-)-Epigallocatechin-3-gallate suppresses liver metastasis of human colorectal cancer |
| EGCG | Colorectal Cancer | 4 | PM | 23741252 | 📋 | (-)-Epigallocatechin Gallate Inhibits the Expression of Indoleamine 2,3-dioxygenase in Human Colorectal Cancer Cells |
| EGCG | Colorectal Cancer | 1 | PM | 22566066 | 📋 | The Synergistic Apoptotic Interaction of Panaxadiol and Epigallocatechin Gallate in Human Colorectal Cancer Cells |
| EGCG | Colorectal Cancer | 8 | PM | 18407592 | 📋 | Prospective Cohort Comparison of Flavonoid Treatment in Patients With Resected Colorectal Cancer to Prevent Recurrence |
| EGCG | Dysbiosis | 8 | PM | 36218221 | 📋 | Epigallocatechin-3-gallate alleviates galactose-induced aging impairment via gut-brain communication |
| EGCG | Dysbiosis | 7 | PM | 36145133 | 📋 | Epigallocatechin-3-Gallate Improves Intestinal Gut Microbiota Homeostasis and Ameliorates Clostridioides difficile Infection |
| EGCG | Dysbiosis | 6 | PM | 35618244 | 📋 | Long-term consumption of green tea EGCG enhances murine healthspan by mitigating multiple aspects of cellular senescence in mitotic and post-mitotic tissues, gut dysbiosis, and immunosenescence |
| EGCG | Dysbiosis | 5 | PM | 33868268 | 📋 | Epigallocatechin Gallate Can Protect Mice From Acute Stress Induced by LPS While Stabilizing Gut Microbes and Serum Metabolites Levels |
| EGCG | Dysbiosis | 4 | PM | 33054538 | 📋 | Dietary Epigallocatechin-3-Gallate Alters the Gut Microbiota of Obese Diabetic db/db Mice: Lactobacillus Is a Putative Target |
| EGCG | Dysbiosis | 3 | PM | 32808768 | 📋 | The reciprocal interactions between epigallocatechin-3-gallate (EGCG) and human gut microbiota in vitro |
| EGCG | Dysbiosis | 2 | PM | 32801462 | 📋 | Epigallocatechin-3-gallate (EGCG) attenuates non-alcoholic fatty liver disease via modulating the interaction between gut microbiota and bile acids |
| EGCG | Dysbiosis | 1 | PM | 31379412 | 📋 | Green Tea Polyphenol (epigallocatechin-3-gallate) Improves Gut Dysbiosis and Serum Bile Acids Dysregulation in High-Fat Diet-Fed Mice |
| EGCG | Dysbiosis | 10 | PM | 29290650 | 📋 | Structural shift of gut microbiota during chemo-preventive effects of epigallocatechin gallate on colorectal carcinogenesis in mice |
| EGCG | Dysbiosis | 9 | PM | 28589947 | 📋 | Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women |
| EGCG | Esophageal Cancer | 5 | PM | 36497110 | 📋 | SERPINB2, an Early Responsive Gene to Epigallocatechin Gallate, Inhibits Migration and Promotes Apoptosis in Esophageal Cancer Cells |
| EGCG | Esophageal Cancer | 2 | PM | 34221057 | 📋 | Carboplatin and epigallocatechin-3-gallate synergistically induce cytotoxic effects in esophageal cancer cells |
| EGCG | Esophageal Cancer | 1 | PM | 30893904 | 📋 | Influence of Tea Consumption on the Development of Second Esophageal Neoplasm in Patients With Head and Neck Cancer |
| EGCG | Esophageal Cancer | 4 | PM | 28964574 | 📋 | Epigallocatechin-3-gallate Promotes Apoptosis and Reversal of Multidrug Resistance in Esophageal Cancer Cells |
| EGCG | Esophageal Cancer | 6 | PM | 28943954 | 📋 | Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis in Ec9706 and Eca109 esophageal carcinoma cells |
| EGCG | Esophageal Cancer | 3 | PM | 16140980 | 📋 | Mechanism of Action of (-)-epigallocatechin-3-gallate: Auto-Oxidation-Dependent Inactivation of Epidermal Growth Factor Receptor and Direct Effects on Growth Inhibition in Human Esophageal Cancer KYSE 150 Cells |
| EGCG | Gallstones | 1 | PM | 18374538 | 📋 | EGCG Reducing the Susceptibility to Cholesterol Gallstone Formation Through the Regulation of Inflammation |
| EGCG | Gastric Cancer | 9 | PM | 37537749 | 📋 | (-)-Epigallocatechin-3-gallate induced apoptosis by dissociation of c-FLIP/Ku70 complex in gastric cancer cells |
| EGCG | Gastric Cancer | 6 | PM | 33906321 | 📋 | Epigallocatechin Gallate Enhances Inhibition Effect of DDP on the Proliferation of Gastric Cancer BGC-823 Cells by Regulating p19Arf-p53-p21Cip1 Signaling Pathway |
| EGCG | Gastric Cancer | 5 | PM | 33628319 | 📋 | Epigallocatechin Gallate Protects against MNNG-Induced Precancerous Lesions of Gastric Carcinoma in Rats via PI3K/Akt/mTOR Pathway |
| EGCG | Gastric Cancer | 4 | PM | 32512188 | 📋 | Epigallocatechin Gallate Reverses Gemcitabine-Resistant Gastric Cancer by Regulating the Long Noncoding RNA LINC00511/miR-29b/KDM2A Axis |
| EGCG | Gastric Cancer | 2 | PM | 29137307 | 📋 | Reversal of 5-fluorouracil Resistance by EGCG Is Mediate by Inactivation of TFAP2A/VEGF Signaling Pathway and Down-Regulation of MDR-1 and P-gp Expression in Gastric Cancer |
| EGCG | Gastric Cancer | 1 | PM | 27338284 | 📋 | Inhibition of Green Tea Polyphenol EGCG((-)-epigallocatechin-3-gallate) on the Proliferation of Gastric Cancer Cells by Suppressing Canonical Wnt/β-Catenin Signalling Pathway |
| EGCG | Gastric Cancer | 8 | PM | 23900621 | 📋 | Regulation of Id1 expression by epigallocatechin‑3‑gallate and its effect on the proliferation and apoptosis of poorly differentiated AGS gastric cancer cells |
| EGCG | Gastric Cancer | 7 | PM | 23884787 | 📋 | Epigallocatechin-3-gallate regulates the expression of Kruppel-like factor 4 through myocyte enhancer factor 2A |
| EGCG | Gastric Cancer | 3 | PM | 20506079 | 📋 | Green and Black Tea Inhibit Cytokine-Induced IL-8 Production and Secretion in AGS Gastric Cancer Cells via Inhibition of NF-κB Activity |
| EGCG | Gastrointestinal Cancer | 1 | PM | 19770581 | 📋 | Green Tea (-)-epigalocatechin-3-gallate Inhibits KIT Activity and Causes Caspase-Dependent Cell Death in Gastrointestinal Stromal Tumor Including Imatinib-Resistant Cells |
| EGCG | Helicobacter Pylori Infection | 1 | PM | 33585739 | 📋 | Epigallocatechin Gallate with Potent Anti- Helicobacter pylori Activity Binds Efficiently to Its Histone-like DNA Binding Protein |
| EGCG | Hepatic Encephalopathy | 1 | PM | 36573265 | 📋 | Green Tea Catechin EGCG Ameliorates Thioacetamide-Induced Hepatic Encephalopathy in Rats via Modulation of the Microbiota-Gut-Liver Axis |
| EGCG | Hepatic Fibrosis | 10 | PM | 38146662 | 📋 | Epigallocatechin-3-gallate attenuates arsenic-induced fibrogenic changes in human kidney epithelial cells through reversal of epigenetic aberrations and antioxidant activities |
| EGCG | Hepatic Fibrosis | 6 | PM | 37122751 | 📋 | Inhibition of macrophages inflammasome activation via autophagic degradation of HMGB1 by EGCG ameliorates HBV-induced liver injury and fibrosis |
| EGCG | Hepatic Fibrosis | 5 | PM | 35594711 | 📋 | Epigallocatechin-3-gallate inhibits osteopontin expression and prevents experimentally induced hepatic fibrosis |
| EGCG | Hepatic Fibrosis | 4 | PM | 35586925 | 📋 | Protective effects of epigallocatechin-3-o-gallate combined with organic selenium against transforming growth factor-beta 1-induced fibrosis in LX-2 cells |
| EGCG | Hepatic Fibrosis | 3 | PM | 32253266 | 📋 | Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma |
| EGCG | Hepatic Fibrosis | 9 | PM | 28815679 | 📋 | (-)-Epigallocatechin-3-gallate and atorvastatin treatment down-regulates liver fibrosis-related genes in non-alcoholic fatty liver disease |
| EGCG | Hepatic Fibrosis | 2 | PM | 27935974 | 📋 | Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis |
| EGCG | Hepatic Fibrosis | 8 | PM | 24129183 | 📋 | Combined taurine, epigallocatechin gallate and genistein therapy reduces HSC-T6 cell proliferation and modulates the expression of fibrogenic factors |
| EGCG | Hepatic Fibrosis | 7 | PM | 23981577 | 📋 | Non-alcoholic steatohepatitis and preneoplastic lesions develop in the liver of obese and hypertensive rats: suppressing effects of EGCG on the development of liver lesions |
| EGCG | Hepatic Fibrosis | 1 | PM | 16682975 | 📋 | The Antifibrogenic Effect of (-)-Epigallocatechin Gallate Results From the Induction of De Novo Synthesis of Glutathione in Passaged Rat Hepatic Stellate Cells |
| EGCG | Hepatic Steatosis | 2 | PM | 38141939 | 📋 | Exploring the effects of epigallocatechin gallate on lipid metabolism in the rat steatotic liver during normothermic machine perfusion: Insights from lipidomics and RNA sequencing |
| EGCG | Hepatic Steatosis | 1 | PM | 18716169 | 📋 | The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice |
| EGCG | Hepatitis B | 3 | PM | 37122751 | 📋 | Inhibition of macrophages inflammasome activation via autophagic degradation of HMGB1 by EGCG ameliorates HBV-induced liver injury and fibrosis |
| EGCG | Hepatitis B | 2 | PM | 26968537 | 📋 | Epigallocatechin Gallate Inhibits Hepatitis B Virus via Farnesoid X Receptor Alpha |
| EGCG | Hepatitis B | 1 | PM | 25996297 | 📋 | Epigallocatechin-3-gallate Opposes HBV-induced Incomplete Autophagy by Enhancing Lysosomal Acidification, Which Is Unfavorable for HBV Replication |
| EGCG | Hepatitis C | 2 | PM | 30949812 | 📋 | Epigallocatechin Gallate (EGCG) and miR-548m Reduce HCV Entry Through Repression of CD81 Receptor in HCV Cell Models |
| EGCG | Hepatitis C | 1 | PM | 26202241 | 📋 | Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action |
| EGCG | Inflammatory Bowel Disease | 5 | PM | 38503153 | 📋 | Therapeutic effects of epigallocatechin-3-gallate for inflammatory bowel disease: A preclinical meta-analysis |
| EGCG | Inflammatory Bowel Disease | 6 | PM | 38003220 | 📋 | Effect of a Flavonoid Combination of Apigenin and Epigallocatechin-3-Gallate on Alleviating Intestinal Inflammation in Experimental Colitis Models |
| EGCG | Inflammatory Bowel Disease | 4 | PM | 37242530 | 📋 | The Potential of Epigallocatechin-3-gallate (EGCG) as Complementary Medicine for the Treatment of Inflammatory Bowel Disease |
| EGCG | Inflammatory Bowel Disease | 3 | PM | 34493333 | 📋 | Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis |
| EGCG | Inflammatory Bowel Disease | 1 | PM | 31362373 | 📋 | Low Dose Epigallocatechin Gallate Alleviates Experimental Colitis by Subduing Inflammatory Cells and Cytokines, and Improving Intestinal Permeability |
| EGCG | Inflammatory Bowel Disease | 2 | PM | 29723847 | 📋 | Epigallocatechin-3-Gallate Regulates Anti-Inflammatory Action Through 67-kDa Laminin Receptor-Mediated Tollip Signaling Induction in Lipopolysaccharide-Stimulated Human Intestinal Epithelial Cells |
| EGCG | Intestinal Injury | 1 | PM | 34730149 | 📋 | (-)-Epigallocatechin-3-gallate mitigates cyclophosphamide-induced intestinal injury by modulating the tight junctions, inflammation and dysbiosis in mice |
| EGCG | Intestinal Ischemia-Reperfusion | 1 | PM | 37621064 | 📋 | (-)-Epigallocatechin-3-gallate promotes intestinal epithelial proliferation and barrier function after ischemia/reperfusion injury via activation of Nurr1 |
| EGCG | Intestinal Metaplasia | 1 | PM | 33628319 | 📋 | Epigallocatechin Gallate Protects against MNNG-Induced Precancerous Lesions of Gastric Carcinoma in Rats via PI3K/Akt/mTOR Pathway |
| EGCG | Intestinal Permeability | 3 | PM | 37621064 | 📋 | (-)-Epigallocatechin-3-gallate promotes intestinal epithelial proliferation and barrier function after ischemia/reperfusion injury via activation of Nurr1 |
| EGCG | Intestinal Permeability | 2 | PM | 36752162 | 📋 | Chlorogenic acid combined with epigallocatechin-3-gallate mitigates D-galactose-induced gut aging in mice |
| EGCG | Intestinal Permeability | 1 | PM | 36145133 | 📋 | Epigallocatechin-3-Gallate Improves Intestinal Gut Microbiota Homeostasis and Ameliorates Clostridioides difficile Infection |
| EGCG | Liver Cancer | 16 | PM | 37292151 | 📋 | The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma |
| EGCG | Liver Cancer | 15 | PM | 36726605 | 📋 | Anti-angiogenic effect of the combination of low-dose sorafenib and EGCG in HCC-induced Wistar rats |
| EGCG | Liver Cancer | 14 | PM | 35792125 | 📋 | Epigallocatechin-3-gallate induced HepG2 cells apoptosis through ROS-Mediated AKT /JNK and p53 signaling pathway |
| EGCG | Liver Cancer | 13 | PM | 35051295 | 📋 | The Invasive Potential of Hepatoma Cells Induced by Radiotherapy is Related to the Activation of Stellate Cells and Could be Inhibited by EGCG Through the TLR4 Signaling Pathway |
| EGCG | Liver Cancer | 12 | PM | 33900350 | 📋 | Oral administration of EGCG solution equivalent to daily achievable dosages of regular tea drinkers effectively suppresses miR483-3p induced metastasis of hepatocellular carcinoma cells in mice |
| EGCG | Liver Cancer | 10 | PM | 33000276 | 📋 | Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A |
| EGCG | Liver Cancer | 2 | PM | 31934166 | 📋 | ERα36 Is an Effective Target of epigallocatechin-3-gallate in Hepatocellular Carcinoma |
| EGCG | Liver Cancer | 9 | PM | 31434088 | 📋 | Synergetic Effect of EP1 Receptor Antagonist and (-)-Epigallocatechin-3-gallate in Hepatocellular Carcinoma |
| EGCG | Liver Cancer | 7 | PM | 30858692 | 📋 | Epigallocatechin-3-gallate in the Prevention and Treatment of Hepatocellular Carcinoma: Experimental Findings and Translational Perspectives |
| EGCG | Liver Cancer | 20 | PM | 29095434 | 📋 | A new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells |
| EGCG | Liver Cancer | 22 | PM | 28977833 | 📋 | Unique synergistic formulation of curcumin, epicatechin gallate and resveratrol, tricurin, suppresses HPV E6, eliminates HPV+ cancer cells, and inhibits tumor progression |
| EGCG | Liver Cancer | 19 | PM | 28817968 | 📋 | Destabilizing the interplay between miR-1275 and IGF2BPs by Tamarix articulata and quercetin in hepatocellular carcinoma |
| EGCG | Liver Cancer | 8 | PM | 27349173 | 📋 | In Vitro and in Vivo Study of epigallocatechin-3-gallate-induced Apoptosis in Aerobic Glycolytic Hepatocellular Carcinoma Cells Involving Inhibition of Phosphofructokinase Activity |
| EGCG | Liver Cancer | 3 | PM | 27058323 | 📋 | Tea Polyphenols EGCG and TF Restrict Tongue and Liver Carcinogenesis Simultaneously Induced by N-nitrosodiethylamine in Mice |
| EGCG | Liver Cancer | 1 | PM | 26386739 | 📋 | Tea Polyphenols Epigallocatechin Gallete and Theaflavin Restrict Mouse Liver Carcinogenesis Through Modulation of Self-Renewal Wnt and Hedgehog Pathways |
| EGCG | Liver Cancer | 4 | PM | 26241688 | 📋 | Epigallocatechin Gallate Hinders Human Hepatoma and Colon Cancer Sphere Formation |
| EGCG | Liver Cancer | 5 | PM | 26189955 | 📋 | Green Tea Component epigallocatechin-3-gallate Decreases Expression of Osteopontin via a Decrease in mRNA Half-Life in Cell Lines of Metastatic Hepatocellular Carcinoma |
| EGCG | Liver Cancer | 21 | PM | 25674420 | 📋 | (-)-Epigallocatechin-3-gallate suppresses hepatic preneoplastic lesions developed in a novel rat model of non-alcoholic steatohepatitis |
| EGCG | Liver Cancer | 18 | PM | 23981577 | 📋 | Non-alcoholic steatohepatitis and preneoplastic lesions develop in the liver of obese and hypertensive rats: suppressing effects of EGCG on the development of liver lesions |
| EGCG | Liver Cancer | 17 | PM | 23863984 | 📋 | Anti-metastatic and differential effects on protein expression of epigallocatechin-3-gallate in HCCLM6 hepatocellular carcinoma cells |
| EGCG | Liver Cancer | 11 | PM | 21372039 | 📋 | Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice |
| EGCG | Liver Cancer | 6 | PM | 19558547 | 📋 | (-)-Epigallocatechin Gallate Suppresses the Growth of Human Hepatocellular Carcinoma Cells by Inhibiting Activation of the Vascular Endothelial Growth Factor-Vascular Endothelial Growth Factor Receptor Axis |
| EGCG | Liver Damage | 2 | PM | 36113316 | 📋 | Epigallocatechin-3-gallate ameliorates liver injury secondary to Pseudomonas aeruginosa pneumonia |
| EGCG | Liver Damage | 1 | PM | 32570121 | 📋 | Epigallocatechin-3-gallate Protects Immunity and Liver Drug-Metabolism Function in Mice Loaded With Restraint Stress |
| EGCG | MAFLD | 15 | PM | 38607257 | 📋 | Tea Polyphenol Epigallocatechin Gallate Protects Against Nonalcoholic Fatty Liver Disease and Associated Endotoxemia in Rats via Modulating Gut Microbiota Dysbiosis and Alleviating Intestinal Barrier Dysfunction and Related Inflammation |
| EGCG | MAFLD | 14 | PM | 37447347 | 📋 | Therapeutic Activity of Green Tea Epigallocatechin-3-Gallate on Metabolic Diseases and Non-Alcoholic Fatty Liver Diseases: The Current Updates |
| EGCG | MAFLD | 10 | PM | 37025486 | 📋 | Epigallocatechin gallate alleviates high-fat diet-induced hepatic lipotoxicity by targeting mitochondrial ROS-mediated ferroptosis |
| EGCG | MAFLD | 9 | PM | 35418153 | 📋 | Epigallocatechin-3-gallate ameliorates hepatic damages by relieve FGF21 resistance and promotion of FGF21-AMPK pathway in mice fed a high fat diet |
| EGCG | MAFLD | 8 | PM | 35323719 | 📋 | Salubrious Effects of Green Tea Catechins on Fatty Liver Disease: A Systematic Review |
| EGCG | MAFLD | 7 | PM | 35119232 | 📋 | Is it possible to treat nonalcoholic liver disease using a flavanol-based nutraceutical approach? Basic and clinical data |
| EGCG | MAFLD | 6 | PM | 34356308 | 📋 | Green Tea and Epigallocatechin Gallate (EGCG) for the Management of Nonalcoholic Fatty Liver Diseases (NAFLD): Insights into the Role of Oxidative Stress and Antioxidant Mechanism |
| EGCG | MAFLD | 5 | PM | 33953830 | 📋 | Epigallocatechin-3-Gallate Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via Inhibition of Apoptosis and Promotion of Autophagy through the ROS/MAPK Signaling Pathway |
| EGCG | MAFLD | 4 | PM | 33670347 | 📋 | Epigallocatechin-3-Gallate Dampens Non-Alcoholic Fatty Liver by Modulating Liver Function, Lipid Profile and Macrophage Polarization |
| EGCG | MAFLD | 3 | PM | 33095225 | 📋 | Green tea polyphenol epigallocatechin-3-gallate alleviates nonalcoholic fatty liver disease and ameliorates intestinal immunity in mice fed a high-fat diet |
| EGCG | MAFLD | 2 | PM | 32801462 | 📋 | Epigallocatechin-3-gallate (EGCG) attenuates non-alcoholic fatty liver disease via modulating the interaction between gut microbiota and bile acids |
| EGCG | MAFLD | 1 | PM | 32281563 | 📋 | Epigallocatechin Gallate Suppresses Inflammatory Responses by Inhibiting Toll-like Receptor 4 Signaling and Alleviates Insulin Resistance in the Livers of High-fat-diet Rats |
| EGCG | MAFLD | 12 | PM | 28815679 | 📋 | (-)-Epigallocatechin-3-gallate and atorvastatin treatment down-regulates liver fibrosis-related genes in non-alcoholic fatty liver disease |
| EGCG | MAFLD | 13 | PM | 28799714 | 📋 | Potential Biological Effects of (-)-Epigallocatechin-3-gallate on the Treatment of Nonalcoholic Fatty Liver Disease |
| EGCG | MAFLD | 11 | PM | 23515587 | 📋 | Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways |
| EGCG | Nasopharyngeal Cancer | 6 | PM | 35548580 | 📋 | EGCG Inhibits Proliferation and Induces Apoptosis Through Downregulation of SIRT1 in Nasopharyngeal Carcinoma Cells |
| EGCG | Nasopharyngeal Cancer | 4 | PM | 32326395 | 📋 | Involvement of MicroRNA-296 in the Inhibitory Effect of Epigallocatechin Gallate Against the Migratory Properties of Anoikis-Resistant Nasopharyngeal Carcinoma Cells |
| EGCG | Nasopharyngeal Cancer | 3 | PM | 31012106 | 📋 | Epigallocatechin-3-gallate Inhibits Migration of Human Nasopharyngeal Carcinoma Cells by Repressing MMP-2 Expression |
| EGCG | Nasopharyngeal Cancer | 1 | PM | 25625511 | 📋 | EGCG Inhibits Proliferation, Invasiveness and Tumor Growth by Up-Regulation of Adhesion Molecules, Suppression of Gelatinases Activity, and Induction of Apoptosis in Nasopharyngeal Carcinoma Cells |
| EGCG | Nasopharyngeal Cancer | 2 | PM | 23110507 | 📋 | Epigallocathechin Gallate, Polyphenol Present in Green Tea, Inhibits Stem-Like Characteristics and Epithelial-Mesenchymal Transition in Nasopharyngeal Cancer Cell Lines |
| EGCG | Nasopharyngeal Cancer | 5 | PM | 15355641 | 📋 | [Epigallocatechin-3-gallate interferes with EBV-encoding AP-1 signal transduction pathway] |
| EGCG | Non-Alcoholic Steatohepatitis | 3 | PM | 34881283 | 📋 | Caffeine and EGCG Alleviate High-Trans Fatty Acid and High-Carbohydrate Diet-Induced NASH in Mice: Commonality and Specificity |
| EGCG | Non-Alcoholic Steatohepatitis | 2 | PM | 32875214 | 📋 | Epigallocatechin Gallate Protects Mice against Methionine-Choline-Deficient-Diet-Induced Nonalcoholic Steatohepatitis by Improving Gut Microbiota To Attenuate Hepatic Injury and Regulate Metabolism |
| EGCG | Non-Alcoholic Steatohepatitis | 1 | PM | 32688217 | 📋 | Epigallocatechin gallate but not catechin prevents nonalcoholic steatohepatitis in mice similar to green tea extract while differentially affecting the gut microbiota |
| EGCG | Non-Alcoholic Steatohepatitis | 5 | PM | 25674420 | 📋 | (-)-Epigallocatechin-3-gallate suppresses hepatic preneoplastic lesions developed in a novel rat model of non-alcoholic steatohepatitis |
| EGCG | Non-Alcoholic Steatohepatitis | 4 | PM | 23981577 | 📋 | Non-alcoholic steatohepatitis and preneoplastic lesions develop in the liver of obese and hypertensive rats: suppressing effects of EGCG on the development of liver lesions |
| EGCG | Oral and Dental Health | 1 | PM | 37867423 | 📋 | Epigallocatechin gallate (EGCG) alleviates the inflammatory response and recovers oral microbiota in acetic acid-induced oral inflammation mice |
| EGCG | Oral Cancer | 10 | PM | 37354753 | 📋 | Molecular mechanisms underlying the epigallocatechin-3-gallate-mediated inhibition of oral squamous cell carcinogenesis |
| EGCG | Oral Cancer | 7 | PM | 33930649 | 📋 | A green tea extract and epigallocatechin-3-gallate attenuate the deleterious effects of irinotecan in an oral epithelial cell model |
| EGCG | Oral Cancer | 5 | PM | 32957726 | 📋 | Natural Compounds Modulate Drug Transporter Mediated Oral Cancer Treatment |
| EGCG | Oral Cancer | 4 | PM | 32475087 | 📋 | Epigallocatechin-3-gallate Sensitises Multidrug-Resistant Oral Carcinoma Xenografts to Vincristine Sulphate |
| EGCG | Oral Cancer | 2 | PM | 31188490 | 📋 | Functional and Molecular Effects of a Green Tea Constituent on Oral Cancer Cells |
| EGCG | Oral Cancer | 6 | PM | 28641180 | 📋 | Potential chemotherapeutic effects of diosgenin, zoledronic acid and epigallocatechin-3-gallate on PE/CA-PJ15 oral squamous cancer cell line |
| EGCG | Oral Cancer | 1 | PM | 27200496 | 📋 | Epigallocatechin Gallate Sensitizes Cisplatin-Resistant Oral Cancer CAR Cell Apoptosis and Autophagy Through Stimulating AKT/STAT3 Pathway and Suppressing Multidrug Resistance 1 Signaling |
| EGCG | Oral Cancer | 9 | PM | 24249144 | 📋 | The role of the mitochondrial oxidative stress in the cytotoxic effects of the green tea catechin, (-)-epigallocatechin-3-gallate, in oral cells |
| EGCG | Oral Cancer | 8 | PM | 23707351 | 📋 | Epigallocatechin-3 gallate inhibits cancer invasion by repressing functional invadopodia formation in oral squamous cell carcinoma |
| EGCG | Oral Cancer | 3 | PM | 9525275 | 📋 | Quantitation of Chemopreventive Synergism Between (-)-epigallocatechin-3-gallate and Curcumin in Normal, Premalignant and Malignant Human Oral Epithelial Cells |
| EGCG | Pancreatic Cancer | 13 | PM | 36867109 | 📋 | Epigallocatechin-3-Gallate Decreases Hypoxia-Inducible Factor-1 in Pancreatic Cancer Cells |
| EGCG | Pancreatic Cancer | 11 | PM | 36712528 | 📋 | Targeting a transcription factor NF-κB by green tea catechins using in silico and in vitro studies in pancreatic cancer |
| EGCG | Pancreatic Cancer | 12 | PM | 36698691 | 📋 | Effect of Sodium Butyrate and Epigallocatechin-3-Gallate on the Genes Expression of Intrinsic Apoptotic Pathway on PA-TU-8902, CFPAC-1, and CAPAN-1 Human Pancreatic Cancer Cell Lines: Epi-drugs and Intrinsic Apoptotic Pathway in Pancreatic Cancer |
| EGCG | Pancreatic Cancer | 1 | PM | 31590367 | 📋 | Targeting Glycolysis With Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts |
| EGCG | Pancreatic Cancer | 5 | PM | 31405071 | 📋 | Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration Partly Through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy When Combined With Gemcitabine |
| EGCG | Pancreatic Cancer | 14 | PM | 29186186 | 📋 | Application of non-invasive low strength pulsed electric field to EGCG treatment synergistically enhanced the inhibition effect on PANC-1 cells |
| EGCG | Pancreatic Cancer | 6 | PM | 26246802 | 📋 | Metabolic Consequences of LDHA Inhibition by Epigallocatechin Gallate and Oxamate in MIA PaCa-2 Pancreatic Cancer Cells |
| EGCG | Pancreatic Cancer | 9 | PM | 25017900 | 📋 | Sulforaphane, Quercetin and Catechins Complement Each Other in Elimination of Advanced Pancreatic Cancer by miR-let-7 Induction and K-ras Inhibition |
| EGCG | Pancreatic Cancer | 3 | PM | 23135610 | 📋 | (-)-Epigallocatechin 3-gallate Inhibits Invasion by Inducing the Expression of Raf Kinase Inhibitor Protein in AsPC‑1 Human Pancreatic Adenocarcinoma Cells Through the Modulation of Histone Deacetylase Activity |
| EGCG | Pancreatic Cancer | 10 | PM | 22583593 | 📋 | Inhibitory effects of (-)-epigallocatechin-3-gallate and pterostilbene on pancreatic cancer growth in vitro |
| EGCG | Pancreatic Cancer | 7 | PM | 19438225 | 📋 | (-)-Epigallocatechin-3-gallate Inhibits Hsp90 Function by Impairing Hsp90 Association With Cochaperones in Pancreatic Cancer Cell Line Mia Paca-2 |
| EGCG | Pancreatic Cancer | 8 | PM | 19082499 | 📋 | Combinatorial Effect of epigallocatechin-3-gallate and TRAIL on Pancreatic Cancer Cell Death |
| EGCG | Pancreatic Cancer | 2 | PM | 17981559 | 📋 | EGCG Inhibits Growth, Invasion, Angiogenesis and Metastasis of Pancreatic Cancer |
| EGCG | Pancreatic Cancer | 4 | PM | 16817635 | 📋 | Effects of (-)Epigallocatechin Gallate and Thymoquinone on Proliferation of a PANC-1 Cell Line in Culture |
| EGCG | Tongue Cancer | 3 | PM | 34407449 | 📋 | EGCG inhibits growth of tumoral lesions on lip and tongue of K-Ras transgenic mice through the Notch pathway |
| EGCG | Tongue Cancer | 2 | PM | 33396696 | 📋 | AG-9, an Elastin-Derived Peptide, Increases In Vitro Oral Tongue Carcinoma Cell Invasion, through an Increase in MMP-2 Secretion and MT1-MMP Expression, in a RPSA-Dependent Manner |
| EGCG | Tongue Cancer | 1 | PM | 27058323 | 📋 | Tea Polyphenols EGCG and TF Restrict Tongue and Liver Carcinogenesis Simultaneously Induced by N-nitrosodiethylamine in Mice |
| EGCG | Ulcerative Colitis | 2 | PM | 28929216 | 📋 | Refractory pouchitis improves after administration of the green tea polyphenol EGCG: a retrospective review |
| EGCG | Ulcerative Colitis | 1 | PM | 23846486 | 📋 | A pilot study to evaluate the safety and efficacy of an oral dose of (-)-epigallocatechin-3-gallate-rich polyphenon E in patients with mild to moderate ulcerative colitis |
| EGCG | Ulcerative Colitis | 3 | PM | 23761791 | 📋 | Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in Colitis Models |
